IJMS, Vol. 21, Pages 3377: SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21093377 Authors: Prete Favoino Catacchio Racanelli Perosa The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3378: Gender-Related Approach to Kidney Cancer Management: Moving Forward International Journal of Molecular Sciences doi: 10.3390/ijms21093378 Authors: Mancini Righetto Baggio Men are more frequently diagnosed with kidney cancer than women, with a more aggressive histology, larger tumors, a higher grade and stage, and worse oncological outcomes. Smoking habits and sex steroid hormones seem to have a possible role in explaining these gender disparities....
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3373: SERS-Based Biosensors for Virus Determination with Oligonucleotides as Recognition Elements International Journal of Molecular Sciences doi: 10.3390/ijms21093373 Authors: Oganes Ambartsumyan Dmitry Gribanyov Vladimir Kukushkin Alexey Kopylov Elena Zavyalova Viral infections are among the main causes of morbidity and mortality of humans; sensitive and specific diagnostic methods for the rapid identification of viral pathogens are required. Surface-enhanced...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3374: Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome International Journal of Molecular Sciences doi: 10.3390/ijms21093374 Authors: Nuria Garrido-Pérez Ana Vela-Sebastián Ester López-Gallardo Sonia Emperador Eldris Iglesias Patricia Meade Cecilia Jiménez-Mallebrera Julio Montoya M. Pilar Bayona-Bafaluy Eduardo Ruiz-Pesini Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3372: On the Stability of Glutaraldehyde in Biocide Compositions International Journal of Molecular Sciences doi: 10.3390/ijms21093372 Authors: Alina Matei Cristina Puscas Iulia Patrascu Maria Lehene Julia Ziebro Florina Scurtu Monica Baia Dan Porumb Robert Totos Radu Silaghi-Dumitrescu Glutaraldehyde (GA) is used as biocide in hospitals. Recent public investigations on the chemical composition of biocides used in Romania have in some cases...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3376: The Conserved Effector UvHrip1 interacts with OsHGW, and Infection of Ustilaginoidea virens Regulates Defense- and Heading Date-Related Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21093376 Authors: Wei Wang Zhou Xiang Sun Peng Li Hai Wang Li Ustilaginoidea virens, which causes rice false smut (RFS), is one of the most detrimental rice fungal diseases and poses a severe threat to rice production...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3375: A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation International Journal of Molecular Sciences doi: 10.3390/ijms21093375 Authors: Bo Young Choi Jeong Hyun Jeong Jae-Won Eom Jae-Young Koh Yang-Hee Kim Sang Won Suh Previous studies in our lab revealed that chemical zinc chelation or zinc transporter 3 (ZnT3) gene deletion suppresses the clinical features and neuropathological...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3371: Actin Mutations and Their Role in Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093371 Authors: Francine Parker Thomas G. Baboolal Michelle Peckham Actin is a widely expressed protein found in almost all eukaryotic cells. In humans, there are six different genes, which encode specific actin isoforms. Disease-causing mutations have been described for each of these, most of which are missense. Analysis of the position of the resulting...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3370: Zinc and Copper Enhance Cucumber Tolerance to Fusaric Acid by Mediating Its Distribution and Toxicity and Modifying the Antioxidant System International Journal of Molecular Sciences doi: 10.3390/ijms21093370 Authors: Wang Huang Liang Wang Mur Wang Guo Fusaric acid (FA), the fungal toxin produced by Fusarium oxysporum, plays a predominant role in the virulence and symptom development of Fusarium wilt disease. As mineral nutrients can...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3369: Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates International Journal of Molecular Sciences doi: 10.3390/ijms21093369 Authors: Park Kang Lee Cells have developed elaborate quality-control mechanisms for proteins and organelles to maintain cellular homeostasis. Such quality-control mechanisms are maintained by conformational folding via molecular chaperones and by degradation through the ubiquitin-proteasome or autophagy-lysosome system....
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3368: Free Fatty Acid-Induced Peptide YY Expression Is Dependent on TG Synthesis Rate and Xbp1 Splicing International Journal of Molecular Sciences doi: 10.3390/ijms21093368 Authors: Paton Son Vaughan Cooper Gut-derived satiety hormones provide negative feedback to suppress food intake and maintain metabolic function in peripheral tissues. Despite the wealth of knowledge of the systemic effects of these hormones, very little is known concerning the mechanisms...
Sun May 10, 2020 03:00
IJMS, Vol. 21, Pages 3367: Systemic Dermatitis Model Mice Exhibit Atrophy of Visceral Adipose Tissue and Increase Stromal Cells via Skin-Derived Inflammatory Cytokines International Journal of Molecular Sciences doi: 10.3390/ijms21093367 Authors: Mizutani Shirakami Ichishi Matsushima Umaoka Okada Yamaguchi Watanabe Morita Yamanaka : Adipose tissue (AT) is the largest endocrine organ, producing bioactive products called adipocytokines, which regulate...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3366: Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation International Journal of Molecular Sciences doi: 10.3390/ijms21093366 Authors: Fu Lay Shibu Tseng Kuo Yang Wang Bharath Yeh Huang Although various advancements in radical surgery and neoadjuvant chemotherapy have been developed in treating osteosarcoma (OS), their clinical prognosis...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3365: Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice International Journal of Molecular Sciences doi: 10.3390/ijms21093365 Authors: Pham Tran Nguyen Le Nguyen Phan Yoneyama Ogita Yamaguchi Folk Yamaguchi Matsumoto Bacopa monnieri L. Wettst. (BM) is a botanical component of Ayurvedic medicines and of dietary supplements used...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3364: Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093364 Authors: Sara Salvador-Martín Irene Raposo-Gutiérrez Víctor Manuel Navas-López Carmen Gallego-Fernández Ana Moreno-Álvarez Alfonso Solar-Boga Rosana Muñoz-Codoceo Lorena Magallares Eva Martínez-Ojinaga María J. Fobelo Antonio Millán-Jiménez Alejandro Rodriguez-Martinez Concepción...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3362: Morphometric, Hemodynamic, and Multi-Omics Analyses in Heart Failure Rats with Preserved Ejection Fraction International Journal of Molecular Sciences doi: 10.3390/ijms21093362 Authors: Zhang Zhang Yao Li Niu Huo Tan (1) Background: There are no successive treatments for heart failure with preserved ejection fraction (HFpEF) because of complex interactions between environmental, histological, and genetic risk factors. The objective...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3360: Diagnostic and Prognostic Potential of Biomarkers CYFRA 21.1, ERCC1, p53, FGFR3 and TATI in Bladder Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21093360 Authors: Milena Matuszczak Maciej Salagierski The high occurrence of bladder cancer and its tendency to recur in combination with a lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3361: Genome-Wide Association and Prediction of Traits Related to Salt Tolerance in Autotetraploid Alfalfa (Medicago sativa L.) International Journal of Molecular Sciences doi: 10.3390/ijms21093361 Authors: Cesar Augusto Medina Charles Hawkins Xiang-Ping Liu Michael Peel Long-Xi Yu Soil salinity is a growing problem in world production agriculture. Continued improvement in crop salt tolerance will require the implementation of innovative breeding strategies...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3363: Mitochondria Targeting as an Effective Strategy for Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21093363 Authors: Ghosh Vidal Dey Zhang Mitochondria are well known for their role in ATP production and biosynthesis of macromolecules. Importantly, increasing experimental evidence points to the roles of mitochondrial bioenergetics, dynamics, and signaling in tumorigenesis. Recent studies have shown that many types of...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3359: Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning International Journal of Molecular Sciences doi: 10.3390/ijms21093359 Authors: Giricz Makkos Schreckenberg Pöling Lörchner Kiss Bencsik Braun Schulz Ferdinandy Schlüter Swiprosin-1 (EFhD2) is a molecule that triggers structural adaptation of isolated adult rat cardiomyocytes to cell culture conditions by initiating...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3356: Drought Stress Tolerance and Photosynthetic Activity of Alloplasmic Lines T. dicoccum x T. aestivum International Journal of Molecular Sciences doi: 10.3390/ijms21093356 Authors: Nina V. Terletskaya Andrey B. Shcherban Michail A. Nesterov Roman N. Perfil’ev Elena A. Salina Nazira A. Altayeva Irina V. Blavachinskaya Tetraploid species T. dicoccum Shuebl is a potential source of drought tolerance for cultivated wheat, including common wheat....
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3357: Correction: Al-Zamel, N., et al. A Dual GLP-1/GIP Receptor Agonist Does Not Antagonize Glucagon at Its Receptor but May Act as a Biased Agonist at the GLP-1 Receptor. Int. J. Mol. Sci. 2019, 20, 3532. International Journal of Molecular Sciences doi: 10.3390/ijms21093357 Authors: Noura Al-Zamel Suleiman Al-Sabah Yunus Luqmani Lobna Adi Siby Chacko Tom Dario Schneider Cornelius Krasel The author wishes to make the following correction to this...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3358: Recent Advances in Porphyrin-Based Inorganic Nanoparticles for Cancer Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21093358 Authors: Montaseri Kruger Abrahamse The application of porphyrins and their derivatives have been investigated extensively over the past years for phototherapy cancer treatment. Phototherapeutic Porphyrins have the ability to generate high levels of reactive oxygen with a low dark toxicity and these properties...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3355: The Protective Role of Bark and Bark Fibers of the Giant Sequoia (Sequoiadendron giganteum) during High-Energy Impacts International Journal of Molecular Sciences doi: 10.3390/ijms21093355 Authors: Georg Bold Max Langer Laura Börnert Thomas Speck The influences of (1) a high fiber content, (2) the arrangement of fibers in fiber groups, and (3) a layered hierarchical composition of the bark of the giant sequoia (Sequoiadendron giganteum) on its energy...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3354: Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery International Journal of Molecular Sciences doi: 10.3390/ijms21093354 Authors: Ryan D. Martin Terence E. Hébert Jason C. Tanny Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we review the molecular targets and mechanisms of action of these compounds, framing them within...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3353: Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21093353 Authors: Esposito D’Alonzo Fenza Gregorio Tamanini Lippi Dechecchi Guaragna Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide range of biological activities exhibited by these glycomimetics associated with their excellent drug profile make them attractive...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3351: Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21093351 Authors: Bela Papp Sophie Launay Pascal Gélébart Atousa Arbabian Agnes Enyedi Jean-Philippe Brouland Edgardo D. Carosella Homa Adle-Biassette Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3352: Influence of Innate Immunity on Cancer Cell Stemness International Journal of Molecular Sciences doi: 10.3390/ijms21093352 Authors: Anna Pastò Francesca Maria Consonni Antonio Sica Even if cancer stem cells (CSCs) represent only a small proportion of the tumor mass, they significantly account for tumor maintenance, resistance to therapies, relapse and metastatic spread, due to their increased capacity of self-renewal, multipotency, tumorigenicity and...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3349: Different Mechanisms of Action of Regorafenib and Lenvatinib on Toll-Like Receptor-Signaling Pathways in Human Hepatoma Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21093349 Authors: Reina Sasaki Tatsuo Kanda Mariko Fujisawa Naoki Matsumoto Ryota Masuzaki Masahiro Ogawa Shunichi Matsuoka Kazumichi Kuroda Mitsuhiko Moriyama Multiple kinase inhibitors are available for patients with advanced hepatocellular carcinoma...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3350: Preliminary Assessment of the Mucosal Toxicity of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis) Essential Oils on Novel Porcine Uterus Models International Journal of Molecular Sciences doi: 10.3390/ijms21093350 Authors: Martina Bertocchi Antonella Rigillo Alberto Elmi Domenico Ventrella Camilla Aniballi Diana G. Scorpio Maurizio Scozzoli Giuliano Bettini Monica Forni Maria Laura Bacci Antimicrobial resistance,...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3348: A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets International Journal of Molecular Sciences doi: 10.3390/ijms21093348 Authors: Dorota Formanowicz Agnieszka Rybarczyk Marcin Radom Piotr Formanowicz Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of...
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3347: The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens International Journal of Molecular Sciences doi: 10.3390/ijms21093347 Authors: Jose-Ignacio Rodriguez-Barbosa Pascal Schneider Luis Graca Leo Bühler Jose-Antonio Perez-Simon Maria-Luisa del Rio Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms....
Sat May 09, 2020 03:00
IJMS, Vol. 21, Pages 3346: Burden of Rare Variants in ALS and Axonal Hereditary Neuropathy Genes Influence Survival in ALS: Insights from a Next Generation Sequencing Study of an Italian ALS Cohort International Journal of Molecular Sciences doi: 10.3390/ijms21093346 Authors: Scarlino Domi Pozzi Romano Pipitone Falzone Mosca Penco Lunetta Sansone Tremolizzo Fazio Agosta Filippi Carrera Riva Quattrini Although the genetic...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3344: Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21093344 Authors: Cash Theus Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3343: A Synergistic Effect of Reactive Oxygen and Reactive Nitrogen Species in Plasma Activated Liquid Media Triggers Astrocyte Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms21093343 Authors: Sardella Mola Gristina Piccione Veronico Bellis Cibelli Buttiglione Armenise Favia Nicchia Astrocyte proliferation and migration toward injured Central Nervous System (CNS) areas are key features of astrogliosis...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3342: The p53–53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure International Journal of Molecular Sciences doi: 10.3390/ijms21093342 Authors: Pustovalova Alhaddad Smetanina Chigasova Blokhina Chuprov-Netochin Osipov Leonov Radiation therapy is one of the main methods of treating patients with non-small cell lung cancer...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3339: Myeloproliferative Diseases as Possible Risk Factor for Development of Chronic Thromboembolic Pulmonary Hypertension—A Genetic Study International Journal of Molecular Sciences doi: 10.3390/ijms21093339 Authors: Christina A. Eichstaedt Jeremias Verweyen Michael Halank Nicola Benjamin Christine Fischer Eckhard Mayer Stefan Guth Christoph B. Wiedenroth Benjamin Egenlauf Satenik Harutyunova Panagiota Xanthouli Alberto M. Marra Heinrike...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3345: An Immunological Glance on Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21093345 Authors: Melzer Arnold Stifter Zengerling Azoitei Seufferlein Bolenz Kleger Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Different factors such as mutational landscape, intra- and intertumoral heterogeneity, stroma, and immune cells impact carcinogenesis of PDAC associated with...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3341: Therapeutic Effect of Rapamycin on Aortic Dissection in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21093341 Authors: Makiko Hayashi-Hori Hiroki Aoki Miho Matsukuma Ryohei Majima Yohei Hashimoto Sohei Ito Saki Hirakata Norifumi Nishida Aya Furusho Satoko Ohno-Urabe Yoshihiro Fukumoto Aortic dissection (AD) is a serious clinical condition that is unpredictable and frequently results in fatal outcome. Although...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3340: 18F-FDG PET-Based Imaging of Myocardial Inflammation Following Acute Myocardial Infarction in a Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21093340 Authors: Praveen Vasudevan Ralf Gäbel Jan Stenzel Joanna Förster Jens Kurth Brigitte Vollmar Bernd Joachim Krause Hüseyin Ince Robert David Cajetan Immanuel Lang Cellular inflammation is an integral part of the healing process following acute myocardial infarction...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3327: Epigallocatechin Gallate Enhances MAL-PDT Cytotoxic Effect on PDT-Resistant Skin Cancer Squamous Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093327 Authors: Daniela León Kurt Buchegger Ramón Silva Ismael Riquelme Tamara Viscarra Bárbara Mora-Lagos Louise Zanella Fabiola Schafer Cristina Kurachi Juan Carlos Roa Carmen Ili Priscilla Brebi Photodynamic therapy (PDT) has been used to treat certain types...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3326: Biochemical Convergence of Mitochondrial Hsp70 System Specialized in Iron–Sulfur Cluster Biogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21093326 Authors: Malgorzata Kleczewska Aneta Grabinska Marcin Jelen Milena Stolarska Brenda Schilke Jaroslaw Marszalek Elizabeth A. Craig Rafal Dutkiewicz Mitochondria play a central role in the biogenesis of iron–sulfur cluster(s) (FeS), protein cofactors needed for...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3334: 14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity International Journal of Molecular Sciences doi: 10.3390/ijms21093334 Authors: Kerstin Duscha Cristina Martins Rodrigues Maria Müller Ruth Wartenberg Larry Fliegel Joachim W. Deitmer Martin Jung Richard Zimmermann H. Ekkehard Neuhaus The plasma membrane transporter SOS1 (SALT-OVERLY SENSITIVE1)...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3338: Resveratrol Induces Expression of Metabolic and Antioxidant Machinery and Protects Tilapia under Cold Stress International Journal of Molecular Sciences doi: 10.3390/ijms21093338 Authors: Min-Chen Wang Yu-Chun Wang Hui-Wen Peng Jinn-Rong Hseu Guan-Chung Wu Ching-Fong Chang Yung-Che Tseng Exposures to low ambient temperature require ectothermic fish to not only adjust their metabolic machinery but also to mount protective responses against...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3337: NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y2R Activation in Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093337 Authors: Jin Kim The inflammasomes are reported to be associated with tumor progression. In our previous study, we determined that extracellular ATP enhances invasion and tumor growth by inducing inflammasome activation in a P2Y purinergic receptor 2 (P2Y2R)-dependent manner....
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3335: Kandelia candel Thioredoxin f Confers Osmotic Stress Tolerance in Transgenic Tobacco International Journal of Molecular Sciences doi: 10.3390/ijms21093335 Authors: Jing Yao Ma Zhang Sun Xiang Hou Li Zhao Li Zhou Chen Water deficit caused by osmotic stress and drought limits crop yield and tree growth worldwide. Screening and identifying candidate genes from stress-resistant species are a genetic engineering strategy...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3336: Legume Genetics and Biology: From Mendel’s Pea to Legume Genomics International Journal of Molecular Sciences doi: 10.3390/ijms21093336 Authors: Smýkal Wettberg McPhee Legumes have played an important part in cropping systems since the dawn of agriculture, both as human food and as animal feed. The legume family is arguably one of the most abundantly domesticated crop plant families. Their ability to symbiotically fix nitrogen and improve soil fertility...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3333: MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor International Journal of Molecular Sciences doi: 10.3390/ijms21093333 Authors: Riganti Giampietro Kopecka Costamagna Abatematteo Contino Abate Multidrug resistance (MDR) is the main obstacle to current chemotherapy and it is mainly due to the overexpression of some efflux transporters such as...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3332: Polysaccharide-Based Injection Matrix for Serial Crystallography International Journal of Molecular Sciences doi: 10.3390/ijms21093332 Authors: Ki Hyun Nam Serial crystallography (SX) provides an opportunity to observe the molecular dynamics of macromolecular structures at room temperature via pump-probe studies. The delivery of crystals embedded in a viscous medium via an injector or syringe is widely performed in synchrotrons or X-ray free-electron laser...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3330: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity International Journal of Molecular Sciences doi: 10.3390/ijms21093330 Authors: Andrea Picchianti Diamanti Maria Manuela Rosado Claudio Pioli Giorgio Sesti Bruno Laganà On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2,...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3329: Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093329 Authors: Gu Han Periodontitis is known to be initiated by periodontal microbiota derived from biofilm formation. The microbial dysbiotic changes in the biofilm trigger the host immune and inflammatory responses that can be both beneficial for the protection of the host from infection, and detrimental...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3331: Immunomodulation in Cystic Fibrosis: Why and How? International Journal of Molecular Sciences doi: 10.3390/ijms21093331 Authors: Giacalone Dobosh Gaggar Tirouvanziam Margaroli Cystic fibrosis (CF) lung disease is characterized by unconventional mechanisms of inflammation, implicating a chronic immune response dominated by innate immune cells. Historically, therapeutic development has focused on the mutated cystic fibrosis transmembrane conductance...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3324: Small RNA and Transcriptome Sequencing Reveals miRNA Regulation of Floral Thermogenesis in Nelumbo nucifera International Journal of Molecular Sciences doi: 10.3390/ijms21093324 Authors: Yu Zou Guanglong Chen Jing Jin Ying Wang Meiling Xu Jing Peng Yi Ding The sacred lotus (Nelumbo nucifera Gaertn.) can produce heat autonomously and maintain a relatively stable floral chamber temperature for several days when blooming. Floral thermogenesis...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3328: Role of microRNA-21 and Its Underlying Mechanisms in Inflammatory Responses in Diabetic Wounds International Journal of Molecular Sciences doi: 10.3390/ijms21093328 Authors: Liechty Hu Zhang Liechty Xu A central feature of diabetic wounds is the persistence of chronic inflammation, which is partly due to the prolonged presence of pro-inflammatory (M1) macrophages in diabetic wounds. Persistence of the M1 macrophage phenotype and failure to...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3325: Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia International Journal of Molecular Sciences doi: 10.3390/ijms21093325 Authors: Olga Raducka-Jaszul Dżamila M. Bogusławska Natalia Jędruchniewicz Aleksander F. Sikorski Apoptosis is a process of programmed cell death which has an important role in tissue homeostasis and in the control of organism development. Here, we...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3323: Identification of Lenalidomide Sensitivity and Resistance Mechanisms in Non-Del(5q) Myelodysplastic Syndromes International Journal of Molecular Sciences doi: 10.3390/ijms21093323 Authors: Leylah M. Drusbosky Christopher R. Cogle Whereas lenalidomide is an effective therapy for del(5q) MDS patients, a minority of non-del(5q) MDS patients achieve hematologic improvement with lenalidomide. We used computational biology modeling and digital drug simulation...
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3322: Legumes Protease Inhibitors as Biopesticides and Their Defense Mechanisms against Biotic Factors International Journal of Molecular Sciences doi: 10.3390/ijms21093322 Authors: Lucio Rodríguez-Sifuentes Jolanta Elzbieta Marszalek Cristina Chuck-Hernández Sergio O. Serna-Saldívar Legumes are affected by biotic factors such as insects, molds, bacteria, and viruses. These plants can produce many different molecules in response to the attack of phytopathogens....
Fri May 08, 2020 03:00
IJMS, Vol. 21, Pages 3321: Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21093321 Authors: Wenjin Guo Juxiong Liu Wen Li He Ma Qian Gong Xingchi Kan Yu Cao Jianfa Wang Shoupeng Fu Mastitis is one of three bovine diseases recognized as a cause of substantial economic losses every year throughout the world. Niacin is an important feed additive that is used extensively...
Fri May 08, 2020 03:00
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