Πέμπτη 21 Μαΐου 2020

Medicina, Vol. 56, Pages 248: Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review

Medicina, Vol. 56, Pages 248: Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review:

Medicina, Vol. 56, Pages 248: Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review

Medicina doi: 10.3390/medicina56050248

Authors:
Sven Beckmann
Matthias S. Dettmer
Marco D. Caversaccio
Roland Giger
Lukas Anschuetz


Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Here, we describe an 87-year old female patient with a growing spherical mass in the right external auditory canal. After exclusive endoscopic tumor resection, a ceruminous pleomorphic adenoma was histologically diagnosed. Due to the absence of nuclear pleomorphism, no increased mitotic rate, no perineural invasion and no fusion transcripts of the MYB or MYBL1 gene loci, an adenoid cystic carcinoma could be excluded. The postoperative course was without any evidence of complications. A literature review identified 44 articles with 49 patients that were considered. Hearing loss and ear sensations were the most commonly reported symptoms. Most cases underwent an excision via an endaural or retroauricular approach. Recurrences were described in four patients, three of which had a malignant transformation.

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