Secreting pituitary adenomas are tumors for which few treatment options are available, including surgical treatment and management of hormonal imbalance due to altered pituitary secretion. In case of inoperable relapse, radiotherapy or chemotherapeutic treatment can be considered; the effectiveness of these treatments, however, remains limited. In the immunotherapy era, it is necessary to select patients who can benefit from immunotherapeutic treatment. Mismatch repair deficiency is strongly associated...
Thu Nov 07, 2019 02:00
Sen. Tina Smith has introduced legislation to reduce the barriers many veterans face when trying to get care for hearing loss as a result of their service ahead of Veterans Day. The Veterans Hearing Benefits Act would provide presumption for hearing loss and tinnitus to veterans who served in combat or in a military specialty where they were exposed to repeated loud noises, such as those who worked around heavy artillery, thus making it easier for veterans to establish service-connection and get...
Fri Nov 08, 2019 15:46
Sen. Tina Smith has introduced legislation to reduce the barriers many veterans face when trying to get care for hearing loss as a result of their service ahead of Veterans Day. The Veterans Hearing Benefits Act would provide presumption for hearing loss and tinnitus to veterans who served in combat or in a military specialty where they were exposed to repeated loud noises, such as those who worked around heavy artillery, thus making it easier for veterans to establish service-connection and get...
Fri Nov 08, 2019 15:46
Summary The PI3K/AKT/mTOR pathway activation plays a central role in glioblastoma multiforme (GBM) development and progression, and in resistance to anti-cancer therapies. Inhibition of the PI3K pathway has been shown to sensitize cultured glioma cells and tumor xenografts to the effects of temozolomide (TMZ) and radiation. Vistusertib is an oral inhibitor of mTORC1/2 complexes. The primary objective of this Canadian Cancer Trials Group phase I study was to determine the recommended...
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Abstract The purpose of this study was to assess behavioral expectations and related psychosocial factors regarding an age-expanded human papillomavirus (HPV) vaccine schedule among male sexual minorities (MSM). A measure of behavioral expectation (BE) (“How likely are you to get the HPV vaccine if the CDC recommendation was changed to include men older than 26?”) was evaluated on an ethnoracially diverse sample (N = 318) of MSM. Sixty-seven percent would likely initiate vaccination...
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Abstract Social media has transformed the way cancer patients search for information about their chronic health problems. The purpose of this systematic review is to identify the use of online digital videos to increase cancer knowledge and to understand information preference, behavioral changes, and attitudes towards online cancer education videos. The databases used for this review included MedLine, PsychINFO, and PubMed. These medical databases were used to locate peer-reviewed...
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Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundThe literature contains conflicting reports on the epidemiology and frequency of hidradenitis suppurativa (HS), a chronic, recurrent inflammatory disease of the apocrine glands.ObjectiveTo evaluate the clinical and demographic characteristics of HS cases in Turkey and investigate the similarities with world epidemiology.MethodThe records of 208 patients that presented to our polyclinics and were diagnosed with HS between June 2012...
Fri Nov 08, 2019 08:12
There is evidence of a female carrier phenotype in the majority of XLID conditions. Sixty‐seven percent of XLID conditions have an associated phenotype in female carriers, with reduced cognition function as part of the phenotype in 91% of these conditions. For 31% of XLID conditions there is no reported phenotypic expression in female carriers. XLID: X‐linked intellectual disability. ABSTRACT To better understand the landscape of female phenotypic expression in X‐linked intellectual disability...
Fri Nov 08, 2019 19:13
Abstract Background Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage. Objective To study the feasibility and repeatability of T1ρ for assessing knee cartilage in JIA and also to describe T1ρ values and study correlation between T1ρ and conventional MRI scores for disease activity. ...
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Abstract A wide range of genitourinary pathologies can be diagnosed in utero, from a simple vesicoureteral reflux to a more complex disorder of sexual differentiation. The prognosis and neonatal management of these conditions differ significantly. Evaluation of the fetal perineal anatomy is paramount to making the right diagnosis. The aim of this pictorial essay is to show sonographers how to acquire a perineal midsagittal view in a male fetus, and to demonstrate how this specific...
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Abstract Background Iterative reconstruction is offered by all vendors to achieve similar or better CT image quality at lower doses than images reconstructed with filtered back-projection. Objective The purpose of this study was to investigate the dose-reduction potential for pediatric abdominal CT imaging when using either a commercially available hybrid...
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I didn’t set out to become a filmmaker. Although I’ve had a camera in hand since I was a kid and made a documentary for a visual anthropology class, I mainly saw photography and filmmaking as hobbies and tools for sharing research. This began to change in 2012. I was on a one-year visiting position, teaching cultural and methods at the University of South Florida where I’d received my doctorate in applied cultural anthropology the year before. I met filmmaker Jacob Okada and, for fun, gave notes...
Fri Nov 08, 2019 22:00
The Association for Africanist Anthropology is proud to announce the 2019 Student Paper Prize Winners. Each winner will be formally recognized at the AfAA Business Meeting at the AAA/CASCA Annual Meeting in Vancouver on Thursday, November 21 at 8:00 p.m. 2019 Nancy “Penny” Schwartz Undergraduate Essay Award winner: Jamie O’Leary, “Mangi Deeti Doorati: Marian Performativity in a Senegalese Daara” In June 2019, Jamie O’Leary graduated summa cum laude from Princeton University’s Department of Anthropology,...
Fri Nov 08, 2019 18:30
Abstract Two main contributors of sterile neurogenic inflammation underlying migraine pain, calcitonin gene–related peptide (CGRP), and meningeal mast cells (MMCs) play a key role in the activation of the inflammatory cascade resulting in the sensitization of trigeminal nociceptors. It is well established that phytochemical agent thymoquinone exhibits multiple anti-inflammatory effects in different in vitro and in vivo models of neuroinflammation....
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Abstract Purpose One-third of patients with RAS wild-type mCRC do not benefit from anti-EGFR monoclonal antibodies. This might be a result of variable pharmacokinetics and insufficient tumor targeting. We evaluated cetuximab tumor accumulation on [89Zr]Zr-cetuximab PET/CT as a potential predictive biomarker and determinant for an escalating dosing strategy. Patients and methods...
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Abstract Purpose Accurate evaluation of hypoxia is particularly important in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The aim of this study was to propose a novel imaging strategy for quantitative three-dimensional (3D) evaluation of hypoxia in a small animal model of NPC. Methods A carbonic anhydrase IX (CAIX)-specific molecular...
Fri Nov 08, 2019 02:00
Abstract Purpose The novel PET tracer [11C]SMW139 binds with high affinity to the P2X7 receptor, which is expressed on pro-inflammatory microglia. The purposes of this first in-man study were to characterise pharmacokinetics of [11C]SMW139 in patients with active relapsing remitting multiple sclerosis (RRMS) and healthy controls (HC) and to evaluate its potential to identify in vivo neuroinflammation in RRMS. ...
Fri Nov 08, 2019 02:00
Abstract The supplementary motor area (SMA) syndrome is characterized by transient weakness and akinesia contralateral to the side of the affected hemisphere. The underlying pathology of the syndrome is not fully understood but is thought to be related to lesions in the SMA, residing principally in the mesial superior frontal gyrus (Broadmann’s area 6c). Although the SMA syndrome a well-characterized clinical entity, we report herein, to our knowledge, the first case of isolated...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Nov 08, 2019 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Nov 08, 2019 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Nov 08, 2019 10:00
Abstract The hypothalamo‐pituitary‐adrenal (HPA) axis plays a key role in the neuroendocrine response to stress and in maintaining physiological homeostasis. However, stress that is chronic in nature can lead to HPA axis dysfunction and increase the risk for developing affective disorders, particularly if the stress is experienced during vulnerable periods in life. Sex differences in how the HPA axis responds to stress are well established, with females typically displaying heightened responses....
Fri Nov 08, 2019 18:36
Abstract The discrimination of mass-forming chronic pancreatitis (MFCP) from pancreatic ductal adenocarcinoma (PDAC) is a central diagnostic dilemma. It is important to differentiate these entities since they have markedly different prognoses and management. Importantly, the appearance of these two entities significantly overlaps on a variety of imaging modalities. However, there are imaging features that may be suggestive of one entity more than the other. MFCP and PDAC may show...
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Abstract Purpose Prior iterative reconstruction (PIR) spatially registers CT image data from multiple phases of enhancement to reduce image noise. We evaluated PIR in contrast-enhanced multiphase liver CT. Methods Patients with archived projection CT data with proven malignant or benign liver lesions, or without lesions, by reference criteria were included....
Fri Nov 08, 2019 02:00
Abstract Multiparametric MRI (mpMRI) of the prostate has evolved to be an integral component for the diagnosis, risk stratification, staging, and targeting of prostate cancer. However, anatomic and histologic mimics of prostate cancer on mpMRI exist. Anatomic feature that mimic prostate cancer on mpMRI include anterior fibromuscular stroma, normal central zone, periprostatic venous plexus, and thickened surgical capsule (transition zone pseudocapsule). Benign conditions such as...
Fri Nov 08, 2019 02:00
Abstract Purpose To evaluate the diagnostic accuracy of intravoxel incoherent motion (IVIM) model parameters for the diagnosis and staging of liver fibrosis and inflammation in patients with chronic hepatitis B. Methods Fifty-four patients with chronic hepatitis B and 42 healthy volunteers were included in the study. All subjects were examined by 3 T magnetic...
Fri Nov 08, 2019 02:00
Abstract Purpose To assess the diagnostic effectiveness of arterial spin labeling (ASL) MR imaging in differentiating fat-poor AML from clear cell renal cell carcinoma (ccRCC). Methods In this prospective study, 29 ccRCC patients and 9 fat-poor AML patients underwent routine anatomical MRI and ASL at 3T before surgery after signing written informed consent...
Fri Nov 08, 2019 02:00
The Choosing Wisely Canada Campaign aims to raise awareness amongst physicians and patients regarding unnecessary tests and treatment. The otology/neurotology subspecialty group within the Canadian Society of ...
Fri Nov 08, 2019 02:00
Abstract The actinobacterium Streptomyces sp. MC1 has previously shown the capacity to resist and remove Cr(VI) from liquid culture media. The aim of this work is to analyze the differential expression pattern of intracellular proteins when Streptomyces sp. MC1 is exposed to Cr(VI) in order to explain the molecular mechanisms of resistance that this microorganism possesses. For this purpose, 2D-PAGE and shotgun proteomic analyses (2D-nanoUPLC-ESI-MS/MS) were applied. The presence...
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Abstract Lactococcus lactis subsp. lactis KF147 as a non-dairy strain from lactic acid bacteria (LAB) can inhabit plant tissues. It can grow on complex carbohydrates derived from plant cell walls. Its genome size is one of the largest among the sequenced lactococcal strains, possessing many genes that do not have homologues in the published genome sequences of dairy-associated L. lactis strains. In silico analysis has identified a gene cluster encoding a hybrid NRPS-PKS system...
Fri Nov 08, 2019 02:00
Abstract Anaerobic growth defect of pyruvate formate lyase (PFL)-deficient Klebsiella pneumoniae limits its industrial application, and the reason for this growth defect was analyzed in this study. The obtained evidences, combined with normal intracellular redox status and no further inhibition by adhE deletion, strongly suggested that growth defect in PFL-deficient K. pneumoniae was probably caused by lack of carbon flux from pyruvate to acetyl-CoA (AcCoA). Correspondingly, the...
Fri Nov 08, 2019 02:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri Nov 08, 2019 10:00
Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei [Article]
Most mitochondrial mRNAs are transcribed as polycistronic precursors that are cleaved by endonucleases to produce mature mRNA transcripts. However, recent studies have shown that mitochondrial transcripts in the kinetoplastid protozoan, Trypanosoma brucei, are transcribed individually. Also unlike most mitochondrial mRNAs, the 5' end of these transcripts harbor a triphosphate that is hydrolyzed. This modification is carried out by a putative Nudix hydrolase called MERS1. The Nudix motif in MERS1...
Fri Nov 08, 2019 17:00
A considerable proportion of adults with low back pain (LBP) suffer from depressive symptoms or depression. Those with depressive symptoms or depression may be at risk of poorer LBP recovery and require more h...
Fri Nov 08, 2019 02:00
Investing in women’s health is an inevitable investment in our future. We systematically reviewed the available evidence and summarized the weighted prevalence of type 2 diabetes (T2DM) and pre-diabetes mellit...
Fri Nov 08, 2019 02:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Nov 08, 2019 10:00
Phosphoinositides are lipid signaling molecules that regulate several conserved sub-cellular processes in eukaryotes, including cell growth. Phosphoinositides are generated by the enzymatic activity of highly specific lipid kinases and phosphatases. For example, the lipid PIP3, the Class I PI3 kinase that generates it and the phosphatase PTEN that metabolizes it are all established regulators of growth control in metazoans. To identify additional functions for phosphoinositides in growth control,...
Fri Nov 08, 2019 22:31
Abstract Rationale Because chronic cocaine exposure produces profound effects on brain glutamate function, this system has been investigated as a target for novel medications for cocaine use disorder. Studies in animal models have provided encouraging results for drugs that target metabotropic glutamate receptors (mGluR), particularly group II mGluRs which includes mGluR2 and mGluR3 receptors. ...
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Breast cancer is the most prevalent cancer among women worldwide. WZ35, an analog of curcumin, has been demonstrated to remarkably improve the pharmacokinetic profiles in vivo compared with curcumin. WZ35 exhi...
Fri Nov 08, 2019 02:00
The biological behavior of epithelial ovarian cancer (EOC) is unique since EOC cells metastasize early to the peritoneum. Thereby, new anti-target agents designed to block trans-coelomic dissemination of EOC c...
Fri Nov 08, 2019 02:00
Hepatocellular carcinoma (HCC) still remains a dominating medical challenge in early diagnosis and clinical therapy. Centromere protein M (CENPM) has been proved to be over-expressed in HCC tissues, but carcin...
Fri Nov 08, 2019 02:00
MYO1C, an actin-based motor protein, is involved in the late stages of autophagosome maturation and fusion with the lysosome. The molecular mechanism by which MYO1C regulates autophagosome-lysosome fusion rema...
Thu Nov 07, 2019 02:00
Clinically, distant metastasis after primary treatment remains a key problem in nasopharyngeal carcinoma (NPC). Thus, identification of the underlying mechanisms and development of novel therapeutic strategies...
Thu Nov 07, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN02056J, PaperJuntao Cao, Xiao-Long Fu, Fu-Rao Liu, Shu-Wei Ren, Yan-Ming LiuA novel spatial-resolved electrochemiluminescent (ECL) ratiometry for cardiac troponin I (cTnI) analysis was developed using resonance energy transfer (RET) and coreactant consumption strategy for signal amplification. Specifically, the spatial-resolved dual-disk...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01737B, PaperTianyang Zheng, Gerhard Baaken, Jan C. Behrends, Jürgen RüheHigh electrostability and long life-time of planar chip technology are crucial for electrophysiological measurements such as ionic current recording through ion channel proteins embedded in biological cell membrane. In this...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Nov 08, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01764J, PaperJie Zhou, Kai Cheng, Xuan Chen, Rui Yang, Mudan Lu, Lan Ming, Yu Chen, Zhenyu Lin, Daozhen ChenCD44 is a promising biomarker in the diagnosis and prognosis of malignancies. The serum CD44 level is closely related to disease progression and metastasis of the malignancies. It is of...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Nov 08, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01754B, PaperMingyu Ma, Yang Zhou, jinhua li, Zhiqi Ge, Hanping He, Tian Tao, Zhiwei Cai, Xianbao Wang, Gang Chang, Yunbin HeOwing to the high sensitivity, solution-gated graphene transistor has emerged as the cutting edge technology in the area of electrochemical sensing. In this work, composites of gold nanoparticles and reduced...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Nov 08, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01366K, PaperSergii Kravchenko, Boris A SnopokComplex loadings that appear on a surface with flexible spatial organisation can reveal anti-Sauerbrey behaviour due to their variable interfacial architecture even for an ultrathin monomolecular sensitive layer. Presented results...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Nov 08, 2019 02:00
J Neurol Surg BDOI: 10.1055/s-0039-3399519 Objective Pseudo-cerebrospinal fluid (CSF) leaks are a rare cause of unilateral, watery rhinorrhea. We proposed a step-wise approach to evaluate these cases. Design It involves a single-center retrospective cohort study. Setting The setting is that of a tertiary academic medical center. Participants Ten patients with diagnosis of pseudo-CSF leak over a 21-year period were evaluated using our proposed algorithm...
Fri Nov 08, 2019 01:00
Background/Aim: In the present retrospective study, we assessed the molecular profile and clinicopathological correlations of Greek colorectal carcinoma (CRC) patients. Patients and Methods: Data from 157 CRC patients were collected. High Resolution Melting Analysis and Pyrosequencing/Sanger sequencing were applied to identify KRAS, BRAF, NRAS mutations and microsatellite instability (MSI) status. Immunohistochemistry was performed to characterize the associated Mismatch Repair Protein loss. Statistical...
Fri Nov 08, 2019 19:26
Background/Aim: Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a known cancer/testis antigen. Our group has previously shown KK-LC-1 gene expression in gastric cancer. However, could not be detected the KK-LC-1 protein due to the lack of an appropriate antibody. Here, we assessed our original monoclonal antibody (Kmab34B3) and, using it, assessed the expression of KK-LC-1 in gastric cancer. Patients and Methods: We evaluated an original monoclonal antibody against KK-LC-1 (Kmab34B3), and used this...
Fri Nov 08, 2019 19:26
Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and...
Fri Nov 08, 2019 19:26
Background/Aim: Carbohydrate antigen 19-9 (CA19-9) is a tumor marker for pancreatic cancer. Irreversible electroporation (IRE) is an experimental treatment modality for pancreatic cancer. The aim of this study was to evaluate whether percutaneous IRE lowers the CA19-9 level in pancreatic cancer and whether this correlates with improved overall survival. Patients and Methods: Seventy-one patients with locally advanced pancreatic cancer or local recurrence after resection were treated. Patients with...
Fri Nov 08, 2019 19:26
Background/Aim: The aim of this study was to examine clonal heterogeneity, to test the utility of liquid biopsy in monitoring disease progression and to evaluate the usefulness of ex vivo drug screening in a BRAF L597Q-mutated colorectal cancer (CRC) patient developing metastases during adjuvant therapy. Materials and Methods: Next generation sequencing (NGS) and droplet digital PCR (ddPCR) were performed in samples from tumor tissues and liquid biopsies. Live cancer cells from a metastatic lesion...
Fri Nov 08, 2019 19:26
Background/Aim: We aimed to assess surgical outcome and long-term survival after elective hepatic resection for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM) in patients aged 80 years or older. Patients and Methods: This study included 100 patients aged 70 years or older, who underwent hepatic resection for HCC or CRLM between January 2000 and December 2012. Outcomes and clinicopathological data were compared between the elderly (aged 70-79 years; n=84) and extremely elderly...
Fri Nov 08, 2019 19:26
Background/Aim: The aim of the study was to investigate the prognostic role of androgen receptor (AR), mineralocorticoid receptor (MR) and glucocorticoid receptor β (GRβ) expression in HER-2 negative breast cancer patients. Materials and Methods: The study population (n=152) was enriched with triple-negative breast cancers (TNBC) (n=96; 63.2%). The median follow-up time was 100 months. AR, MR and GRβ immunocytochemical staining was compared with that of epithelial-mesenchymal transition (EMT) markers...
Fri Nov 08, 2019 19:26
Background/Aim: The objective of the study was to propose clinical guidelines for the use of minimally invasive surgery (MIS) in pediatric oncology. Patients and Methods: Two groups of experts, including pediatric surgeons and pediatric oncologists were created in order to establish strategies of diagnostic and therapeutic surgical management in pediatric oncology. Results: On the basis of the analysis of the existing literature, we elaborated guidelines that were graded according to the simple practical...
Fri Nov 08, 2019 19:26
Background/Aim: Induction of endoplasmic reticulum (ER) stress is a novel approach to cancer treatment. This study investigated the ability of the clinically feasible combination of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir to induce ER stress killing urological cancer cells. Materials and Methods: Renal cancer cells (769-P, 786-O) and bladder cancer cells (UMUC-3, T-24) were used to investigate the ability of the combination to induce ER stress and its mechanism...
Fri Nov 08, 2019 19:26
Background/Aim: To describe imaging features of head and neck soft-tissue sarcomas. Patients and Methods: Patients with a diagnosis of head and neck sarcoma between 2011 and 2015 were reviewed. Results: There were a total of 62 patients (24 female; median age=60 years). Most common sarcomas were angiosarcoma, undifferentiated pleomorphic sarcoma and sarcoma not otherwise specified. They were most commonly located in cranial and neck superficial soft tissues. Average tumour size at presentation was...
Fri Nov 08, 2019 19:26
Background: Gastric cancer (GC) exhibits heterogeneous clinical and molecular features, requiring the development of new biomarkers to further understand this disease. Our transcriptomic analysis detected overexpression of melanoma-associated antigen A6 (MAGEA6) in metastatic GC, leading us to determine the clinical significance of MAGEA6 in GC. Materials and Methods: Fourteen GC cell lines and 230 pairs of surgically resected gastric tissues were subjected to mRNA expression analysis. Polymerase...
Fri Nov 08, 2019 19:26
Background/Aim: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation. Patients and Methods: A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry. Results:...
Fri Nov 08, 2019 19:26
Background/Aim: Double-negative T (DNT) cells are phenotypically CD3+CD4–CD8–T cells. This study aimed to investigate the anti-cancer activity of DNT cells against pancreatic cancer cells. Materials and Methods: DNT cells were isolated from human peripheral blood. The effect of DNT cells on proliferation and invasion of the human pancreatic cell line Panc-1 was assessed. Expression of Nrf2 and Fas in Panc-1 cells co-cultured with DNT cells was analyzed with RT-PCR. The supernatants of Panc-1 and...
Fri Nov 08, 2019 19:26
Background/Aim: Pneumonitis is a serious complication after radiotherapy of breast cancer. This study aimed to identify its prevalence and potential risk factors. Patients and Methods: A total of 606 patients irradiated following breast-conserving surgery or mastectomy were retrospectively analyzed. In patients developing pneumonitis, radiation and clinical parameters were investigated to identify potential risk factors. Results: Eleven patients (1.8%) developed a pneumonitis grade ≥2. Mean doses...
Fri Nov 08, 2019 19:26
Background/Aim: The aim of the current study was to investigate the synergistic efficacy of Robo1 bichimeric antigen receptor-natural killer cell (BiCAR-NK) immunotherapy and 125I seed brachytherapy in an orthotopic pancreatic cancer mouse model. Materials and Methods: The orthotopic pancreatic tumor model was established with human pancreatic cancer BxPC-3 cells expressing red fluorescent protein. The mice were treated with 125I seed implantation alone or the combination of 125I seeds with Robo1-specific...
Fri Nov 08, 2019 19:26
Background/Aim: The aim of this study was to present the clinical characteristics, natural history and survival outcomes of primary gastrointestinal non-Hodgkin lymphomas (PGINHL) in the pediatric population. Patients and Methods: Surveillance, Epidemiology, and End Results (SEER) database was queried for patients aged 0 to 19 years with PGINHL between 1973 and 2014. Results: A total of 452 cases were identified [mean age 11.0 (±5.1)] years, whites 84.1%, males (76.5%). The majority of tumors were...
Fri Nov 08, 2019 19:26
Background/Aim: Trastuzumab is the only clinically approved targeted therapy for HER2 gene-amplified gastric cancer at present. However, the clinical significance of multi-targeting tyrosine kinase inhibitors (TKIs) in HER2-positive gastric cancer remains unclear. Materials and Methods: We examined the anti-tumor activity of lapatinib and afatinib, that are reversible and irreversible TKIs, in HER2 gene-amplified trastuzumab-sensitive and - resistant gastric cancer cells (GLM-1 and GLM-1HerR2) in...
Fri Nov 08, 2019 19:26
Background/Aim: Acral lentiginous melanoma (ALM) is a rare entity on the foot. This study aimed to reveal its clinical presentations, histopathology and treatment options. Materials and Methods: Seven cases of ALM involving foot were treated in our Institute in a 3-year period. Results: The patients' age ranged from 38 to 84 years, with a mean of 65. The ratios of males to females and white to non-white were 4:3 and 5:2, respectively. Clinically, ALM presented as asymmetric, irregular shaped, black-brown,...
Fri Nov 08, 2019 19:26
Background/Aim: Perineural invasion (PNI) is a significant pathological feature in head and neck cancer. The molecular mechanisms of PNI are poorly understood. Contrary to the previous belief that cancer cells invade nerves, recent studies have shown that Schwann cells (SC) can dedifferentiate, intercalate between cancer cells, and promote cancer dispersion. Communication between cells through brain-derived neurotrophic factor (BDNF) activation of its receptor tropomyosin receptor kinase B (TRKB)...
Fri Nov 08, 2019 19:26
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