FRIDAY, Nov. 1, 2019 -- Fighting cancer can be a long, hard battle, not to mention expensive. Now, new research shows that a quarter of oncologists don't discuss the cost of expensive tests with their patients. Genomic tests on cancer cells can... (Source: Drugs.com - Daily MedNews)
Fri Nov 01, 2019 17:11
(Source: The Doctors Lounge - Oncology)
Fri Nov 01, 2019 15:00
(Source: The Doctors Lounge - Oncology)
Fri Nov 01, 2019 10:15
The probiotics and prebiotics of yogurt and fiber consumption is associated with decreased risk of lung cancer. (Source: CancerNetwork)
Fri Nov 01, 2019 05:00
Treatment with gilteritinib improved survival and increased remission rates, compared with salvage chemotherapy, among patients with relapsed or refractory FLT3-mutated acute myeloid leukemia. (Source: CancerNetwork)
Fri Nov 01, 2019 05:00
A compound called MRTX849 is showing signs of being the first effective inhibitor of the KRAS G12C-mutant subtype of non-small cell lung and colorectal cancers. (Source: CancerNetwork)
Fri Nov 01, 2019 05:00
Endometrial cancer survival correlates with total number of chemotherapy cycles – but not whether they are started earlier than radiation, according to the results of a new study. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Fri Nov 01, 2019 05:00
Increase due to several factors including deprivation and rise in obesity says Cancer Research UKDeaths from liver cancer in the UK have shot up in recent years, with a rise of almost 80% in numbers between 2007 to 2017, new figures reveal.Experts say there are several factors behind the rise, including the fact that more people are being diagnosed with the disease, which is notoriously difficult to detect in its early stages, meaning it has a poor prognosis.Continue reading... (Source: Guardian...
Fri Nov 01, 2019 20:50
Three medical stories that we didn't cover, explained.Medscape (Source: Medscape Internal Medicine Headlines)
Fri Nov 01, 2019 19:38
PURPOSE: To evaluate internet-delivered cognitive behavioural therapy (iCBT) on clinical depression and/or anxiety, distress, fear of cancer recurrence and quality of life in cancer survivors. METHODS: Random assignation of 114 participants to iCBT... (Source: SafetyLit)
Fri Nov 01, 2019 19:14
A shortage of radiologists, pensions issues and rising demand have driven the worst breast cancer wait times for at least nine years, some of the worst performing trusts told HSJ. (Source: HSJ)
Fri Nov 01, 2019 06:38
Opens up possibility of modifiable risk factors to stave off disease, say researchers Related items fromOnMedica One-off PSA test doesn ’t save lives, finds largest study of its kind Immune system boosters fight prostate cancer Nearly four in ten prostate cancers 'diagnosed late' Prime minister announces £75 million to fund prostate cancer research Genetic risk model could guide prostate cancer screening (Source: OnMedica Latest News)
Fri Nov 01, 2019 00:00
Among all types of cancer, deaths from this disease have increased the most and risen the fastest Related items fromOnMedica UK falls behind other nations in preventing avoidable death Obesity as cause of cancer set to overtake smoking Doctors urge government to act on rising alcohol impact We are ‘sitting on a young people’s health time bomb’ NHS must improve access to screening to save lives (Source: OnMedica Latest News)MedWorm Message: If you are looking to buy something in the January Sales...
Fri Nov 01, 2019 00:00
And the risk of subsequent malignant neoplasm increases with chemo treatment, research suggests Related items fromOnMedica One in 10 children in phase I cancer trials respond to drugs Cancer mortality cut by a third in young people Decision to give boys HPV jab will save thousands of lives Cancer patients using complementary meds die sooner UK cancer survival improved, but lags behind similar nations (Source: OnMedica Latest News)
Fri Nov 01, 2019 00:00
Elsie Franz Finley's legacy will live on for years due to her support of cancer research, nurses and nutrition. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Fri Nov 01, 2019 15:20
Top HHS official to run FDA on temporary basis while Trump readies nomination of Texas cancer doctor
If confirmed, Stephen Hahn would succeed acting commissioner Norman "Ned" Sharpless (Source: Washington Post: To Your Health)
Fri Nov 01, 2019 16:09
MATHEW KNOWLES, the father of Beyonce and Solange Knowles, was diagnosed with a potentially deadly cancer, breast cancer, after noticing dots of blood on shirt. What are the symptoms of breast cancer in men? (Source: Daily Express - Health)
Fri Nov 01, 2019 09:38
DEATHS from liver cancer have soared in the past decade, fuelled by binge drinking and poor diets. (Source: Daily Express - Health)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Fri Nov 01, 2019 08:28
Hormones testosterone and IGF-I, found in the blood, could predict risk of cancer after a study of 200,000 British men found high levels were linked to prostate cancer. (Source: the Mail online | Health)
Fri Nov 01, 2019 04:07
Cancer Research UK said 5,700 people died from the killer disease in the UK in 2017 - up from 3,200 ten years before. It warned deaths from the disease are rising quicker than any other type of cancer. (Source: the Mail online | Health)
Fri Nov 01, 2019 01:21
(Natural News) Cancer is widespread in America, killing thousands of people each year. However, various studies have found that pomegranates have anti-cancer properties, which can be used for the prevention and treatment of this dreaded disease. How pomegranates fight cancer The American Cancer Society estimated 1,762,450 individuals would be diagnosed with cancer this year, and another 606,880... (Source: NaturalNews.com)
Thu Oct 31, 2019 23:22
High levels of testosterone and insulin-like growth factor-I may increase risk of prostate cancer in men, according to research presented at the 2019 National Cancer Research Institute Cancer Conference in Glasgow, Scotland.STV News (Source: Society for Endocrinology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Fri Nov 01, 2019 13:00
New research at Case Western Reserve University could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone. (Source: eHealth News EU)
Thu Oct 31, 2019 12:00
(Source: PharmacoEconomics and Outcomes News)
Fri Nov 01, 2019 00:00
(Source: PharmacoEconomics and Outcomes News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Fri Nov 01, 2019 00:00
(Source: PharmacoEconomics and Outcomes News)
Fri Nov 01, 2019 00:00
Title: Most Seniors 85+ Do Well After Colon Cancer Surgery: StudyCategory: Health NewsCreated: 10/30/2019 12:00:00 AMLast Editorial Review: 10/31/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Thu Oct 31, 2019 08:00
Authors: Terashima T, Umemoto K, Takahashi H, Hosoi H, Takai E, Kondo S, Sakamoto Y, Mitsunaga S, Ohno I, Hashimoto Y, Sasaki M, Ikeda M, Shimada K, Kaneko S, Yachida S, Sugano K, Okusaka T, Morizane C Abstract The prevalence of germline mutations in patients with biliary tract carcinoma (BTC) remains unclear. Here, we investigated the prevalence and types of germline mutations in patients with BTC. We reviewed 269 patients with pathologically proven BTC and collected clinical characteristics,...
08:23
Authors: Kasinski AL PMID: 31666921 [PubMed] (Source: Oncotarget)
08:23
Authors: Koedoot E, Wolters L, van de Water B, Dévédec SEL Abstract By regulating transcript isoform expression levels, alternative splicing provides an additional layer of protein control. Recent studies show evidence that cancer cells use different splicing events to fulfill their requirements in order to develop, progress and metastasize. However, there has been less attention for the role of the complex catalyzing the complicated multistep splicing reaction: the spliceosome. The spliceosome...
08:23
ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer. Oncotarget. 2019 Oct 15;10(57):5970-5982 Authors: Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N, Sze SK Abstract Pancreatic cancer is a leading cause of mortality worldwide due to the difficulty of detecting early-stage disease and our poor understanding of the mediators that drive progression of hypoxic solid tumors. We therefore used a heavy isotope 'pulse/trace' proteomic...
08:23
Conclusion: About 37% of PPGL without family history of such tumors harbor germline mutations. The most commonly mutated gene is SDHB followed by SDHC, SDHD, VHL, MAX and rarely RET, SDHA, SDHAF2, TMEM127 and NF1. SDHB mutations were associated with metastatic PPGL in more than a quarter of cases. PMID: 31666924 [PubMed] (Source: Oncotarget)
08:23
We report a case of a patient with newly diagnosed, locally extensive and cystic, suprasellar papillary craniopharyngioma successfully treated with single-agent Dabrafenib. The patient was symptomatic with gait imbalance with falls, lethargic episodes, fatigue and incontinence. Diagnostic imaging demonstrated a cystic suprasellar tumor extending into the third ventricle causing obstructive hydrocephalus. The tumor was partially debulked, and bilateral shunts were placed. NGS sequencing demonstrated...
08:23
Authors: Tan H, Zeng C, Xie J, Alghamdi NJ, Song Y, Zhang H, Zhou A, Jin D Abstract [This corrects the article DOI: 10.18632/oncotarget.5508.]. PMID: 31666935 [PubMed - in process] (Source: Oncotarget)
08:23
Authors: Khatri A, Gu JJ, McKernan CM, Xu X, Pendergast AM Abstract [This corrects the article DOI: 10.18632/oncotarget.26740.]. PMID: 31666936 [PubMed - in process] (Source: Oncotarget)
08:23
Authors: Chamseddin BH, Lee EE, Kim J, Zhan X, Yang R, Murphy KM, Lewis C, Hosler GA, Hammer ST, Wang RC Abstract Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1) expression remains controversial, and glucose transporter 1 (GLUT1) expression has never been examined in ASCC. Covalently closed circular RNAs have recently been shown to be widespread...
08:23
In conclusion, the results presented here establish that PEDF is a therapeutic target and that PEDF from ascites or SBT could be utilized as a therapeutic strategy for the treatment of ovarian cancer. PMID: 31666922 [PubMed] (Source: Oncotarget)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
08:23
Authors: Dijk FJ, van Dijk M, Dorresteijn B, van Norren K Abstract Dietary supplementation with ω-3 polyunsaturated fatty acids (PUFAs) has been reported to enhance the sensitivity of tumor cells towards chemotherapy. Most enhancing effects are described for ω-3 PUFAs EPA and DHA; less evidence is available with the intermediate DPA. We studied the chemotherapy enhancing effects of EPA, DPA and DHA in murine colon C26 adenocarcinoma cells and showed that DPA displayed similar chemosensitizing...
08:23
Authors: Ooizumi Y, Katoh H, Yokota M, Watanabe M, Yamashita K Abstract HOPX is involved in multiple organ development and acts as a tumor suppressor in various cancers. Epigenetic silencing of HOPX via its promoter methylation has been shown frequent and cancer-specific in human cancers. The proliferation of thyroid cancer cells and cancer progression are strongly influenced by epigenetic alterations as well as genetic changes. Papillary thyroid cancer (PTC) comprises the vast majority...
08:23
Authors: Namjoshi P, Showalter L, Czerniecki BJ, Koski GK Abstract A recent neoadjuvant vaccine trial for early breast cancer induced strong Th1 immunity against the HER-2 oncodriver, complete pathologic responses in 18% of subjects, and for many individuals, dramatically reduced HER-2 expression on residual disease. To explain these observations, we investigated actions of Th1 cytokines (TNF-α and IFN-γ) on murine and human breast cancer cell lines that varied in the surface expression...
08:23
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Oncotarget. 2019 Oct 15;10(57):5932-5948 Authors: Fukui S, Nagasaka K, Miyagawa Y, Kikuchi-Koike R, Kawata Y, Kanda R, Ichinose T, Sugihara T, Hiraike H, Wada-Hiraike O, Sasajima Y, Ayabe T Abstract The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins. As an alternative to the proteasome itself,...
08:23
Authors: Sestini S, Boeri M, Marchiano A, Pelosi G, Galeone C, Verri C, Suatoni P, Sverzellati N, Vecchia C, Sozzi G, Pastorino U Abstract [This corrects the article DOI: 10.18632/oncotarget.5210.]. PMID: 31666934 [PubMed - in process] (Source: Oncotarget)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
08:23
Authors: Qiu Q, Li M, Yang L, Tang M, Zheng L, Wang F, Qiu H, Liang C, Li N, Yi D, Yi Y, Pan C, Yang S, Chen L, Hu Y Abstract Multiple myeloma (MM) pathogenesis remains incompletely understood and biomarkers predicting treatment response still remain lacking. Here we describe the rational mechanisms of combining targeting glautaminase1 (GLS1) with other chemo-reagents for MM treatment. Gls1 is highly expressed cMYC/KRAS12V-drived plasmacytoma (PCT) cells. Down-regulation of Gls1 with miRNAi...
08:23
Authors: Chen GL, Wang SC, Shen TC, Tsai CW, Chang WS, Li HT, Wu CN, Chao CY, Hsia TC, Bau DT Abstract Matrix metalloproteinases-2 (MMP2) has been reported to be overexpressed in various types of cancer. However, the contribution of various genotypes of MMP2 to lung cancer is controversial and not yet been examined in Taiwan. Therefore, in the current study, we investigated the association of MMP2 genotypes with lung cancer risk among Taiwanese. In this hospital-based, case-control study,...
07:12
DISCUSSION: New personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of...
07:04
In this study, the level of HIF-1α and NEDD4L mRNA and protein in 25 freshly frozen GC- and matched normal-tissues were determined by western blot and quantitative PCR (qPCR). Additionally, immunohistochemistry assay was performed to measure the protein level of NEDD4L and HIF-1α in 124 GC and 25 normal control tissues. We observed that the NEDD4L mRNA and protein levels decreased significantly (P < 0.001) in GC tissues, while that of HIF-1α increased (P < 0.001), and they both were associated...
06:27
Authors: Bui HTT, Le NH, Le QA, Kim SE, Lee S, Kang D Abstract Resistance against tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death of cancer cells is a major obstacle in clinical application of TRAIL. Variable response to TRAIL of gastric cancer cells, synergy of TRAIL with bortezomib and potential mechanisms behind the phenomena were investigated in this study. The response to TRAIL varied among six gastric cancer cell lines, which correlated with the...
06:27
Authors: Angius A, Pira G, Scanu AM, Uva P, Sotgiu G, Saderi L, Manca A, Serra C, Uleri E, Piu C, Caocci M, Ibba G, Zinellu A, Cesaraccio MR, Sanges F, Muroni MR, Dolei A, Cossu-Rocca P, De Miglio MR Abstract Colorectal cancer (CRC) is a leading cause of cancer death worldwide and about 20% is metastatic at diagnosis and untreatable. The anti-EGFR therapy in metastatic patients is led by the presence of KRAS-mutations in tumor tissue. KRAS-wild-type CRC patients showed a positive response...
06:27
In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis. PMID: 31673232 [PubMed - in process] (Source: International Journal of Medical Sciences)
06:27
In this study, recently-developed fluorescence micro-endoscopic technology provides non-invasive, high-resolution, real-time imaging at the cellular level. Moreover, with the application of high-resolution imaging technologies and micro-endoscopy, which enable improved monitoring of adverse effects in GFP-expressing mouse models, changes in the oral vasculature and lymphatic vessels are quantified in real time for 10 days following a mild localized single fractionation, 10 Gy radiotherapy treatments....
06:27
Authors: Paulson B, Kim IH, Namgoong JM, Kim YG, Lee S, Moon Y, Shin DM, Choo MS, Kim JK Abstract Colorectal cancer (CRC) is one of the most frequently lethal forms of cancer. Intramucosal injection allows development of better mouse models of CRC, as orthotopic xenografts allow development of adenocarcinoma in the submucosa of the mouse colon wall. In this paper, a method of orthotopic injection is monitored longitudinally using cellular-resolution real-time in vivo fluorescence microendoscopy,...
06:27
Discussion: siRNA alone or combined with cisplatin can effectively inhibit the growth of human ovarian cancer in nude mice models of subcutaneous transplantation of tumor cells. RRM2 gene silencing may be a potential treatment regimen for ovarian cancer in future. PMID: 31673243 [PubMed - in process] (Source: International Journal of Medical Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales...
06:27
Authors: Valles SL, Iradi A, Aldasoro M, Vila JM, Aldasoro C, de la Torre J, Campos-Campos J, Jorda A Abstract Microglia cells during aging, neurodegeneration and neuroinflammation show different morphological and transcriptional profiles (related to axonal direction and cell adhesion). Furthermore, expressions of the receptors on the surface and actin formation compared to young are also different. This review delves into the role of glia during aging and the development of the diseases....
06:27
Publication date: Available online 31 October 2019Source: Journal of Biomedical InformaticsAuthor(s): Xi Hang Cao, Chao Han, Lucas M Glass, Allen Kindman, Zoran ObradovicAbstractThe primary goal of a time-to-event estimation model is to accurately infer the occurrence time of a target event. Most existing studies focus on developing new models to effectively utilize the information in the censored observations. In this paper, we propose a model to tackle the time-to-event estimation problem from...
06:14
ConclusionDigitized features derived from the CT were effective in predicting subsequent occurrence of HCC in cirrhosis patients. The bone mineral density measured on CT was an effective predictor for patients in both Taiwan and USA. (Source: Digestive Diseases and Sciences)
00:00
Publication date: Available online 31 October 2019Source: Trends in Pharmacological SciencesAuthor(s): Peter John, Yao Wei, Weifeng Liu, Meirong Du, Fangxia Guan, Xingxing ZangB7x (B7 homolog x, also known as B7-H4, B7S1, and VTCN1) was discovered by ourselves and others in 2003 as the seventh member of the B7 family. It is an inhibitory immune checkpoint of great significance to human disease. Tissue-expressed B7x minimizes autoimmune and inflammatory responses. It is overexpressed in a broad spectrum...
05:16
Publication date: Available online 31 October 2019Source: Trends in Pharmacological SciencesAuthor(s): Thanh Kha Phan, Guneet K. Bindra, Scott A. Williams, Ivan K.H. Poon, Mark D. HulettPathogens and tumor cells have adopted various adept strategies to evade immunosurveillance and promote their growth and survival. There has been substantial evidence demonstrating phosphoinositide lipids and their modifying enzymes as essential host targets that are often hijacked by pathogens and tumor cells. The...
05:16
In the original publication of the article, the reference 14 was published incorrectly. The correct reference is given below. (Source: European Archives of Oto-Rhino-Laryngology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
00:00
ConclusionsAF recurs in approximately 30% of patients with POAF with malignancy in the subsequent year; most recurrences are asymptomatic.RésuméContexteIl arrive fréquemment qu’un patient subissant une intervention chirurgicale non cardiaque présente une fibrillation auriculaire périopératoire (FAPO). On ne sait toutefois pas si d’autres épisodes de fibrillation auriculaire (FA) surviennent par la suite.MéthodologieLes auteurs ont mené une étude d’observation prospective unicentrique auprès de patients...
04:37
ConclusionGiving a constraint to the swallowing structure and limiting it to <45 Gy resulted in earlier recovery of swallowing function resulted in good physical, mental and social well being of the patients when compared to those who received>45 Gy. (Source: Reports of Practical Oncology and Radiotherapy)
04:17
ConclusionsThe majority of PeSCC are intrinsically radioresistant with a low GARD-based therapeutic effect from PORT dose of 50 Gy, consistent with the observed high rate of LRR in the clinical cohort. A GARD-based strategy will allow personalizing PORT dose prescription to individual tumor biology and improve outcomes. (Source: Reports of Practical Oncology and Radiotherapy)
04:17
Publication date: Available online 1 November 2019Source: Cancer GeneticsAuthor(s): Calogero Vetro, Torsten Haferlach, Manja Meggendorfer, Anna Stengel, Sabine Jeromin, Wolfgang Kern, Claudia HaferlachAbstractTo define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvements and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD by performing cytogenetic and molecular genetic analyses....
04:17
ConclusionsBlack women in the Delta had higher rates of late-stage cancers across subtypes. Culturally competent interventions targeting risk-appropriate screening modalities should be scaled up in the Delta to improve early detection. (Source: Cancer Epidemiology)
04:17
Publication date: Available online 31 October 2019Source: Cancer CellAuthor(s): Huiying Han, Atul D. Jain, Mihai I. Truica, Javier Izquierdo-Ferrer, Jonathan F. Anker, Barbara Lysy, Vinay Sagar, Yi Luan, Zachary R. Chalmers, Kenji Unno, Hanlin Mok, Rajita Vatapalli, Young A. Yoo, Yara Rodriguez, Irawati Kandela, J. Brandon Parker, Debabrata Chakravarti, Rama K. Mishra, Gary E. Schiltz, Sarki A. AbdulkadirSummarySmall molecules that directly target MYC and are also well tolerated in vivo will provide...
04:14
Authors: Dai X, Zhang X, Lu P Abstract Powered by rapid technology developments, biomarkers become increasingly diverse, including those detected at genomic, transcriptomic, proteomic, metabolomic and cellular levels. While diverse sets of biomarkers have been utilized in breast cancer predisposition, diagnosis, prognosis, treatment and management, recent additions derived from lincRNA, circular RNA, circulating DNA together with its methylated and hydroxymethylated forms and immune signatures...
04:12
Cancer Gene Therapy, Published online: 02 November 2019; doi:10.1038/s41417-019-0141-7Liposomal delivery of CRISPR/Cas9 (Source: Cancer Gene Therapy)
00:00
Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages
Publication date: Available online 31 October 2019Source: Stem Cell ReportsAuthor(s): Hyo-Won Han, Hyang-Hee Seo, Hye-Yeong Jo, Hyeong-jun Han, Virgínia C.A. Falcão, Vincent Delorme, Jinyeong Heo, David Shum, Jang-Hoon Choi, Jin-Moo Lee, Seung Hun Lee, Hye-Ryeon Heo, Seok-Ho Hong, Mi-Hyun Park, Rajesh K. Thimmulappa, Jung-Hyun KimSummaryA major limitation in anti-tuberculosis drug screening is the lack of reliable and scalable models for homogeneous human primary macrophage cells of non-cancer origin....
03:08
Publication date: 31 October 2019Source: Cell, Volume 179, Issue 4Author(s): Qiming Zhang, Yao He, Nan Luo, Shashank J. Patel, Yanjie Han, Ranran Gao, Madhura Modak, Sebastian Carotta, Christian Haslinger, David Kind, Gregory W. Peet, Guojie Zhong, Shuangjia Lu, Weihua Zhu, Yilei Mao, Mengmeng Xiao, Michael Bergmann, Xueda Hu, Sid P. Kerkar, Anne B. VogtSummaryThe immune microenvironment of hepatocellular carcinoma (HCC) is poorly characterized. Combining two single-cell RNA sequencing technologies,...
02:35
This study reports a large-scale proteogenomic analysis of ccRCC to discern the functional impact of genomic alterations and provides evidence for rational treatment selection stemming from ccRCC pathobiology.Graphical Abstract (Source: Cell)
02:35
Publication date: 31 October 2019Source: Cell, Volume 179, Issue 4Author(s): Patrick CramerThis year we celebrate the 50th anniversary of the discovery of the three eukaryotic RNA polymerases. Ever since this seminal event in 1969, researchers have investigated the intricate mechanisms of gene transcription with great dedication. The transcription field continues to influence developmental, stem cell, and cancer biology. (Source: Cell)MedWorm Message: Have you tried our new medical search engine?...
02:35
Publication date: Available online 31 October 2019Source: Clinica Chimica ActaAuthor(s): Ill-Min Chung, Govindasamy Rajakumar, Baskar Venkidasamy, Umadevi Subramanian, Muthu ThiruvengadamAbstractExosomes are endosomal-derived vesicles that play a critical role in cell-to-cell communication and are secreted in several biological fluids including serum, saliva, urine, ascites, and cerebro-spinal fluid amongst others. Exosomes are small (30-150 nm diameter) with a distinctive bilipid protein structure....
02:02
ConclusionsWe found no benefit in delayed testing for 3 days post collection. FIT provides equivalent results to gFOBT in hospitalized patients. (Source: Clinica Chimica Acta)
02:02
Publication date: Available online 31 October 2019Source: Clinica Chimica ActaAuthor(s): Shi Chen, Zheng Xiao, Jun Zhou, Manli Yang, Shujun Feng, Qiulin Huang, Juan Zou, Tian Zeng, Yukun Li, Lijun Peng, Ying Zeng, Xi ZengAbstractZinc finger protein 382 (ZNF382), a member of the Krüppel-associated box zinc finger proteins (KRAB-ZFPs) family, plays critical roles in regulating certain downstream genes expression as a transcription inhibitor. ZNF382 is downregulated in multiple tumors due to hypermethylation...
02:02
Authors: Wilding CP, Elms ML, Judson I, Tan AC, Jones RL, Huang PH Abstract Introduction: Tyrosine kinases are key mediators of intracellular signalling cascades and aberrations in these proteins have been implicated in driving oncogenesis through the dysregulation of fundamental cellular processes including proliferation, migration, and apoptosis. As such, targeting these proteins with small molecule tyrosine kinase inhibitors (TKI) has led to significant advances in the treatment of a...
Fri Nov 01, 2019 23:23
Authors: Dunaeva M, Pruijn GJM Abstract Circulating nucleic acids (CNAs) include genomic and mitochondrial DNA fragments, small RNAs, and bacterial and viral DNA/RNA. Different mechanisms such as cell apoptosis, necrosis, and active CNA release from cells have been proposed to result in nucleic acids in the circulation. Application of next generation sequencing technology demonstrated that CNAs contain specific mutations, indels, microsatellite alterations, and epigenetic changes (DNA methylation)...
Fri Nov 01, 2019 22:52
Authors: Abdulrahman Jnr GO, Das N, Lutchman Singh K Abstract Ovarian cancer is a lethal gynecological malignancy. Although CA-125 is commonly measured in women with adnexal mass, it is estimated that it only has a positive predictive value (PPV) of 69% and a negative predictive value (NPV) of 88% for the detection of ovarian cancer. The aim of this study was to investigate the diagnostic significance and predictive impact of thrombocytosis in women with suspected or confirmed ovarian cancer....
Fri Nov 01, 2019 22:36
Publication date: Available online 31 October 2019Source: Biosensors and BioelectronicsAuthor(s): Xiaoxue Xie, Zhenqi Peng, Xinyi Hua, Zhifang Wang, Keqin Deng, Xiumei Yang, Haowen HuangAbstractGlutathione (GSH) plays a variety of vital functions in biological systems. Growth-associated change of GSH level in cells might be critical for cell survival and monitoring of GSH in living cells are of great significance for understanding the dynamic link between GSH and some diseases. In this work, chitason...
Fri Nov 01, 2019 22:14
Fri Nov 01, 2019 22:05
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