Abstract In English literature, there are only few reports of Warthin‐like papillary thyroid carcinoma. We presented three cases and provided clinical, grossing, cytological, and histological correlation. In our point of view, the diagnosis of Warthin‐like papillary thyroid carcinoma is feasible based on cytomorphological aspects. Usually those cases present moderately or highly cellular smears with many atypical Hürthle cells showing obvious papillary thyroid carcinoma nuclear features and without...
Thu Sep 12, 2019 17:25
Abstract We report a case of solid papillary carcinoma (SPC) of the breast, of which the cytologic findings of the nipple discharge and the fine needle aspiration (FNA), and the pathology of the resected tumour are described in detail. Imaging studies demonstrated an intra‐ductal tumour of the breast, which seemed responsible for the bloody nipple discharge. The cytologic features of the nipple discharge and the FNA targeted to the intra‐ductal tumour suggested low‐grade carcinoma. Additional findings...
Thu Sep 12, 2019 17:45
Abstract The aim of this study was to determine the accuracy of fine‐needle aspiration (FNA) and core needle biopsy (CNB) for palpable breast tumors (PBTs). FNA and CNB of 492 PBTs from 477 patients were analyzed. Tumors were malignant in 473 cases and benign in 19 cases. There was a strong correlation (P > .05) between FNA and CNB in terms of malignancy. Among 473 malignant tumors, FNA had better accuracy and less unsatisfactory results (95.6%; 2.7%) than CNB (94.9%; 4.9%). Among 19 benign tumors,...
Thu Sep 12, 2019 21:49
The few studies on the association of smoking with gallbladder cancer risk have given conflicting results. Here we provide the most accurate and up‐to‐date quantification of the effect of cigarette smoking on gallbladder cancer risk, and investigate for the first time the dose‐response relationships. Using an innovative approach for the identification of publications, we conducted a systematic review and meta‐analysis of epidemiological studies published until March 2019 on the association of smoking...
Thu Sep 12, 2019 18:47
Although smoking and oxidative stress are known contributors to lung carcinogenesis, their mechanisms of action remain poorly understood. To shed light into these mechanisms, we applied a novel approach using Cys34‐adductomics in a lung cancer nested case‐control study (n=212). Adductomics profiles were integrated with DNA‐methylation data at established smoking‐related CpG sites measured in the same individuals. Our analysis identified 42 Cys34‐albumin adducts, of which 2 were significantly differentially...
Thu Sep 12, 2019 18:49
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s):
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): Q. Lisan, C. Martin, O. Laccourreye
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): O. Laccourreye, H. Maisonneuve
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): F. Blanc, F. Merklen, C. Blanchet, M. Mondain, M. AkkariRésuméObjectifsLa polygraphie ventilatoire (PV) peut constituer un défi technique pour le diagnostic de syndrome d’apnées hypopnées obstructives du sommeil (SAHOS) de l’enfant : acceptation de l’appareil, désadaptations des capteurs. Chez l’enfant, la détection automatique des évènements respiratoires...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): T. de Saint Hilaire, D.T. Nguyen, R. Jankowski, C. RumeauRésuméLe syndrome de Binder est un syndrome malformatif rare dont la définition est clinique. L’étude scanographique d’une patiente présentant ce morphotype retrouvait un aspect de subduction de l’articulation palato-prémaxillaire en coupe sagittale. L’objectif de cette étude était d’analyser cette...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): S. Ayache, M. Beltran, N. GuevaraRésuméObjectifsÉvaluation d’une classification anatomique endoscopique du conduit auditif externe pour la chirurgie otologique endoscopique transcanalaire (COET).Patients et méthodeLa classification (Canal Endoscopic Scale, CES) du conduit auditif externe (CAE) a été établie initialement en fonction de la présence éventuelle...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): H. Li, Q. Yao, X. Huang, X. Zhuo, J. Lin, Y. TangRésuméObjectifsUne étude rétrospective en milieu hospitalier a été menée afin d’évaluer l’effet de la prégabaline sur le trismus induit par la radiothérapie chez des patients atteints de carcinome du nasopharynx.Matériels et méthodesDes données ont été recueillies sur les patients présentant un trismus...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): A. Rambeau, I. Licaj, B. Géry, R. Gervais, C. Florescu, E. Babin, D. De Raucourt, A. Johnson, J. ThariatRésuméObjectifsÉvaluer l’efficacité et la tolérance du rechallenge en sel de platine chez les patients présentant un carcinome épidermoïde des voies aérodigestives supérieures (CE VADS) récidivant après une radiochimiothérapie à base de sels de platine.Matériel...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): G. Dumas, H. Tan, L. Dumas, P. Perrin, A. Lion, S. SchmerberRésuméObjectifOptimiser la fréquence et la topographie des stimulations utilisées par le test de vibration osseux vestibulaire (TVOV) dans les déhiscences du canal semi-circulaire antérieur.MéthodesLa comparaison 3D des composantes du nystagmus induit par vibration (NIV) a été effectuée chez...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): C. Eyermann, T. Raguin, D. Rohmer, E. Noel, A. CharpiotRésuméObjectifsLa maladie de Fabry (MF) est une maladie de surcharge lysosomale de transmission liée à l’X. La pathologie est multi-systémique et comporte des atteintes ORL. L’objectif est d’étudier les manifestations cochléo-vestibulaires dans la MF pour montrer l’importance du dépistage et d’un...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): Q. Lisan, F. Rubin, A. Werner, S. Guiquerro, P. Bonfils, O. LaccourreyeRésuméRevue de la littérature médicale selon les critères PRISMA, dédiée au traitement du syndrome stylo hyoïdien. Lecture de 349 articles (bases de données Pub Med et Cochrane) obtenus en utilisant la terminologie syndrome stylo hyoïdien et ses synonymes. Sélection des articles détaillant...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): E. Truffert, E. Fournier-Charrière, J.-M. Treluyer, C. Blanchet, R. Cohen, B. Gardini, H. Haas, F. Liard, J.-L. Montastruc, R. Nicollas, S. Pondaven, J.-P. Stahl, C. Wood, V. CouloignerRésuméObjectifsPrésenter les recommandations de pratique clinique (RCP) de la Société française d’otorhinolaryngologie–chirurgie de la face et du cou concernant l’utilisation...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): J.C. Leclere, R. Marianowski, P.J. Monteyrol, M. Akkari, F. Chalumeau, P. Fayoux, N. Leboulanger, P. Franco, V. Couloigner, M. MondainRésuméObjectifsPrésenter les recommandations de pratique clinique (RPC) rédigées en 2017 sous l’égide de la Société française d’ORL-chirurgie de la face et du cou concernant le rôle de l’ORL dans le diagnostic du syndrome...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): J.C. Leclere, R. Marianowski, P.J. Monteyrol, M. Akkari, F. Chalumeau, P. Fayoux, N. Leboulanger, P. Franco, V. Couloigner, M. MondainRésuméObjectifsPrésenter les recommandations de pratique clinique (RPC) rédigées en 2017 sous l’égide de la Société française d’ORL-chirurgie de la face et du cou concernant le rôle de l’ORL dans le diagnostic du syndrome...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): P. Gallet, D.T. Nguyen, B. Toussaint, C. RumeauRésuméIntroductionLa luxation aryténoïdienne est une pathologie rare, dont les mécanismes restent discutés.MéthodeNous rapportons ici un cas exceptionnel de luxation spontanée, qui remet en question la classique théorie de l’hémarthrose.Résultats et conclusionsCe cas et la revue de la littérature suggèrent...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): F. Jahshan, E. Sela, O. RonenRésuméIntroductionLa thrombose veineuse profonde du membre supérieur (ueDVT) est souvent causée par un traumatisme de la veine sous-clavière, un cathéter veineux central et des troubles d’hypercoagulation.Cas cliniqueNous présentons le cas d’une ueDVT due à un goitre rétrosternal comprimant le tronc brachiocéphalique (TVBC)...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): J.N.M. Lukassen, M.W. Aalbers, M.H. Coppes, R.J.M. GroenRésuméContexteLa survenue d’une spondylodiscite cervicale iatrogène est rare, mais peut se produire après diverses interventions.MéthodesNous rapportons le cas d’une femme de 70 ans diabétique porteuse d’une spondylodiscite C5-C6 et d’un abcès épidural symptomatique engendrant une douleur cervicale...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): É.G.A. Melo, P.A.L. Silveira, C.A. MelloRésuméIntroductionLe cancer gastrique (CG) compte parmi les néoplasmes les plus fréquents, doué d’une des plus fortes morbidité et mortalité. Le contrôle de l’angiogenèse tumorale représente l’un des objectifs majeurs du traitement antinéoplasique, car l’angiogenèse a un rôle important dans la croissance et le développement...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): A.J.K. Chua, D.C.W. Chin, X.Y. HuangRésuméIntroductionL’ouverture du sinus frontal avec effondrement du septum séparant les deux sinus frontaux (FISST) a été décrite pour la première fois en 1976. Nous rapportons notre expérience d’une tel geste réalisé à l’aide d’une approche endoscopique trans-nasale pour traiter un abcès sinusien secondaire à une obstruction...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): V. Patron, M. Hitier, R. Gamby, V. Finocchi, B. ÇakirRésuméLa rhinoplastie, qu’elle soit par voie externe ou dissimulée se réalise classiquement dans le plan sus-périchondral c’est-à-dire sous le SMAS. Depuis quelques années ont été décrites des voies d’abord sous-périchondrales totales et sous périostées permettant une large exposition de l’ensemble...
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): C. Fabre, H. Gil, C.A. Righini
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): L. Nakhleh, S. Zink, J.M. Raguin, T. Raguin
Fri Sep 13, 2019 10:51
Publication date: September 2019Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 136, Issue 4Author(s): J. Perruisseau-Carrier, C. Debry, S. Riehm, I. Djennaoui
Fri Sep 13, 2019 10:51
Purpose:Conflicting data have been reported on the prognostic value of PD-L1 protein and gene expression in breast cancer. Experimental Design: Medline, Embase, Cochrane Library, and Web of Science Core Collection were searched, and data were extracted independently by two researchers. Outcomes included pooled PD-L1 protein positivity in tumor cells, immune cells, or both, per subtype and per antibody used, and its prognostic value for disease-free and overall survival. A pooled gene expression...
Fri Sep 13, 2019 10:05
Purpose:APOBEC3-UNG imbalance contributes to hepatitis B virus (HBV) inhibition and somatic mutations. We aimed to explore the associations between hepatocellular carcinoma (HCC) risk and genetic polymorphisms predisposing the imbalance. Experimental Design: Genetic polymorphisms at APOBEC3 promoter and UNG enhancer regions were genotyped in 5,621 participants using quantitative PCR. HBV mutations (nt.1600–nt.1945, nt.2848–nt.155) were determined by Sanger sequencing. Dual-luciferase reporter assay...
Fri Sep 13, 2019 10:05
Purpose:The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. This study has used multiomics approaches and drug screens to identify the pan-HDAC inhibitor panobinostat as an effective strategy to limit MEK inhibitor resistance. Experimental Design: Mass spectrometry–based proteomics and RNA-Seq were used to identify the signaling pathways involved in the escape of uveal melanoma cells from MEK inhibitor therapy. Mechanistic studies were performed...
Fri Sep 13, 2019 10:05
Purpose:Uveal melanomas (UM) are genetically simple tumors carrying few copy number alterations (CNA) and a low mutation burden, except in rare MBD4-deficient, hypermutated cases. The genomics of uveal melanoma metastatic progression has not been described. We assessed the genetic heterogeneity of primary and metastatic MBD4-proficient and -deficient uveal melanomas. Experimental Design: We prospectively collected 75 metastatic and 16 primary samples from 25 consecutive uveal melanoma patients,...
Fri Sep 13, 2019 10:05
Purpose:The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methylome in UM. Experimental Design: Global DNA methylation was analyzed in 47 Class 1 and 45 Class 2 primary UMs and in UM cells engineered to inducibly deplete BAP1. RNA-Seq was analyzed in 80 UM samples and engineered UM cells. Results:Hypermethylation...
Fri Sep 13, 2019 10:05
Purpose:Protein expression in formalin-fixed, paraffin-embedded tissue is routinely measured by IHC or quantitative fluorescence (QIF) on a handful of markers on a single section. Digital spatial profiling (DSP) allows spatially informed simultaneous assessment of multiple biomarkers. Here we demonstrate the DSP technology using a 44-plex antibody cocktail to find protein expression that could potentially be used to predict response to immune therapy in melanoma. Experimental Design: The NanoString...
Fri Sep 13, 2019 10:05
Purpose:Myelodysplastic syndromes (MDS) with deletion of chromosome 7q/7 [-7/(del)7q MDS] is associated with worse outcomes and needs novel insights into pathogenesis. Reduced expression of signaling protein dedicator of cytokinesis 4 (DOCK4) in patients with -7/(del)7q MDS leads to a block in hematopoietic stem cell (HSC) differentiation. Identification of targetable signaling networks downstream of DOCK4 will provide means to restore hematopoietic differentiation in MDS. Experimental Design: We...
Fri Sep 13, 2019 10:05
Purpose:Limited options exist for patients with advanced pancreatic cancer progressing after 1 or more lines of therapy. A phase II study in patients with previously treated metastatic pancreatic cancer showed that combining GVAX pancreas (granulocyte-macrophage colony-stimulating factor-secreting allogeneic pancreatic tumor cells) with cyclophosphamide (Cy) and CRS-207 (live, attenuated Listeria monocytogenes expressing mesothelin) resulted in median overall survival (OS) of 6.1 months, which compares...
Fri Sep 13, 2019 10:05
Purpose:Protein kinases are known to play a prominent role in oncogenic progression across multiple cancer subtypes, yet their role in prostate cancer progression remains underexplored. The purpose of this study was to identify kinases that drive prostate cancer progression. Experimental Design: To discover kinases that drive prostate cancer progression, we investigated the association between gene expression of all known kinases and long-term clinical outcomes in tumor samples from 545 patients...
Fri Sep 13, 2019 10:05
Purpose:Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with poor prognosis. Patients with MPM who do not respond to standard first-line chemotherapy have limited treatment options. We evaluated the efficacy and safety of nivolumab, an immune checkpoint inhibitor, for the treatment of advanced or metastatic MPM. Patients and Methods:Japanese patients with unresectable, advanced, or metastatic MPM resistant or intolerant to ≤2 regimens of chemotherapy and ≥1 measurable lesion(s)...
Fri Sep 13, 2019 10:05
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