British Journal of Cancer, Published online: 16 September 2019; doi:10.1038/s41416-019-0571-xPrognosis and modulation mechanisms of COMMD6 in human tumours based on expression profiling and comprehensive bioinformatics analysis
03:00
British Journal of Cancer, Published online: 16 September 2019; doi:10.1038/s41416-019-0572-9Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion
03:00
We wish to thank the following reviewers for their generous assistance in evaluating manuscripts submitted to the JNCI: Journal of the National Cancer Institute during the past year.
Fri Sep 13, 2019 03:00
BackgroundMalaria vector control and research rely heavily on monitoring mosquito populations for the development of resistance to public health insecticides. One standard method for determining susceptibility in adult mosquito populations is the World Health Organization test (WHO bioassay). The WHO bioassay kit consists of several acrylic pieces that are assembled into a unit. Parts of the kit commonly break, reducing the capacity of insectaries to carry out resistance profiling. Since there is...
Sun Sep 15, 2019 03:00
Hybridization has frequently been observed between wild and domestic species and can substantially impact genetic diversity of both counterparts. Geese show some of the highest levels of interspecific hybridization across all bird orders, and two of the goose species in genus Anser have been domesticated providing excellent opportunity for joint study of domestication and hybridization. Until now, knowledge on the details of the goose domestication process has come from archaeological findings and...
Sun Sep 15, 2019 03:00
Reactive oxygen species (ROS) contribute to health and disease. CaMKII is a widely expressed enzyme whose activation by oxidation of regulatory domain methionines (ox-CaMKII) contributes to cardiovascular disease, asthma, and cancer. Here we integrate comparative genomic and experimental data to show that CaMKII activation by ROS arose more than half-a-billion years ago on the vertebrate stem lineage where it constituted a bridge between ROS and increased intracellular Ca2+ release, exercise responsive...
Fri Sep 13, 2019 03:00
BackgroundThe traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritable information can be passed from somatic cells. Previous studies have implicated the critical involvement of RNA in heritable transgenerational effects and the high degree of mobility...
Sun Sep 15, 2019 03:00
Alternative reproductive tactics occur when individuals of the same sex have a suite of morphological and/or behavioural traits that allow them to pursue different reproductive strategies. A common pattern is e.g. the existence of "courter" and "sneaker" tactics within males. We have previously argued that alternative reproductive tactics should be subject to genetic conflict over the phenotypic expression of traits, similar to sexual antagonism. In this process, which we called intra-locus tactical...
Sat Sep 14, 2019 03:00
Morphometrics has become an indispensable component of the statistical analysis of size and shape variation in biological structures. Morphometric data has traditionally been gathered through low-throughput manual landmark annotation, which represents a significant bottleneck for morphometric-based phenomics. Here we propose a machine-learning-based high-throughput pipeline to collect high-dimensional morphometric data in images of semi rigid biological structures. The proposed framework has four...
Sat Sep 14, 2019 03:00
The gene products that drive early development are critical for setting up developmental trajectories in all animals. The earliest stages of development are fueled by maternally provided mRNAs until the zygote can take over transcription of its own genome. In early development, both maternally deposited and zygotically transcribed gene products have been well characterized in model systems. Previously, we demonstrated that across the genus Drosophila, maternal and zygotic mRNAs are largely conserved...
Sat Sep 14, 2019 03:00
Asgard archaea genomes contain potential eukaryotic-like genes that provide intriguing insight for the evolution of eukaryotes. The actin polymerization/depolymerization cycle is critical for providing force and structure for a variety of processes in eukaryotes, including membrane remodelling. Here, we identify actin filament severing, capping, annealing and bundling, and monomer sequestration activities by gelsolin proteins from Thorarchaeota (Thor), which complete a eukaryote-like actin depolymerization...
Sat Sep 14, 2019 03:00
Cancer genomes exhibit surprisingly weak signatures of negative selection1,2. This may be because tumors evolve either under very weak selective pressures (weak selection) or under conditions that prevent the elimination of many deleterious passenger mutations (poor efficacy of selection). The weak selection model argues that the majority of genes are only important for multicellular function. The poor efficacy of selection model argues, in contrast, that genome-wide linkage in cancer prevents many...
Sat Sep 14, 2019 03:00
Current phylogenetic comparative methods modeling quantitative trait evolution generally assume that, during speciation, phenotypes are inherited identically between the two daughter species. This, however, neglects the fact that species consist of a set of individuals, each bearing its own trait value. Indeed, because descendent populations after speciation are samples of a parent population, we can expect their mean phenotypes to randomly differ from one another potentially generating a "jump"...
Sat Sep 14, 2019 03:00
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious diseases and animal models of TB, we hypothesized that the genomes of the two interact to modulate risk of developing active TB or increasing the severity of disease, when present. We examined this hypothesis in our TB household contact study in Kampala,...
Sat Sep 14, 2019 03:00
Genomic outcomes of hybridization depend on selection and recombination in hybrids. Whether these processes have similar effects on hybrid genome composition in contemporary hybrid zones versus ancient, stabilized hybrid lineages is unknown. Here we show that patterns of introgression in a contemporary hybrid zone in Lycaeides butterflies predict patterns of ancestry in geographically adjacent, ancient hybrid populations. We find a particularly striking lack of ancestry from one of the hybridizing...
Sat Sep 14, 2019 03:00
Previous analyses of the UK Biobank (UKB) genotyping array data in the CCR5-{Delta}32 locus show evidence for deviations from Hardy-Weinberg Equilibrium (HWE) and an increased mortality rate of homozygous individuals, consistent with a recessive deleterious effect of the deletion mutation. We here examine if similar deviations from HWE can be observed in the newly released UKB Whole Exome Sequencing (WES) data and in the sequencing data of the Genome Aggregation Database (gnomAD). We also examine...
Sat Sep 14, 2019 03:00
Recent analyses suggest that cross-species gene flow or introgression is common in nature, especially during species divergences. Genomic sequence data can be used to infer introgression events and to estimate the timing and intensity of introgression, providing an important means to advance our understanding of the role of gene flow in speciation. Here we implement the multispecies-coalescent-with-introgression (MSci) model, an extension of the multispecies-coalescent (MSC) model to incorporate...
Sat Sep 14, 2019 03:00
Recent comparative studies have suggested that cooperative breeding is associated with increases in maximum lifespan among mammals, replicating a pattern also seen in birds and insects. In this study, I re-examine the case for increased lifespan in mammalian cooperative breeders by analysing a large dataset of maximum longevity records. Unlike one previous study, I found no consistent, strong evidence that cooperative breeders have longer lifespans than other mammals, after having controlled for...
Sat Sep 14, 2019 03:00
The antibiotic defense substance allicin (diallylthiosulfinate) is produced by garlic (Allium sativum L.) after tissue damage, giving garlic its characteristic odor. Allicin is a redox-toxin that oxidizes thiols in glutathione and cellular proteins. A highly allicin-resistant Pseudomonas fluorescens strain (PfAR-1) was isolated from garlic, and genomic clones were shotgun electroporated into an allicin-susceptible P. syringae strain (Ps4612). Recipients showing allicin-resistance had all inherited...
Sat Sep 14, 2019 03:00
The Rapidly Accelerated Fibrosarcoma (RAF) kinases are part of large group of serine/threonine-specific protein kinases that play important roles in cell differentiation and organism development. Animal RAF kinases are key connectors in the signaling cascade that links the small G protein RAS and the Mitogen-activated protein kinase phosphorylation pathway. Mutations in the RAF genes have been linked to a number of cancers including melanoma, lung cancer, colorectal cancer, thyroid cancer, and ovarian...
Sat Sep 14, 2019 03:00
Time-calibrated molecular phylogenies of extant species ("extant timetrees") are widely used for estimating the dynamics of speciation and extinction rates and reconstructing macroevolutionary events such as mass extinctions. However, there has been considerable debate surrounding the reliability of these inferences in the absence of fossil data, and to date this critical question remains unresolved. Here we mathematically clarify the precise information that can be extracted from extant timetrees...
Sat Sep 14, 2019 03:00
In order to understand how oxidative stress signal transduction pathways evolve, we analyzed the molecular evolution of the p38 MAPK (p38K) gene family across the genus Drosophila. p38K family genes play a vital role in oxidative stress resistance and are also important for organismal development and immunity. We find that the p38Ka and p38Kb genes are highly conserved across the genus and that p38Kc is more recently evolved. We further find that the p38Kb genomic locus includes conserved binding...
Sat Sep 14, 2019 03:00
In a number of animal species, divergent natural selection has repeatedly and independently driven the evolution of reproductive isolation between populations adapted to contrasting, but not to similar environments1. This process is known as parallel ecological speciation, and examples in plants are enigmatically rare2. Here, we perform a comprehensive test of the ecological speciation hypothesis in an Australian wildflower where parapatric populations found in coastal sand dunes (Dune ecotype) and...
Sun Sep 15, 2019 03:00
In a number of animal species, divergent natural selection has repeatedly and independently driven the evolution of reproductive isolation between populations adapted to contrasting, but not to similar environments. This process is known as parallel ecological speciation, and examples in plants are enigmatically rare. Here, we perform a comprehensive test of the ecological speciation hypothesis in an Australian wildflower where parapatric populations found in coastal sand dunes (Dune ecotype) and...
Sun Sep 15, 2019 03:00
In a number of animal species, divergent natural selection has repeatedly and independently driven the evolution of reproductive isolation between populations adapted to contrasting, but not to similar environments. This process is known as parallel ecological speciation, and examples in plants are enigmatically rare. Here, we perform a comprehensive test of the ecological speciation hypothesis in an Australian wildflower where parapatric populations found in coastal sand dunes (Dune ecotype) and...
Sun Sep 15, 2019 03:00
Abstract This short report clarifies the heterogeneity of structural magnetic resonance imaging (MRI) findings in seven demented patients due to pathologically accumulated TAR DNA-binding protein-43 (TDP-43) protein using visual analyses including visual rating scales (i.e., global cortical atrophy and medial temporal atrophy scales). In addition to the well-known frontotemporal lobar atrophy, structural MRI has revealed multifaceted imaging findings including asymmetric atrophy...
Fri Sep 13, 2019 03:00
Abstract Purpose Flat-panel computed tomography (FP-CT) is increasingly available in angiographic rooms and hybrid OR’s. Considering its easy access, cerebral imaging using FP-CT is an appealing modality for intra-procedural applications. The purpose of this systematic review is to assess the diagnostic accuracy of FP-CT compared with perfusion computed tomography (CTP) and perfusion magnetic resonance (MRP) in cerebral perfusion imaging....
03:00
This course demonstrates the importance of simulation in clinical training and outlines specific lessons in which CARL can be incorporated in. From basic lessons introducing the components of a hearing aid to advanced fitting of a high-gain hearing aid, this patient simulator provides several validated benefits to existing audiology curriculums.
07:00
Abstract To identify relation between prevalence of hearing impairment and risk factors at the time of birth in high risk neonates. A year-long study is performed at HBT Medical College and Dr. R. N. Cooper Municipal General Hospital, Vile Parle (west), Mumbai. The Study comprised of 478 high risk babies born between March 2016 and February 2017 and admitted in NICU of the hospital. Out of these 68 babies were either transferred to higher centre or took discharge against medical...
03:00
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma of soft tissue representing about 1% of all tumors. In addition, DFSP occurs commonly on the trunk and extremities, and only a few cases of DFSP have been observed on the breast. In men, only 11 cases, including this case, have been reported. In this article, we present a case of left breast DFSP that occurred in a 44-year-old man. The physical...
07:34
To investigate the agreement between two data reduction approaches for detecting sedentary breaks from uni-axial accelerometry data collected in human participants. Free-living, uni-axial accelerometer data (n...
Thu Sep 12, 2019 03:00
This study has analyzed the policy-making requirements related to basic health insurance package at the national level with a systematic view.
Fri Sep 13, 2019 03:00
The study objectives are to describe the sensory processing patterns of women diagnosed with genito-pelvic pain/penetration disorder (GPPPD), to explore the level of anxiety when both GPPPD and sensory process...
Fri Sep 13, 2019 03:00
Staphylococcus aureus with the ability of biofilm formation and the drug resistance acquisition is one of the most frequently isolated pathogens from chronic rhinosinusitis patients. Ultrasound as an alternative ...
Fri Sep 13, 2019 03:00
The present study aimed to investigate the prevalence and the reasons of issuing permission for therapeutic abortion in department of forensic medicine, Kermanshah-Iran.
Fri Sep 13, 2019 03:00
The aim is to compare the cost-effectiveness of two long-lasting insecticidal nets (LLINs) delivery models (standard vs. new) in universal coverage (UC) campaigns in rural Mozambique.
Sat Sep 14, 2019 03:00
microRNA (miRNA) is a small non-coding RNA that regulates gene expression by sequence-dependent binding to protein-coding mRNA in eukaryotic cells. In plants, miRNA plays important roles in a plethora of physi...
Sat Sep 14, 2019 03:00
Interprofessional team training has a positive impact on team behavior and patient safety culture. The overall objective of the study was to explore the impact of an interprofessional teamwork intervention in ...
Sat Sep 14, 2019 03:00
We have assessed the risk factors for the occurrence of hospital-acquired (HA) and community-acquired (CA) viral acute respiratory tract infections (ARTIs) in children. Children (1–60 months) who were having A...
Sat Sep 14, 2019 03:00
The objective of this study was to identify determinants of stillbirth in Felege Hiwot comprehensive specialized referral hospital, North-west, Ethiopia: 2019. To conduct this study an institutional-based unma...
Sat Sep 14, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου