Sialodochitis fibrinosa: salivary duct obstruction by eosinophil extracellular traps?

Sialodochitis fibrinosa: salivary duct obstruction by eosinophil extracellular traps?:

Abstract

Sialodochitis fibrinosa (also known as Kussmaul disease) was originally described by Kussmaul in 1879. This condition involves recurrent parotid grand swelling and mucus plugs containing leukocytes and Charcot–Leyden crystals (CLCs) (Ray et al., 2015) (Baer et al., 2017) (Flores et al., 2016). Sialodochitis fibrinosa also includes recurrent salivary gland swelling with fibrinous eosinophil‐rich mucus plugs. Although the disease is relatively rare, a recent review of Japanese and English literature revealed 59 previous cases (Baer et al., 2017). The authors of that review emphasised the major role of eosinophilic inflammation in sialodochitis fibrinosa and recommended redefinition of the disease as ‘eosinophilic sialodochitis’.