Conflicting verdicts on peanut OIT from the ICER and FDA Advisory Committee; where do we go from here?

JACI (AOP)

Fri Nov 01, 2019 02:00

Morbidity and mortality associated with ventral skull base surgery: analysis of the National Surgical Quality Improvement Program

Background Ventral skull base (VSB) surgery has associated morbidity and mortality that is poorly defined. In this study we aim to identify factors associated with adverse events in VSB surgery. Methods We queried the database of the American College of Surgeons National Surgical Quality Improvement Program for cases of VSB surgery during the period 2005‐2014. Patients with complications, readmissions, reoperations, or mortality were compared to those without adverse events. Results Nine...

International Forum of Allergy & Rhinology

Thu Oct 31, 2019 10:33

The effect of topical epinephrine 1:1000 with and without infiltration of 1% lidocaine with epinephrine 1:100,000 on endoscopic surgical field visualization: a double‐blind randomized controlled study

Background The objective of this study is to determine whether the infiltration of 1% lidocaine with 1:100,000 epinephrine in addition to topical application of 1:1000 epinephrine significantly improves surgical field grading scale score over topical 1:1000 epinephrine alone. Methods A prospective, double‐blind, randomized, controlled study was performed of 40 patients undergoing bilateral endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). Patients were enrolled and randomly...

International Forum of Allergy & Rhinology

Thu Oct 31, 2019 10:28

Prospective characterization of postoperative nasal deformities in patients undergoing endoscopic endonasal skull‐base surgery

Background Surgeons have become increasingly aware of the impact of endoscopic endonasal surgery (EES) of the skull base on sinonasal‐related quality of life. Prior retrospective investigation described a correlation between nasoseptal flap (NSF) reconstruction in EES with postoperative nasal deformities, such as nasal dorsum collapse. The primary objective of this study was to prospectively evaluate the incidence of, and contributing factors to, postoperative changes in nasal structure following...

International Forum of Allergy & Rhinology

Wed Oct 30, 2019 20:01

Association of air pollutants, airborne occupational exposures, and chronic rhinosinusitis disease severity

Background Previous work has shown that chronic rhinosinusitis (CRS) severity may be associated with particulate matter 2.5 (PM2.5) and black carbon (BC) in CRS patients without nasal polyps (CRSsNP). Data regarding occupational exposures, however, are lacking. We assessed the impact of PM2.5, BC, as well as occupational airborne exposure on CRS disease severity. Methods Patients with CRS with nasal polyps (CRSwNP), CRSsNP, and aspirin‐exacerbated respiratory disease (AERD) were identified...

International Forum of Allergy & Rhinology

Tue Oct 29, 2019 18:11

The TNF-like weak inducer of the apoptosis/fibroblast growth factor–inducible molecule 14 axis mediates histamine and platelet-activating factor–induced subcutaneous vascular leakage and anaphylactic shock

Publication date: Available online 31 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Nerea Mendez-Barbero, Alma Yuste-Montalvo, Emilio Nuñez-Borque, Bettina M. Jensen, Carmen Gutiérrez-Muñoz, Jaime Tome-Amat, María Garrido-Arandia, Araceli Díaz-Perales, Contanza Ballesteros-Martinez, Jose Julio Laguna, J.M. Beitia, Lars K. Poulsen, Javier Cuesta-Herranz, Luis Miguel Blanco-Colio, Vanesa EstebanBackgroundAnaphylaxis includes mast cell (MC) activation, but less is known about...

Journal of Allergy and Clinical Immunology

Fri Nov 01, 2019 16:22

Advances in Asthma and Allergic Disease Genetics – Is Bigger Always Better?

Publication date: Available online 31 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Nathan Schoettler, Elke Rodríguez, Stephan Weidinger, Carole OberAbstractThis review focuses on genome-wide association studies (GWASs) of asthma and allergic diseases published between January 1, 2018 and June 30, 2019. During this time period there were 38 GWASs reported in 19 papers, including the largest performed to date for many of these conditions. Overall, we learned that childhood...

Journal of Allergy and Clinical Immunology

Fri Nov 01, 2019 16:22

Editorial Board

Publication date: November 2019Source: Autoimmunity Reviews, Volume 18, Issue 11Author(s):

Autoimmunity Reviews

Fri Nov 01, 2019 16:12

Pen a 1-specific IgE does not improve the accuracy of a shrimp allergy diagnosis among Japanese children due to cross-reactivity with Der p 10

Publication date: Available online 1 November 2019Source: Allergology InternationalAuthor(s): Kazunori Tagami, Satoshi Nakayama, Tomoko Furuta, Teruaki Matsui, Yoshihiro Takasato, Shiro Sugiura, Komei Ito

Allergology International

Fri Nov 01, 2019 16:08

Component-resolved diagnostics can be useful for identifying hazelnut allergy in Japanese children

Publication date: Available online 1 November 2019Source: Allergology InternationalAuthor(s): Yoko Inoue, Sakura Sato, Kyohei Takahashi, Noriyuki Yanagida, Hitoshi Yamamoto, Naoki Shimizu, Motohiro EbisawaAbstractBackgroundCor a 9 and Cor a 14 are effective markers for predicting hazelnut allergy. However, there have been no reports on the component-resolved diagnostics (CRD) of hazelnut allergy using an oral food challenge (OFC) for diagnosis in Asia. We hypothesized that CRD would improve the accuracy...

Allergology International

Fri Nov 01, 2019 16:08