– Vista de la Puerta de Alcalá en Madrid, desde las oficinas de Abante. Esta tarde en el #AuditorioAbante @ssatrustegui habla con Álvaro Fernández, uno de los autores de “El cerebro que cura”. #ConferenciaAbante #ElCerebroQueCura pic.twitter.com/P1aaxE6bfO — abanteasesores (@abanteasesores) November 11, 2019 “Vivimos más años y el entorno ha cambiado. Ahora tenemos que seguir aprendiendo constantemente. Tenemos una oportunidad para mejorar nuestra mente”, destaca Álvaro Fernández #ElCerebroQueCura...
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Vascular invasion has been identified as an informative risk factor for relapse in stage I testicular nonseminomas, used to tailor treatment. We investigated interobserver agreement in vascular invasion reporting and studied the potential additional value of immunohistochemistry for vascular markers for predicting relapse. Patients (n=52) with stage I testicular nonseminomas undergoing surveillance (1993-2006) were included (median follow-up of 66 mo). Two formalin-fixed paraffin-embedded blocks...
09:50
Supratentorial extraventricular ependymomas (STEEs) are relatively rare ependymomas, and their pathologic and genetic characteristics are still poorly understood. The aim of this study was to determine the histologic, immunohistochemical, and RELA fusion features, as well as to clarify in more detail the clinical courses of STEEs. Data from a total of 43 patients with STEEs was analyzed retrospectively. The status of RELA fusion was evaluated using fluorescence in situ hybridization. The expression...
09:50
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. We enrolled 389 patients who underwent cisplatin-based chemotherapy before radical cystectomy in 8 centers between 2010 and 2016. Median...
09:50
The PROMISE diagnostic algorithm, which uses p53, mismatch repair (MMR) protein immunohistochemistry, and DNA polymerase ε (POLE) exonuclease domain mutation testing, is a reliable surrogate of the molecular group in endometrial carcinoma. Its prognostic value has been validated in endometrial carcinoma and ovarian endometrioid carcinoma. Moreover, a similar prognostic grouping has been recently documented in endometrial clear cell carcinoma. Thus, we aimed to explore the role of these markers in...
09:50
Chronic active Epstein-Barr virus (EBV) infection of T-cell and NK-cell type, systemic form (CAEBV-T/NK-S) is characterized by EBV+ T-cell and/or NK-cell proliferation with no changes suggesting malignancy. Therefore, when Hodgkin/Reed-Sternberg (HRS)-like cells are scattered in CAEBV-T/NK-S, it is more likely to be misdiagnosed as classic Hodgkin lymphoma. We encountered a case wherein the patient showed HRS-like cells with typical NK phenotype. Therefore, we further investigated 8 similar cases...
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Secretory carcinoma is a special-type breast carcinoma underpinned by a recurrent t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 gene fusion. Immunohistochemistry (IHC) using a pan-TRK antibody has been recently shown to help identify NTRK rearrangements in other tumor types. The purpose of this study was to assess the diagnostic utility of pan-TRK IHC in secretory carcinoma of the breast. Pan-TRK IHC was performed using a rabbit monoclonal antibody on whole sections of 24 breast secretory...
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ATF1, CREB1, and CREM constitute the CREB family of transcription factors. The genes encoding these factors are involved in gene fusion events in human tumors. EWSR1-ATF1 and EWSR1-CREB1 are the 2 most characterized fusions, whereas EWSR1-CREM has been less studied. To better understand the phenotypic spectrum of mesenchymal tumors associated with the EWSR1-CREM fusion, we investigated archival cases using fluorescence in situ hybridization and/or RNA sequencing. Among 33 clear cell sarcomas of soft...
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No abstract available
09:50
Spitz melanoma is a rare variant of melanoma defined by distinct clinical, histologic, and genetic features and affecting patients of all ages. Half of these tumors are driven by fusion of kinase genes including ALK, NTRK1/3, ROS1, RET, MET, or BRAF. We recently reported recurrent fusion or truncation of the potentially targetable serine-threonine kinase gene MAP3K8 in 33% of Spitz melanomas. Here we describe the histologic features of these MAP3K8-rearranged tumors (16 pediatric Spitz melanomas;...
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Many gallbladder adenocarcinomas (ACs) are detected incidentally in routine cholecystectomy specimens, yet sampling practices vary when intestinal metaplasia (IM) or dysplasia are found via routine sampling. Our practice has been to submit 5 additional sections when IM is found, but cases with dysplasia are entirely submitted. We sought to determine an appropriate sampling protocol when encountering these findings. We retrospectively identified cholecystectomy specimens with these features over a...
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Although there are 5 well-described morphologic patterns of (nonglandular) urothelial carcinoma in situ (CIS), we have encountered a novel pattern of flat urothelial carcinoma with plasmacytoid features characterized by a triad of morphologic findings including abnormal architecture with cellular rounding, enlarged nuclei with eccentric nuclear localization, and dense globular eosinophilic cytoplasm. A total of 23 cases of plasmacytoid CIS (mean age: 74.1 y, range: 58 to 91 y) were collected and...
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The entity “pericytoma with t(7;12)” was described as a rare, distinct perivascular myoid neoplasm provisionally classified within the family of myopericytic tumors that demonstrates t(7;12)(p22;q13) translocation with resultant ACTB-GLI1 fusion and biologically was felt to behave in an indolent fashion. However, a recent study showed that tumors with this and similar translocations may have variable morphology and immunohistochemical phenotype with inconsistent myopericytic characteristics and a...
09:50
Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferation that occurs in nodal and extranodal sites. Rare examples of the disease involving the digestive system have been described. To characterize the digestive tract manifestations of this disease, 12 specimens from 11 patients with extranodal RDD affecting the digestive organs were analyzed. Hematoxylin and eosin sections and available immunohistochemical stains were reviewed, and the clinical information was obtained...
09:50
Identifying tumor characteristics that correlate with metastasis and survival in patients with conjunctival melanoma can potentially lead to better outcomes through a better selection of patients for adjuvant treatments including potentially life-saving new melanoma therapy. The objective of this study was to validate the conjunctival melanoma staging criteria in the American Joint Committee on Cancer (AJCC) Cancer Staging Manual (8th edition) and explore the prognostic importance of tumor thickness,...
09:50
Rosai-Dorfman disease (RDD) is an uncommon disorder, characterized by an atypical expansion of histiocytes which classically shows emperipolesis and immunoreactivity with S-100 protein. RDD affects the lymph nodes as well as extranodal sites; however, RDD of the breast is exceptionally rare. Herein, we describe the histopathologic features of 22 cases of RDD occurring in the breast, with an emphasis on the differential diagnosis. All cases were notable for an exuberant lymphocytic infiltrate with...
09:50
Systemic high-grade B-cell lymphomas (HGBCLs) with MYC gene rearrangements are clinically aggressive. In situ lesions with indolent behavior have not been described to date. We have identified 2 cases of in situ B-cell neoplasms with MYC rearrangements (IS-BCN, MYC+) occurring, and focally confined to ≤4 lymphoid follicles in otherwise healthy individuals and without clinical progression despite minimal intervention (surgical only). Morphologically similar to systemic HGBCLs, the low power view of...
09:50
Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, the aim of this study is to evaluate the value of immunohistochemistry in osteoid osteoma, osteoblastoma, and osteosarcoma for diagnostic purposes. A total of 337 cases were tested with antibodies against c-FOS: 84...
09:50
No abstract available
09:50
Abstract Curcumin, extracted from the roots of Curcuma longa, has been used as an anti-inflammatory agent since the time of Ayurveda. The present work was designed to evaluate the potential of curcumin in amelioration of ovalbumin (OVA) induced AD in mice. Female BALB/c mice were subjected to skin OVA-patch application for a period of 1 week followed by resting period of 2 weeks, and the same protocol was repeated thrice. Curcumin was administered...
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Abstract -20pt?>Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium that causes contagious tuberculosis (TB). Recently, Mtb-secreted proteins have been considered virulence factors and candidates for drugs and vaccines. Among these proteins, 6-kDa early secreted antigenic target (ESAT-6) is known to be able to induce component of matrix metalloproteinase-9 (MMP-9) in epithelial cells, leading to recruitment of macrophages. However,...
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We can't find any trace of cosmic dark matter – perhaps because our models of the early universe are missing a crucial piece, says astrophysicist Dan Hooper
08:00
Energy use from gaming in the US produces carbon emissions on a par with Sri Lanka’s total annual carbon footprint
Tue Nov 12, 2019 19:30
The space rock that the New Horizons probe visited earlier this year had been nicknamed Ultima Thule, but it was pointed out this name has links to the Nazis
Tue Nov 12, 2019 19:09
We've seen the remains of a collision between two planets in a distant star system - and these planetary smash-ups are thought to be surprisingly common
Tue Nov 12, 2019 18:46
A document released just days after the government announced a halt to fracking suggests that future applications will be considered
Tue Nov 12, 2019 14:36
Streaming video services like Netflix, Apple TV+ and Disney+ are on the rise - but so are their carbon emissions
Tue Nov 12, 2019 13:35
Making mistakes helps us learn and get better at stuff, says neuroscientist Henning Beck, but be wary of thinking what works for humans will work for AI
Wed Nov 06, 2019 20:00
Australia is preparing for catastrophic bushfires as one state minister warns that this could be the worst week of wildfires in the country’s history
Tue Nov 12, 2019 13:11
Abstract Common variable immunodeficiency disorders (CVID) are the most frequent symptomatic primary immune deficiency in adults. At this time, the causes of these conditions are unknown. Patients with CVID experience immune system failure consequent to late onset antibody failure. They have increased susceptibility to infections and are also at risk of severe autoimmune and inflammatory disorders as a result of immune dysregulation. An increasing number of monogenic causes as...
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The number of MRI accidents currently reported is only the tip of the iceberg,...Read more on AuntMinnieEurope.comRelated Reading: New details emerge of 2nd MRI accident in Sweden Police investigate serious MRI accident in Sweden Hospital staff injured in MRI accident in Sweden What exactly lies behind MRI safety incidents? MRI provider calls for urgent action on patient safety
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German researchers have found that shear-wave elastography (SWE) is a viable...Read more on AuntMinnieEurope.comRelated Reading: ESR to present Children in Focus program Postmortem pediatric imaging proves value Spanish apply 3D printing to pediatric tumor surgery RCR, SCoR release updated pediatric radiotherapy guide Ultralow-cost neonatal ultrasound unit developed
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Antioxidants, Vol. 8, Pages 545: Evidence for an Allosteric S-Nitrosoglutathione Binding Site in S-Nitrosoglutathione Reductase (GSNOR) Antioxidants doi: 10.3390/antiox8110545 Authors: Kathleen Fontana Nneamaka Onukwue Bei-Lei Sun Cristina Lento Leslie Ventimiglia Sahar Nikoo James W. Gauld Derek J. Wilson Bulent Mutus Current research has identified S-nitrosoglutathione reductase (GSNOR) as the central enzyme for regulating protein S-nitrosylation. In addition,...
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Antioxidants, Vol. 8, Pages 544: Caveats for the Good and Bad of Dietary Red Meat Antioxidants doi: 10.3390/antiox8110544 Authors: Omaye Omaye Red meat and its constituents of heme iron or free iron have been the target of scrutiny related to their purported association to many chronic diseases. However, in contrast, red meat provides a rich source of nutrition. In 2007, Al Tappel hypothesized that the mechanistic explanation for the adverse impact of iron and heme iron could be...
Tue Nov 12, 2019 02:00
Journal of Clinical Medicine, JCM, Vol. 8, Pages 1947: Acute Effects of Immersive Virtual Reality… Journal of Clinical Medicine,JCM, Vol. 8, Pages 1947: Acute Effects of Immersive Virtual Reality Exercise on Young Adults’ Situational MotivationJCM, Vol. 8, Pages 1947: Acute Effects of Immersive Virtual Reality Exercise on Young Adults’ Situational Motivation Journal of Clinical Medicine doi: 10.3390/jcm8111947 Authors: Wenxi Liu Nan Zeng Zachary C. Pope Daniel J. McDonough Zan Gao The development...
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Brain Sciences, Vol. 9, Pages 321: Lost in Classification: Lower Cognitive Functioning in Apparently Cognitive Normal Newly Diagnosed RRMS Patients Brain Sciences doi: 10.3390/brainsci9110321 Authors: Marco Pitteri Stefano Ziccardi Caterina Dapor Maddalena Guandalini Massimiliano Calabrese Cognitive functioning in multiple sclerosis (MS) patients is usually related to the classic, dichotomic classification of impaired vs. unimpaired cognition. However, this approach is far...
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Abstract Background Acute exacerbation (AE) of interstitial lung disease (ILD) is a fatal adverse event in the treatment of lung cancer patients with ILD. The value of pre-treatment radiological findings obtained by high-resolution computed tomography for the detection of anticancer treatment-related AE of ILD has not been established. Methods Two medical...
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Abstract Background HPV vaccines are well known to prevent several devastating HPV-associated cancers—when administered before sexual activity begins. We have previously found that mothers in Japan play an important role in a young girl’s vaccination decision-making, and that educational intervention with the mothers positively changed their attitude towards the HPV vaccine. The role of fathers is still unclear. We report here similar...
Tue Nov 12, 2019 02:00
Abstract Background Autologous fat transfer is widely used in plastic surgery for both reconstructive and esthetic purposes. The aim of this study is to identify the results of autologous fat graft to the breast through the rate of fat necrosis, cyst formation, and calcification patterns to avoid unnecessary breast biopsies. Methods This prospective study...
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Abstract Background Psychological functioning of rhinoplasty must be evaluated in the community of Iran as the most prevalent center of rhinoplasty worldwide. Making a realistic public view about rhinoplasty psychological outcomes is necessary. In the present study, quality of life, anxiety, depression, and self-esteem alteration in rhinoplasty patients among the Iranian population were assessed....
Tue Nov 12, 2019 02:00
Abstract The aim was to develop a predictive model of infection by multidrug-resistant microorganisms (MDRO). A national, retrospective cohort study was carried out including all patients attended for an infectious disease in 54 Spanish Emergency Departments (ED), in whom a microbiological isolation was available from a culture obtained during their attention in the ED. A MDRO infection prediction model was created in a derivation cohort using backward logistic regression. Those...
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Abstract The disc diffusion test is used for antimicrobial susceptibility testing worldwide. In this study, the performance of both Bio-Rad® antibiotic discs (as compared with Oxoid® discs) and the ADAGIO™ automated system for the reading of disc diffusion test results was evaluated with American Type Culture Collection (ATCC) quality control (QC) and wild strains of bacteria. Inhibition zones of both disc brands were read manually and through use of the ADAGIO™ system. Categorized...
Tue Nov 12, 2019 02:00
Abstract This study surveys the clinical relevance of the nasal Staphylococcus aureus colonization status on intensive care unit (ICU)–acquired S. aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified through a second (negative) culture. Spa typing and virulence gene profiling...
Tue Nov 12, 2019 02:00
Abstract Microbiological diagnosis of central nervous system (CNS) infections is challenging due to limited access to CNS samples, overlap between meningitis and encephalitis, and the multiplicity of pathogens potentially involved. We aimed to estimate the impact of a commercial multiplex PCR assay (FilmArray® meningitis/encephalitis) on the management of patients with suspicion of meningitis or encephalitis, in terms of time to diagnosis, antimicrobial agents use, duration of...
Tue Nov 12, 2019 02:00
Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a ...
Tue Nov 12, 2019 02:00
We examined factors related to the uptake of two malaria prevention measures, insecticide-treated bed-nets and prophylactic sulphadoxine-pyrimethamine (SP), among pregnant women in Nnewi, Nigeria. The survey had a quantitative and qualitative part. For each part, the subjects meeting our inclusion criteria were systematically identified in a population-based manner. For the qualitative part, focused group discussions, in-depth interviews with a wide variety of stakeholders (e.g., health workers,...
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ObjectivesTo assess the impact of lower socioeconomic status on the outcome of major torso trauma patients under the single-payer system by the National Health Insurance (NHI) in Taiwan. DesignA nationwide, retrospective cohort study. SettingAn observational study from the NHI Research Database (NHIRD), involving all the insurees in the NHI. ParticipantsPatients with major torso trauma (injury severity score ≥16) from 2003 to 2013 in Taiwan were included. International Classification of Disease,...
06:56
PurposeEffects of fetal, perinatal and childhood environment on the health of children at birth and during later life have become a topic of concern. The Aichi regional sub-cohort of the Japan Environment and Children’s Study (JECS-A) is an ongoing birth cohort of pregnant women and their children which has been used to provide unique data, as adjunct studies of JECS, on multifaceted potential factors affecting children’s health. ParticipantsThe JECS-A is part of the JECS which follows a total of...
06:56
IntroductionThe surviving opioid overdose with naloxone education and resuscitation (SOONER) project uses co-design and trial methods to develop and evaluate a point-of-care overdose education and naloxone distribution (OEND) tool. We plan to conduct a randomised controlled trial to assess the effectiveness of our OEND tool in comparison with best available standard of care by observing participants’ performance as a responder to a simulated overdose. Recruiting and retaining people at risk of or...
06:56
IntroductionVasoplegia is common and associated with a poor prognosis in patients with sepsis and septic shock. Vitamin C therapy in combination with vitamin B1 and glucocorticoid, as well as monotherapy in various doses, has been investigated as a treatment for the vasoplegic state in sepsis, through targeting the inflammatory cascade. However, the combination effect and the relative contribution of each drug have not been well evaluated. Furthermore, the best combination between the three agents...
06:56
ObjectiveThis study aimed to investigate the perceptions of elderly caregivers in Chinese nursing homes (NHs) and associated factors with regard to knowledge, attitude about elderly and self-efficacy. SettingA cross-sectional questionnaire survey was conducted in 12 NHs in Liaoning Province, China. ParticipantsA total of 403 caregivers from 12 NHs were surveyed. Outcome measuresData were collected using a self-administered questionnaire composed of the Palmore’s Facts on Aging Quiz I, Kogan’s...
06:56
ObjectivesUnderestimation of overweight/obesity may prevent weight loss attempts, resulting in further weight gain and maintenance of overweight. Mental health benefits may nevertheless surpass negative consequences. Our main objective was to study the association between underestimation of overweight/obesity and symptoms of anxiety and depression in Sami and non-Sami populations. DesignPopulation-based cross-sectional study. SettingThe SAMINOR 2 Clinical Study with participants from 10 municipalities...
06:56
ObjectivesWe aimed to develop and validate a postoperative delirium (POD) prediction model for patients admitted to the intensive care unit (ICU). DesignA prospective study was conducted. SettingThe study was conducted in the surgical, cardiovascular surgical and trauma surgical ICUs of an affiliated hospital of a medical university in Heilongjiang Province, China. ParticipantsThis study included 400 patients (≥18 years old) admitted to the ICU after surgery. Primary and secondary outcome measuresThe...
06:56
ObjectiveTo assess the feasibility of a randomised controlled trial (RCT) and acceptability of an asthma self-management digital intervention to improve asthma-specific quality of life in comparison with usual care. Design and settingA two-arm feasibility RCT conducted across seven general practices in Wessex, UK. ParticipantsPrimary care patients with asthma aged 18 years and over, with impaired asthma-specific quality of life and access to the internet. Interventions‘My Breathing Matters’ (MBM)...
06:56
IntroductionRisk calculators (RCs) are easy-to-use tools considering available clinical variables that could help to select those patients with risk of prostate cancer (PCa) who should undergo a prostate biopsy. ObjectiveTo perform a comparison for the prediction of significant PCa (SigPCa) between the European Randomised Study of Screening for PCa (ERSPC) and the PCa Prevention Trial (PCPT) RCs in patients with prostate-specific antigen (PSA) between 3 and 10 ng/mL through an evaluation of the...
06:56
IntroductionThe over-prescription and overuse of opioid analgesics for chronic non-cancer pain (CNCP) is a growing issue. Synthesis of evidence about the barriers and enablers to reducing long-term opioid prescribing and use will enable the development of tailored interventions to address both problems. ObjectiveTo synthesise the barriers and enablers to monitoring the ongoing appropriateness of opioid treatment and deprescribing opioids for CNCP from the clinician, patient and general public point...
06:56
IntroductionObservational studies have demonstrated an association between vitamin D deficiency and increased risk of morbidity and mortality in critically ill patients. Cohort studies and pilot trials have suggested promising beneficial effects of vitamin D replacement in the critical ill, at least in patients with severe vitamin D deficiency. As vitamin D is a simple, low-cost and safe intervention, it has potential to improve survival in critically ill patients. Methods and analysisIn this randomised,...
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IntroductionNeurotrauma is an important global health problem. This ‘silent epidemic’ is a major cause of death and disability in adolescents and young adults, with significant societal and economic impacts. Globally, the largest cause of neurotrauma is road traffic collisions (RTCs). Neurotrauma and RTCs are largely preventable, and many preventative strategies and interventions have been established and implemented over the last decades, particularly in high-income countries. However, these approaches...
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ObjectiveTo estimate the prevalence and incidence of placenta previa complicated by placenta accreta spectrum (PAS) and to examine the different criteria being used for the diagnosis. DesignSystematic review and meta-analysis. Data sourcesPubMed, Google Scholar, ClinicalTrials.gov and MEDLINE were searched between August 1982 and September 2018. Eligibility criteriaStudies reporting on placenta previa complicated by PAS diagnosed in a defined obstetric population. Data extraction and synthesisTwo...
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ObjectiveTo explore what affects sustainable responses to intimate partner violence within New Zealand primary care settings using complexity theory. DesignPrimary care professional interviews on intimate partner violence as a health issue are analysed using a complexity theory-led qualitative research methodology grounded in poststructuralism. SettingFour general practices in one region of the North Island of New Zealand, two serving a general patient population and two adopting an indigenous...
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ObjectivesWe examined the factors related to lost-to-follow-up of a birth cohort study during the first year after delivery. DesignLongitudinal cohort study. SettingQuestionnaires were provided by mail. Mothers answered the questionnaires about the children twice: at 6 months and 1 year. ParticipantsOf 103 062 pregnancies who consented to participate in the Japan Environment and Children’s Study (JECS), 93 417 mothers were included in the study after excluding those with multiple births, miscarriages...
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IntroductionTemporomandibular disorders (TMDs) are principally characterised by pain in the craniomandibular area and probable limitations of jaw opening. Manual therapy, like other recommended conservative treatments included in clinical guidelines, is commonly used to treat patients with TMD to reduce pain and improve function. However, outcomes may be variable. The aim of this study is to identify predictors associated with pain reduction in patients with TMD following manual therapy by analysing...
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IntroductionHospital stays are critical events as they often disrupt continuity of care. This process evaluation aims to describe and explore the implementation of the VESPEERA programme (Improving continuity of patient care across sectors: An admission and discharge model in general practices and hospitals, Versorgungskontinuitaet sichern: Patientenorientiertes Einweisungs- und Entlassmanagement in Hausarztpraxen und Krankenhauesern). The evaluation concerns the intervention fidelity, reach in targeted...
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ObjectiveTo assess the value of using frailty measures in primary care for predicting death, nursing home transfer (NHT) and hospital admission. DesignCohort study. Setting and participantsAll 380 people, mean age 88.4, living in the community and receiving home-based primary geriatric care from one practice in Victoria, Canada. Interventions/measurementsA 60 min baseline assessment which included: Clinical Frailty Scale (CFS), EuroQol EQ-5D-5L (EQ-5D), EuroQol Visual Analogue Scale (EQ-VAS) and...
06:56
IntroductionIn recent years, a hypothesis has been raised that people with tuberculosis are at risk for developing venous thromboembolism (VTE). However, much remains to be understood about the interplay between VTE and tuberculosis. Therefore, through a global systematic review and meta-analysis, the current study aims at investigating the association between exposure to active tuberculosis and risk of VTE, and determining the prevalence and incidence of VTE in people with active tuberculosis. Methods...
06:56
IntroductionPatients with bladder cancer (BC) have been found to have worse experiences than those with other cancers which may partly be due to impact on quality of life. Currently, little is known about the impact of physical activity (PA) on BC outcomes. This scoping review aims to identify what interventions are available, their reported efficacy and feasibility, and a description of potential underlying biological mechanisms for their effects. Methods and analysisPreferred Reporting Items for...
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ObjectiveFamily planning is unique among health interventions in its breadth of health, development and economic benefits. The complexity of formulating effective strategies to promote women’s and girls’ access to family planning calls for closer coordination of resources and attention from all stakeholders. Our objective was to quantify the concordance of two global initiatives: Family Planning 2020’s adding 120 million modern contraceptive users by 2020 (proposed during The London Summit 2012 by...
06:56
ObjectiveTo estimate the effects of repeat assessments, rater and time of day on mobility measures and to estimate their variation between and within participants in a population-based sample of Irish adults aged ≥50 years. DesignTest–retest study in a population representative sample. SettingAcademic health assessment centre of The Irish Longitudinal Study on Ageing (TILDA). Participants128 community-dwelling adults from the Survey for Health, Ageing and Retirement in Europe (SHARE) Ireland study...
Tue Nov 12, 2019 08:29
ObjectiveTo determine the effect of occupational therapy provided at home on activities of daily living, behavioural and psychological symptoms of dementia (BPSD) and quality of life (QOL) for people with dementia, and the effect on family carer burden, depression and QOL. DesignSystematic review and meta-analysis. MethodsEight databases were searched to February 2018. Randomised controlled trials of occupational therapy delivered at home for people with dementia and their family carers that measured...
Tue Nov 12, 2019 08:29
AbstractAntimicrobial resistance has become one of the greatest threats to public health, with rising resistance to carbapenems being a particular concern due to the lack of effective and safe alternative treatment options. Carbapenem-resistant gram-negative bacteria of clinical relevance include the Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and more recently, Stenotrophomonas maltophilia. Colistin and tigecycline have been used as first-line agents for the treatment of...
02:00
AbstractCarbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of...
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AbstractHistorically, the regulatory requirements of the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for developing new antibiotics have not addressed pathogen-focused indications for drug approval. The design of the necessary randomized controlled trials traditionally involves the enrollment of patients with site-specific infections caused by susceptible as well as resistant pathogens. Cefiderocol has undergone a streamlined clinical development program to address...
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AbstractCarbapenem-resistant gram-negative bacteria including Enterobacteriaceae as well as nonfermenters, such as Pseudomonas aeruginosa and Acinetobacter baumannii, have emerged as significant global clinical threats. Although new agents have recently been approved, none are active across the entire range of resistance mechanisms presented by carbapenem-resistant gram-negative bacteria. Cefiderocol, a novel siderophore cephalosporin, has been shown in large surveillance programs and independent...
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AbstractThe emergence of antimicrobial resistance is a significant public health issue worldwide, particularly for healthcare-associated infections caused by carbapenem-resistant gram-negative pathogens. Cefiderocol is a novel siderophore cephalosporin targeting gram-negative bacteria, including strains with carbapenem resistance. The structural characteristics of cefiderocol show similarity to both ceftazidime and cefepime, which enable cefiderocol to withstand hydrolysis by β-lactamases. The unique...
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AbstractIron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for pathogenic bacteria. However, bacteria have developed various mechanisms to sequester or scavenge iron from the host environment. Iron can be taken up by means of active transport systems that consist of bacterial small molecule siderophores, outer membrane...
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AbstractCefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a “Trojan horse” active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.
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AbstractCefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent in vitro activity and in vivo efficacy against most gram-negative bacteria, including carbapenem-resistant strains of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia. In phase 1 studies, cefiderocol demonstrated linear pharmacokinetics, primarily urinary excretion, an elimination half-life of 2–3 hours, and a protein binding of 58% in human plasma. Cefiderocol is...
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01759C, PaperSayyed Hashem Sajjadi, Hossein Ahmadzadeh, Elaheh K GoharshadNanoparticles (NPs) are able to improve the separation efficiency of proteins in SDS-polyacrylamide gel electrophoresis (SDS-PAGE) due to their capability in enhancing heat dissipation during electrophoresis. However, the intrinsic surface...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01848D, PaperNuo Zhang, Yaoguang Wang, Guanhui Zhao, Chao Wang, Yueyuan Li, Yong Zhang, Huan Wang, Qin WeiAn ultrasensitive label-free photoelectrochemical (PEC) immunosensor was developed to detect amyloid β-protein (Aβ) based on CdS/CdTe cosensitized SnO2 nanoflowers. Specifically, SnO2 with flower-like porous nanostructure was utilized as a perfect...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01679A, PaperKyu Shik Eom, Yijae Lee, Hye Won Seo, Ji Yoon Kang, Joon S. Shim, Soo Hyun LeeAn excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol in the blood would improve the...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01758E, PaperCorentin Jacquemmoz, François Giraud, Jean-Nicolas DumezNuclear magnetic resonance (NMR) spectroscopy is a powerful tool for reaction monitoring. Several devices have been recently developed for online monitoring, using flow NMR, of batch reactions carried out in...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Nov 12, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN02007A, PaperMingying Zhao, Fagong Xu, Lun Wang, Hongqi Chenerrous ion (Fe2+) is an important component of hemoglobin and plays a role in transporting O2 to human tissues. If iron deficiency is found, iron deficiency anemia may occur, so...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Nov 12, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01628G, PaperMahsa Taleghan Ghafari, Fahimeh Varmaghani, Babak Karimi, Vahid KhakyzadehTwo-electron oxidation of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) results in highly unstable TMPD2+ in aqueous solutions. Despite its low redox potential, TMPD2+/TMPD couple is not considered as a suitable charge transfer functional group...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Nov 12, 2019 02:00
A 44-year-old man with a 9-day-old left displaced midshaft clavicle fracture was initially treated conservatively. The patient experienced an increase of pain with tickling and cold sensation in the left upper extremity. CT angiography showed left subclavian artery occlusion over 3 cm at the level of the fracture. At surgical repair, a subclavian-brachial bypass was constructed and fracture fixation was done with an eight-hole locking compression plate. Follow-up at 6 months showed full range of...
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Chimeric antigen receptor (CAR) T-cell therapy is a novel and promising form of cellular immunotherapy using genetically engineered, tumour-specific autologous T cells. CD19-specific CAR T-cells have been shown to be very effective as a treatment for relapsed/refractory B-cell acute lymphoblastic leukaemia and aggressive B-cell non-Hodgkin’s lymphoma. ICANS (immune effector cell-associated neurotoxicity syndrome) is one of the most frequently occurring toxicities of CAR T-cell treatment. We describe...
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Συγγραφείς: Κάλλια Ανδρικοπούλου, Γιώτα Αντωνοπούλου-Στεφανή, Σπυριδούλα Κατσιφή-Χαραλαμπίδη, Άννα Ντιντή Εκπαιδευτικό ΠρόγραμμαΟδηγός εκπαιδευτικού & εκπαιδευτικό υλικό Το προτεινόμενο Εκπαιδευτικό Πρόγραμμα για την κοινωνική ανάπτυξη των μαθητών προέκυψε από την αναγνώριση της έλλειψης κοινωνικής εκπαίδευσης στο σχολείο και την ανάγκη να καλυφθεί το κενό αυτό. Στόχος του παρόντος προγράμματος είναι να καλλιεργήσει βασικές κοινωνικές δεξιότητες και να συμβάλει στην ομαλότερη συμβίωση στο...
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Abstract Background The purpose of this study was to investigate if FDG uptake metrics in primary tumor and lymph node metastases in patients with oropharyngeal squamous cell carcinoma (OPSCC) has a prognostic value beyond UICC8 staging in a multiple endpoint model. Methods Patients with OPSCC treated with primary radiotherapy at Rigshospitalet in the period...
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Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Πες αντίο στο κοιλιακό λίπος με τις ασκήσεις της Ντορέττα Παπαδημητρίου.
06:20
Ο όρος burnout χρησιμοποιήθηκε για πρώτη φορά στα μέσα της δεκαετίας του ’70 στις Η.Π.Α.…
Tue Nov 12, 2019 20:00
Θα σε βοηθήσουν όσο δεν φαντάζεσαι
Tue Nov 12, 2019 18:15
Οι ασκήσεις που έψαχνες καιρό
Tue Nov 12, 2019 15:30
Τροφές και ποτά όπως τα καυτερά και το πράσινο τσάι μπορούν να ενισχύσουν τον μεταβολισμό…
Tue Nov 12, 2019 13:04
Ο κόσμος μας αλλάζει και μαζί με αυτόν και εμείς.
Tue Nov 12, 2019 10:02
Abstract Purpose The treatment efficiency of 90Y and providing reliable estimates of activity are evaluated by SPECT imaging of bremsstrahlung radiation released during beta therapy. In this technique, the resulting spectrum from 90Y is very complex and continuous, which creates difficulties on the imaging protocol. Moreover, collimator geometry has an impressive effect on the spatial resolution, system sensitivity, image contrast, and...
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Abstract Annually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor–related antigens or antigens...
Tue Nov 12, 2019 02:00
The Production of Gesture and Speech by People With Aphasia: Influence of Communicative Constraints.
Conclusions The current results suggest that PWA use gestures to compensate for their verbal limitations under varying communicative constraints. The properties of the communicative task influence the use of different gesture types in people with and without aphasia. Thus, the influence of communicative constraints needs to be considered when assessing PWA's multimodal communicative abilities. PMID: 31710512 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing...
Mon Nov 11, 2019 00:00
Conclusions These findings indicate that, even though explicit and implicit biases were evident when listeners heard stuttering, both explicit and implicit biases seemed to extinguish over time after a self-disclosure. Although the bias was not completely extinguished, these results provide promising evidence toward developing methods to reduce negative beliefs and reactions toward PWS. Supplemental Material http://osf.io/mwrp7/. PMID: 31697574 [PubMed - as supplied by publisher] (Source: Journal...
Thu Nov 07, 2019 00:00
Conclusion Because children with SLI produced a lower proportion of pseudowords as scorable incorrect responses than peers with typical language, we conclude that they have less developed lexical-morphological networks and, thus, less derivational morphology knowledge than peers with typical language. PMID: 31693430 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Wed Nov 06, 2019 00:00
Conclusions The questionnaire can be applied as a structured approach to inventory hearing problems in 6 dimensions prior to hearing aid fitting and to systematically evaluate the effects of hearing aid fitting after a trial period. The data presented here can serve as normative data for comparison of individual subjects in clinical practice. PMID: 31693431 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Wed Nov 06, 2019 00:00
Conclusion Phonetic features of German IDS are robust with respect to the factors gender, parental involvement, speech material (read vs. spontaneous speech), and time. Some phonetic features of ADS changed within the child's first year depending on gender and parental involvement/gender identity. Thus, further research on IDS needs to address also potential changes in ADS. PMID: 31693443 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Wed Nov 06, 2019 00:00
Abstract Background Many studies examine the use of medicines among pregnant women, however few studies report the pregnant women’s belief for taking medication during pregnancy. Individual factors such as patients’ beliefs about their medications have been known to influence medication adherence. Objective This study aimed to examine beliefs about medicines among pregnant women in Indonesia and how these varied across pregnancy trimesters. Setting We conducted a cross-sectional...
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Abstract Background Multimorbidity and polypharmacy are common in older people. Despite the existence of quality criteria for medication use among this population, there is little guidance for managing the complex pharmacological arsenal in a multimorbidity context. Objective To establish consensus on benefits, risks and impacts on quality of life of medications used in an older adult with three chronic diseases that require complex pharmacotherapy. Setting International experts...
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Proprotein convertase subtilisin/kexin 9 (PCSK9) has been proposed as a novel target for coronary artery disease (CAD). Familial hypercholesterolemia (FH) is characterized by high prevalence of CAD and major c...
Mon Nov 11, 2019 02:00
Myelodysplastic syndrome (MDS) can progress to acute myeloid leukemia (AML), and conventional chemotherapy (decitabine) does not effectively inhibit tumor cells. Enhancer of zeste homologue 2 (EZH2) and Heme o...
Mon Nov 11, 2019 02:00
There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small mole...
Mon Nov 11, 2019 02:00
Abstract Adults exposed to intimate partner violence (IPV) in their childhood are often considered in studies to be a homogeneous group and are not questioned about the meanings that they give to IPV. This study focuses specifically on the 18–25 age group and seeks to answer the following questions: 1) How do young adults exposed to IPV explain what IPV meant to them? 2) In their opinion, which experiences in their life course contributed to construction of meanings?. Semi-structured...
Tue Nov 12, 2019 02:00
Abstract Background Craniofacial morphogenesis is the result of an intricate multistep network of tightly controlled spatial and temporal signalling that involves several molecules and transcription factors organised into highly coordinated pathways. Any alteration in even one step of this delicate process can lead to congenital malformations such as cleft palate. One of the first steps in embryonal orofacial development is the migration of cells from the neural crests to the branchial arches....
Tue Nov 12, 2019 14:28
Sprache Stimme GehörDOI: 10.1055/a-0949-7081© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Nov 12, 2019 01:00
Sprache Stimme GehörDOI: 10.1055/a-0949-6520The aim of the present study was a systematic literature review on selected evidence-based voice therapy programs for the treatment of various types of dysphonia. The results showed that nine of seventeen voice therapy programs complied the selection criteria. All nine voice therapy programs revealed significant improvements in various aspects of laryngeal evaluation, voice quality, vocal function, and/or self-evaluation. These improvements might be expected...
Tue Nov 12, 2019 01:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07952
Tue Nov 12, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10983
Tue Nov 12, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06956
Tue Nov 12, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09833
Tue Nov 12, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12173
Tue Nov 12, 2019 07:00
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