Antibiotics, Vol. 9, Pages 266: Examining Safety of Biocolourants from Fungal and Plant Sources-Examples from Cortinarius and Tapinella, Salix and Tanacetum spp. and Dyed Woollen Fabrics Antibiotics doi: 10.3390/antibiotics9050266 Authors: Räisänen Primetta Nikunen Honkalampi Nygren Pihlava Berghe Wright Biocolourants have been investigated as alternatives to synthetic dyes. However, natural origin per se is not a label of harmlessness and research is needed...
Wed May 20, 2020 03:00
Antibiotics, Vol. 9, Pages 267: In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains Antibiotics doi: 10.3390/antibiotics9050267 Authors: Nguyen Pinto Vu Lee Cho Byun D’Souza Yong This study investigates GT-1 (also known as LCB10-0200), a novel-siderophore cephalosporin, inhibited multidrug-resistant (MDR) Gram-negative...
Wed May 20, 2020 03:00
Antibiotics, Vol. 9, Pages 265: Infectious Disease and Primary Care Research—What English General Practitioners Say They Need Antibiotics doi: 10.3390/antibiotics9050265 Authors: Donna M. Lecky Steve Granier Rosalie Allison Neville Q. Verlander Simon M. Collin Cliodna A. M. McNulty Background: Infections are one of the most common reasons for patients attending primary care. Antimicrobial resistance (AMR) is perhaps one of the biggest threats to modern medicine; data show...
Wed May 20, 2020 03:00
Antibodies, Vol. 9, Pages 17: Combined Anti-Cancer Strategies Based on Anti-Checkpoint Inhibitor Antibodies Antibodies doi: 10.3390/antib9020017 Authors: Josée Golay Alain E. Andrea Therapeutic monoclonal antibodies for the treatment of cancer came of age in 1997, with the approval of anti-CD20 Rituximab. Since then, a wide variety of antibodies have been developed with many different formats and mechanisms of action. Among these, antibodies blocking immune checkpoint inhibitors (ICI)...
Wed May 20, 2020 03:00
Antioxidants, Vol. 9, Pages 443: Metabolite Profiling and Antioxidant Activity of 10 New Early- to Mid-Season Apple Cultivars and 14 Traditional Cultivars Antioxidants doi: 10.3390/antiox9050443 Authors: Kim Ku Jeong Kwon Lee Early- to mid-season apple cultivars have recently been developed in response to global warming; however, their metabolite compositions remain unclear. Herein, metabolites, such as free sugars, and organic acids and antioxidant activity were determined...
Wed May 20, 2020 03:00
Antioxidants, Vol. 9, Pages 442: Transcriptomic Evidence of Molecular Mechanisms Underlying the Response of Lactobacillus Plantarum WCFS1 to Hydroxytyrosol Antioxidants doi: 10.3390/antiox9050442 Authors: Reverón Plaza-Vinuesa Santamaría Oliveros Rivas Muñoz López de Felipe Abstract: This study was aimed to gain new insights into the molecular mechanisms used by Lactobacillus plantarum WCFS1 to respond to hydroxytyrosol (HXT), one of the main and health-relevant...
Wed May 20, 2020 03:00
Antioxidants, Vol. 9, Pages 441: Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All? Antioxidants doi: 10.3390/antiox9050441 Authors: Ema Valentina Brovč Stane Pajk Roman Šink Janez Mravljak Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species....
Wed May 20, 2020 03:00
Arts, Vol. 9, Pages 61: Disappearance on Display: Vanished Torah Arks in Medieval Synagogues and Their Presentation Arts doi: 10.3390/arts9020061 Authors: Stürzebecher In planning the museum in the medieval Synagogue in Erfurt more than 10 years ago, there was one big problem: the building had gone through many changes over the centuries, which wiped out almost all traces of the synagogue’s use. The Bimah was destroyed, presumably during the pogrom on 21 March 1349. By converting...
Wed May 20, 2020 03:00
Atmosphere, Vol. 11, Pages 528: Transcriptomics of Mature Rice (Oryza Sativa L. Koshihikari) Seed under Hot Conditions by DNA Microarray Analyses Atmosphere doi: 10.3390/atmos11050528 Authors: Ranjith Kumar Bakku Randeep Rakwal Junko Shibato Kyoungwon Cho Soshi Kikuchi Masami Yonekura Abhijit Sarkar Seiji Shioda Ganesh Kumar Agrawal Higher temperature conditions during the final stages of rice seed development (seed filling and maturation) are known to cause damage...
Wed May 20, 2020 03:00
Atmosphere, Vol. 11, Pages 527: Microbial Community Composition Analysis in Spring Aerosols at Urban and Remote Sites over the Tibetan Plateau Atmosphere doi: 10.3390/atmos11050527 Authors: Prakriti Sharma Ghimire Shichang Kang Wasim Sajjad Barkat Ali Lekhendra Tripathee Pengfei Chen This study presents features of airborne culturable bacteria and fungi from three different sites (Lanzhou; LZ; 1520 m ASL, Lhasa; LS; 3640 m ASL and Qomolangma; ZF; 4276 m ASL) representing...
Wed May 20, 2020 03:00
Atmosphere, Vol. 11, Pages 525: SSH-Aerosol v1.1: A Modular Box Model to Simulate the Evolution of Primary and Secondary Aerosols Atmosphere doi: 10.3390/atmos11050525 Authors: Karine Sartelet Florian Couvidat Zhizhao Wang Cédric Flageul Youngseob Kim Particles are emitted by different sources and are also formed in the atmosphere. Despite the large impact of atmospheric particles on health and climate, large uncertainties remain concerning their representation in models....
Wed May 20, 2020 03:00
Atmosphere, Vol. 11, Pages 526: Seasonal Asian Dust Forecasting Using GloSea5-ADAM Atmosphere doi: 10.3390/atmos11050526 Authors: Ryoo Sang-Boom Lim Yun-Kyu Park Young-San The springtime dust events in Northeast Asia pose many economic, social, and health-related risks. Statistical models in the forecasting of seasonal dust events do not fully account for environmental variations in dust sources due to climate change. The Korea Meteorological Administration (KMA) recently developed...
Wed May 20, 2020 03:00
Atmosphere, Vol. 11, Pages 524: The Record-Breaking High Temperature over Europe in June of 2019 Atmosphere doi: 10.3390/atmos11050524 Authors: Wei Zhao Ningfang Zhou Shangfeng Chen Observational and reanalysis data show that the surface air temperature (SAT) over most parts of Europe in June of 2019 broke the highest temperature on record. In this study, we investigate the factors for the formation of this record-breaking high temperature over Europe, focusing on the role of atmospheric...
Wed May 20, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 92: Eye Movements in Response to Pain-Related Feelings in the Presence of Low and High Cognitive Loads Behavioral Sciences doi: 10.3390/bs10050092 Authors: Zargari Marandi Fjelsted Hrustanovic Dan Olesen Gazerani The affective dimension of pain contributes to pain perception. Cognitive load may influence pain-related feelings. Eye tracking has proven useful for detecting cognitive load effects objectively by using relevant eye movement...
Wed May 20, 2020 03:00
Biology, Vol. 9, Pages 106: Evolution of Hemoglobin Genes in a Subterranean Rodent Species (Lasiopodomys mandarinus) Biology doi: 10.3390/biology9050106 Authors: Hong Sun Kaihong Ye Denghui Liu Dan Pan Shiming Gu Zhenlong Wang The Mandarin vole (Lasiopodomys mandarinus), a typical subterranean rodent, has undergone hematological adaptations to tolerate the hypoxic/hypercapnic underground environment. Hemoglobin (Hb) genes encode respiratory proteins functioning principally...
Wed May 20, 2020 03:00
Biology, Vol. 9, Pages 105: Period of Boar Ejaculate Collection Contributes to the Yearly Intra-Male Variability of Seminal Plasma Cytokines Biology doi: 10.3390/biology9050105 Authors: Lorena Padilla Xiomara Lucas Inmaculada Parrilla Cristina Perez-Patiño Heriberto Rodriguez-Martinez Jordi Roca Isabel Barranco The concentrations of cytokines in seminal plasma (SP) fluctuate over time in healthy males, weakening their practical usefulness as diagnostic tools. This study...
Wed May 20, 2020 03:00
Biomedicines, Vol. 8, Pages 128: Characterisation of a Novel A-Superfamily Conotoxin Biomedicines doi: 10.3390/biomedicines8050128 Authors: David T. Wilson Paramjit S. Bansal David A. Carter Irina Vetter Annette Nicke Sébastien Dutertre Norelle L. Daly Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their...
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 790: Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps Biomolecules doi: 10.3390/biom10050790 Authors: Carlos José Correia Santana Ana Carolina Martins Magalhães César Augusto Prías-Márquez Diego A. Falico Agenor C. M. dos Santos Júnior Beatriz D. Lima Carlos André Ornelas Ricart Denise Regina Bairros de Pilger Rafaela Milan Bonotto Carolina Borsoi Moraes...
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 794: Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids Biomolecules doi: 10.3390/biom10050794 Authors: Marco Aurelio Sartim Camila O. S. Souza Cassiano Ricardo A. F. Diniz Vanessa M. B. da Fonseca Lucas O. Sousa Ana Paula F. Peti Tassia Rafaella Costa Alan G. Lourenço Marcos C. Borges Carlos A. Sorgi Lucia Helena Faccioli Suely Vilela Sampaio Respiratory compromise...
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 792: Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor Biomolecules doi: 10.3390/biom10050792 Authors: Vieira Cavalli Gonçalves Braga Ferreira Santos Cola Raposo Capasso Dutra Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic...
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 793: Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Maintenance Association between Environmental Cues and Rewarding Properties of Ethanol in Rats Biomolecules doi: 10.3390/biom10050793 Authors: Marszalek-Grabska Gawel Matosiuk Gibula-Tarlowska Listos Kotlinska : Metabotropic glutamate subtype 5 (mGlu5) receptors are implicated in various forms of synaptic plasticity, including drugs of abuse....
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 791: The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives Biomolecules doi: 10.3390/biom10050791 Authors: Emiliano Panieri Pelin Telkoparan-Akillilar Sibel Suzen Luciano Saso The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic...
Wed May 20, 2020 03:00
Biomolecules, Vol. 10, Pages 789: MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy Biomolecules doi: 10.3390/biom10050789 Authors: Anas Shamsi Saleha Anwar Taj Mohammad Mohamed F. Alajmi Afzal Hussain Md. Tabish Rehman Gulam Mustafa Hasan Asimul Islam Md. Imtaiyaz Hassan Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer’s disease (AD) development as its overexpression...
Wed May 20, 2020 03:00
Brain Sciences, Vol. 10, Pages 309: Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder Brain Sciences doi: 10.3390/brainsci10050309 Authors: Ahmad Naqib Shuid Putri Ayu Jayusman Nazrun Shuid Juriza Ismail Norazlin Kamal Nor Naina Mohamed Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined, neurodevelopmental disorder that has been modeled as a brain-based disease. The behavioral and cognitive features of ASD are associated...
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1294: A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12051294 Authors: Toshio Fujisawa Takeshi Shimamura Kaku Goto Ryo Nakagawa Ryosuke Muroyama Yoshinori Ino Hajime Horiuchi Itaru Endo Shin Maeda Yasushi Harihara Atsushi Nakajima Nobuyuki Matsuhashi Naoya Kato Hiroyuki Isayama Ankit Puri...
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1292: Rho GTPases in Gynecologic Cancers: In-Depth Analysis toward the Paradigm Change from Reactive to Predictive, Preventive, and Personalized Medical Approach Benefiting the Patient and Healthcare Cancers doi: 10.3390/cancers12051292 Authors: Pavol Zubor Zuzana Dankova Zuzana Kolkova Veronika Holubekova Dusan Brany Sandra Mersakova Marek Samec Alena Liskova Lenka Koklesova Peter Kubatka Jan Bujnak Karol Kajo Milos Mlyncek Frank...
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1291: Venous Thromboembolism in Lymphoma: Risk Stratification and Antithrombotic Prophylaxis Cancers doi: 10.3390/cancers12051291 Authors: Stefan Hohaus Francesca Bartolomei Annarosa Cuccaro Elena Maiolo Eleonora Alma Francesco D’Alò Silvia Bellesi Elena Rossi Valerio De Stefano Lymphoma is listed among the neoplasias with a high risk of venous thromboembolism (VTE). Risk factors for VTE appear to differ from risk factors in solid tumors....
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1293: Common and Differential Traits of the Membrane Lipidome of Colon Cancer Cell Lines and their Secreted Vesicles: Impact on Studies Using Cell Lines Cancers doi: 10.3390/cancers12051293 Authors: Joan Bestard-Escalas Albert Maimó-Barceló Daniel H. Lopez Rebeca Reigada Francisca Guardiola-Serrano José Ramos-Vivas Thorsten Hornemann Toshiro Okazaki Gwendolyn Barceló-Coblijn Colorectal cancer (CRC) is the fourth leading cause of cancer...
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1290: Molecular Mechanisms Regulating Obesity-Associated Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051290 Authors: Yetirajam Rajesh Devanand Sarkar Obesity is a global, intractable issue, altering inflammatory and stress response pathways, and promoting tissue adiposity and tumorigenesis. Visceral fat accumulation is correlated with primary tumor recurrence, poor prognosis and chemotherapeutic resistance. Accumulating evidence highlights a close...
Wed May 20, 2020 03:00
Cancers, Vol. 12, Pages 1289: Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer Cancers doi: 10.3390/cancers12051289 Authors: Maisa Pinheiro Fernanda Cristina Sulla Lupinacci Karina Miranda Santiago Sandra Aparecida Drigo Fabio Albuquerque Marchi Carlos Eduardo Fonseca-Alves Sonia Cristina da Silva Andrade Mads Malik Aagaard Tatiane Ramos Basso Mariana Bisarro dos Reis Rolando André Rios Villacis...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1273: Extracellular Vesicles as Drug Carriers for Enzyme Replacement Therapy to Treat CLN2 Batten Disease: Optimization of Drug Administration Routes Cells doi: 10.3390/cells9051273 Authors: Matthew J. Haney Yuling Zhao Yeon S. Jin Elena V. Batrakova CLN2 Batten disease (BD) is one of a broad class of lysosomal storage disorders that is characterized by the deficiency of lysosomal enzyme, TPP1, resulting in a build-up of toxic intracellular storage material...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1264: HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation Cells doi: 10.3390/cells9051264 Authors: Sebastian Klobuch Kathrin Hammon Sarah Vatter-Leising Elisabeth Neidlinger Michael Zwerger Annika Wandel Laura Maria Neuber Bernhard Heilmeier Regina Fichtner Carina Mirbeth Wolfgang Herr Simone Thomas HLA-DPB1 antigens are mismatched in about 80% of allogeneic hematopoietic stem cell...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1272: Secretome of Mesenchymal Stromal Cells Prevents Myofibroblasts Differentiation by Transferring Fibrosis-Associated microRNAs within Extracellular Vesicles Cells doi: 10.3390/cells9051272 Authors: Nataliya Basalova Georgy Sagaradze Mikhail Arbatskiy Evgeniy Evtushenko Konstantin Kulebyakin Olga Grigorieva Zhanna Akopyan Natalia Kalinina Anastasia Efimenko Fibroblasts differentiation into myofibroblasts is a central event of tissue fibrosis....
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1267: A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping Cells doi: 10.3390/cells9051267 Authors: Maria Romano Alessia Ruggiero Flavia Squeglia Giovanni Maga Rita Berisio The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus SARS-CoV-2. The scientific community has mounted a strong response by accelerating research and innovation, and has quickly set the foundation...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1270: Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism Cells doi: 10.3390/cells9051270 Authors: Przemysław Błyszczuk Christian Zuppinger Ana Costa Daria Nurzynska Franca Di Di Meglio Mara Stellato Irina Agarkova Godfrey L. Smith Oliver Distler Gabriela Kania Cardiac fibrosis represents a serious clinical problem. Development of novel treatment strategies is...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1269: A Multiparametric Assay Platform for Simultaneous In Vivo Assessment of Pronephric Morphology, Renal Function and Heart Rate in Larval Zebrafish Cells doi: 10.3390/cells9051269 Authors: Petrus J. Steenbergen Jana Heigwer Gunjan Pandey Burkhard Tönshoff Jochen Gehrig Jens H. Westhoff Automated high-throughput workflows allow for chemical toxicity testing and drug discovery in zebrafish disease models. Due to its conserved structural and functional...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1266: GPS-PBS: A Deep Learning Framework to Predict Phosphorylation Sites that Specifically Interact with Phosphoprotein-Binding Domains Cells doi: 10.3390/cells9051266 Authors: Yaping Guo Wanshan Ning Peiran Jiang Shaofeng Lin Chenwei Wang Xiaodan Tan Lan Yao Di Peng Yu Xue Protein phosphorylation is essential for regulating cellular activities by modifying substrates at specific residues, which frequently interact with proteins containing...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1268: Tendon and Cytokine Marker Expression by Human Bone Marrow Mesenchymal Stem Cells in a Hyaluronate/Poly-Lactic-Co-Glycolic Acid (PLGA)/Fibrin Three-Dimensional (3D) Scaffold Cells doi: 10.3390/cells9051268 Authors: Maria C. Ciardulli Luigi Marino Joseph Lovecchio Emanuele Giordano Nicholas R. Forsyth Carmine Selleri Nicola Maffulli Giovanna Della Porta We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-transmission...
Wed May 20, 2020 03:00
Cells, Vol. 9, Pages 1271: Advances of Single-Cell Protein Analysis Cells doi: 10.3390/cells9051271 Authors: Lixing Liu Deyong Chen Junbo Wang Jian Chen Proteins play a significant role in the key activities of cells. Single-cell protein analysis provides crucial insights in studying cellular heterogeneities. However, the low abundance and enormous complexity of the proteome posit challenges in analyzing protein expressions at the single-cell level. This review summarizes recent...
Wed May 20, 2020 03:00
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