Cancer Research September 2019; 79 (18)
Breaking Insights
Highlights from Recent Cancer LiteratureReviews
The Tumor Microenvironment Innately Modulates Cancer ProgressionDominique C. Hinshaw et al.
Chemotherapy-Induced Metastasis: Molecular Mechanisms, Clinical Manifestations, Therapeutic Interventions
George S. Karagiannis et al.
Cancer Research Highlights
Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3DAlexander L. Klibanov et al.
Unsuspected Protumorigenic Signaling Role for the Oncometabolite GABA in Advanced Prostate Cancer
Renea A. Taylor et al.
Controversy and Consensus
Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad FocusCatherine Pham-Danis et al.
Priority Report
Selective Targeting of Myoblast Fusogenic Signaling and Differentiation-Arrest Antagonizes Rhabdomyosarcoma CellsValerie A. Granados et al.
Genome and Epigenome
Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer RiskLang Wu et al.
Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer
Stephen Shang et al.
Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3
Zi-Qi
Metabolism and Chemical Biology
AuthorChoice Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer CellsMark R. Jackson et al.
Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer
Yi Gao et al.
Molecular Cell Biology
Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes TumorigenesisXiaoqian Jing et al.
Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14
Alexandra Surcel et al.
IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma
Phyllis S.Y. Chong et al.
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis
Imran Khan et al.
Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer
Cynthia S. Rubenstein et al.
Tumor Biology and Immunology
Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 SignalingViktor Fleming et al.
SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence
Sen Ye et al.
Translational Science
Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein DegradationGeorge M. Burslem et al.
Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival
Yu-Chan Chang et al.
Convergence and Technologies
Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast CancerAvihai Ron et al.
Time-Resolved MRI Assessment of Convection-Enhanced Delivery by Targeted and Nontargeted Nanoparticles in a Human Glioblastoma Mouse Model
Zachary R. Stephen et al.
A Near-Infrared Phosphorescent Nanoprobe Enables Quantitative, Longitudinal Imaging of Tumor Hypoxia Dynamics during Radiotherapy
Xianchuang Zheng et al.
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