Σε απειλητικά επίπεδα για τη Δημόσια Υγεία φτάνει η υπερκατανάλωση αντιβιοτικών στην Ελλάδα, η οποία συνεχίζει να κατέχει την πρώτη θέση στην Ευρώπη. Κάθε χρόνο, το 68% των πολιτών λαμβάνει αντιβιοτικά, όταν στη Φιλανδία το ποσοστό των πολιτών που καταναλώνουν αντιβιοτικά δεν ξεπερνά το 3%. Και, δυστυχώς, σύμφωνα με τους ειδικούς, δεν φαίνεται να υπάρχει τάση βελτίωσης. Οι Έλληνες, πάντως, δεν «αποθηκεύουν» πλέον αντιβιοτικά, καθώς το ποσοστό έπεσε στο 1%, από 20% που ήταν. Στο ερώτημα γιατί...
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submitted by /u/jordiwmata [link] [comments]
10:04
MUNICH--(BUSINESS WIRE)--Daiichi Sankyo Europe GmbH (ci-après « Daiichi Sankyo ») a annoncé aujourd'hui que les résultats de l'essai de phase III CLEAR Wisdom ont été publiés dans le Journal of the American Medical Association (JAMA).1 L'acide bempédoïque est actuellement en cours d'évaluation en vue d'une autorisation de mise sur le marché par l'Agence européenne des médicaments (EMA) et par l'Agence américaine des produits alimentaires et médicamenteux (FDA). L'essai randomisé de phase III CL
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Tue Nov 12, 2019 20:18
Abstract Background Differentiating parathyroid from thyroid lesions can be difficult on fine‐needle aspiration (FNA) due to overlapping cytomorphologic features. While the traditional parathyroid hormone (PTH) assays can help in the distinction, these tests may be cumbersome, particularly when the lesion is unexpected clinically and a needle wash is not collected at the time of FNA. Therefore, we chose to investigate the application of immunohistochemical staining (IHC) with GATA 3 and thyroid...
Tue Nov 12, 2019 14:49
Abstract Vaping‐induced lung injury is a recently recognized phenomenon owing to the rising popularity of e‐cigarette use. A cluster of cases of varying severity, including six deaths, was recently reported in the United States by the Centers for Disease Control. The objective of this report is to highlight the cytologic features suggestive of vaping‐induced lung injury. A 20‐year‐old previously healthy man presented with a 7‐day history of progressively worsening respiratory symptoms including...
Tue Nov 12, 2019 14:45
Abstract Cryptococcal meningitis commonly affects immunocompromised cases and can have varied presentation. In some instances, the presence of a plethora of inflammatory cells on cerebrospinal fluid (CSF) in an immunosuppressed patient can lead to further investigations, which unravel the presence of cryptococcal meningitis. The aim of this retrospective study was to analyze the spectrum of CSF findings of immunosuppressed patients who were diagnosed to have cryptococcal meningitis. Retrospective...
Tue Nov 12, 2019 14:40
Tue Nov 12, 2019 14:29
Objectives The purpose of this manuscript is to review the successive regulatory actions and decisions following the initial publication by Kanda and colleagues in 2014 regarding gadolinium retention in the human brain after multiple gadolinium-based contrast agents (GBCAs) administrations. Materials and Methods Starting from 2014, the actions and decisions made by all regulatory authorities were collected and summarized region by region. Volumes of GBCA sales in 2018 per region and main...
Wed Oct 16, 2019 03:00
Objectives This study aimed to develop a dual-input convolutional neural network (CNN)–based deep-learning algorithm that utilizes both anteroposterior (AP) and lateral elbow radiographs for the automated detection of pediatric supracondylar fracture in conventional radiography, and assess its feasibility and diagnostic performance. Materials and Methods To develop the deep-learning model, 1266 pairs of AP and lateral elbow radiographs examined between January 2013 and December 2017 at a...
Wed Oct 16, 2019 03:00
Objective The aim of this study was to compare bone imaging between ultrashort echo-time (UTE) magnetic resonance (MR) imaging and cone-beam computed tomography (CBCT) as the reference standard in patients with medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods A 1-year retrospective, blinded, and randomized qualitative analysis of UTE MR images and CBCT from 19 patients with clinically diagnosed MRONJ was performed by 2 independent radiologists. Medication-related...
Wed Oct 16, 2019 03:00
Pharmaceutics, Vol. 11, Pages 605: Design and Development of Liquid Drug Reservoirs for Microneedle Delivery of Poorly Soluble Drug Molecules Pharmaceutics doi: 10.3390/pharmaceutics11110605 Authors: Mary-Carmel Kearney Peter E. McKenna Helen L. Quinn Aaron J. Courtenay Eneko Larrañeta Ryan F. Donnelly The poor aqueous solubility of existing and emerging drugs is a major issue faced by the pharmaceutical industry. Water-miscible organic solvents, termed co-solvents, can...
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JCM, Vol. 8, Pages 1953: Oxidative Stress in COPD Journal of Clinical Medicine doi: 10.3390/jcm8111953 Authors: María Magallón María Mercedes Navarro-García Francisco Dasí Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating...
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Annals of Otology, Rhinology &Laryngology, Ahead of Print.
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Annals of Otology, Rhinology &Laryngology, Ahead of Print.
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Beverages, Vol. 5, Pages 65: Effect of Maize as Adjunct and the Mashing Proteolytic Step on the Brewer Wort Composition Beverages doi: 10.3390/beverages5040065 Authors: Thiago Rocha dos Santos Mathias Leonardo Moreira Menezes Eliana Flávia Camporese Sérvulo The partial substitution of barley malt has been one of the main strategies of breweries to reduce production costs. In Brazil, as in other countries, maize is a raw material that is used mostly for this purpose. Aiming for...
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Machines, Vol. 7, Pages 71: Influence of Geometric Dimensions on the Performance of Switched Reluctance Machine Machines doi: 10.3390/machines7040071 Authors: Ana Camila F. Mamede José Roberto Camacho Rui Esteves Araújo In a design of a switched reluctance machine, there are a number of parameters that are chosen empirically inside a certain interval, therefore to find an optimum geometry it is necessary to determine how each parameter acts on the performance of the machine. This...
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IJMS, Vol. 20, Pages 5681: Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20225681 Authors: Chien-Ning Hsu Li-Tung Huang You-Lin Tain Cardiovascular and neurological diseases can originate in early life. Melatonin, a biologically active substance, acts as a pleiotropic hormone essential for pregnancy and fetal development. Maternal melatonin can easily pass the placenta...
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Remote Sensing, Vol. 11, Pages 2649: A Multi-Temporal Object-Based Image Analysis to Detect Long-Lived Shrub Cover Changes in Drylands Remote Sensing doi: 10.3390/rs11222649 Authors: Emilio Guirado Javier Blanco-Sacristán Juan Pedro Rigol-Sánchez Domingo Alcaraz-Segura Javier Cabello Climate change and human actions condition the spatial distribution and structure of vegetation, especially in drylands. In this context, object-based image analysis (OBIA) has been used to monitor...
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Social Sciences, Vol. 8, Pages 312: Fathers’ Parental Leave Uptake in Belgium and Sweden: Self-Evident or Subject to Employment Characteristics? Social Sciences doi: 10.3390/socsci8110312 Authors: Leen Marynissen Eleonora Mussino Jonas Wood Ann-Zofie Duvander The limited increase in fathers’ involvement in childcare tasks in response to the unprecedented rise in female labour market participation illustrates the incomplete nature of the gender revolution. Available...
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Polymers, Vol. 11, Pages 1871: Thermomechanical Characterization and Modeling of Cold-Drawing of Poly(ethylene Terephthalate) Polymers doi: 10.3390/polym11111871 Authors: Jürgen Oberer Konrad Schneider Jens-Peter Majschak The tensile testing of amorphous polyethylene terephthalate is observed until failure by IR thermography and optical strain measurement. The deformation can be subdivided in six deformation phases: elastic deformation, neck formation with a localized sharp temperature...
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Remote Sensing, Vol. 11, Pages 2648: Lifting Scheme-Based Deep Neural Network for Remote Sensing Scene Classification Remote Sensing doi: 10.3390/rs11222648 Authors: Chu He Zishan Shi Tao Qu Dingwen Wang Mingsheng Liao Recently, convolutional neural networks (CNNs) achieve impressive results on remote sensing scene classification, which is a fundamental problem for scene semantic understanding. However, convolution, the most essential operation in CNNs, restricts the development...
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Applied Sciences, Vol. 9, Pages 4851: Estimation of Fatigue Crack AE Emissivity Based on the Palmer–Heald Model Applied Sciences doi: 10.3390/app9224851 Authors: Vera Barat Artem Marchenkov Sergey Elizarov This article is devoted to materials testing by the acoustic emission (AE) method, which is the analysis of models and diagnostic parameters to assess the probability of detection of a defect in steel structures. The paper proposes to evaluate the emissivity of the material quantitatively...
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Metabolites, Vol. 9, Pages 279: Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice Metabolites doi: 10.3390/metabo9110279 Authors: Tatiana J. Carneiro Rita Araújo Martin Vojtek Salomé Gonçalves-Monteiro Carmen Diniz Ana L.M. Batista de Carvalho Maria Paula M. Marques Ana M. Gil This work describes, to our knowledge, the first NMR metabolomics analysis of mice kidney, liver, and breast tissue in response to cisplatin exposure,...
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IJMS, Vol. 20, Pages 5679: Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus International Journal of Molecular Sciences doi: 10.3390/ijms20225679 Authors: Elkin Navarro Quiroz Valeria Chavez-Estrada Karime Macias-Ochoa María Fernanda Ayala-Navarro Aniyensy Sarai Flores-Aguilar Francisco Morales-Navarrete Fernando de la Cruz Lopez Lorena Gomez Escorcia Carlos G. Musso Gustavo Aroca Martinez Henry Gonzales Torres Anderson...
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Pathogens, Vol. 8, Pages 234: Porcine Alveolar Macrophages’ Nitric Oxide Synthase-Mediated Generation of Nitric Oxide Exerts Important Defensive Effects against Glaesserella parasuis Infection Pathogens doi: 10.3390/pathogens8040234 Authors: Qi Cao Huan Wang Wenbin Wei Yujin Lv Zhao Wen Xiaojuan Xu Xuwang Cai Huanchun Chen Xiangru Wang Glaesserella parasuis is a habitual bacterium of pigs’ upper respiratory tracts. Its infection initiates with the invasion...
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IJERPH, Vol. 16, Pages 4452: A Study on The Driving Factors and Spatial Spillover of Carbon Emission Intensity in The Yangtze River Economic Belt under Double Control Action International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16224452 Authors: Xuhui Ding Zhongyao Cai Qianqian Xiao Suhui Gao It is greatly important to promote low-carbon green transformations in China, for implementing the emission reduction commitments and global climate governance....
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Energies, Vol. 12, Pages 4319: Reduction of DC Current Ripples by Virtual Space Vector Modulation for Three-Phase AC–DC Matrix Converters Energies doi: 10.3390/en12224319 Authors: Hoang-Long Dang Eun-Su Jun Sangshin Kwak In this paper, the virtual space vector modulation for the AC–DC (alternating current–direct current) matrix converters is proposed to reduce the DC current ripples in the whole modulation index range. In the proposed method, each virtual vector...
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Atmosphere, Vol. 10, Pages 702: Improved Dust Emission Reduction Factor in the ADAM2 Model Using Real-Time MODIS NDVI Atmosphere doi: 10.3390/atmos10110702 Authors: Sang-Sam Lee Yun-Kyu Lim Jeong Hoon Cho Hee Choon Lee Sang-Boom Ryoo The Korea Meteorological Administration has employed the Asian Dust Aerosol Model 2 (ADAM2) to forecast Asian dust events since 2010, where the dust emission flux is proportional to the fourth power of the friction velocity. Currently, the dust...
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Membranes, Vol. 9, Pages 152: Effect of Carbon Dioxide Loading on Removal of Heat Stable Salts from Amine Solvent by Electrodialysis Membranes doi: 10.3390/membranes9110152 Authors: Evgeniia Grushevenko Stepan Bazhenov Vladimir Vasilevsky Eduard Novitsky Maxim Shalygin Alexey Volkov Heat stable salts (HSS) formed and continuously accumulated in the amine-based solvents due to solvent degradation and impurities in the feed gas can dramatically change the efficiency of the...
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IJMS, Vol. 20, Pages 5678: Goals and Challenges in Bacterial Phosphoproteomics International Journal of Molecular Sciences doi: 10.3390/ijms20225678 Authors: Paula Yagüe Nathaly Gonzalez-Quiñonez Gemma Fernánez-García Sergio Alonso-Fernández Angel Manteca Reversible protein phosphorylation at serine, threonine and tyrosine is a well-known dynamic post-translational modification with stunning regulatory and signalling functions in eukaryotes. Shotgun phosphoproteomic analyses...
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Toxins, Vol. 11, Pages 660: Hemolysis Derived Products Toxicity and Endothelium: Model of the Second Hit Toxins doi: 10.3390/toxins11110660 Authors: Marie Frimat Idris Boudhabhay Lubka T. Roumenina Vascular diseases are multifactorial, often requiring multiple challenges, or ‘hits’, for their initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event lyses red blood cells, releasing hemolysis-derived products, in particular...
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Nanomaterials, Vol. 9, Pages 1609: Effects of Divacancy and Extended Line Defects on the Thermal Transport Properties of Graphene Nanoribbons Nanomaterials doi: 10.3390/nano9111609 Authors: Min Luo Bo-Lin Li Dengfeng Li The effects of divacancy, including isolated defects and extended line defects (ELD), on the thermal transport properties of graphene nanoribbons (GNRs) are investigated using the Nonequilibrium Green’s function method. Different divacancy defects can...
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A method for analysis of psychotropic drugs in urine is investigated using a novel single-drop liquid-liquid-liquid microextraction (SDLLLME) apparatus as an electrospray emitter in ion mobility spectrometry (IMS). In this method, ketamine and pethidine are back-extracted into the acceptor phase (water and methanol) from the water and methanol immiscible organic phase. Sensitivity of extraction is improved as it does not require further methanol-adding procedure. Factors affecting the extraction...
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The problem of parameter estimation of coherent signals impinging on an array with vector sensors is considered from a new perspective by means of the decomposition of tensors. Signal parameters to be estimated include the direction of arrival (DOA) and the state of polarization. In this paper, mild deterministic conditions are used for canonical polyadic decomposition (CPD) of the tensor-based signal model; i.e., the factor matrices can be recovered, as long as the matrices satisfy the requirement...
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Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). Hepcidin as a key regulator of iron metabolism is pivotal in mediating the occurrence of anemia of chronic disease. Herein, we analyzed the levels of hepcidin in sera from IBD patients by enzyme-linked immunosorbent assay and investigated its potential role in regulating the anemia in IBD. We observed that the levels of serum hepcidin were increased in active IBD patients compared with those in remitted...
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Simulated moving bed (SMB) chromatographic separation technology is a new adsorption separation technology with strong separation ability. Based on the principle of the adaptive neural fuzzy inference system (ANFIS), a soft sensing modeling method was proposed for realizing the prediction of the purity of the extract and raffinate components in the SMB chromatographic separation process. The input data space of the established soft sensor model is divided, and the premise parameters are determined...
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Έρευνες που έγιναν σε γυναίκες επιχείρησαν να διερευνήσουν πώς η κατανάλωση πολλών θερμίδων στο δείπνο αλλά και η απασχόλησή τους σε ορισμένα επαγγέλματα μπορεί να επιδεινώσουν την υγεία τους. Τα εγχειρήματα αυτά πρόκειται να παρουσιαστούν στο φετινό ιατρικό συνέδριο της Αμερικανικής Ένωσης Καρδιολογίας που θα διεξαχθεί 16 – 18 Νοεμβρίου στη Φιλαδέλφεια. Στην πρώτη έρευνα, που είχε ως δείγμα 112 γυναίκες, εκτιμήθηκε ότι αυτές που καταναλώνουν περισσότερες θερμίδες πιο αργά κατά τη διάρκεια της ημέρας...
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Έρευνες έδειξαν ότι το φαγητό μετά τις 6- 7 το απόγευμα θεωρείται το πιο «επικύνδυνο» για την υγεία. Σε αυτό πολλοί επιστήμονες απαντάνε ότι σχετίζεται με την ποιότητα, με το φύλο, με την ηλικία και με τις ορμόνες. Όταν τρώει κάποιος μετά τις 7 το απόγευμα δε συγχρονίζεται με τον ίδιο τον οργανισμό του. Αυτό πρακτικά σημαίνει ότι το βιολογικό του ρολόι δε βοηθά στην εύρυθυμη κατανομή των λιπιδίων στο αίμα. Κατά συνέπεια λοιπόν αυξάνεται ο κίνδυνος ανάπτυξης παθήσεων. Τέτοιες παθήσεις μπορεί να είναι...
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Σε «πάγωμα» των τιμών των φαρμάκων, αλλά και μειώσεις έως και 7% για κάποια από αυτά, προχωρά η κυβέρνηση: σχετικές δηλώσεις έκανε ο αρμόδιος υπουργός Β. Κικίλιας και ο κυβερνητικός εκπρόσωπος Στ. Πέτσας, ενώ κατατέθηκε ήδη και η σχετική τροπολογία. Ειδικότερα, μετά τη συνάντηση με τον πρωθυπουργό, στο Μέγαρο Μαξίμου, ο υπουργός Υγείας, Βασίλης Κικίλιας θύμισε ότι «ο πρωθυπουργός, Κυριάκος Μητσοτάκης, είχε πει προεκλογικά «το καλύτερο φάρμακο στην καλύτερη τιμή», με την ταυτόχρονη επισήμανση ότι...
Tue Nov 12, 2019 17:54
Ο οργασμός δεν έχει να κάνει μόνο με την ικανοποίηση και την ευχαρίστηση. Συνιστά και σημαντικό παράγοντα στην ψυχική ηρεμία και ισορροπία μιας γυναίκας. Ορμόνες Ενεργοποιεί ορμόνες και νευροδιαβιβαστές της χαράς και της ευτυχίας, νορεπινεφρίνη, σεροτονίνη, ντοπαμίνη και ωκυτοκίνη. Αυτές οι ουσίες βοηθούν στην ψυχική διάθεση της γυναίκας. Επιπλέον το σεξ και ο οργασμός είναι απαραίτητα και για τη σωματική ανάπτυξη πέραν της ψυχολογικής. Ορισμένες έρευνες δείχνουν ότι το στήθος της γυναίκας πρήζεται...
Tue Nov 12, 2019 17:39
Σε απειλητικά επίπεδα για τη Δημόσια Υγεία φτάνει η υπερκατανάλωση αντιβιοτικών στην Ελλάδα, η οποία συνεχίζει να κατέχει την πρώτη θέση στην Ευρώπη. Κάθε χρόνο, το 68% των πολιτών λαμβάνει αντιβιοτικά, όταν στη Φιλανδία το ποσοστό των πολιτών που καταναλώνουν αντιβιοτικά δεν ξεπερνά το 3%. Υπερκατανάλωση αντιβιοτικών Και, δυστυχώς, σύμφωνα με τους ειδικούς, δεν φαίνεται να υπάρχει τάση βελτίωσης. Οι Έλληνες, πάντως, δεν «αποθηκεύουν» πλέον αντιβιοτικά, καθώς το ποσοστό έπεσε στο 1%, από 20% που...
Tue Nov 12, 2019 17:35
Επανακαθορίζεται το σύστημα τιμολόγησης των φαρμάκων και το σύστημα κοστολόγησής τους, σύμφωνα με τροπολογία που κατέθεσε ο υπουργός Υγείας Βασίλης Κικίλιας στο νομοσχέδιο για την κύρωση ΠΝΠ των υπουργείων Οικονομικών, Υγείας, Περιβάλλοντος και Εσωτερικών. Στη νέα ρύθμιση προβλέπεται ότι: -Ορίζεται ως τιμή διαμόρφωσης του φαρμάκου, ο μέσος όρος των δύο χαμηλότερων διαφορετικών τιμών των κρατών-μελών της Ευρωζώνης, ενώ κατά την ανατιμολόγηση δεν επιτρέπονται αυξήσεις. -Μειώνεται σε κάθε ανατιμολόγηση,...
Tue Nov 12, 2019 11:29
Όλα τα έμβια όντα χρειάζονται το νερό για να επιβιώσουν. Σε περιπτώσεις που η κατανάλωσή του είναι μειωμένη το αποτέλεσμα είναι η αφυδάτωση. Για αυτό πρέπει να γνωρίζουν όλοι πόση ποσότητα νερού πρέπει να καταναλώνεται σε καθημερινή βάση. Η ποσότητα είναι αντίστοιχη της αίσθησης της δίψας που έχουμε. Δε μπορεί να απαντηθεί με έναν αριθμό επειδή είναι κάτι το εξατομικευμένο. Παράγοντες Πρέπει πάντα να συνυπολογίζονται παράγοντες όπως η γενική κατάσταση της υγείας. Αν κάποιος είναι άρρωστος, ανάλογα...
Tue Nov 12, 2019 11:26
Σε μία κούπα τσαγιού περιέχονται κατεχίνες, οι οποίες είναι εώς και 20 φορές πιο ισχύρες -ως αντιοξειδωτικά- από τη βιταμίνη C. Αυξάνει την καύση του λίπους, διότι ενισχύει τον μεταβολικό ρυθμό. Περιέχει καφείνη, σε μικρότερες ποσότητες από τον καφέ, με αποτέλεσμα να ενισχύει την προσοχή και την ικανότητα «multitasking». Όραση Τα μάτια και γενικά το σώμα μας επηρεάζονται άμεσα από το οξειδωτικό στρες. Η κατανάλωση ορισμένης ποσότητας πράσινου τσαγιού καθημερινά θα μπορούσε να προλάβει διάφορες...
Tue Nov 12, 2019 11:25
Η πνευμονία ευθύνεται για τον θάνατο περισσότερων από 800.000 παιδιών κάτω των 5 ετών πέρυσι –ένα παιδί κάθε 39 δευτερόλεπτα–, παρότι πρόκειται για μια ιάσιμη ασθένεια, η οποία συνήθως μπορεί να προληφθεί, προειδοποίησαν σήμερα έξι οργανώσεις, μεταξύ των οποίων και η Unicef. Σε έκθεσή τους, στην οποία χαρακτήρισαν την πνευμονία «ξεχασμένη επιδημία», η Unicef, η Save the Children και ακόμη τέσσερις οργανώσεις που ασχολούνται με τα παιδιά κάλεσαν τις κυβερνήσεις σε όλο τον κόσμο να αυξήσουν τις επενδύσεις...
Tue Nov 12, 2019 10:04
Αυτοί που έχουν επιβιώσει από καρδιακή προσβολή ενδέχεται να διατρέχουν αυξημένο κίνδυνο εμφάνισης καρκίνου συγκριτικά με εκείνους που δεν είχαν ποτέ κάποιο καρδιαγγειακό πρόβλημα, σύμφωνα με μελέτη που θα παρουσιαστεί στο φετινό ετήσιο Συνέδριο της Αμερικανικής Καρδιολογικής Ένωσης που θα διεξαχθεί το 16 -18 Νοεμβρίου στη Φιλαδέλφεια. Πρόληψη καρδιακών νοσημάτων και καρκίνου «Είναι διπλή κατάρα. Τα καρδιακά νοσήματα και ο καρκίνος είναι τα δύο βασικά αίτια θανάτου στις ΗΠΑ. Αυτή τη στιγμή αναγνωρίζουμε...
Tue Nov 12, 2019 08:30
The most common postoperative complication after reconstructive surgery is flap necrosis. Adipose-derived stem cells (ADSCs) and their secretomes are reported to mediate skin repair. This study was designed to investigate whether conditioned media from ADSCs (ADSC-CM) protects ischemia/reperfusion- (I/R-) induced injury in skin flaps by promoting cell proliferation and increasing the number of hair follicles. The mouse flap model of ischemia was ligating the long thoracic vessels for 3 h, followed...
06:05
Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors including cytokines which form a complex network of cell humoral correlation, called cytokine network. Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis...
Tue Nov 12, 2019 10:05
Leptin resistance is either a condition induced by human obesity or a natural phenomenon associated with seasonality in ruminants. In the cardiovascular system, the leptin resistance state presence is a complex issue. Moreover, the perivascular adipose tissue (PVAT) appears to be crucial as a source of proinflammatory cytokines and as a site of interaction for leptin contributing to endothelium dysfunction and atherosclerosis progression. So the aim of this study was to examine the influence of the...
Tue Nov 12, 2019 10:05
The literature shows that phenolic compounds possess important antioxidant and anti-inflammatory activities; however, the mechanism underlying these effects is not elucidated yet. The genus Calea is used in folk medicine to treat rheumatism, respiratory diseases, and digestive problems. In this context, some phenolic compounds were isolated with high purity from Calea uniflora Less. and identified as noreugenin (NRG) and α-hydroxy-butein (AH-BU). The aim of this study was to analyze the effect of...
Tue Nov 12, 2019 09:05
Background Circular RNAs serve as key players in the development of tumorigenesis and chemoresistance. Circular RNA CEP128 has been reported to be involved in the development of chemoresistance. However, the role of circular RNA CEP128 in the resistance of glioma cells to temozolomide has not yet been characterized. Methods The expression of circular RNA CEP128, miR-145-5p, and ATP-binding cassette super-family G member 2 was evaluated using quantitative real-time PCR and western blot. The...
10:09
As a basic organizing principle of the human brain, hemispheric specialization is an important perspective to explore the pathology of schizophrenia. However, it remains unclearly whether the hemispheric specialization of functional connectivity plays a role in mediating auditory verbal hallucinations in schizophrenia. In this study, 18 schizophrenic patients with auditory verbal hallucinations, 18 patients without auditory verbal hallucinations, and 18 matched healthy controls underwent resting-state...
10:09
The aim of the study was to explore the effect of atorvastatin on improvement of the function of the spinal cord in rats with chronic fluorosis. Sixty 3-month-old Wistar rats were separated randomly into three groups: normal group (N group), control group (C group) and atorvastatin group (A group). The Basso Beattie and Bresnahan scale and oblique board test showed that the rats in A group got higher score and better hind-limb motor function than C group. Immunohistochemistry and western blotting...
10:09
Emotional expressions and attentional processes interact such that emotion increases perceptual sensitivity in modality-specific brain areas leading to more efficient processing of the stimulus. In the current study, we asked the question of whether the emotional expressions can be processed subliminally when faces are attended but the emotional expression is irrelevant. We presented angry and neutral male and female faces supraliminally and subliminally to participants in an attention-shifting paradigm....
10:09
The neuritogenicity and the neuroregenerative potential of asiaticoside (AS) and its aglycone, asiatic acid (AA), has been generally reported. We recently identified the participation of extracellular signal-regulated protein kinases 1/2 (ERK1/2) and protein kinase B (Akt) in the neuritogenic mechanism of AS and AA. In this study, we further investigated the possible upstream target molecule and the associated downstream signaling of both triterpenoids in mouse neuroblastoma Neuro-2a cells. Our immunoblotting...
10:09
The present study examined the characteristics of somatosensory processing in healthy prepubescent children (mean age: 124.9 ± 3.8 months) compared with young adults. Somatosensory evoked potentials at the frontal (Fz) and centroparietal (C3′) electrodes were recorded by delivering an electrical stimulus to the right median nerve at a rate of 3 Hz. The characteristics of somatosensory evoked potential waveforms at C3′ were markedly different between the two groups, while those at Fz were similar....
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The blood–brain barrier (BBB) plays critical roles in maintaining the stability of the brain's internal milieu, providing nutrients for the brain, and preventing toxic materials from the blood from entering the brain. The cellular structure of the BBB is mainly composed of brain microvascular endothelial cells (BMVECs), which are surrounded by astrocytic endfeet that are connected by tight junction proteins, pericytes and astrocytes. Recently, several studies have shown that aberrant increase in...
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Objective The purpose of this study was to investigate the attentional networks function characteristics of interceptive and strategic sports athletes from open-skill sports. Methods We used a revised lateralized attention network task to measure attentional networks efficiency and activation related to flanker conflict effects, alerting effects, and orienting effects changes on the right frontoparietal network using functional near-infrared spectroscopy in 20 strategic sports athletes, 20...
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Our previous studies showed that propane-2-sulfonic acid octadec-9-enyl-amide (N15), a novel peroxisome proliferator-activated receptors α and γ (PPARα/γ) dual agonist, protected against ischaemia-induced acute brain damage in mice and improved cognitive ability in the chronic phase of ischaemic stroke. It is well known that hippocampal neurogenesis is closely related to cognitive function. In the present study, we investigated the effect of N15 on hippocampal neurogenesis and neuroplasticity in...
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Objective: We aimed to identify brain changes associated with preserved cognitive function in patients with chronic brainstem stroke. Methods: Twelve patients with chronic brainstem stroke and 24 age-matched healthy controls were included in this retrospective study. All participants underwent T1-weighted, diffusion tensor, and resting-state functional MRI. Gray matter density, fractional anisotropy, and mean diffusivity maps from diffusion tensor imaging and seven cognition-related independent...
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Serotonin modulates cognitive processes and is related to various psychiatric disorders, including major depression. Administration of citalopram reduces the amplitude of auditory evoked potentials in depressed people and animal models, suggesting that 5-HT has an inhibitory role. Here, we characterize the modulation of excitatory post-synaptic currents by application of either 5-HT or agonists of 5-HT1A and 5-HT2 receptors, or by endogenous 5-HT evoked by citalopram on pyramidal neurons from layer...
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Neuroimaging studies revealed that emotion and cognition dysfunction after sleep deprivation is associated with the disturbance of the salience network. However, the age effect on the functional connectivity changes of the network after sleep deprivation remains unclear. The current study investigated the functional connectivity changes of the right anterior insula after partial sleep deprivation in young and old adults by using resting-state functional magnetic resonance imaging. We found a significant...
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Several studies have investigated possible role of repetitive transcranial magnetic stimulation (rTMS) in patients with disorder of consciousness (DOC). But the details of patients’ brain responses to the rTMS are yet to be disclosed. The aim of the study is to explore the neural electrical responses of DOC patients to rTMS modulation. DOC Patients [14 vegetative state, seven minimally conscious state (MCS)] and healthy subjects were enrolled and received one session of rTMS. The TMS-electroencephalogram...
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Torrance Test of Creative Thinking is the most widely used form of creativity test. Although creativity assessed using the figural form of Torrance Test of Creative Thinking has been considered non-unidimensional, the structural correlates for each separable dimension have yet to be explored. The present study investigated the underlying cortical structure of separable dimensions for creativity using the figural Torrance Test of Creative Thinking. To this end, we recruited healthy young adults and...
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Pathogens, Vol. 8, Pages 233: Quantification of Enterocytozoon hepatopenaei (EHP) in Penaeid Shrimps from Southeast Asia and Latin America Using TaqMan Probe-Based Quantitative PCR Pathogens doi: 10.3390/pathogens8040233 Authors: Patharapol Piamsomboon Seong-Kyoon Choi Bambang Hanggono Yani Lestari Nuraini Fatma Wati Kathy F. J. Tang Song Park Dongmi Kwak Man Hee Rhee Jee Eun Han Ji Hyung Kim We developed a qPCR assay based on the β-tubulin gene...
Tue Nov 12, 2019 02:00
Pathogens, Vol. 8, Pages 231: A Single and Un-Adjuvanted Dose of a Chimpanzee Adenovirus-Vectored Vaccine against Chikungunya Virus Fully Protects Mice from Lethal Disease Pathogens doi: 10.3390/pathogens8040231 Authors: Rafael Kroon Campos Lorena Preciado-Llanes Sasha R. Azar Cesar Lopez-Camacho Arturo Reyes-Sandoval Shannan L. Rossi The mosquito-borne chikungunya virus (CHIKV) has become a major global health problem. Upon infection, chikungunya fever (CHIKF) can result...
Tue Nov 12, 2019 02:00
Pathogens, Vol. 8, Pages 232: Immunohistochemical Expression Patterns of Inflammatory Cells Involved in Chronic Hyperplastic Candidosis Pathogens doi: 10.3390/pathogens8040232 Authors: Ailish Williams David Williams Helen Rogers Xiaoqing Wei Michael Lewis Sue Wozniak Damian Farnell Adam Jones The profile of the inflammatory cell infiltrate in chronic hyperplastic candidosis (CHC) was determined in oral mucosal biopsies by immunohistochemistry. One tonsillar tissue...
Tue Nov 12, 2019 02:00
Pathogens, Vol. 8, Pages 230: Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in Mycobacterium tuberculosis by Competing with tmRNA Pathogens doi: 10.3390/pathogens8040230 Authors: Lei He Peng Cui Wanliang Shi Qiong Li Wenhong Zhang Min Li Ying Zhang Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 560: Analysis of the Indole Diterpene Gene Cluster for Biosynthesis of the Epoxy-Janthitrems in Epichloë EndophytesMicroorganisms doi: 10.3390/microorganisms7110560Authors:Emma J. LudlowSimone VassiliadisPiyumi N. EkanayakeInoka K. HettiarachchigePriyanka ReddyTim I. SawbridgeSimone J. RochfortGerman C. SpangenbergKathryn M. GuthridgeEpoxy-janthitrems are a class of indole diterpenes with structural similarity to lolitrem B. Two taxa of asexual Epichloë endophytes...
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Microorganisms, Vol. 7, Pages 559: Cell-Wall Hydrolases as Antimicrobials against Staphylococcus Species: Focus on Sle1Microorganisms doi: 10.3390/microorganisms7110559Authors: Vermassen Talon Andant Provot Desvaux LeroySome staphylococcal species are opportunistic pathogens of humans and/or animals with Staphylococcus epidermidis as one of the most important. It causes a broad spectrum of diseases in humans and animals. This species is able to form biofilms and has developed antibiotic resistance,...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 558: Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 GeneMicroorganisms doi: 10.3390/microorganisms7110558Authors: Peng Hu Li Li Jia Zhang Wu Chen WangEnterobacteriaceae having chromosomally-encoded mcr-1 is rarely reported. In this study, we recovered a chromosomal mcr-1 carrying Escherichia coli, designated HeN100, from the feces of a diarrheal pig in China. Antimicrobial susceptibility testing showed that HeN100...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 556: Combined Use of the Ab105-2φΔCI Lytic Mutant Phage and Different Antibiotics in Clinical Isolates of Multi-Resistant Acinetobacter baumanniiMicroorganisms doi: 10.3390/microorganisms7110556Authors:Lucia BlascoAnton AmbroaMaria LopezLaura Fernandez-GarciaInes BleriotRocio TrastoyJose Ramos-VivasTom CoenyeFelipe Fernandez-CuencaJordi VilaLuis Martinez-MartinezJesus Rodriguez-BañoAlvaro PascualJose Miguel CisnerosJeronimo PachonGerman BouMaria TomasPhage therapy is...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 554: Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed by Cronobacter Species where C. sakazakii Homologs Follow Sequence Type LineagesMicroorganisms doi: 10.3390/microorganisms7110554Authors:Samantha FinkelsteinFlavia NegreteHyein JangJayanthi GangiredlaMark MammelIsha R. PatelHannah R. ChaseJungHa WooYouYoung LeeCaroline Z. WangLeah WeinsteinBen D. TallGopal R. GopinathCronobacter species are a group of foodborne pathogenic bacteria...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 555: Asymmetrical Flow Field-Flow Fractionation on Virus and Virus-Like Particle ApplicationsMicroorganisms doi: 10.3390/microorganisms7110555Authors:Katri EskelinMinna M. PoranenHanna M. OksanenAsymmetrical flow field-flow fractionation (AF4) separates sample components based on their sizes in the absence of a stationary phase. It is well suited for high molecular weight samples such as virus-sized particles. The AF4 experiment can potentially separate molecules within...
Tue Nov 12, 2019 02:00
Microorganisms, Vol. 7, Pages 557: Sexually Transmitted Infections and Behavioral Determinants of Sexual and Reproductive Health in the Allahabad District (India) Based on Data from the ChlamIndia StudyMicroorganisms doi: 10.3390/microorganisms7110557Authors:Pierre P. M. ThomasJay YadavRajiv KantElena AmbrosinoSmita SrivastavaGurpreet BatraArvind DayalNidhi MasihAkash PandeySaurav SahaRoel HeijmansJonathan A. LalServaas A. MorréBackground: Sexually transmitted infections (STIs), like Chlamydia trachomatis...
Tue Nov 12, 2019 02:00
How To Connect With Conversations Today you are going to have opportunities to communicate. Here’s how to create conversations that connect: 1) Meet folks where they are. Pay attention to how their day is going. Step into their NOW. 2) Establishing something in common. “Wow! Has this day been crazy for you too?” 3) Establish an undeniable truth. “I promise it’s going to get crazier with the holidays coming.” 4) Move toward an idea that everybody can agree. “Holidays are coming fast. We should get...
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Το κάλιο είναι ένα μέταλλο απαραίτητο για την καλή λειτουργία του οργανισμού.
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Αναλυτική πρόγνωση για όλη τη χώρα - Δείτε τους προγνωστικούς χάρτες της Εθνικής Μετεωρολογικής Υπηρεσίας (ΕΜΥ)
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Toxins, Vol. 11, Pages 659: Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims Toxins doi: 10.3390/toxins11110659 Authors: Kolawole Meneely Greer Chevallier Jones Connolly Elliott Contamination of animal feed with multiple mycotoxins is an ongoing and growing issue, as over 60% of cereal crops worldwide have been shown to be contaminated with mycotoxins. The present study was carried out to assess the...
Tue Nov 12, 2019 02:00
Toxins, Vol. 11, Pages 658: Multiple Mycotoxins Determination in Food by LC-MS/MS: An International Collaborative Study Toxins doi: 10.3390/toxins11110658 Authors: Thomas Bessaire Claudia Mujahid Pascal Mottier Aurélien Desmarchelier An intercollaborative study was organized to evaluate the performance characteristics of a liquid chromatography tandem mass spectrometry procedure for the simultaneous determination of 12 mycotoxins in food, which were ochratoxin A, aflatoxins...
Tue Nov 12, 2019 02:00
We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer.
Tue Nov 12, 2019 02:00
Myxofibrosarcoma (MFS) is most often found on the limbs of aged male people, but extremely uncommon in the liver.
Tue Nov 12, 2019 02:00
There are differences in the quality of care among breast cancer patients. Narrowing the quality differences could be achieved by increasing the utilization rate of indicators. Here we explored key indicators ...
Tue Nov 12, 2019 02:00
Anaplastic thyroid cancer (ATC) is considered to be a rare type of thyroid cancer but takes up the most important proportion of thyroid cancer-related deaths. Therefore, the development of molecular targeted t...
Tue Nov 12, 2019 02:00
Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma
Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum ...
Tue Nov 12, 2019 02:00
Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a ...
Tue Nov 12, 2019 02:00
Viruses, Vol. 11, Pages 1053: New Insights into Parvovirus Research Viruses doi: 10.3390/v11111053 Authors: Giorgio Gallinella The family Parvoviridae includes an ample and most diverse collection of viruses. Exploring the biological diversity and the inherent complexity in these apparently simple viruses has been a continuous commitment for the scientific community since their first discovery more than fifty years ago. The Special Issue of ‘Viruses’ dedicated to...
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Ένα 17χρονο αγόρι από το Μίσιγκαν, που «κινδύνευε άμεσα να πεθάνει» εξαιτίας των επιπτώσεων του ατμίσματος, υποβλήθηκε σε διπλή μεταμόσχευση πνευμόνων, ανακοίνωσε νοσοκομείο του Ντιτρόιτ. The post Διπλή μεταμόσχυεση πνευμόνων σε 17χρονο εξαιτίας του ηλεκτρονικού τσιγάρου! Τι συμπτώματα είχε παρουσιάσει appeared first on Iatropedia.
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– Vista de la Puerta de Alcalá en Madrid, desde las oficinas de Abante. Esta tarde en el #AuditorioAbante @ssatrustegui habla con Álvaro Fernández, uno de los autores de “El cerebro que cura”. #ConferenciaAbante #ElCerebroQueCura pic.twitter.com/P1aaxE6bfO — abanteasesores (@abanteasesores) November 11, 2019 “Vivimos más años y el entorno ha cambiado. Ahora tenemos que seguir aprendiendo constantemente. Tenemos una oportunidad para mejorar nuestra mente”, destaca Álvaro Fernández #ElCerebroQueCura...
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