Abstract The BRAFV600E mutation is the most prevalent genetic event in patients with papillary thyroid cancer (PTC). However, no study has investigated the expression of PAQR3 in papillary thyroid tissues in relation to the BRAFV600E mutation and the clinicopathological features of PTC patients. Furthermore, the potential associations of the BRAFV600E mutation, PAQR3 expression and clinicopathological parameters in the cancerous tissues of PTC patients have not been investigated....
Fri Nov 22, 2019 02:00
Abstract The aim of this study was to characterize secondary kinase mutations in Chinese patients with imatinib-resistant gastrointestinal stromal tumors (GISTs). Mutations in receptor tyrosine kinase (KIT; exons 9, 11, 13, 14, 17, and 18) and platelet-derived growth factor-alpha (PDGFRA; exons 12, 14, and 18) were analyzed by direct sequencing. After imatinib treatment, 425 cancer-related target genes were analyzed by next generation sequencing (NGS) in imatinib-resistant patients....
Fri Nov 22, 2019 02:00
Background Cell blocks are being used more frequently in cytology for ancillary testing, including molecular diagnostics. There are several different methods of processing cell blocks, with plasma‐thrombin being one of the most common. Plasma is a blood‐derived product and may be a source of DNA. The aim of this study was to determine whether the plasma used for the plasma‐thrombin cell block method has amplifiable DNA that may potentially interfere with molecular testing results. Methods Expired...
Fri Nov 22, 2019 16:46
Abstract Nowadays, the complementary diagnostics based on the suspicious thyroid lesion specific mutational state analysis is indispensable in the clinical practice. We aimed to test and validate our novel 568-mutational hotspot panel (23 cancer-related genes) on papillary thyroid cancers (PTCs) and their tumor-free pairs to find the most powerful mutation pattern related to PTC. The sequencing method was carried on with Ion Torrent PGM on 67 thyroid tissue samples. The most commonly...
Fri Nov 22, 2019 02:00
Publication date: Available online 22 November 2019Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Yun Sol Jo, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee
Fri Nov 22, 2019 18:57
Publication date: Available online 22 November 2019Source: Pathology - Research and PracticeAuthor(s): Wenwen Liu, Yi Li, Yan Zhang, Xianjuan Shen, Zhangyao Su, Lin Chen, Weihua Cai, Feng Wang, Shaoqing JuAbstractBackgroundGrowing evidence indicates that two long non-coding RNAs (lncRNAs), FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) and Actin filament associated protein 1 antisenseRNA1 (AFAP1-AS1), are highly expressed in different cancers, including gastric cancer (GC). However, the expression...
Fri Nov 22, 2019 18:57
Publication date: Available online 21 November 2019Source: Acta HistochemicaAuthor(s): Hideki Suzuki, Yuki Yoshikawa, Hisaya Tsujimoto, Takashi Kitaura, Isao MuraokaAbstractUsing immunohistochemistry, we investigated whether daily administration of clenbuterol (CLE; 1 mg/kg body weight per day) accelerates recovery after casted immobilization(IMM)-induced atrophy of fast-twitch plantaris and slow-twitch soleus muscles. Adult male Sprague-Dawley rats were assigned to the control (CON), casted immobilization...
Fri Nov 22, 2019 15:26
Introduction Preoperative coronary angiography for cardiac myxoma not only excludes coronary artery disease but also detects the artery feeding the cardiac myxoma, which has several clinical implications. In this study, we examined cardiac myxoma cases in two tertiary hospitals using coronary angiography to identify the artery feeding the myxoma. Mateirals and Methods We retrospectively reviewed 42 patients with cardiac myxoma who had undergone surgical removal between July 2008 and December...
Thu Nov 21, 2019 22:59
Introduction There is a paucity in the literature regarding bilateral symmetry between the facets of the subtalar joint. Often surgeons use the contralateral side as a reference when dealing with a fracture or other joint pathology. Moreover, the presence of osteoarthritic changes in the subtalar joint are suggested to have a relation with its morphology. In this study we addressed both these issues. Methods Forty pairs of cadaveric tali and calcanei were analyzed by dissection and measurement....
Thu Nov 21, 2019 22:49
Introduction Localized differences in tissue degeneration throughout intact and torn rotator cuff tendons has not been well quantified. The objective of this study was to investigate histological differences in localized degeneration in tendons with and without rotator cuff tears isolated to the supraspinatus tendon. Materials & Methods Four intact shoulders and four shoulders with rotator cuff tears isolated to the supraspinatus tendon were dissected down to the infraspinatus and supraspinatus...
Thu Nov 21, 2019 12:19
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