Κυριακή 15 Σεπτεμβρίου 2019

Prognostic role of blood eosinophil and basophil levels in allergic fungal rhinosinusitis (AFRS),
Author links open overlay panelGiuseppeBresciaaLeonardoFranzaLaraAlessandrinibDanielaParrinoaUmbertoBarionaGinoMarionia
a
Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy
b
Department of Medicine DIMED, Pathology Unit, Padova University, Padova, Italy
Received 6 September 2019, Available online 13 September 2019.

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https://doi.org/10.1016/j.amjoto.2019.102301Get rights and content
Abstract
Purpose
Allergic fungal rhinosinusitis (AFRS) forms a subset of chronic rhinosinusitis with nasal polyps (CRSwNP) that is mainly characterized by eosinophilic nasal polyps, allergic mucin detected in the sinuses at surgery, and specific features on computerized tomography.

Which biological markers predict disease recurrence in AFRS is still not clear, and the role of blood inflammatory cells in predicting recurrent polyps after surgery has yet to be investigated. The aim of this study was to newly investigate the prognostic role (in terms of recurrence rate) of preoperative blood eosinophil and basophil levels in AFRS.

Materials and methods
A consecutive series of 17 adult patients who underwent endoscopic sinus surgery for AFRS was retrospectively assessed.

Results
Sinonasal polyps recurred in 7 of 17 patients. Considering the whole cohort, a significant positive correlation emerged between blood eosinophil and basophil counts, but not between blood and tissue eosinophil counts. Statistical analysis found significantly higher blood eosinophil and basophil levels in AFRS patients who relapsed than in those who did not.

Conclusions
Considering the current difficulty of identifying more effective, personalized approaches to postoperative disease management in AFRS, our preliminary data support the impression that blood eosinophil and basophil levels warrant testing in further prospective and larger (preferably multi-institutional) investigations as part of the preoperative work-up for patients with AFRS in order to administer dedicated postoperative medical treatments for patients at higher risk of relapse.

Keywords
Allergic fungal rhinosinusitisAFRSNasal polypsBloodEosinophilsBasophilRecurrence rate
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© 2019 Published by Elsevier Inc.

Figures (1)

  1. Fig. 1. Microscopic images showing histopathological features of patients with AFRS

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