Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Jing-Ru Weng, Tse-Hung Huang, Zih-Chan Lin, Ahmed Alalaiwe, Jia-You FangAbstract[1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM) has been used as a bioactive agent for inhibiting tumor growth and angiogenesis via mitogen-activated protein kinase (MAPK) and NF-κB blocking. The present work was undertaken to investigate the potential of CIM against psoriasis using imiquimod (IMQ)-stimulated...
Thu Sep 05, 2019 20:13
Accelerated partial breast irradiation (APBI), using high-dose rate (HDR) interstitial multi-catheter brachytherapy (iBT), is a treatment option after breast conserving surgery and proved to be non-inferior to whole breast irradiation for a selected patient population considering local recurrence rate, disease free survival, overall survival, quality of life, late side effects and cosmetic outcome [1–7].
Thu Sep 05, 2019 03:00
Although dose-escalation to the whole prostate gland improves biochemical control of prostate cancer, it is at the expense of increased rectal toxicity [1–7]. The most important site for local recurrence is the dominant intra-prostatic tumour lesion (DIL) [8–11] suggesting that focal radiation boosts to the DIL may improve the therapeutic ratio of prostate radiotherapy [12,13]. Therefore, to achieve this improvement, the accuracy of imaging to detect the DIL needs to be established.
Thu Sep 05, 2019 03:00
Radiation Oncology (Radiotherapy) is the branch of clinical medicine that uses ionising radiation, either alone or in combination with other therapeutic modalities, for the treatment of patients with malignant or benign diseases. It may be practiced as an independent oncological specialty or may be integrated in the broader practice of clinical oncology.
Thu Sep 05, 2019 03:00
Brachytherapy (BT) is a mandatory part of curative treatment for locally advanced cervical cancer (LACC). In order to decide on optimum BT techniques, the tumor topography at BT may be classified into following categories: tumors limited to cervix at the time of BT with cconventional intracavitary BT techniques providing sufficient dose distribution (category 0); tumors with up to medial half parametrial infiltration (category I) may benefit from additional parallel interstitial needles [1,2]; tumors...
Thu Sep 05, 2019 03:00
Worldwide, lung cancer is the most common malignant tumor, accounting for 1.69 million new cases in 2015 [1], and remains the leading cause of cancer-related mortality with a predicted 5-year survival rate of 8–13% [2]. Histopathologically, lung cancer is broadly categorized as small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) with the latter constituting approximately 85% of the cases [3]. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) with demonstrated high sensitivity...
Thu Sep 05, 2019 03:00
Publication date: Available online 5 September 2019Source: Radiotherapy and OncologyAuthor(s): E.J. Alexander, J.R. Murray, V.A. Morgan, S.L. Giles, S.F. Riches, S. Hazell, K. Thomas, S.A. Sohaib, A. Thompson, A. Gao, D.P. Dearnaley, N.M. DeSouzaAbstractBackground and purposeTo assess the diagnostic accuracy and inter-observer agreement of T2-weighted (T2W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) for mapping intra-prostatic tumour lesions (IPLs) for the purpose of focal dose-escalation...
Thu Sep 05, 2019 20:28
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Shang Zhu, Xiaorong Zhang, Hongbing Guan, Feng Huang, Lihong Wu, Dan Hou, Zhichao Zheng, Miao Yu, Liwen Huang, Linhu GeAbstractWe previously demonstrated that decreased expression of miR-140-5p was associated with the progression of multiple sclerosis (MS) and miR-140-5p targeted STAT1 and interfered with the expression of IFN-γ. However, the underlying mechanisms how miR-140-5p regulated the differentiation...
Thu Sep 05, 2019 14:29
Stem Cells and Development, Ahead of Print.
Thu Sep 05, 2019 10:00
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