Abstract Background Both photosynthetic pigments and chloroplasts in plant leaf cells play an important role in deciding on the photosynthetic capacity and efficiency in plants. Systematical investigating the regulatory mechanism of chloroplast development and chlorophyll (Chl) content variation is necessary for clarifying the photosynthesis mechanism for crops. Objective ...
Fri Nov 01, 2019 02:00
Publication date: Available online 31 October 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Sara Elena Rebuzzi, Roberta Alfieri, Silvia La Monica, Roberta Minari, Pier Giorgio Petronini, Marcello TiseoAbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) improved clinical outcome compared to chemotherapy in EGFR mutated advanced non-small cell lung cancer (NSCLC) patients. Nonetheless, acquired resistance develops within 10-14 months and 20-30% of EGFR-mutated...
Fri Nov 01, 2019 19:48
Thoracic and head and neck cancer radiation therapy (RT) can cause damage to nearby healthy organs such as the esophagus, causing acute radiation-induced esophageal damage (ARIED). A non-invasive method to det...
Wed Oct 30, 2019 02:00
To determine if the performance of a knowledge based RapidPlan (RP) planning model could be improved with an iterative learning process, i.e. if plans generated by an RP model could be used as new input to re-...
Wed Oct 30, 2019 02:00
While sudden hearing loss after stereotactic radiosurgery has been demonstrated in some cases a recent article by Linge et al. and have demonstrated the need for further discussion on this topic. We attempt to...
Wed Oct 30, 2019 02:00
Publication date: Available online 1 November 2019Source: Journal of Infection and ChemotherapyAuthor(s): Rin Yoshizato, Hiroshi KogaAbstractBackgroundThis study aimed to elucidate the etiologies and diagnostic errors of early-phase pediatric fever without an obvious cause.MethodsThis single-center, retrospective, descriptive study included 1334 febrile children hospitalized at Beppu Medical Center in Japan between 2014 and 2018. Eligibility criteria were age ≤12 years, axillary temperature ≥38.0°C,...
Fri Nov 01, 2019 18:43
Publication date: Available online 1 November 2019Source: Journal of Infection and ChemotherapyAuthor(s): Kazuaki Tatara, Kenji Gotoh, Kiyohito Okumiya, Mariko Teramachi, Kazuhisa Ishimoto, Yuhei Tanaka, Jun Iwahashi, Shizuo Shindou, Yushiro Yamashita, Hiroshi WatanabeAbstractStreptococcus pyogenes (Group A streptococci: GAS) are known to cause a wide variety of human illnesses, some of which can be life-threatening. Usually, penicillin is the first-choice agent for the treatment of GAS infections....
Fri Nov 01, 2019 18:43
Publication date: Available online 1 November 2019Source: Journal of Infection and ChemotherapyAuthor(s): Ryosuke Yamamuro, Naoto Hosokawa, Mitsuya KatayamaAbstractAcinetobacter spp. are known to be a cause of nosocomial infections and to have diverse mechanisms of resistance to antimicrobials. Here, we report the case of a patient who presented to our emergency department with necrotizing fasciitis due to Acinetobacter junii as confirmed by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight...
Fri Nov 01, 2019 18:43
Publication date: Available online 31 October 2019Source: Journal of Infection and ChemotherapyAuthor(s): Toshihito Mihara, Takeshi Kimura, Kyoko Momiyama, Atsushi Kainuma, Koichi Akiyama, Junya Ohara, Keita Inoue, Mao Kinoshita, Masaru Shimizu, Kiyoshi Moriyama, Naohisa Fujita, Teiji SawaAbstractThe secondary in-hospital epidemiological investigation for drug-resistant Pseudomonas aeruginosa infections was conducted to evaluate the in-hospital situation and identify any associations between exoenzyme...
Fri Nov 01, 2019 18:43
Publication date: Available online 31 October 2019Source: Journal of Infection and ChemotherapyAuthor(s): Yoshiaki Yokoyama, Naoto Hosokawa, Toshiyuki Kudo, Hitomi Goda, Kiyomi Ito, Masanori Suzuki, Ryohkan FunakoshiAbstractCeftriaxone (CTRX) is a third-generation cephalosporin commonly used to treat infections such as community-acquired pneumonia and urinary tract infections caused by mainly Gram-negative bacteria and some Gram-positive bacteria. Here, we report a case of a patient on hemodialysis...
Fri Nov 01, 2019 18:43
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Whitney E. Zahnd, Recinda L. Sherman, Hillary Klonoff-Cohen, Sara L. McLafferty, Susan Farner, Karin A. RosenblattAbstractIntroductionTo evaluate disparities in breast cancer stage by subtype (categorizations of breast cancer based upon molecular characteristics) in the Delta Regional Authority (Delta), an impoverished region across eight Lower Mississippi Delta Region (LMDR) states with a high proportion of Black residents...
Fri Nov 01, 2019 18:24
Publication date: November 2019Source: Cancer Treatment Reviews, Volume 80Author(s):
Fri Nov 01, 2019 17:49
Cancers, Vol. 11, Pages 1707: Development of a MEL Cell-Derived Allograft Mouse Model for Cancer Research Cancers doi: 10.3390/cancers11111707 Authors: Kim Choi Lee Kim Son Lim Kim Ryu Uversky Lee Kim Murine erythroleukemia (MEL) cells are often employed as a model to dissect mechanisms of erythropoiesis and erythroleukemia in vitro. Here, an allograft model using MEL cells resulting in splenomegaly was established to develop a diagnostic model...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1708: Mutation Induction in Humans and Mice: Where Are We Now? Cancers doi: 10.3390/cancers11111708 Authors: Dubrova The analysis of mutation induction in human families exposed to mutagens provides the only source of reliable estimates of factors contributing to the genetic risk of human exposure to mutagens. In this paper, I briefly summarize the results of recent studies on the pattern of mutation induction in the human and mouse germline. The results of recent...
Fri Nov 01, 2019 02:00
Publication date: Available online 31 October 2019Source: Cancer CellAuthor(s): Huiying Han, Atul D. Jain, Mihai I. Truica, Javier Izquierdo-Ferrer, Jonathan F. Anker, Barbara Lysy, Vinay Sagar, Yi Luan, Zachary R. Chalmers, Kenji Unno, Hanlin Mok, Rajita Vatapalli, Young A. Yoo, Yara Rodriguez, Irawati Kandela, J. Brandon Parker, Debabrata Chakravarti, Rama K. Mishra, Gary E. Schiltz, Sarki A. AbdulkadirSummarySmall molecules that directly target MYC and are also well tolerated in vivo will provide...
Fri Nov 01, 2019 17:26
Abstract This paper summarises the view of the German Commission on Radiological Protection (“Strahlenschutzkommission”, SSK) on the rationale behind the currently valid dose limits and dose constraints for workers recommended by the International Commission on Radiological Protection (ICRP). The paper includes a discussion of the reasoning behind current dose limits followed by a discussion of the detriment used by ICRP as a measure for stochastic health effects. Studies on radiation-induced...
Fri Nov 01, 2019 02:00
Abstract Purpose A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour. ...
Fri Nov 01, 2019 02:00
Abstract Purpose Vitexin, an inhibitor of hypoxia-inducible factor (HIF)-1α, has anti-tumor effect. However, whether it can enhance the radiotherapy sensitization of hyperbaric oxygen (HBO) on glioma is unclear. This study aimed to investigate the effect of vitexin. Methods The nude mice with paw-transplanted glioma were divided into four groups: control...
Fri Nov 01, 2019 02:00
Publication date: Available online 31 October 2019Source: Cancer LettersAuthor(s): Yusuke Nakatsu, Takeshi Yamamotoya, Koji Ueda, Hiraku Ono, Masa-Ki Inoue, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Akio Matsubara, Tomoichiro AsanoAbstractPin1 is one member of a group consisting of three prolyl isomerases. Pin1 interacts with the motif containing phospho-Ser/Thr-Pro of substrates and enhances cis-trans isomerization of peptide bonds, thereby controlling the functions...
Fri Nov 01, 2019 16:51
Publication date: Available online 31 October 2019Source: Cancer LettersAuthor(s): Ina A. Eilertsen, Seyed H. Moosavi, Jonas M. Strømme, Arild Nesbakken, Bjarne Johannessen, Ragnhild A. Lothe, Anita SveenAbstractGene expression profiling has increasing relevance in the molecular screening of patients with colorectal cancer (CRC). We investigated potential platform-specific effects on transcriptomic subtyping according to established frameworks by comparisons of expression profiles from RNA sequencing...
Fri Nov 01, 2019 16:51
Publication date: Available online 31 October 2019Source: Cancer LettersAuthor(s): Christina Georgikou, Libo Yin, Jury Gladkich, Xi Xiao, Carsten Sticht, Carolina de la Torre, Norbert Gretz, Wolfgang Gross, Michael Schäfer, Svetlana Karakhanova, Ingrid HerrAbstractThe therapy resistance of pancreatic cancer is associated with the loss of gap junction intercellular communication and connexin 43 expression. The broccoli isothiocyanate sulforaphane restored these features and therapy sensitivity. We...
Fri Nov 01, 2019 16:51
Publication date: Available online 31 October 2019Source: Cancer LettersAuthor(s): Lina Zhang, Xinyong Zhang, Yanxia Liu, Tongmei Zhang, Ziyu Wang, Meng Gu, Yilin Li, Daisy Dandan Wang, Weiying Li, Peter Ping LinAbstractSustained angiogenesis and increased PD-L1 expression on endothelial and carcinoma cells contribute toward fostering an immunosuppressive microenvironment suitable for tumor growth. PD-L1+ CTCs were reported to associate with poor prognosis in NSCLC patients. However, whether or not...
Fri Nov 01, 2019 16:51
A study by UK researchers has highlighted the potential financial advantages of using respiratory inhalers that have less global warming impacts than those commonly in use.Their paper, published in...
Fri Nov 01, 2019 14:56
The US electronic cigarette company Juul has been accused of shipping one million contaminated e-cigarette nicotine pods, in a lawsuit filed by a former employee.Siddharth Breja, who was the...
Fri Nov 01, 2019 13:51
What you need to knowThis guideline update focuses on maintaining remission in people with ileocolonic Crohn’s disease who have had complete macroscopic resection within the last three monthsConsider...
Fri Nov 01, 2019 12:46
Since the decriminalisation of abortion in Northern Ireland on 22 October,1 women have been attending doctors as patients, not as criminals, as one obstetrician put it.Previously, abortion was...
Fri Nov 01, 2019 12:21
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Ram Abhinav Kannan, TR Arul PonniAbstractAimTo analyse the long term swallowing function in head and neck cancer patients and correlate with the dose to midline swallowing structures.BackgroundThe use of concurrent chemo radiation (CRT) as the present standard of care resulted in high rates of early and late toxicities. Dysphagia, aspiration, and xerostomia are early as well...
Fri Nov 01, 2019 16:07
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Zhigang Yuan, G.Daniel Grass, Mounsif Azizi, Kamran A. Ahmed, G. Sean J. Yoder, Eric A. Welsh, William J. Fulp, Jasreman Dhillon, Javier F. Torres-Roca, Anna R. Giuliano, Philippe E. Spiess, Peter A. JohnstoneAbstractPurposeOptimal postoperative radiation therapy (PORT) dose is unclear in penile squamous cell carcinoma (PeSCC). Herein, we characterized the radiosensitivity...
Fri Nov 01, 2019 16:07
Publication date: Available online 31 October 2019Source: Cancer/RadiothérapieAuthor(s): D. Dumont Lecomte, J. Lequesne, J. Geffrelot, P. Lesueur, V. Barraux, C. Loiseau, J. Lacroix, A. Leconte, É. Émery, J. Thariat, D. StefanAbstractPurposeStereotactic radiosurgery and hypofractionated stereotactic radiotherapy are standard treatments for brain metastases when they are small in size (at the most 3 cm in diameter) and limited in number, in patients with controlled extracerebral disease and a good...
Fri Nov 01, 2019 14:41
Publication date: Available online 31 October 2019Source: Cancer/RadiothérapieAuthor(s): Khalid Hadadi, M. Hommadi, Maroa Belemlih, Noha Zaghba, Abdelhak Maghous, El-Amin Marnouch, K.A. Saghir, Mohamed Elmarjany, Hassan Sifat, Mohamed Oukabli, Hamid MansouriRésuméObjectif de l’étudeL’objectif principal de cette étude était de déterminer dans notre département le taux de survie sans progression du plasmocytome solitaire osseux et secondairement d’évaluer ses aspects diagnostiques, thérapeutiques et...
Fri Nov 01, 2019 14:41
Cancers, Vol. 11, Pages 1706: Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment Cancers doi: 10.3390/cancers11111706 Authors: van Tienderen Groot Koerkamp IJzermans van der Laan Verstegen Primary liver cancer, consisting predominantly of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), remains one of the most lethal malignancies worldwide. This high malignancy is related to the complex...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1702: A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma Cancers doi: 10.3390/cancers11111702 Authors: White Jayasekara Picard Chen Watkins Cain Remke Gough Medulloblastoma is the most common malignant brain tumor in children and represents 20% of all pediatric central nervous system neoplasms. While advances in surgery, radiation and chemotherapy have improved overall survival, the lifelong sequelae of these treatments...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1705: Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience Cancers doi: 10.3390/cancers11111705 Authors: Sati Akbaba Dina Ahmed Andreas Mock Thomas Held Suzan Bahadir Kristin Lang Mustafa Syed Juliane Hoerner-Rieber Tobias Forster Philippe Federspil Klaus Herfarth Peter Plinkert Juergen...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1704: Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11111704 Authors: Lokau Schoeder Haybaeck Garbers Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It can be caused by chronic liver cell injury with resulting sustained inflammation, e.g., triggered by infections with hepatitis viruses B (HBV) and C (HCV). Death of hepatocytes leads to the...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1703: A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers11111703 Authors: Hui-Wen Chiu Ya-Ling Yeh Sheng-Yow Ho Yuan-Hua Wu Bour-Jr Wang Wei-Jan Huang Yuan-Soon Ho Ying-Jan Wang Li-Ching Chen Shih-Hsin Tu Radiation therapy (RT) is one of the main treatments for triple-negative breast cancer...
Fri Nov 01, 2019 02:00
Abstract Background KIF18A is a kinesin family member that is involved in various cellular processes including cell division, cell transformation, and carcinogenesis. However, its possible role in the regulation of host immunity has not been examined. Objective The aim of this study is to investigate the functional role of KIF18A in the differentiation and...
Fri Nov 01, 2019 02:00
Publication date: Available online 1 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): David Anwanwan, Santosh Kumar Singh, Shriti Singh, Varma Saikam, Rajesh SinghAbstractGlobally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth. Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor prognosis. Of all liver cancer cases, >90% are hepatocellular carcinomas (HCCs) for which chemotherapy...
Fri Nov 01, 2019 13:52
Abstract Schwann cells are the principal glial cells of the peripheral nervous system which maintain neuronal homeostasis. Schwann cells support peripheral nerve functions and play a critical role in many pathological processes including injury-induced nerve repair, neurodegenerative diseases, infections, neuropathic pain and cancer. Schwann cells are implicated in a wide range of diseases due, in part, to their ability to interact and modulate immune cells. We discuss the accumulating...
Fri Nov 01, 2019 02:00
Publication date: November 2019Source: Practical Radiation Oncology, Volume 9, Issue 6Author(s): Ankit Agarwal, Trevor J. Royce, Chelain R. Goodman, Mudit Chowdhary
Fri Nov 01, 2019 12:52
Publication date: November 2019Source: Practical Radiation Oncology, Volume 9, Issue 6Author(s):
Fri Nov 01, 2019 12:52
Publication date: November 2019Source: Practical Radiation Oncology, Volume 9, Issue 6Author(s):
Fri Nov 01, 2019 12:52
Publication date: November 2019Source: Practical Radiation Oncology, Volume 9, Issue 6Author(s): Jolie Ringash
Fri Nov 01, 2019 12:52
Cancers, Vol. 11, Pages 1699: Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11111699 Authors: Jong Yeob Kim Keum Hwa Lee Jeonghyun Kang Edith Borcoman Esma Saada-Bouzid Andreas Kronbichler Sung Hwi Hong Leandro Fórnias Machado de Rezende Shuji Ogino Nana Keum Mingyang Song Claudio Luchini Hans J. van der Vliet Jae Il Shin Gabriele Gamerith Hyperprogressive...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1700: Segmentation and Grade Prediction of Colon Cancer Digital Pathology Images Across Multiple Institutions Cancers doi: 10.3390/cancers11111700 Authors: Saima Rathore Muhammad Aksam Iftikhar Ahmad Chaddad Tamim Niazi Thomas Karasic Michel Bilello Distinguishing benign from malignant disease is a primary challenge for colon histopathologists. Current clinical methods rely on qualitative visual analysis of features such as glandular architecture...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1698: Next-Generation Multimodality of Nanomedicine Therapy: Size and Structure Dependence of Folic Acid Conjugated Copolymers Actively Target Cancer Cells in Disabling Cell Division and Inducing Apoptosis Cancers doi: 10.3390/cancers11111698 Authors: Sambi DeCarlo Malardier-Jugroot Szewczuk Nanomedicine as a multimodality treatment of cancer utilizes the advantages of nanodelivery systems of drugs. They are superior to the clinical administration...
Fri Nov 01, 2019 02:00
Cancers, Vol. 11, Pages 1701: Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1 Cancers doi: 10.3390/cancers11111701 Authors: Nicholas P. D. Liau Artem Laktyushin Rhiannon Morris Jarrod J. Sandow Nicos A. Nicola Nadia J. Kershaw Jeffrey J. Babon Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias,...
Fri Nov 01, 2019 02:00
Abstract Purpose Partial nephrectomy has been persuaded as a widely accepted surgical procedure for T1a (≤ 4 cm) renal tumors. However, when treating T1b (4–7 cm) renal cell carcinoma (RCC), the “optimal” method of surgery is still debatable. The aim of the research is to evaluate the long-term oncological and renal functional outcomes of laparoscopic radical nephrectomy (LRN) versus laparoscopic partial nephrectomy (LPN) for patients...
Fri Nov 01, 2019 02:00
Abstract ETS variant 4 (ETV4), together with ETV1 and ETV5, constitute the PEA3 subfamily of ETS transcription factors, which are implicated in the progression of many cancers. However, the clinicopathologic significance and molecular events regulated by ETV4 in lung cancer are still poorly understood, especially in squamous cell carcinoma of the lung. Here, we aimed to identify functional targets involved in ETV4‐driven lung tumorigenesis. Microarray analysis and validation data revealed that ETV4...
Thu Oct 31, 2019 15:01
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): B. Soldevilla, C. Carretero-Puche, G. Gomez-Lopez, F. Al-Shahrour, M.C. Riesco, B. Gil-Calderon, L. Alvarez-Vallina, P. Espinosa-Olarte, G. Gomez-Esteves, B. Rubio-Cuesta, J. Sarmentero, A. La Salvia, R. Garcia-CarboneroAbstractBackgroundSolid tumour growth is the consequence of a complex interplay between cancer cells and their microenvironment. Recently, a new global transcriptomic immune classification of solid...
Fri Nov 01, 2019 11:36
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Aurore Vozy, Eleonora De Martin, Douglas B. Johnson, Bénédicte Lebrun-Vignes, Javid J. Moslehi, Joe-Elie Salem
Fri Nov 01, 2019 11:36
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Ulrich Ronellenfitsch, Katrin Jensen, Svenja Seide, Meinhard Kieser, Matthias Schwarzbach, Tracy E. Slanger, Bryan Burmeister, David Kelsen, Donna Niedzwiecki, Guillaume Piessen, Christoph Schuhmacher, Susan Urba, Cornelis van de Velde, Marc Ychou, Ralf Hofheinz, Sylvie LorenzenAbstractIntroductionDisease-free survival (DFS) is increasingly being used as surrogate end-point for overall survival (OS) in cancer...
Fri Nov 01, 2019 11:36
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Thomas Walter, Come Lepage, Romain Coriat, Emilie Barbier, Guillaume Cadiot, Francois-Xavier Caroli-Bosc, Thomas Aparicio, Karine Bouhier-Leporrier, Olivia Hentic-Dhome, Frédérique Gay, Anne-Claire Dupont-Gossart, Muriel Duluc, Céline Lepere, Thierry Lecomte, Denis Smith, Caroline Petorin, Frédéric Di-Fiore, Francois Ghiringhelli, Jean-Louis Legoux, Rosine GuimbaudAbstractBackgroundHepatic arterial embolisation...
Fri Nov 01, 2019 11:36
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Stefan Michiels, James Wason
Fri Nov 01, 2019 11:36
Abstract Caveolin-1, the major protein component of caveolae, plays vital functions in tumorigenesis and metastasis. Previous evidence demonstrated the positive role of Caveolin-1 in the regulation of endothelial cell differentiation and the involvement of Caveolin-1 in vascular endothelial growth factor (VEGF) mediated angiogenesis. The correlation of Caveolin-1 expression and angiogenesis is not yet elucidated in osteosarcoma. This study aimed to investigate the expression levels...
Fri Nov 01, 2019 02:00
Abstract Purpose To compare the clinical results and functional outcomes between two-dimensional conventional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC) with skull-base invasion. Methods A total of 1258 patients were subclassified into two groups: mild skull-base invasion group (792; 63%) and...
Fri Nov 01, 2019 02:00
Abstract Objective In the present study, we aimed to assess sense of coherence (SOC) and health‐related quality of life (HRQOL) during and after adjuvant chemotherapy by mobile phone‐based reporting in patients with colorectal cancer experiencing neurotoxicity. Methods In this prospective descriptive cohort study, a mobile phone‐based system was used to receive a series of real‐time longitudinal patient‐reported assessments of SOC (13‐item), HRQOL (Functional Assessment of Cancer Therapy‐General...
Thu Oct 31, 2019 13:39
Melanoma is an aggressive form of skin cancer, and a worldwide problem with increasing incidence. Little is known about the burden of melanoma in Chinese population. We evaluated temporal trends and geographic variation in melanoma‐associated burden, to narrow an important knowledge gap concerning the consequences of this disorder across time, provinces in China. Following the general analytic strategy used in the 2017 Global Burden of Disease study, we analyzed the incidence, mortality, prevalence...
Thu Oct 31, 2019 20:34
The exosome is a small functional vesicle enriched in selected proteins, lipids, and nucleic acids, displaying distinct molecular heterogeneity. Exosomes released can transform the extracellular matrix microenvironments, transmit signals and molecules to recipient cells, and trigger changes in their pathophysiological functions. Tumor‐derived exosomes mediate the interactions of tumor cells and microenvironment significantly, and they stimulate tumor growth and development through specific signaling...
Thu Oct 31, 2019 20:29
Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer worldwide. Measurements of circulating inflammation‐related biomarkers may inform etiology or provide non‐invasive signatures for early diagnosis. We therefore examined levels of inflammation molecules for associations with ESCC risk. Using a case‐cohort study designed within the Japan Public Health Center‐based Prospective Study, we measured baseline plasma levels of 92 biomarkers using a multiplex...
Thu Oct 31, 2019 20:28
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