Abstract Background Since the early days of molecular biology, organ and tissue regeneration represents a challenging medical goal. However, only recently the advances in the understanding of the cellular components have enabled the promise to become a reality. In this vast panorama of new technologies, stem cells have progressively established themselves as the most effective and user-friendly regenerative therapeutic tool. ...
Fri Nov 01, 2019 02:00
ABSTRACT Existing clinical approaches and tools to measure burn tissue destruction are limited resulting in misdiagnosis of injury depth in over 40% of cases. Thus, our objective in this study is to characterize the ability of short wave infrared (SWIR) imaging to detect different moisture levels which could serve as surrogate for tissue viability as well as the ability to differentiate between superficial and deep burns damaging the epidermis and dermis at different depths. To accomplish our aim...
Fri Nov 01, 2019 18:04
ABSTRACT Venous leg ulcers (VLU) represent a major clinical unmet need, impairing quality of life for millions worldwide. The bioengineered living cell construct (BLCC) is the only FDA‐approved therapy demonstrating efficacy in healing chronic VLU, yet its in vivo mechanisms of action are not well understood. Previously, we reported a BLCC‐mediated acute wounding response at the ulcer edge; in this study we elucidated the BLCC‐specific effects on the epidermis‐free ulcer bed. We conducted a randomized...
Thu Oct 31, 2019 18:18
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