Cells, Vol. 9, Pages 1186: TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response Cells doi: 10.3390/cells9051186 Authors: Sandra Pisonero-Vaquero Chiara Soldati Marcella Cesana Andrea Ballabio Diego Luis Medina The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional programs for autophagy and lysosome biogenesis have emerged as regulators of energy metabolism in cancer. Thus, their activation increases lysosomal catabolic function...
Sun May 10, 2020 03:00
Cells, Vol. 9, Pages 1185: Cellular Response to Vitamin C-Enriched Chitosan/Agarose Film with Potential Application as Artificial Skin Substitute for Chronic Wound Treatment Cells doi: 10.3390/cells9051185 Authors: Vladyslav Vivcharenko Michal Wojcik Agata Przekora The treatment of chronic wounds is still a meaningful challenge to physicians. The aim of this work was to produce vitamin C-enriched chitosan/agarose (CHN/A) film that could serve as potential artificial skin substitute...
Sun May 10, 2020 03:00
Cells, Vol. 9, Pages 1184: Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy Cells doi: 10.3390/cells9051184 Authors: Verena Kohler Andreas Aufschnaiter Sabrina Büttner In all eukaryotic cells, intracellular organization and spatial separation of incompatible biochemical processes is established by individual cellular subcompartments in form of membrane-bound organelles. Virtually all of these organelles are physically connected via membrane contact sites (MCS),...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1181: The Aging of γδ T Cells Cells doi: 10.3390/cells9051181 Authors: Weili Xu Zandrea Wan Xuan Lau Tamas Fulop Anis Larbi In the coming decades, many developed countries in the world are expecting the “greying” of their populations. This phenomenon poses unprecedented challenges to healthcare systems. Aging is one of the most important risk factors for infections and a myriad of diseases such as cancer, cardiovascular and neurodegenerative...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1183: Truncated Pneumolysin from Streptococcus pneumoniae as a TLR4-Antagonizing New Drug for Chronic Inflammatory Conditions Cells doi: 10.3390/cells9051183 Authors: Shun-Fu Chang Cheng-Nan Chen Jung-Chung Lin Hsin-Ell Wang Shigetarou Mori Jia-Je Li Chia-Kuang Yen Ching-Yun Hsu Chang-Phone Fung Pele Choi-Sing Chong Chih-Hsiang Leng Yi-Jun Ding Feng-Yee Chang L. Kristopher Siu Microbial proteins have recently been found to have...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1179: Functional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum Cells doi: 10.3390/cells9051179 Authors: Karow Fischer Meßling Konertz Riehl Xiong Rijal Wagle Clemen Eichinger Macroautophagy, a highly conserved and complex intracellular degradative pathway, involves more than 20 core autophagy (ATG) proteins, among them the hexameric ATG12~5/16 complex, which is part of the essential ubiquitin-like...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1180: Innovative Visualization and Quantification of Extracellular Vesicles Interaction with and Incorporation in Target Cells in 3D Microenvironments Cells doi: 10.3390/cells9051180 Authors: Enrico Ragni Silvia Palombella Silvia Lopa Giuseppe Talò Carlotta Perucca Orfei Paola De Luca Matteo Moretti Laura de Girolamo Extracellular vesicles (EVs) showed therapeutic properties in several applications, many in regenerative medicine. A clear example...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1178: Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model Cells doi: 10.3390/cells9051178 Authors: Yasuda Nagano Kobayashi Nishimura Asthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1182: Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold Cells doi: 10.3390/cells9051182 Authors: Kento Fujiwara Ayaka Tsunei Hotaka Kusabuka Erika Ogaki Masashi Tachibana Naoki Okada Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy and safe CAR-T cell therapy,...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1176: Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy Cells doi: 10.3390/cells9051176 Authors: Wei Wang Atif Zafar Mehrdad Rajaei Ruiwen Zhang The tumor suppressor p53 is believed to be the mostly studied molecule in modern biomedical research. Although p53 interacts with hundreds of molecules to exert its biological functions, there are only a few modulators regulating its expression and function, with murine double minute 2 (MDM2)...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1175: Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure Cells doi: 10.3390/cells9051175 Authors: Marlene Christina Nielsen Rasmus Hvidbjerg Gantzel Joan Clària Jonel Trebicka Holger Jon Møller Henning Grønbæk Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger receptors including CD163 and CD206, which are upregulated...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1177: Mitochondria in Health and Diseases Cells doi: 10.3390/cells9051177 Authors: Sabzali Javadov Andrey V. Kozlov Amadou K. S. Camara Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death. Mitochondria are engaged in the pathogenesis of human diseases and aging directly or indirectly through a broad...
Sat May 09, 2020 03:00
Cells, Vol. 9, Pages 1174: Creatine Kinase and Progression Rate in Amyotrophic Lateral Sclerosis Cells doi: 10.3390/cells9051174 Authors: Ceccanti Pozzilli Cambieri Libonati Onesti Frasca Fiorini Petrucci Garibaldi Palma Bendotti Fabbrizio Trolese Nardo Inghilleri Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1173: The Expression of microRNA in Adult Rat Heart with Isoproterenol-Induced Cardiac Hypertrophy Cells doi: 10.3390/cells9051173 Authors: Mailin Gan Shunhua Zhang Yuan Fan Ya Tan Zhixian Guo Lei Chen Lin Bai Dongmei Jiang Xiaoxia Hao Xuewei Li Linyuan Shen Li Zhu Cardiac hypertrophy is a common pathological condition and an independent risk factor that triggers cardiovascular morbidity. As an important epigenetic regulator, miRNA...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1172: Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes Cells doi: 10.3390/cells9051172 Authors: Stéphanie Maupetit-Mehouas Chantal Vaury Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However,...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1167: Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions Cells doi: 10.3390/cells9051167 Authors: Manjinder S. Cheema Katrina V. Good Bohyun Kim Heddy Soufari Connor O’Sullivan Melissa E. Freeman Gilda Stefanelli Ciro Rivera Casas Kristine E. Zengeler Andrew J. Kennedy Jose Maria Eirin Lopez Perry L. Howard Iva B. Zovkic Jeffrey Shabanowitz Deanna D. Dryhurst Donald F. Hunt...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1171: Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges Cells doi: 10.3390/cells9051171 Authors: Vadims Parfejevs Krizia Sagini Arturs Buss Kristine Sobolevska Alicia Llorente Una Riekstina Arturs Abols Adult stem cells (SCs) participate in tissue repair and homeostasis regulation. The relative ease of SC handling and their therapeutic effect has made of these cell popular candidates for cellular therapy....
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1169: Membrane Binding Promotes Annexin A2 Oligomerization Cells doi: 10.3390/cells9051169 Authors: Anna Lívia Linard Matos Sergej Kudruk Johanna Moratz Milena Heflik David Grill Bart Jan Ravoo Volker Gerke Annexin A2 (AnxA2) is a cytosolic Ca2+ regulated membrane binding protein that can induce lipid domain formation and plays a role in exocytosis and endocytosis. To better understand the mode of annexin-membrane interaction, we analyzed membrane-bound...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1170: Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca2+ Transport Cells doi: 10.3390/cells9051170 Authors: Tory M. Schaaf Evan Kleinboehl Samantha L. Yuen Lauren N. Roelike Bengt Svensson Andrew R. Thompson Razvan L. Cornea David D. Thomas We engineered a concatenated fluorescent biosensor and dual-wavelength fluorescence lifetime (FLT) detection, to perform high-throughput screening (HTS)...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1168: The β-Carboline Harmine Induces Actin Dynamic Remodeling and Abrogates the Malignant Phenotype in Tumorigenic Cells Cells doi: 10.3390/cells9051168 Authors: Ronan Le Moigne Frédéric Subra Manale Karam Christian Auclair Numerous studies have shown that alteration of actin remodeling plays a pivotal role in the regulation of morphologic and phenotypic changes leading to malignancy. In the present study, we searched for drugs that can regulate actin polymerization...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1164: Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives Cells doi: 10.3390/cells9051164 Authors: Flavia Lima Costa Faldoni Cláudia Aparecida Rainho Silvia Regina Rogatto Evidence has emerged implicating epigenetic alterations in inflammatory breast cancer (IBC) origin and progression. IBC is a rare and rapidly progressing disease, considered the most aggressive type of breast cancer (BC). At clinical presentation, IBC...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1165: Alpha Radiation as a Way to Target Heterochromatic and Gamma Radiation-Exposed Breast Cancer Cells Cells doi: 10.3390/cells9051165 Authors: Maja Svetličič Anton Bomhard Christoph Sterr Fabian Brückner Magdalena Płódowska Halina Lisowska Lovisa Lundholm Compact chromatin is linked to a poor tumour prognosis and resistance to radiotherapy from photons. We investigated DNA damage induction and repair in the context of chromatin structure for...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1166: RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment Cells doi: 10.3390/cells9051166 Authors: Alvaro Torres-Gomez Jose Luis Sanchez-Trincado Víctor Toribio Raul Torres-Ruiz Sandra Rodríguez-Perales María Yáñez-Mó Pedro A. Reche Carlos Cabañas Esther M. Lafuente The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1160: Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation Cells doi: 10.3390/cells9051160 Authors: Thoufiqul Alam Riaz Raghu Patil Junjappa Mallikarjun Handigund Jannatul Ferdous Hyung-Ryong Kim Han-Jung Chae Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1162: Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project Cells doi: 10.3390/cells9051162 Authors: Suzanne J. K. Mund Eiko Kawamura Awang Hazmi Awang-Junaidi John Campbell Bruce Wobeser Daniel J. MacPhee Ali Honaramooz Spencer Barber Limb wounds on horses are often slow to heal and are prone to developing exuberant...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1161: The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells Cells doi: 10.3390/cells9051161 Authors: Magdalena Cal Irwin Matyjaszczyk Ireneusz Litwin Daria Augustyniak Rafał Ogórek Young Ko Stanisław Ułaszewski 3-bromopyruvate (3-BP) is a small molecule with anticancer and antimicrobial activities. 3-BP is taken up selectively by cancer cells’ mono-carboxylate...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1159: Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation Cells doi: 10.3390/cells9051159 Authors: Marit Wiersma Denise M.S. van Marion Emma J. Bouman Jin Li Deli Zhang Kennedy S. Ramos Eva A.H. Lanters Natasja M.S. de Groot Bianca J.J.M. Brundel Atrial fibrillation (AF), the most common, progressive tachyarrhythmia is associated with serious complications, such as stroke and heart failure. Early...
Fri May 08, 2020 03:00
Cells, Vol. 9, Pages 1163: Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier For Regenerative Medicine? Cells doi: 10.3390/cells9051163 Authors: Maria Magdalena Barreca Patrizia Cancemi Fabiana Geraci Regenerative medicine aims to repair damaged, tissues or organs for the treatment of various diseases, which have been poorly managed with conventional drugs and medical procedures. To date, multimodal regenerative methods include transplant...
Fri May 08, 2020 03:00
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