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The roles of DNA, RNA and histone methylation in ageing and cancer Ewa M. Michalak, Marian L. Burr, Andrew J. Bannister & Mark A. Dawsonpp573 - 589 | doi:10.1038/s41580-019-0143-1The dynamic methylation of chromatin components — DNA, histones and RNA — is crucial in development, ageing and cancer. Therapies that target regulators of DNA and histone methylation in cancer have recently been developed. These promising therapies, which include strategies that may improve tumour immune surveillance, are already being tested in early-phase clinical trials. Full Text | PDF | ||||||||||||||
The diverse roles of DNA methylation in mammalian development and disease Maxim V. C. Greenberg & Deborah Bourc’hispp590 - 607 | doi:10.1038/s41580-019-0159-6DNA methylation is essential for mammalian embryogenesis owing to its repression of transposons and genes, but it is also associated with gene activation. The recent use of sensitive technologies has revealed that DNA methylation dynamics vary considerably between embryonic, germline and somatic cell development, with implications for genetic diseases and cancer. Full Text | PDF | ||||||||||||||
Reading, writing and erasing mRNA methylation Sara Zaccara, Ryan J. Ries & Samie R. Jaffreypp608 - 624 | doi:10.1038/s41580-019-0168-5N6-methyladenosine (m6A) is the most abundant mRNA internal modification. The recent mapping of m6A has provided insights into which and how mRNAs are modified, how m6A affects gene expression and how it is linked to cellular differentiation, cancer progression and other biological processes. Full Text | PDF | ||||||||||||||
Roles and regulation of histone methylation in animal development Ashwini Jambhekar, Abhinav Dhall & Yang Shipp625 - 641 | doi:10.1038/s41580-019-0151-1Histone methylation regulates gene expression throughout animal development, governing processes as diverse as cell fate decisions, lineage specification, body patterning and organogenesis. Better understanding of the complex, context-specific roles of histone methylation in development will shed new light on the aetiology of developmental disorders. Full Text | PDF | ||||||||||||||
The regulation, functions and clinical relevance of arginine methylation Ernesto Guccione & Stéphane Richardpp642 - 657 | doi:10.1038/s41580-019-0155-xThe methylation of arginine residues regulates gene expression, DNA repair, growth factor signalling and liquid–liquid phase separation. Targeting this modification can thus be therapeutically relevant and inhibitors of arginine methylation are being tested in clinical trials, especially for neurodegenerative diseases and cancer. Full Text | PDF |
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Κυριακή 22 Σεπτεμβρίου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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