Related ArticlesActinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells. Front Oncol. 2019;9:1086 Authors: Yin H, Jiang Z, Wang S, Zhang P Abstract Background: Chemotherapy is an essential component for comprehensive cancer treatment, while drug resistance usually fails therapy. DNA repair mechanism of cancer cells restrains the efficacy of therapeutics targeting DNA damage. Investigating target-inducing...
Fri Nov 22, 2019 14:27
Related ArticlesAntitumor and apoptotic effects of 5-methoxypsoralen in U87MG human glioma cells and its effect on cell cycle, autophagy and PI3K/Akt signaling pathway. Arch Med Sci. 2019 Oct;15(6):1530-1538 Authors: Guo H, He Y, Bu C, Peng Z Abstract Introduction: The main purpose of the current study was to investigate the antitumor effects of 5-methoxypsoralen in U87MG human glioma cells along with studying its effects on cell cycle progression, autophagy...
Fri Nov 22, 2019 14:27
Related ArticlesSe-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells. Onco Targets Ther. 2019;12:8751-8763 Authors: Luo L, Ran R, Yao J, Zhang F, Xing M, Jin M, Wang L, Zhang T Abstract Background: The anticancer effects of cordyceps on various tumors have been reported. However, little is known about the role of selenium (Se)-enriched Cordyceps militaris...
Fri Nov 22, 2019 14:27
Related ArticlesThe Effects of Butyric Acid on the Differentiation, Proliferation, Apoptosis, and Autophagy of IPEC-J2 Cells. Curr Mol Med. 2019 Oct 24;: Authors: Yang Y, Huang J, Li J, Yang H, Yin Y Abstract Butyric acid (BT), a short-chain fatty acid, is the preferred colonocyte energy source. The effects of BT on the differentiation, proliferation, and apoptosis of small intestinal epithelial cells of piglets and its underlying mechanisms are not...
Fri Nov 22, 2019 14:27
Related ArticlesInactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2019 Nov 21;:1-15 Authors: Klimovich B, Stiewe T, Timofeev O Abstract TP53 mutations are found in 50% of all cancers and mutated TP53 status is considered poor for treatment. However, some TP53 mutations exhibit only partial loss-of-function (LOF), meaning they retain residual transcriptional and non-transcriptional activities that are...
Fri Nov 22, 2019 14:27
Related ArticlesIncreased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met. Kaohsiung J Med Sci. 2019 Nov 20;: Authors: Chen JJ, Sun X, Mao QQ, Jiang XY, Zhao XG, Xu WJ, Zhong L Abstract Hematologic and neurological expression 1 (HN1) has been reported to involved in certain cancers, but...
Fri Nov 22, 2019 13:29
Related ArticlesSuperior mesenteric artery first approach can improve the clinical outcomes of pancreaticoduodenectomy: a meta-analysis. Int J Surg. 2019 Nov 18;: Authors: Jiang X, Yu Z, Ma Z, Deng H, Ren W, Shi W, Jiao Z Abstract BACKGROUND AND AIM: Superior mesenteric artery (SMA) first approach was a new improvement for pancreaticoduodenectomy (PD), but there is no evidence whether this approach is advantageous to PD. This meta-analysis aimed to determine...
Fri Nov 22, 2019 14:25
Related ArticlesDrained Mucosal Advancement Flap Versus Rerouting Seton around the Internal Anal Sphincter in Treatment of High Trans-sphincteric Anal Fistula: a Randomized Trial. Int J Surg. 2019 Nov 18;: Authors: Abdelnaby M, Emile S, El-Said M, Abdallah E, AbdelMawla A Abstract BACKGROUND: Several sphincter saving techniques have been described for complex anal fistula (CAF) with variable outcomes. The present trial aimed to compare two techniques...
Fri Nov 22, 2019 14:25
Related ArticlesA Commentary on "Continuous adductor canal block is a better choice compared to single shot after primary total knee arthroplasty: A meta-analysis of randomized controlled trials" (Int J Surg 2019; Epub ahead of print). Int J Surg. 2019 Nov 18;: Authors: Zhao S, Zhu Y, Ruan Z PMID: 31751789 [PubMed - as supplied by publisher]
Fri Nov 22, 2019 14:25
Related ArticlesCo-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells. Cancer Biol Ther. 2019 Nov 21;:1-9 Authors: Wang H, Liao P, Zeng SX, Lu H Abstract p53-R249S (p53-RS) is frequently detected in human hepatocellular carcinoma (HCC) that is highly associated with hepatitis B infection and aflatoxin B1 exposure. Our previous study showed that CDK4/Cyclin D1 phosphorylates p53-RS at the cancer-derived...
Fri Nov 22, 2019 13:19
Related ArticlesTRIM58 suppresses the tumor growth in gastric cancer by inactivation of β-catenin signaling via ubiquitination. Cancer Biol Ther. 2019 Nov 21;:1-10 Authors: Liu X, Long Z, Cai H, Yu S, Wu J Abstract Objective: To investigate and define the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in regulating the tumor growth of gastric cancer (GC).Methods: TRIM58 expression in GC tissues and cells was detected by real-time...
Fri Nov 22, 2019 13:19
Related ArticlesEarly Onset, Long Illness Duration, Epilepsy Type, and Polypharmacy Have an Adverse Effect on Psychosocial Outcome in Children with Epilepsy. Neuropediatrics. 2019 Nov 21;: Authors: Valova V, Kochan A, Werry B, John R, Prager C, Schneider J, Kaindl AM Abstract Epilepsy is often associated with psychosocial comorbidity and this can be more disabling than the seizure activity. Still, these associated conditions are often underdiagnosed...
Fri Nov 22, 2019 15:08
Related ArticlesHuman Left Anterior Cingulate Stimulation Elicits a Reproducible Micturition Response. Stereotact Funct Neurosurg. 2019 Nov 21;:1-4 Authors: Patra S, Valls L, Heredia G, Burdette D, Elisevich K Abstract Electrical stimulation of a brain region producing a micturition response has never previously been described in the human. This report identifies the anterior cingulate gyrus as a brain region important in the micturition response. Stereo...
Fri Nov 22, 2019 15:08
Related ArticlesWhy we urgently need improved seizure and epilepsy therapies for children and neonates. Neuropharmacology. 2019 Nov 18;:107854 Authors: Pressler R, Lagae L Abstract In contrast to epilepsy in adolescents and adults, neonatal seizures and early onset epilepsy poses unique challenges with significant repercussion for treatment choices. Most importantly, high seizure burden and epileptic encephalopathy are associated with developmental,...
Fri Nov 22, 2019 15:08
Related ArticlesWhy we urgently need improved epilepsy therapies for adult patients. Neuropharmacology. 2019 Nov 18;:107855 Authors: Billakota S, Devinsky O, Kim KW Abstract PURPOSE: Up to a third of patients with epilepsy suffer from recurrent seizures despite therapeutic advances. RESULTS: Current epilepsy treatments are limited by experiential data from treating different types of epilepsy. For example, we lack evidence-based approaches to...
Fri Nov 22, 2019 15:08
Related ArticlesmicroRNA-139-5p confers sensitivity to antiepileptic drugs in refractory epilepsy by inhibition of MRP1. CNS Neurosci Ther. 2019 Nov 21;: Authors: Wang L, Song L, Chen X, Suo J, Ma Y, Shi J, Liu K, Chen G Abstract AIM: Drug resistance is an intractable issue urgently needed to be overcome for improving efficiency of antiepileptic drugs in treating refractory epilepsy. microRNAs (miRNAs) have been proved as key regulators and therapeutic...
Fri Nov 22, 2019 15:08
Related ArticlesBone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs. Front Pharmacol. 2019;10:1278 Authors: Brady RD, Wong KR, Robinson DL, Mychasiuk R, McDonald SJ, D'Cunha RA, Yamakawa GR, Sun M, Wark JD, Lee PVS, O'Brien TJ, Casillas-Espinosa PM, Shultz SR Abstract Rationale: Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether these bone abnormalities...
Fri Nov 22, 2019 15:08
Related ArticlesExperience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy. Neurol Med Chir (Tokyo). 2019 Nov 21;: Authors: Chonan M, Saito R, Kanamori M, Osawa SI, Watanabe M, Suzuki H, Nakasato N, Tominaga T Abstract After introduction of levetiracetam (LEV), treatment of seizures in patients with malignant brain tumors has prominently improved. On the other hand, we still experience some cases with LEV-uncontrollable...
Fri Nov 22, 2019 13:17
Related ArticlesCurrent and future directions of deep brain stimulation for neurological and psychiatric disorders. J Neurosurg. 2019 08 01;131(2):333-342 Authors: Lee DJ, Lozano CS, Dallapiazza RF, Lozano AM Abstract Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it has primarily been used to treat movement disorders such as Parkinson's disease, essential tremor, and dystonia, recently it has been approved to...
Fri Nov 22, 2019 13:17
Related ArticlesQuantitative Signal Characteristics of Electrocorticography and Stereoelectroencephalography: The Effect of Contact Depth. J Clin Neurophysiol. 2019 May;36(3):195-203 Authors: Young JJ, Friedman JS, Panov F, Camara D, Yoo JY, Fields MC, Marcuse LV, Jette N, Ghatan S Abstract PURPOSE: Patients undergoing epilepsy surgery often require invasive EEG, but few studies have examined the signal characteristics of contacts on the surface of...
Fri Nov 22, 2019 13:17
Related ArticlesBaclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy. J Clin Neurophysiol. 2019 May;36(3):209-212 Authors: Triplett JD, Lawn ND, Dunne JW Abstract PURPOSE: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal...
Fri Nov 22, 2019 13:17
Related ArticlesClaims data analyses unable to properly characterize the value of neurologists in epilepsy care. Neurology. 2019 02 26;92(9):e973-e987 Authors: Hill CE, Lin CC, Burke JF, Kerber KA, Skolarus LE, Esper GJ, Magliocco B, Callaghan BC Abstract OBJECTIVE: To determine the association of a neurologist visit with health care use and cost outcomes for patients with incident epilepsy. METHODS: Using health care claims data for individuals...
Fri Nov 22, 2019 13:17
Related ArticlesPREFACE: Antiepileptogenesis following traumatic brain injury. Neurobiol Dis. 2019 03;123:1-2 Authors: Galanopoulou AS, Engel J, Moshé SL PMID: 30312758 [PubMed - indexed for MEDLINE]
Fri Nov 22, 2019 13:17
Related ArticlesErector spinae plane: a collapsible potential space. Reg Anesth Pain Med. 2019 Nov 20;: Authors: Xu L, Leng JC, Mariano E, Tsui BCH PMID: 31748425 [PubMed - as supplied by publisher]
Fri Nov 22, 2019 13:15
Related ArticlesEffect of lidocaine cream analgesia for chest drain tube removal after video-assisted thoracoscopic surgery for lung cancer: a randomized clinical trial. Reg Anesth Pain Med. 2019 Nov 20;: Authors: Watanabe SN, Imai K, Kimura T, Saito Y, Takashima S, Matsuzaki I, Kurihara N, Atari M, Matsuo T, Iwai H, Sato Y, Motoyama S, Nomura K, Nishikawa T, Minamiya Y Abstract BACKGROUND AND OBJECTIVES: Pain management makes an important contribution...
Fri Nov 22, 2019 13:15
Related ArticlesPatients' Perspectives on What Makes a Better Care Experience While Undergoing Treatment for Oropharyngeal Dysphagia Secondary to Head and Neck Cancer. Dysphagia. 2019 Nov 20;: Authors: Checklin M, Bain J, Bath L, Lethbridge K Abstract Patients' perceptions on what makes a better care experience for head and neck cancer (HNca) have not been widely sought. Patients' perceptions can play a crucial role in shaping quality care and client...
Fri Nov 22, 2019 13:12
Related ArticlesEffects of weakness of orofacial muscles on swallowing and communication in FSHD. Neurology. 2019 02 26;92(9):e957-e963 Authors: Mul K, Berggren KN, Sills MY, McCalley A, van Engelen BGM, Johnson NE, Statland JM Abstract OBJECTIVE: This study explores the use of quantitative data on strength and fatigability of orofacial muscles in patients with facioscapulohumeral muscular dystrophy (FSHD) and assesses the frequency of swallowing and...
Fri Nov 22, 2019 13:12
Related ArticlesExploring the therapeutic potential of atorvastatin against Gram-positive and Gram-negative bacteria: In-silico, In-vitro and In- vivo evidence. Infect Disord Drug Targets. 2019 Oct 24;: Authors: Sethi K, Singh A, Kumar A Abstract The incidences of opportunistic bacterial infections have increased from the past two decades or threaten to increase in the near future. Inspite of the availability of various classes of antibiotics, bacterial...
Fri Nov 22, 2019 16:16
Related ArticlesPrimary and recurrent growing teratoma syndrome in central nervous system non-germinomatous germ cell tumors: case series and review of the literature. World Neurosurg. 2019 Nov 18;: Authors: Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F Abstract BACKGROUND: The term "growing teratoma syndrome (GTS)" has been used as follows: patients...
Fri Nov 22, 2019 14:46
Related ArticlesPurely Meningeal Intracranial Relapse of Melanoma Brain Metastases after Surgical Resection and Immunotherapy as a Unique Disease Progression pattern: Our Experience and Review of the Literature. World Neurosurg. 2019 Nov 18;: Authors: Armocida D, Marzetti F, Pesce A, Caporlingua A, D'Angelo L, Santoro A Abstract BACKGROUND: We present a case of 72-years-old man, with history of metastatic melanoma diagnosed up in 2015 presenting a stable...
Fri Nov 22, 2019 14:46
Related ArticlesPredicting Hearing Loss After Radiotherapy and Cisplatin Chemotherapy in Patients With Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2019 Nov 21;: Authors: Schuette A, Lander DP, Kallogjeri D, Collopy C, Goddu S, Wildes TM, Daly M, Piccirillo JF Abstract Importance: Accurate, accessible predictions of posttreatment hearing loss for patients with head and neck cancer prior to the initiation of treatment are a necessary part of...
Fri Nov 22, 2019 15:07
Related ArticlesA review on immunohistochemical and histopathologic validation in PET-CT findings with consideration to microRNAs. Med Pharm Rep. 2019 Oct;92(4):337-345 Authors: Bădan MI, Bonci EA, Piciu D Abstract Purpose: This review provides an overview of some of the most recent clinical trials which investigated various types of cancer and other diseases, through the use of PET-CT imaging, highlighting the use of immunohistochemical stains or conventional...
Fri Nov 22, 2019 15:07
Related ArticlesEstablishing a Cohort of Transgender Men and Gender Nonconforming Individuals to Understand the Molecular Impact of Testosterone on Breast Physiology. Transgend Health. 2019;4(1):326-330 Authors: Baker GM, Pyle ME, Tobias AM, Bartlett RA, Phillips J, Fein-Zachary VJ, Wulf GM, Heng YJ Abstract Purpose: To characterize a cohort of transgender men and masculine-centered gender nonconforming individuals who underwent gender-affirming chest-contouring...
Fri Nov 22, 2019 15:07
Related ArticlesImpact of nonappendiceal cancer-specific death on overall survival: a competing risk analysis. Future Oncol. 2019 Nov 21;: Authors: Wu J, Man D, Wang K, Li L Abstract Aim: The occurrence of nonappendiceal cancer-specific death (non-ACSD) and its impact on overall survival are unclear. Methods: Patients were extracted from the Surveillance, Epidemiology, and End Results. Results: Nearly 33.2 and 24.0% patients suffered ACSD and non-ACSD....
Fri Nov 22, 2019 15:07
Related ArticlesImmune Checkpoint Inhibition in Non-metastatic Non-small Cell Lung Cancer: Chance for Cure? Drugs. 2019 Nov 20;: Authors: Heigener DF, Reck M Abstract Immune checkpoint inhibition of programmed-death receptor 1 (PD-1) or its ligand (PD-L1) has become a standard in the treatment of metastatic non-small cell lung cancer, either as monotherapy or in combination. Recently, it could be shown that immunotherapy works as consolidation after...
Fri Nov 22, 2019 13:08
Related ArticlesEnrichment of circulating myeloma cells by immunomagnetic beads combined with flow cytometry for monitoring minimal residual disease and relapse in patients with multiple myeloma. Ann Hematol. 2019 Nov 20;: Authors: Wang N, Tesfaluul N, Li J, Gao X, Liu S, Yue B Abstract Difficulty in regularly analyzing marrow myeloma cells (MMCs) and low frequency of circulating myeloma cells (CMCs) in blood presents challenges for monitoring minimal...
Fri Nov 22, 2019 13:08
Related ArticlesMutation Variants and Co-Mutations as Genomic Modifiers of Response to Afatinib in HER2-Mutant Lung Adenocarcinoma. Oncologist. 2019 Nov 20;: Authors: Fang W, Zhao S, Liang Y, Yang Y, Yang L, Dong X, Zhang L, Tang Y, Wang S, Yang Y, Ma X, Wang M, Wang W, Zhao S, Wang K, Gao S, Zhang L Abstract BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-mutant lung cancer remains an orphan of specific targeted therapy. The variable responses...
Fri Nov 22, 2019 13:08
Related ArticlesDaily life participation in childhood chronic disease: a qualitative study. Arch Dis Child. 2019 Nov 20;: Authors: Nap-van der Vlist MM, Kars MC, Berkelbach van der Sprenkel EE, Nijhof LN, Grootenhuis MA, van Geelen SM, van der Ent CK, Swart JF, van Royen-Kerkhof A, van Grotel M, van de Putte EM, Nijhof SL Abstract OBJECTIVE: Opportunities to participate in daily life have improved considerably for children with chronic disease. Nevertheless,...
Fri Nov 22, 2019 13:08
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