Publication date: Available online 23 November 2019Source: NeuroImageAuthor(s): Paul F. Hill, Danielle R. King, Bradley C. Lega, Michael D. RuggAbstractIntra-cranial electroencephalographic brain recordings (iEEG) provide a powerful tool for investigating the neural processes supporting episodic memory encoding and form the basis of experimental therapies aimed at improving memory dysfunction. However, given the invasiveness of iEEG, investigations are constrained to patients with drug-resistant...
Sun Nov 24, 2019 13:59
Publication date: Available online 23 November 2019Source: NeuroImageAuthor(s): Nima Bigdely-Shamlo, Jonathan Touryan, Alejandro Ojeda, Christian Kothe, Tim Mullen, Kay RobbinsAbstractSignificant achievements have been made in the fMRI field by pooling statistical results from multiple studies (meta-analysis). More recently, fMRI standardization efforts have focused on enabling the joint analysis of raw fMRI data across studies (mega-analysis), with the hope of achieving more detailed insights. However,...
Sun Nov 24, 2019 13:59
Related ArticlesBenefits in Speech Recognition in Noise with Remote Wireless Microphones in Group Settings. J Am Acad Audiol. 2019 Nov 15;:0 Authors: Thibodeau LM Abstract BACKGROUND: Although hearing aids (HAs) and cochlear implants (CIs) can provide significant benefits to persons with hearing loss, users frequently report difficulty hearing in noisy environments, particularly when there are multiple talkers. Little is known about the benefits...
Sun Nov 24, 2019 17:52
Related ArticlesNormative Values of Saccades and Smooth Pursuit in Children Aged 5 to 17 Years. J Am Acad Audiol. 2019 Nov 21;:0 Authors: Sinno S, Najem F, Smith Abouchacra K, Perrin P, Dumas G Abstract BACKGROUND: Pediatric oculomotor function can be evaluated via videonystagmography. Adult normative data for saccades and smooth pursuit tests cannot be used as a benchmark for pediatric patients because children's peripheral and central systems continue...
Sun Nov 24, 2019 17:52
Related ArticlesA Trigeminal Schwannoma Masked by Solely Vestibulocochlear Symptoms. J Am Acad Audiol. 2019 Nov 15;:0 Authors: Evans LK, Peraza L, Zamboni A Abstract BACKGROUND: Intracranial schwannomas are most commonly associated with the vestibulocochlear nerve, often leading to hearing loss, tinnitus, and vestibular dysfunction. Much less often, a schwannoma can arise from the trigeminal nerve which can lead to facial pain, numbness, and weakness....
Sun Nov 24, 2019 17:52
Related ArticlesA Commentary on "Postoperative outcomes in elderly patients undergoing pancreatic resection for pancreatic adenocarcinoma: A systematic review and meta-analysis" (Int J Surg 2019;72:59-68.). Int J Surg. 2019 Nov 20;: Authors: Altoukhi KH, Morris DL PMID: 31759117 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 14:49
Related ArticlesAn Invited Commentary on "Electrochemotherapy for Advanced Cutaneous Angiosarcoma: A European Register-based Cohort Study from the International Network for Sharing Practices of Electrochemotherapy (InspECT)" (Int J Surg 2019;72:34-42). Int J Surg. 2019 Nov 20;: Authors: Zhou G, Mei Z PMID: 31759116 [PubMed - as supplied by publisher]
Sun Nov 24, 2019 14:49
Related ArticlesMultidisciplinary management of stage II-III gastric and gastro-oesophageal junction cancer. Eur J Cancer. 2019 Nov 20;124:67-76 Authors: Wagner AD, Lordick F, Grabsch HI, Terashima M, Terada M, Yoshikawa T, Boku N, Kataoka K, Smyth EC, Mauer M, Haustermans K, Moehler MH Abstract The aim of this manuscript is to discuss the viewpoint of the European Organisation for Research and Treatment of Cancer (EORTC) Gastric Cancer Taskforce and...
Sun Nov 24, 2019 14:48
Related ArticlesMetal-based photosensitizers for photodynamic therapy: the future of multimodal oncology? Curr Opin Chem Biol. 2019 Nov 20;56:23-27 Authors: McFarland SA, Mandel A, Dumoulin-White R, Gasser G Abstract Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace...
Sun Nov 24, 2019 14:48
Related ArticlesSUV95th as a Reliable Alternative to SUVmax for Determining Renal Uptake in [68Ga] PSMA PET/CT. Mol Imaging Biol. 2019 Nov 22;: Authors: Baiocco S, Matteucci F, Mezzenga E, Caroli P, Di Iorio V, Cittanti C, Bevilacqua A, Paganelli G, Sarnelli A Abstract PURPOSE: Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable...
Sun Nov 24, 2019 13:48
Related ArticlesMelanoma pathology reporting and staging. Mod Pathol. 2019 Nov 22;: Authors: Scolyer RA, Rawson RV, Gershenwald JE, Ferguson PM, Prieto VG Abstract The pathological diagnosis of melanoma can be challenging. The provision of an appropriate biopsy and pertinent history can assist in establishing an accurate diagnosis and reliable estimate of prognosis. In their reports, pathologists should document both the criteria on which the diagnosis...
Sun Nov 24, 2019 13:48
Related ArticlesRapid generation of sustainable HER2-specific T cell immunity in HER2 breast cancer patients using a degenerate HLA class II epitope vaccine. Clin Cancer Res. 2019 Nov 22;: Authors: Knutson KL, Block MS, Norton N, Erskine CL, Hobday TJ, Dietz AB, Padley D, Gustafson MP, Puglisi-Knutson D, Mangskau TK, Chumsri S, Dueck AC, Karyampudi L, Wilson G, Degnim AC Abstract PURPOSE: HER2+ breast cancer patients benefit from trastuzumab-containing...
Sun Nov 24, 2019 13:48
Related ArticlesComparative Analysis of Radiotherapy Linear Accelerator Downtime and Failure Modes in the UK, Nigeria and Botswana. Clin Oncol (R Coll Radiol). 2019 Nov 19;: Authors: Wroe LM, Ige TA, Asogwa OC, Aruah SC, Grover S, Makufa R, Fitz-Gibbon M, Sheehy SL Abstract The lack of radiotherapy linear accelerators (linacs) in low- and middle-income countries (LMICs) has been recognised as a major barrier to providing quality cancer care in these...
Sun Nov 24, 2019 13:48
Related ArticlesLongitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using OCT Angiography. Ophthalmol Retina. 2019 Oct 11;: Authors: Skalet AH, Liu L, Binder C, Miller AK, Crilly R, Hung AY, Wilson DJ, Huang D, Jia Y Abstract PURPOSE: To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I125) plaque brachytherapy for uveal melanoma using OCT angiography (OCTA). ...
Sun Nov 24, 2019 13:48
Related ArticlesPrecision Medicine in Colorectal Surgery. Surg Oncol Clin N Am. 2020 Jan;29(1):23-34 Authors: Prabhakaran S, Leong J, Petrelli NJ, Khatri VP Abstract This article reviews advances in precision medicine for colorectal carcinoma that have influenced screening and treatment, and potentially prevention. Advances in molecular techniques have made it possible for better patient selection for therapies; therefore, mutational analysis should...
Sun Nov 24, 2019 13:48
Publication date: Available online 23 November 2019Source: Gene Expression PatternsAuthor(s): Li Zheng, Cheng-Zhou Mao, Yun-Qian Bi, Yi-Min Zhou, Zhou Zhang, Hui Zhao, Kyu-Sang Park, Ruijin Huang, Dong-Qing Cai, Xu-Feng QiAbstractThe forkhead-box transcription factors of O subfamily (FOXO) play important roles in regulation of various biological functions. We cloned foxo1, foxo3, foxo4, and foxo6 from Xenopus tropicalis (hereafter X. tropicalis), and examined their expression in embryos and adult...
Sun Nov 24, 2019 13:42
Related ArticlesInvestigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J Inorg Biochem. 2019 Nov 13;203:110913 Authors: Podgorski MN, Coleman T, Chao RR, De Voss JJ, Bruning JB, Bell SG Abstract The cytochrome P450 metalloenzyme (CYP) CYP199A4 from Rhodopseudomonas palustris HaA2 catalyzes the highly efficient oxidation of para-substituted benzoic acids. Here we determined crystal...
Sun Nov 24, 2019 15:42
Related ArticlesCopper(I) complexes with phosphines P(p-OCH3-Ph)2CH2OH and P(p-OCH3-Ph)2CH2SarGly. Synthesis, multimodal DNA interactions, and prooxidative and in vitro antiproliferative activity. J Inorg Biochem. 2019 Nov 15;203:110926 Authors: Komarnicka UK, Kozieł S, Zabierowski P, Kruszyński R, Lesiów MK, Tisato F, Porchia M, Kyzioł A Abstract Phosphonium salt (p-OCH3-Ph)2P(CH2OH)2Cl (MPOHC), derived phosphine ligands without and with SarGly (Sarcosine-Glycine)...
Sun Nov 24, 2019 15:42
Related ArticlesSalen‑manganese complexes for controlling ROS damage: Neuroprotective effects, antioxidant activity and kinetic studies. J Inorg Biochem. 2019 Nov 14;203:110918 Authors: Rouco L, Liberato A, Fernández-Trujillo MJ, Máñez A, Basallote MG, Alvariño R, Alfonso A, Botana LM, Maneiro M Abstract A new manganese(III) complex [MnL1(DCA)(H2O)](H2O),1 [H2L1 is the chelating ligand N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminopropane, and...
Sun Nov 24, 2019 15:42
Related ArticlesTACITuS: transcriptomic data collector, integrator, and selector on big data platform. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):366 Authors: Alaimo S, Di Maria A, Shasha D, Ferro A, Pulvirenti A Abstract BACKGROUND: Several large public repositories of microarray datasets and RNA-seq data are available. Two prominent examples include ArrayExpress and NCBI GEO. Unfortunately, there is no easy way to import and manipulate data from such...
Sun Nov 24, 2019 13:36
Related ArticlesImpact of polymorphic transposable elements on transcription in lymphoblastoid cell lines from public data. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):495 Authors: Spirito G, Mangoni D, Sanges R, Gustincich S Abstract BACKGROUND: Transposable elements (TEs) are DNA sequences able to mobilize themselves and to increase their copy-number in the host genome. In the past, they have been considered mainly selfish DNA without evident functions....
Sun Nov 24, 2019 13:36
Related ArticlesMiRNA therapeutics based on logic circuits of biological pathways. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):344 Authors: Boscaino V, Fiannaca A, La Paglia L, La Rosa M, Rizzo R, Urso A Abstract BACKGROUND: In silico experiments, with the aid of computer simulation, speed up the process of in vitro or in vivo experiments. Cancer therapy design is often based on signalling pathway. MicroRNAs (miRNA) are small non-coding RNA molecules....
Sun Nov 24, 2019 13:36
Related ArticlesExploratory analysis of transposable elements expression in the C. elegans early embryo. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):484 Authors: Ansaloni F, Scarpato M, Di Schiavi E, Gustincich S, Sanges R Abstract BACKGROUND: Transposable Elements (TE) are mobile sequences that make up large portions of eukaryote genomes. The functions they play within the complex cellular architecture are still not clearly understood, but it is becoming...
Sun Nov 24, 2019 13:36
Related ArticlesImaGene: a convolutional neural network to quantify natural selection from genomic data. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):337 Authors: Torada L, Lorenzon L, Beddis A, Isildak U, Pattini L, Mathieson S, Fumagalli M Abstract BACKGROUND: The genetic bases of many complex phenotypes are still largely unknown, mostly due to the polygenic nature of the traits and the small effect of each associated mutation. An alternative approach...
Sun Nov 24, 2019 13:36
Related ArticlesmetaSPARSim: a 16S rRNA gene sequencing count data simulator. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):416 Authors: Patuzzi I, Baruzzo G, Losasso C, Ricci A, Di Camillo B Abstract BACKGROUND: In the last few years, 16S rRNA gene sequencing (16S rDNA-seq) has seen a surprisingly rapid increase in election rate as a methodology to perform microbial community studies. Despite the considerable popularity of this technique, an exiguous...
Sun Nov 24, 2019 13:36
Related ArticlesGenes with human-specific features are primarily involved with brain, immune and metabolic evolution. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):406 Authors: Bitar M, Kuiper S, O'Brien EA, Barry G Abstract BACKGROUND: Humans have adapted to widespread changes during the past 2 million years in both environmental and lifestyle factors. This is evident in overall body alterations such as average height and brain size. Although we can appreciate...
Sun Nov 24, 2019 13:36
Related ArticlesBITS2018: the fifteenth annual meeting of the Italian Society of Bioinformatics. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):562 Authors: Cordero F, Calogero RA, Caselle M Abstract This preface introduces the content of the BioMed Central Bioinformatics journal Supplement related to the 15th annual meeting of the Bioinformatics Italian Society, BITS2018. The Conference was held in Torino, Italy, from June 27th to 29th, 2018.PMID: 31757202...
Sun Nov 24, 2019 13:36
Related ArticlesSTRAIN: an R package for multi-locus sequence typing from whole genome sequencing data. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):347 Authors: Dalsass M, Bodini M, Lambert C, Mortier MC, Romanelli M, Medini D, Muzzi A, Brozzi A Abstract BACKGROUND: Multi-locus sequence typing (MLST) is a standard typing technique used to associate a sequence type (ST) to a bacterial isolate. When the output of whole genome sequencing (WGS) of a sample...
Sun Nov 24, 2019 13:36
Related ArticlesAnalyzing gene expression data for pediatric and adult cancer diagnosis using logic learning machine and standard supervised methods. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):390 Authors: Verda D, Parodi S, Ferrari E, Muselli M Abstract BACKGROUND: Logic Learning Machine (LLM) is an innovative method of supervised analysis capable of constructing models based on simple and intelligible rules. In this investigation the performance of...
Sun Nov 24, 2019 13:36
Related ArticlesBetter quality score compression through sequence-based quality smoothing. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):302 Authors: Shibuya Y, Comin M Abstract MOTIVATION: Current NGS techniques are becoming exponentially cheaper. As a result, there is an exponential growth of genomic data unfortunately not followed by an exponential growth of storage, leading to the necessity of compression. Most of the entropy of NGS data lies in the...
Sun Nov 24, 2019 13:36
Related ArticlesMetaCon: unsupervised clustering of metagenomic contigs with probabilistic k-mers statistics and coverage. BMC Bioinformatics. 2019 Nov 22;20(Suppl 9):367 Authors: Qian J, Comin M Abstract MOTIVATION: Sequencing technologies allow the sequencing of microbial communities directly from the environment without prior culturing. Because assembly typically produces only genome fragments, also known as contigs, it is crucial to group them into...
Sun Nov 24, 2019 13:36
Related ArticlesIdentification of Pivotal Genes and Pathways in Osteoarthritic Degenerative Meniscal Lesions via Bioinformatics Analysis of the GSE52042 Dataset. Med Sci Monit. 2019 Nov 23;25:8891-8904 Authors: Huan X, Jinhe Y, Rongzong Z Abstract BACKGROUND To better understand the process of osteoarthritic degenerative meniscal lesions (DMLs) formation, this study analyzed the dataset GSE52042 using bioinformatics methods to identify the pivotal genes...
Sun Nov 24, 2019 14:30
Related ArticlesGTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer. Cancer Sci. 2019 Nov 23;: Authors: Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K Abstract Chromosome 7q (Ch.7q) is clonally amplified in colorectal cancer (CRC). Here, we aimed to identify oncogenes on Ch.7q that are overexpressed through DNA copy...
Sun Nov 24, 2019 13:30
Related ArticlesTherapeutic efficacy and imaging assessment of the HER2-targeting chemotherapy drug ZHER2:V2-pemetrexed in lung adenocarcinoma Xenografts. Invest New Drugs. 2019 Nov 23;: Authors: Han J, Zhao Y, Zhao X, Ma T, Hao T, Liu J, Zhang Z, Zhang J, Wang J Abstract Chemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has...
Sun Nov 24, 2019 13:30
Related ArticlesAn epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells. Sci Rep. 2019 Nov 22;9(1):17363 Authors: Xavier PLP, Cordeiro YG, Alexandre PA, Pires PRL, Saranholi BH, Silva ER, Müller S, Fukumasu H Abstract Targeting self-renewal and tumorigenicity has been proposed as a potential strategy against cancer stem cells (CSCs). Epigenetic proteins are key modulators of...
Sun Nov 24, 2019 13:30
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