Authors: Dunaeva M, Pruijn GJM Abstract Circulating nucleic acids (CNAs) include genomic and mitochondrial DNA fragments, small RNAs, and bacterial and viral DNA/RNA. Different mechanisms such as cell apoptosis, necrosis, and active CNA release from cells have been proposed to result in nucleic acids in the circulation. Application of next generation sequencing technology demonstrated that CNAs contain specific mutations, indels, microsatellite alterations, and epigenetic changes (DNA methylation)...
Fri Nov 01, 2019 22:52
Authors: Abdulrahman Jnr GO, Das N, Lutchman Singh K Abstract Ovarian cancer is a lethal gynecological malignancy. Although CA-125 is commonly measured in women with adnexal mass, it is estimated that it only has a positive predictive value (PPV) of 69% and a negative predictive value (NPV) of 88% for the detection of ovarian cancer. The aim of this study was to investigate the diagnostic significance and predictive impact of thrombocytosis in women with suspected or confirmed ovarian cancer....
Fri Nov 01, 2019 22:36
Publication date: Available online 31 October 2019Source: Biosensors and BioelectronicsAuthor(s): Xiaoxue Xie, Zhenqi Peng, Xinyi Hua, Zhifang Wang, Keqin Deng, Xiumei Yang, Haowen HuangAbstractGlutathione (GSH) plays a variety of vital functions in biological systems. Growth-associated change of GSH level in cells might be critical for cell survival and monitoring of GSH in living cells are of great significance for understanding the dynamic link between GSH and some diseases. In this work, chitason...
Fri Nov 01, 2019 22:14
Publication date: Available online 1 November 2019Source: Redox BiologyAuthor(s): Veena Somasundaram, Anne C. Gilmore, Debashree Basudhar, Erika Mariana Palmieri, David A. Scheiblin, William F. Heinz, Robert.Y.S. Cheng, Lisa A. Ridnour, Grégoire Altan-Bonnet, Stephen J. Lockett, Daniel W. McVicar, David A. WinkAbstractThe role of nitric oxide (NO) in cancer progression has largely been studied in the context of tumor NOS2 expression. However, pro- versus anti-tumor signaling is also affected by tumor...
Fri Nov 01, 2019 21:15
In conclusion, superior and persistent therapeutic efficacy of co-treatment provides a new insight into antiangiogenic therapy of malignant gliomas, suggesting to be a potential substitute in selected patients. (Source: Life Sciences)
Fri Nov 01, 2019 21:14
Publication date: Available online 31 October 2019Source: Life SciencesAuthor(s): Houman Kahroba, Masoud Shirmohamadi, Mohammad Saeid Hejazi, Nasser SamadiAbstractCancer stem cells (CSCs) are subpopulation of tumor mass with exclusive abilities in self-renewing, stemness maintaining, and differentiation into the various non-stem cancer cells to provoke tumorigenesis, metastasis dissemination, drug-resistant, and cancer recurrence. Reactive oxygen species (ROS) impair cellular function by oxidizing...
Fri Nov 01, 2019 21:14
Publication date: Available online 31 October 2019Source: Life SciencesAuthor(s): Zhengfeng Wang, Xinxin Duan, Yinghao Lv, Yongfu ZhaoAbstractAimsLiver cancer is one of the leading causes of cancer mortality worldwide. Inspired by the biological structure and function of low-density lipoprotein (LDL), in this study, an ApopB-100 based targeted lipid nanoparticles was synthesized to improve the therapeutic efficacy in liver cancer treatment.Main methodsThe biological composition of ApopB is similar...
Fri Nov 01, 2019 21:14
In this study, we have developed a gene-based anti-VEGF mAb system which is expected to produce a high concentration of anti-VEGFA mAb upon a single administration in cancer patients. The full-length cDNA bevacizumab light and heavy chains joint with T2A sequence were cloned in pCDH lentivirus vector. The lentiviral particles expressing bevacizumab was produced in HEK-293 T cells. Recombinant lentiviral particles containing bevacizumab (rLV-bev) efficiently transduced HEK-293 cells and produced functional...
Fri Nov 01, 2019 21:14
Publication date: Available online 31 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Shih-I. Tan, Shao-Chun You, I-Tai Shih, I-Son Ng5-Aminolevulinic acid (5-ALA) is an unnatural amino acid and has been approved as a biodegradable, non-toxic pesticide and herbicide with applications in sustainable agriculture. 5-ALA can also be applied for cancer targeting via tumor localization and photodynamic therapy. Herein, we developed a feasible quantification, regulation and production...
Fri Nov 01, 2019 21:11
(Source: Journal of Clinical Investigation)
Fri Nov 01, 2019 21:11
Publication date: Available online 31 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Gitanjali Javir, Kalpana Joshi, Vijay Khedkar, Supada RojatkarAbstractCyathocline purpurea has potential biological activities and has been widely used in traditional Chinese and Ayurvedic medicine. The aim of the present study is to elucidate the anticancer effect of its 6 α-hydroxy-4[14], 10[15]-guainadien-8β, 12-olide (SRCP1) against HER-2 positive subtype of breast carcinoma....
Fri Nov 01, 2019 21:08
In conclusion, we identified a comprehensive candidate list of genes associated with serum 25(OH)D concentrations, most of which are not commercially available, but would prove of importance in clinical practice in screening for patients that should respond to supplementation because of alterations in absorption, patients that would have little benefit because alterations in the downstream metabolism of vitamin D, and to study non-responsiveness to supplementation with vitamin D. (Source: The Journal...
Fri Nov 01, 2019 21:08
Publication date: Available online 31 October 2019Source: Process BiochemistryAuthor(s): Alapati Kavitha, Handanahal S. SavithriABSTRACTA marine actinobacterial strain (designated as AKHSS) capable of producing cholesterol oxidase on the enzyme indicator plates was identified as Streptomyces sp. The cell-free lysate of the strain was used for monitoring the production of cholesterol oxidase and the maximal enzyme yields were recorded at 72 h post inoculation. The cholesterol oxidase was purified...
Fri Nov 01, 2019 21:08
ConclusionActivation of A2B receptor mediates γ-radiation-induced translocation of EGFR and phosphorylation of src and EGFR, thereby promoting recovery of irradiated lung cancer cells from DNA damage.General significanceOur results indicate that A2B receptors contribute to radiation resistance in a cancer-cell-specific manner, and may be a promising target for radiosensitizers in cancer radiotherapy.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)MedWorm Message:...
Fri Nov 01, 2019 21:08
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Karishma Bakshi, Saheli Mitra, Veerendra Kumar Sharma, Magani Sri Krishna Jayadev, Victoria Garcia Sakai, Ramaprasad Mukhopadhyay, Ashish Gupta, Sajal Kumar GhoshAbstractHere, we report the toxic effects of various imidazolium-based ionic liquids (ILs) with varying hydrocarbon chain lengths, on different human cell lines. Multiple biological assays have shown that the ILs with long...
Fri Nov 01, 2019 21:08
This study developed an ultrasensitive and reliable electrochemical scaffold for the individual and sensitive simultaneous determination of DHB isomers. The nitrogen-doped carbon nano-onions (N-CNOs) synthesized in-situ is much less expensive (only 1/80) than the expensive nanodiamond-based process because the synthesis of CNO from nano-diamond requires a high vacuum (10–6 torr) and a high-temperature (1800 °C), whereas the present process requires atmospheric pressure and approximately 1000 °C....
Fri Nov 01, 2019 21:07
Publication date: Available online 31 October 2019Source: Journal of Organometallic ChemistryAuthor(s): Marina Yu. Stogniy, Svetlana A. Erokhina, Anna A. Druzina, Igor B. Sivaev, Vladimir I. BregadzeAbstractNovel nido-carboranyl azide [7-N3CH2CH2OCH2CH2O-7,8-C2B9H11]- was prepared by the reaction of 1-hydroxy-ortho-carborane with bis(2-chloroethyl) ether followed by the conversion to its nido-form and reactions with sodium iodide and sodium azide. Previously undescribed carboranyl azides 1-N3CH2CH2OCH2CH2S-1,2-C2B10H11...
Fri Nov 01, 2019 21:06
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03288F, PaperRam Sagar, Priti Kumari, Shraddha Dubey, S V Sneha, Chintam Narayana, Ashish Gupta Carbohybrids are important class of molecules which exhibits diverse biological activities and are present as structural motif in many natural products. Two series of new triazole linked N-glycosides of coumarins... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Fri Nov 01, 2019 21:05
This study aimed to investigate the effects of low-dose ethanol (0.5%, 1%, and 2% [v/v] ethanol in drinking water) for 28 wk on colon tumor incidence in rats injected with 1,2-dimethylhydrazine. Body weight, fluid and food consumption, and the total numbers of colon adenomas (mild-, moderate-, and severe-grade dysplasia) per rat were unaffected by ethanol consumption. However, the numbers of severe-grade dysplasia were significantly reduced by 1% ethanol compared with the control (0% ethanol; -93%)...
Fri Nov 01, 2019 20:58
Vegetable-Fruit-Soybean Dietary Pattern and Breast Cancer: A Meta-Analysis of Observational Studies.
Authors: Zhang L, Huang S, Cao L, Ge M, Li Y, Shao J Abstract Breast cancer is one of the most common cancers among women worldwide, and several studies have investigated the association of dietary patterns and breast cancer. However, findings of studies are inconclusive. Therefore, we aimed to conduct a meta-analysis to summarize the available data regarding the association of vegetable-fruit-soybean dietary pattern and breast cancer. A systematic literature search was conducted via PubMed,...
Fri Nov 01, 2019 20:58
Authors: Seura T, Fukuwatari T Abstract The Japanese diet (JD) is accepted as a healthy dietary pattern, which has protective effects against cancer and cardiovascular diseases. However, it remains unclear whether there is any association between the JD and fecal microbiota composition. This cross-sectional study examined the relationship between JD scores and fecal microbiota in young Japanese adults, through the analysis of fecal microbiota using the terminal restriction fragment length...
Fri Nov 01, 2019 20:58
Publication date: Available online 31 October 2019Source: Toxicology ReportsAuthor(s): Litty Joseph, K.K. SrinivasanAbstractTriacontanoic ester of 5ʺ -hydroxyjustisolin, a lignan from Justicia simplex D. Don, possesses antitumor activity. However, the molecular mechanism underlying this is not yet clearly understood. The present study showed significant inhibition in cell viability on HeLa cell line and induced minor toxicity in normal cells. This compound induced mitotic arrest at G0/G1 phase followed...
Fri Nov 01, 2019 20:41
Publication date: Available online 31 October 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Michael L. Manning, Matthew D. Thompson, Haleh Saber, Virginia E. Maher, Joyce Z. Crich, John K. LeightonAbstractA systematic analysis of new commercial investigational new drug applications (IND) submitted to the FDA's Office of Hematology and Oncology Products (OHOP) in the Center for Drug Evaluation and Research was conducted to quantify the most common reasons INDs for oncology indications...
Fri Nov 01, 2019 20:41
Authors: Barnett C, Tabasinejad R, Bril V Abstract Introduction: Novel options for immune-based therapy in myasthenia gravis are improving the therapeutic outlook for patients. Multiple clinical trials on immunomodulation, complement inhibitors, and FcR inhibitors are providing evidence for novel immune-based therapies that promise to improve outcomes in myasthenia patients. These more focused immune treatments are reviewed in this paper.Areas covered: This paper outlines classical treatment...
Fri Nov 01, 2019 20:32
ConclusionThe results suggest that WP tobacco smoking and genetic polymorphisms in CYP1A1 are most likely important risk factors for lung cancer in the Iraqi population. (Source: Meta Gene)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Fri Nov 01, 2019 20:03
Publication date: Available online 31 October 2019Source: Meta GeneAuthor(s): Samir Kumar Sett, Subir Hazra, Anupam GhoshAbstractRecent progressions in the field of clustering have by this time led to the emergence of fuzzification systems for different medical applications. Furthermore, in the last few decades computational tools have been designed to advance the proficiencies and abilities of physicians/biologists for detecting cancer mediating biomarkers about their patients. In this article we...
Fri Nov 01, 2019 20:03
Publication date: Available online 31 October 2019Source: Meta GeneAuthor(s): Swetha Sunkar, Madineni Aravind, S. Surya Chandan Reddy, Desam NeeharikaAbstractCancer is a deadly disease caused by several factors such as variations in genes that influence cell growth and division. Wnt pathway is commonly involved in controlling gene expression and cellular behavior in many types of cancer. Our study focused on cancer related novel gene candidates namely DKK3, SFRP2, SFRP4 and SFRP5 involved in Wnt...
Fri Nov 01, 2019 20:03
We report a case of 71-year-old female with primary bladder transitional cell carcinoma who presented with the initial presentation of cutaneous skin lesions that covered the entire lower abdominal wall. (Source: Urology Case Reports)
Fri Nov 01, 2019 19:36
ConclusionsCombination therapy with any of docetaxel, abiraterone acetate, enzalutamide, or apalutamide provides a significant OS benefit when compared with ADT alone. We did not identify significant differences in OS between different combination therapies. Subtle differences between these options provide clinicians considerable flexibility when selecting options for individual patients.Patient summaryMany men with metastatic, hormone-sensitive prostate cancer should be managed with upfront combination...
Fri Nov 01, 2019 19:35
Publication date: Available online 1 November 2019Source: Preventive MedicineAuthor(s): Jan M. Eberth, Whitney E. Zahnd, Swann Arp Adams, Daniela B. Friedman, Stephanie B. Wheeler, James R. HébertAbstractThe mortality-to-incidence ratio (MIR) can be computed from readily accessible, public-use data on cancer incidence and mortality, and a high MIR value is an indicator of poor survival relative to incidence. Newly available data on congressional district-specific cancer incidence and mortality from...
Fri Nov 01, 2019 19:15
ConclusionsAll three surveys show that cervical cancer screening rates in women 45–65 years are insufficient to reduce cervical cancer incidence. Insurance is the major positive predictor of screening, followed by younger age and more education. Race/ethnicity are variable predictors depending on the survey. (Source: Preventive Medicine)
Fri Nov 01, 2019 19:15
Authors: Liu Y, Teng Z, Zhao L, Yue M, Cheng B Abstract PMID: 31670492 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Fri Nov 01, 2019 18:40
Authors: Borro P, Testino G, Pellicano R, Caputo F Abstract PMID: 31670497 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Fri Nov 01, 2019 18:40
Authors: Sun Q, Sun Z Abstract PMID: 31663306 [PubMed - as supplied by publisher] (Source: Panminerva Medica)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Fri Nov 01, 2019 18:40
Aspirin inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via wnt/β-catenin signaling pathway. Panminerva Med. 2019 Oct 24;: Authors: Sun J, Guo C, Zheng W, Zhang X Abstract PMID: 31663307 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Fri Nov 01, 2019 18:40
Authors: Yuan C, Wei Y, Hu L, Tian Y, Liu Y PMID: 31670493 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Fri Nov 01, 2019 18:40
Authors: Liu S, Qiao Z, Ma Q, Liu X, Ma X Abstract PMID: 31663303 [PubMed - as supplied by publisher] (Source: Panminerva Medica)
Fri Nov 01, 2019 18:40
Authors: Wu M, Cai P, Chen Z, Zhang B, Hou Z, Zhang X Abstract PMID: 31670496 [PubMed - as supplied by publisher] (Source: Panminerva Medica)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Fri Nov 01, 2019 18:40
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Breast Imaging, Alana A. Lewin, Linda Moy, Paul Baron, Aarati D. Didwania, Roberta M. diFlorio-Alexander, Jessica H. Hayward, Huong T. Le-Petross, Mary S. Newell, Amar Rewari, John R. Scheel, Ashley R. Stuckey, W. Warren Suh, Gary A. Ulaner, Nina S. Vincoff, Susan P. Weinstein, Priscilla J. SlanetzAbstractAs the proportion of women diagnosed with early stage...
Fri Nov 01, 2019 18:13
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Women’s Imaging Panel, Kika M. Dudiak, Katherine E. Maturen, Esma A. Akin, Maria Bell, Priyadarshani R. Bhosale, Stella K. Kang, Aoife Kilcoyne, Yulia Lakhman, Refky Nicola, Pari V. Pandharipande, Rajmohan Paspulati, Caroline Reinhold, Stephanie Ricci, Atul B. Shinagare, Hebert Alberto Vargas, Bradford P. Whitcomb, Phyllis GlancAbstractGestational trophoblastic...
Fri Nov 01, 2019 18:13
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Urological Imaging, Andrei S. Purysko, Paul Nikolaidis, Vikram S. Dogra, Dhakshinamoorthy Ganeshan, John L. Gore, Rajan T. Gupta, Marta E. Heilbrun, Gaurav Khatri, Amar U. Kishan, Andrej Lyshchik, Stephen J. Savage, Andrew D. Smith, Zhen J. Wang, Darcy J. Wolfman, Jade J. Wong-You-Cheong, Don C. Yoo, Mark E. LockhartAbstractRenal cell carcinoma (RCC) accounts...
Fri Nov 01, 2019 18:13
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Neurologic Imaging, Matthew T. Whitehead, Agustin M. Cardenas, Amanda S. Corey, Bruno Policeni, Judah Burns, Santanu Chakraborty, R. Webster Crowley, Pascal Jabbour, Luke N. Ledbetter, Ryan K. Lee, Jeffrey S. Pannell, Jeffrey M. Pollock, William J. Powers, Gavin Setzen, Robert Y. Shih, Rathan M. Subramaniam, Pallavi S. Utukuri, Julie BykowskiAbstractHeadache...
Fri Nov 01, 2019 18:13
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Thoracic Imaging, Christopher Lee, Patrick M. Colletti, Jonathan H. Chung, Jeanne B. Ackman, Mark F. Berry, Brett W. Carter, Patricia M. de Groot, Stephen B. Hobbs, Geoffrey B. Johnson, Fabien Maldonado, Barbara L. McComb, Betty C. Tong, Christopher M. Walker, Jeffrey P. KanneAbstractThe immunocompromised patient with an acute respiratory illness (ARI) may...
Fri Nov 01, 2019 18:13
This article is a review of the current literature for urothelial cancer and resulting recommendations for surveillance imaging.The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA...
Fri Nov 01, 2019 18:13
Publication date: November 2019Source: Journal of the American College of Radiology, Volume 16, Issue 11, SupplementAuthor(s): Expert Panel on Gastrointestinal Imaging, Kathryn J. Fowler, Evelyn M. Garcia, David H. Kim, Brooks D. Cash, Kevin J. Chang, Barry W. Feig, Kenneth L. Gage, Avinash R. Kambadakone, Angela D. Levy, Peter S. Liu, Daniele Marin, Courtney Moreno, Christine M. Peterson, Jason A. Pietryga, Martin P. Smith, Laura R. CarucciAbstractPalpable abdominal masses may arise from the abdominal...
Fri Nov 01, 2019 18:13
In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this...
Fri Nov 01, 2019 17:14
ConclusionsThe polymorphisms rs2239895 were associated with the risk of lung squamous cell carcinoma. The interaction between the two SNPs and the cigarette smoking was no notable difference. (Source: Pathology Research and Practice)
Fri Nov 01, 2019 17:14
Publication date: Available online 31 October 2019Source: Pathology - Research and PracticeAuthor(s): Xinyi Chen, Yanhua Yang, Wei Wang, Bo Han, Mei Qi, Shaoqing Geng, Jing Xu, Qian Zhang, Xueli Wang, Shouzhen Chen, Kai Shi, Xuexuan Ke, Jing ZhangAbstractIntraductal carcinoma of the prostate (IDC-P) and bone metastasis have been both identified to associate with unfavorable clinical outcome of the prostate carcinoma (PCa). Our objective is to examine whether IDC-P or bone metastasis at diagnostic...
Fri Nov 01, 2019 17:14
Fri Nov 01, 2019 17:14
We report an uncommon case of septic arthritis of the ankle from a Streptococcus pneumoniae infection and provide an update of the literature reported since 2002. A 58-year-old female presented to the hospital with right ankle pain and an inability to bear weight. She reported a history of productive cough, vomiting, diarrhea, and subjective fevers 4 days earlier. Streptococcus pneumonia was identified in her ankle aspirate, and she was treated urgently with operative incision and debridement, followed...
Fri Nov 01, 2019 17:12
ConclusionICIs have demonstrated the ability to induce improved long-term survival in metastatic cutaneous or mucosal melanomas, including those of gynecologic origin. As ICI therapy becomes more widespread, healthcare providers across all fields of medicine need be vigilant to recognize the symptoms of irAEs that can often masquerade as common illnesses to prevent potentially dangerous irreversible immune toxicities. (Source: Gynecologic Oncology Reports)
Fri Nov 01, 2019 17:06
We present the images of ultrasound, magnetic resonance and histology of a patient with suggestive findings of xanthogranulomatous cholecystitis. Gallbladder cancer cannot be completely ruled out until the histological study of the surgical sample is performed. PMID: 31663361 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100%...
Fri Nov 01, 2019 16:52
Authors: A-Cienfuegos J, Rotellar F, Azcárate V Abstract We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days after hepatocellular transplantation and no differences were found in the animals...
Fri Nov 01, 2019 16:52
Publication date: 2–8 November 2019Source: The Lancet, Volume 394, Issue 10209Author(s): Richard Horton (Source: The Lancet)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Fri Nov 01, 2019 16:03
This study is registered at ClinicalTrials.gov, number NCT02358031.FindingsBetween April 20, 2015, and Jan 17, 2017, 882 participants were allocated to receive pembrolizumab alone (n=301), pembrolizumab with chemotherapy (n=281), or cetuximab with chemotherapy (n=300); of these, 754 (85%) had CPS of 1 or more and 381 (43%) had CPS of 20 or more. At the second interim analysis, pembrolizumab alone improved overall survival versus cetuximab with chemotherapy in the CPS of 20 or more population (median...
Fri Nov 01, 2019 16:03
ConclusionFCR7-C is a brief screening tool with good psychometrics. Patients with early-stage lung cancer still revealed mild to moderate level of FCR. Applying the FCR7-C for to screen cancer patients’ distress and further develop personalized psychological interventions would be strongly suggested. (Source: Journal of the Formosan Medical Association)
Fri Nov 01, 2019 16:03
ConclusionThe optimal management of anogenital giant condyloma acuminata remains to be determined. Staged surgical excision should be conducted to achieve an optimum outcome. Radical reconstructive surgery should be reserved for patients with recurrence, malignant transformation or sphincter involvement. (Source: Annals of Medicine and Surgery)
Fri Nov 01, 2019 16:03
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Tony Y. Eng, Mustafa Abugideiri, Tiffany W. Chen, Nicholas Madden, Tiffany Morgan, Daniel Tanenbaum, Narine Wandrey, Sarah Westergaard, Karen Xu (Source: Hematology Oncology Clinics of North America)
Fri Nov 01, 2019 15:36
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Mannat Narang, Pranshu Mohindra, Mark Mishra, William Regine, Young Kwok (Source: Hematology Oncology Clinics of North America)
Fri Nov 01, 2019 15:36
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Victor Ho-Fun Lee, Li Yang, Yong Jiang, Feng-Ming (Spring) Kong (Source: Hematology Oncology Clinics of North America)
Fri Nov 01, 2019 15:36
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Sujith Baliga, Torunn I. Yock (Source: Hematology Oncology Clinics of North America)
Fri Nov 01, 2019 15:36
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Shraddha Mahesh Dalwadi, Joseph M. Herman, Prajnan Das, Emma B. Holliday (Source: Hematology Oncology Clinics of North America)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Fri Nov 01, 2019 15:36
Publication date: Available online 31 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Sonja Stieb, Kendall Kiser, Lisanne van Dijk, Nadia Roxanne Livingstone, Hesham Elhalawani, Baher Elgohari, Brigid McDonald, Juan Ventura, Abdallah Sherif Radwan Mohamed, Clifton David Fuller (Source: Hematology Oncology Clinics of North America)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales...
Fri Nov 01, 2019 15:36
Fri Nov 01, 2019 15:12
We present here the 2019 Update of INASL Consensus on Prevention, Diagnosis, and Management of Hepatocellular Carcinoma in India: The Puri-2 Recommendations. (Source: Journal of Clinical and Experimental Hepatology)
Fri Nov 01, 2019 15:12
ConclusionsIt was not possible to conclude that the exercise protocols performed in this study are more effective than the usual guidance to prevent reduction in MO in patients undergoing radiotherapy for head and neck cancer. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Fri Nov 01, 2019 15:09
A patient presented with visual changes raising suspicion of progression of underlying brain cancer requiring craniotomy. Final results showed Nocardia farcinica brain infection instead. Nocardiosis should be considered in patients receiving corticosteroids as management can be lifesaving. (Source: Infectious Diseases in Clinical Practice)
Fri Nov 01, 2019 06:00
We present a case wherein a 60-year-old man diagnosed as having renal cell carcinoma (status after pancreaticoduodenectomy) developed recurrent bacteremia with multiple enteric pathogens over a 2-year period because of an infected vascular graft. (Source: Infectious Diseases in Clinical Practice)
Fri Nov 01, 2019 06:00
We describe a case of a diabetic and morbidly obese, but otherwise healthy man, who developed bacteremia and perinephric abscess due to Lactobacillus species. (Source: Infectious Diseases in Clinical Practice)
Fri Nov 01, 2019 06:00
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