Objectives: Arteriovenous malformations (AVM) are the most troublesome vascular malformations to deal with. They tend to behave like low-grade malignancies with infiltrative and disruptive growth. Crucially, the clinical course of an AVM that has been improperly managed is usually characterized by a recurrence that is much more aggressive than the original disease. As in oncology, a comprehensive staging system is highly desirable and is to date lacking in the literature. The authors present...
Tue May 19, 2020 03:00
Objective: Tumors in the deep infratentorial region can be accessed via the supracerebellar-infratentorial (SCIT) or suboccipital-transcerebellar (SOTC) approaches in the sitting or prone position. Diagnosis of tumors in this region and review of their therapies are inseparably connected with cranial tomographic imaging. We retrospectively evaluate a cohort of patients who underwent tumor resection in this region and correlate complication rates to the literature, and evaluate the potential...
Tue May 19, 2020 03:00
The authors retrospectively examined 39 patients with head and neck reconstruction using a free-flap transfer with microsurgery in elderly patients aged over 80 years in our hospital. They investigated postoperative local complications, postoperative systemic complications, day of ambulation, the presence of delirium, the postoperative oral intake ratio, and the reconstructive method in mandibular reconstruction patients. There were 12 postoperative local complications. And postoperative systemic...
Tue May 19, 2020 03:00
The aim of this study was to evaluate the effectiveness of intra-articular injection of liquid platelet-rich fibrin (I-PRF) versus hyaluronic acid (HA) following arthrocentesis in patients suffering from temporomandibular joint (TMJ) pain and dysfunction. A total of 69 patients with internal TMJ derangement were enrolled in this retrospective, matched cohort study. A total of 47 included patients (67 joints) were divided into 3 groups as follows: 16 participants in the arthrocentesis-only group;...
Tue May 19, 2020 03:00
Background: Otoplasty remains an overlapping clinical domain of plastic surgery and otolaryngology. The purpose of this study is to objectively analyze the safety of otoplasty and determine if there are any risk factors, such as surgical training, associated with increased patient morbidity. Methods: Retrospective cohort study was conducted of otoplasty procedures performed in North America by plastic surgeons and otolaryngologists between 2012 and 2017 using the American College of...
Tue May 19, 2020 03:00
Purpose: Presentation about advantages of a new surgical technique in 20 patients with punctal occlusion with a venous catheter during punctoplasty. Methods: The arrangement of a 30-mm venous catheter used during puncoplasty surgery was performed in 10 patients with punctal occlusion. The venous catheter was removed after 15 to 45 days after surgery. Results: The use of the venous catheter supports the recanalization of the lacrimal drainage system 15 days after surgery. The...
Tue May 19, 2020 03:00
Objective: Paranasal sinus mucoceles are accumulation of mucoid secretions and desquamated epithelium within the sinus causing distension of its wall. They occur mostly in the frontal and ethmoid sinuses. Patients with giant frontal or ethmoidal sinus mucoceles suffer from orbital symptoms such as proptosis, visual disturbance, periorbital swelling, pain, or visual disturbance mostly, but they can also have rhinologic or neurologic symptoms. The purpose of this study is to evaluate the efficacy...
Tue May 19, 2020 03:00
For bimaxillary orthognathic surgery, a splint is commonly used to achieve the final occlusion and is then maintained through initial skeletal healing. The purpose of this study is to document how often a final splint is used to achieve the planned intraoperative occlusion, and how often is the final splint retained after surgery to maintain the occlusion during the initial skeletal healing phase. The investigators developed a retrospective case series. The study variables were demographic and...
Tue May 19, 2020 03:00
Background: The most prevalent form of facial bone fractures is nasal fractures. The surgical procedures used for these fractures are relatively simple, but complete correction is not easy because the nasal bone is small and identifying the fracture site by palpation is difficult. This study aimed to investigate the efficacy of intraoperative surgical navigation systems in nasal bone fracture surgery through a prospective analysis. Methods: Between February 2019 and July 2019, 25 navigation-assisted...
Tue May 19, 2020 03:00
The application of dexmedetomidine (precedex) in pediatric settings has increased due to its superior safety and efficacy profile and it has been specifically suggested as an adjunct to IV acetaminophen and a substitute for morphine in craniosynostosis repair. However, reports of its use in pediatrics, let alone in craniosynostosis repair, remain limited and to date there are no studies addressing its use after craniosynostosis repair in children. This study is an IRB-approved retrospective case...
Tue May 19, 2020 03:00
Three-dimensional (3D) printing and bioprinting is gaining lot of momentum, especially in surgical specialties. These two technologies have wide array of applications in presurgical, surgical, and in vitro scenarios. Bioprinting can generate customized patient specific tissue engineered from specialized cells. This technology can be a gold standard in reconstructive and regenerative surgeries, if used in regulated and ethical environment. This communication focuses on basics of these technologies,...
Tue May 19, 2020 03:00
There are patients with craniofacial deformity that can lead to extensive bone loss and severe disfigurement. Autologous reconstruction may be challenging in these patients, and it is usually associated with flap donor area morbidity and unfavorable aesthetic and functional results. A 51-year-old patient with human immunodeficiency virus infection, developed in the context of immunosuppression a fulminant fungal rhino-sinusitis with the need for surgical debridement, and in consequence extensive...
Tue May 19, 2020 03:00
Purpose: Trainee exposure to craniofacial pathology can be limited due to rare disease presentation, revealing a need for tools that assist in visualizing complex 3D pathologic anatomy. 3D-printed models show potential as a useful aid, allowing for physical manipulation and hands-on experience. This study investigates their educational value in teaching craniofacial pathology and surgical repair. Methods: Forty-four medical students randomly assigned to a control group or model group...
Tue May 19, 2020 03:00
Transformation of carbon dioxide to high value‐added chemicals becomes a significant challenge for clean energy study. Here we developed a stable and conductive covalent organic framework for electrocatalytic carbon dioxide reduction to carbon monoxide in aqueous solution. The cobalt(II) phthalocyanine catalysts are topologically connected via robust phenazine linkage into two‐dimensional tetragonal framework that is stable under boiling water, acid, or base conditions. The 2D lattice enables full...
Wed May 20, 2020 20:44
By harnessing a highly efficient metal‐catalysed tandem cycloaddition reaction as the key benzannulation step, a series of cyclopolyarene nanorings of varied sizes are obtained from poly(arylene‐butadiynylene) macrocyclic precursors, which can be synthesized relatively conveniently. Interestingly, due to the nonparallel bond connectivity of the repeat unit, unique Möbius topology is manifested by the cyclopolyarene nanorings composed of an odd number of repeat units, whereas cylindrical tubular structures...
Wed May 20, 2020 18:15
The aluminum (I) compound NacNacAl ( 1 ) shows diverse and substrate‐controlled reactivity in reactions with N ‐heterocycles. DMAP, a basic substrate in which the 4‐position is blocked, induces rearrangement of NacNacAl by shifting a hydrogen atom from the methyl group of the NacNac backbone to the aluminum center. In contrast, CH activation of the methyl group of 4‐picoline takes place to produce a species with a reactive terminal methylene. Reaction of 1 with 3,5‐lutidine results in the first...
Wed May 20, 2020 16:50
Dynamic combinatorial library (DCL) is a powerful tool for ligand discovery in biomedical research; however, the development of DCL has been hampered by its low diversity. Recently, the concept of DNA encoding has been employed in DCL to create DNA‐encoded dynamic libraries (DEDLs); however, all current DEDLs are limited to fragment identification, and a challenging process of fragment linking is required after selection. We report an anchor‐directed DEDL approach that can identify full ligand structures...
Wed May 20, 2020 16:48
Abstract: In this minireview, we describe synthetic polymers densely functionalized with sequence‐defined biomolecular sidechains. We focus on synthetic brush polymers of oligonucleotides, oligosaccharides, and oligopeptides, prepared via graft‐through polymerization from biomolecule functionalized monomers. The resulting structures are brush polymers wherein a biomolecular graft is positioned at each monomer backbone unit. We describe key synthetic milestones, identify synthetic opportunities,...
Wed May 20, 2020 16:47
The applications of the most promising Fe‐N‐C catalysts are prohibited by their limited intrinsic activity. Manipulating the Fe energy level through anchoring electron withdrawing ligands is found effective in boosting the catalytic performance. However, such regulation remains elusive as the ligands are only uncontrollably introduced owning to their energetically instable nature. Here we report a rational manipulation strategy for introducing axial bonded O to the Fe sites, attained through hexa‐coordinating...
Wed May 20, 2020 16:46
At the essence of developing Pt‐based single atom catalyst (SAC) for hydrogen evolution reaction (HER) is to prepare well‐defined and stable single Pt sites with desired electro‐catalytic efficacy. Herein, we report a facile approach to generate uniformly dispersed Pt sites with outstanding HER performance via photochemical reduction method using polyvinylpyrrolidone (PVP) molecules as the key addictive to significantly simplify synthesis routes and enhance the catalytic performance. The as‐prepared...
Wed May 20, 2020 16:46
Abstract Objective In this study, the clinical effect of negative pressure drainage assisted irrigation (NPDI) technique was evaluated in treating maxillofacial space infection (MSI) by comparing with traditional technique. Method A prospective study was conducted in 58 patients with MSI. The patients were randomly divided into two groups based on different treatment techniques. 30 patients receiving NPDI were included in NPDI group, and 28 patients receiving traditional technique were...
Tue May 19, 2020 21:59
Tue May 19, 2020 21:29
Abstract Objective To assess prognostic factors of patients with operable oral cavity squamous cell carcinoma (OSCC), focusing on the associations with smoking/alcohol exposure and age. Materials and Methods A total of 247 patients with OSCC who received curative surgery +/‐ adjuvant radiotherapy were analyzed. The patient subgroups were divided according to pretreatment smoking/alcohol exposure. Individuals aged 45‐year‐old or less were classified as younger patients. Results The...
Tue May 19, 2020 17:43
Abstract Objectives This study aimed to investigate the association between preoperative glycated hemoglobin (HbA1c) levels and the treatment outcomes of oral cavity squamous cell carcinoma (OSCC). Methods 358 OSCC patients were consecutively enrolled between July 2004 and July 2016. Clinicopathological parameters and survival outcomes were analyzed following HbA1c stratification of 6.5% (HbA1c≥ 6.5%: n = 74, 20.6%) and 7.0% (HbA1c ≥ 7.0%: n = 53, 14.8%). Results Higher HbA1c levels...
Tue May 19, 2020 13:43
Abstract On March 11th 2020, the World Health Organization (WHO) declared the coronavirus disease (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) as a pandemic. Until an effective treatment or a vaccine is developed, the current recommendations are to contain the disease, and control its transmission. It is now clear that the primary mode of SARS‐CoV‐2 transmission is aerosol/droplet spread, and by contacting virus contaminated surfaces acting as fomites (inanimate...
Tue May 19, 2020 12:00
Abstract Objective To identify the clinicopathological parameters that influence survival in patients with oral squamous cell carcinoma, in order to allow for the development of individualised surveillance programs and reduce the delay in diagnosis of recurrence. Materials and methods Retrospective chart review of 553 patients with a treatment‐naïve primary oral squamous cell carcinoma, who underwent primarily curative intended surgery. Exclusion criteria were neoadjuvant radio(chemo)therapy,...
Tue May 19, 2020 11:09
Single crystals of a super‐ and ferroelastic organic semiconductor were harnessed to fabricate ultraflexible single‐crystal electronic devices. At a strain greater than 13 %, the charge carrier mobility of the 6,13‐bis(triisopropylsilylethynyl)pentacene crystals remains above 70 % of that of the unstrained crystal because of mechanically induced cooperative structural transitions. Abstract Like silicon, single crystals of organic semiconductors are pursued to attain intrinsic charge transport...
Wed May 20, 2020 22:00
Two‐dimensional (2D) AA′n−1MnX3n+1 type halide perovskites incorporating straight chain symmetric diammonium cations define a new type of structure that holds potential of both highly efficient charge transport and high environmental stability. Unfortunately, their optoelectronic properties are largely unexplored and there is lack of high quality single crystals in large dimension for practical application. Here, we ventured into synthesizing centimeter‐sized AA′n−1MnX3n+1 type perovskite BDAPbI4...
Wed May 20, 2020 21:09
Photochromic systems with ultrahigh rate of thermal relaxation are highly desirable for development of new efficient photochromic oscillators. Based on DFT calculations, we designed a series of 5‐phenylazopyrimidines with strong push‐pull character in silico and observed very low energy barriers of thermal ( Z )‐to‐( E ) isomerization. The structure of the ( Z )‐isomer of the slowest derivative in the series was confirmed by NMR with in situ irradiation at low temperature. The substituents...
Wed May 20, 2020 19:14
The incorporation of highly active but also highly sensitive catalysts (e.g. the [FeFe] hydrogenase from Desulfovibrio desulfuricans ) in biofuel cells is still one of the major challenges in sustainable energy conversion. We report the fabrication of a dual gas diffusion electrode H 2 /O 2 biofuel cell equipped with a [FeFe] hydrogenase/polymer based high‐current density H 2 oxidation bioanode. The bioanodes show benchmark current densities of around 14 mA cm ‐2 and the corresponding...
Wed May 20, 2020 18:09
Capability to control macroscopic molecular properties with external stimuli offers the possibility to exploit molecules as switching devices of various types. However, application of such molecular‐level switching schemes has been often limited by its speed and thus efficiency. Here, we demonstrate the ultrafast, photoinduced polarization switching in the crystal of the [CrCo] dinuclear complex by ultrafast pump‐probe spectroscopy in the visible and mid‐infrared regions. Our data clearly show...
Wed May 20, 2020 17:48
Vicinal diamines are ubiquitous materials in organic and medicinal chemistry, and methods for their preparation are of relevance to a broad range of chemical applications. The direct coupling of olefin and amine building blocks would represent an ideal approach to construct these motifs. However, alkene diamination remains a long‐standing challenge in organic synthesis, especially when two different amine components need to be introduced. Here we report a general strategy for the direct and selective...
Wed May 20, 2020 17:46
Thanks to their intrinsic advantages, aggregation‐induced emission luminogens (AIEgens) have captivated the increasing global interest in an array of application fields. Whereas general synthetic methods towards AIEgens largely rely on tedious procedures and limited reaction types, in the related context, various innovative synthetic methodologies have emerged as complementary even alternative strategies. In this review, we systematically highlight the recent advancements on metal‐catalyzed functionalization...
Wed May 20, 2020 16:44
Aluminum‐ion batteries : Composite films of polyaniline/single‐walled carbon nanotubes (PANI/SWCNTs) are produced for use as electrodes in aluminum‐ion batteries (AIBs). The protonation of PANI in PANI/SWCNTs enables reversible AlCl2+ intercalation/de‐intercalation in an Al/PANI(H+) battery. PANI(H+)@SWCNT electrodes have a stable cycling life and owing to their mechanical stability, can also be used as electrodes of flexible AIBs. Abstract The reversible capacity of AlCl4− intercalation/de‐intercalation...
Wed May 20, 2020 16:29
Activatable photosensitizers (aPSs) possessing a benzothiadiazole fluorophore are designed for glutathione and hydrogen peroxide mutually responsive photodynamic therapy (PDT). Dual type 1 and type 2 photosensitizing pathway is available to generate multiple reactive oxygen species and counteract hypoxic environments. The mitochondria targeted aPS showed prominent antitumor effect by near infrared two‐photon PDT. Abstract Currently, photosensitizers (PSs) that are microenvironment responsive...
Wed May 20, 2020 16:29
An unusual skeletal reorganization of oxetanes is described, in which oxetane‐tethered anilines reacted unexpectedly to form 1,2‐dihydroquinolines in the presence of In(OTf)3 as catalyst. This process proceeds through an intriguing mechanism involving a series of bond cleavage and formation steps. Abstract Skeletal reorganization is a type of fascinating transformations owing to their intriguing mechanisms and utility in complex molecule synthesis. However, only a limited amount of examples...
Wed May 20, 2020 16:28
A series of racemic polypropionates with novel polycyclic skeletons were discovered and structurally elucidated from the South China Sea photosynthetic sacoglossan mollusk Placobranchus ocellatus . An array of new and diversity‐generating rearrangements is proposed to explain the biosynthesis of these unusual compounds. Furthermore, the successful biomimetic semisynthesis of ocellatusone A (1 ) confirmed the proposed rearrangement through an unprecedented acid induced cascade reaction. Abstract...
Wed May 20, 2020 16:28
W e report the design and preparation of multifunctional hybrid nanomaterials through the stabilization of gold nanoparticles with thiol‐functionalised hybrid organic‐inorganic polyoxometalates . The covalent attachment of the hybrid‐POM forms new nanocomposites which are stable at temperatures and pH values, which destroy analogous electrostatically‐functionalised nanocomposites. Photoelectrochemical analyses reveal the unique, cooperative photochemical and redox properties of these systems.
Wed May 20, 2020 15:14
Radio‐photoluminescence (RPL) materials display a distinct phenomenon of radiation induced permanent luminescence center, therefore finding critical applications in detection of ionizing radiation doses. The current inventory of RPL materials have been limited to a small range of metal ion doped inorganic materials with several demerits while old strategy for finding new RPL materials is serendipitous and challenging. Here we document the RPL property in a metal‐organic framework (MOF) for the first...
Wed May 20, 2020 15:14
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