Contact Dermatitis Early View Online Version of Record before inclusion in an issue

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ORIGINAL ARTICLES

Isothiazolinones in cleaning products: Analysis with liquid chromatography tandem mass spectrometry of samples from sensitized patients and market

Gabriel Marrero‐Alemán, Leopoldo Borrego, Ana González Antuña, Ana Macías Montes, Octavio Pérez Luzardo

Version of Record online: 22 November 2019

Highlights

• Some cleaning products with high concentrations of isothiazolinones may cause cutaneous symptoms in sensitized patients, especially in spray form.
• Of all the products analyzed, 76.5% contained at least one isothiazolinone. MI and BIT were the components most commonly detected.
• Suitable quality controls of the final product should be made and the labels should specify the correct way to use the products.

ORIGINAL ARTICLES

Modifications induced by chemical skin allergens on the metabolome of reconstructed human epidermis: A pilot high‐resolution magic angle spinning nuclear magnetic resonance study

François‐Marie Moussallieh, Eric Moss, Karim Elbayed, Guillaume Lereaux, Fleur Tourneix, Jean‐Pierre Lepoittevin

Version of Record online: 21 November 2019

Highlights

• A total of 32 different metabolites were identified in reconstructed human epidermis (RHE) by high‐resolution magic angle spinning nuclear magnetic resonance, among which 20 could be quantified for all samples.
• Statistical univariate analysis showed that the measured metabolites were different in the RHE samples treated with sensitizers vs non‐sensitizers.
• A multivariate partial least‐squares‐discriminant analysis was performed on the two treated groups, discriminating sensitizing and non‐sensitizing chemicals.

 Open Access

ORIGINAL ARTICLES

Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies

Jørgen Serup, Katrina Hutton Carlsen, Nils Dommershausen, Mitra Sepehri, Bernhard Hesse, Christian Seim, Andreas Luch, Ines Schreiver

Version of Record online: 18 November 2019

1. First study on chemical analysis of human skin biopsies from chronic allergic reactions in red tattoos to identify culprit pigment(s) and metals.
2. Pigment Red (P.R.) 22, P.R.170, and P.R.210 were the prevailing pigments behind chronic allergic reactions in red tattoos. The epitope causing the reaction might be a pigment‐degradation product.
3. Metal contamination is very common in any tattoo ink stock product, and its role in red tattoo allergy appears dubious.

ORIGINAL ARTICLES

The methylisothiazolinone epidemic goes along with changing patients' characteristics – After cosmetics industrial applications are the focus

Axel Schnuch, Steffen Schubert, Holger Lessmann, Johannes Geier

Version of Record online: 17 November 2019

HighlightsAfter an epidemic of MI allergy mainly caused by its use in cosmetics, the continuous use of MI in industrial applications, for example, paints, and subsequent sensitization remain a matter of concern.

Contact Dermatitis Accepted Articles Accepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.

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CONTACT POINTS

Contact allergy to 2‐hydroxyethyl methacrylate in Denmark

Martin Havmose, Jacob P. Thyssen, Claus Zachariae, Jeanne D. Johansen

First Published: 21 November 2019

EDUCATION AND DEBATE

A survey of members of ESSCA and COST TD1206 to identify allergens tested in cosmetic series across Europe

Emma Horton, Mark Wilkinson, Kristiina Aalto‐Korte, Andrea Bauer, Mahbub MU Chowdhury, Susan Cooper, Philippa Cousen, Marie‐Noëlle Crépy, Francesca Larese Filon, Rosella Gallo, Johannes Geier, Ana Giménez‐Arnau, Margarida Gonçalo, An Goossens, Cathy Green, Fabrizio Guarneri, Suzana LjubojeviĆ HadžavdiĆ, Jeanne Duus Johansen, Graham A Johnston, Maria Pesonen, Thomas Rustemeyer, Javier Sanchez‐Perez, Marie‐Louise A. Schuttelaar, Natalie Stone, Jacob P Thyssen, Wolfgang Uter, Collaborators

First Published: 20 November 2019

CONTACT POINTS

Safe use of imipenem after delayed hypersensitivity to meropenem – value of patch tests

Francisca Morgado, Luis Santiago, Margarida Gonçalo

First Published: 19 November 2019

CONTACT POINTS

Generalized bullous fixed drug eruption: trazodone as a new culprit

Loraine Combemale, Benoit Ben Saïd, Gwendy Dupire

First Published: 19 November 2019

CONTACT POINTS

Irritant reactions to leave‐on cosmetic and other products

An Goossens, Sara Huygens, Liesbeth Gilissen

First Published: 19 November 2019