Reza Mohebbati, Yasamin Kamkar-Del, Mohammad Naser ShafeiJournal of Reports in Pharmaceutical Sciences 2019 8(2):224-228Introduction: Despite the numerous therapeutic effects of the Ziziphus jujuba (ZJ), its effect on biochemical and hematological parameters are unknown. Therefore, in this study, the effect of ethyl acetate (EA) and aqueous (AQ) fractions of the ZJ fruit extract on biochemical and hematological parameters were explored. Material and Methods: Thirty-six male Wistar rats randomly were...
Wed Oct 30, 2019 00:00
Asmaa I Owis, Nada S Abdelwahab, Adel A Abul-SoadJournal of Reports in Pharmaceutical Sciences 2019 8(2):124-127Background: Calligonum polygonoides L. subsp. Comosum (L’Hér.) Sosk. is an endangered plant species belonging to family Polygonaceae. Although the plant is rich in phytoconstituents and has multipurpose medicinal applications, but in vitro root culture studies and phytochemical investigations of these cultures are rare. Objectives: To establish in vitro root, callus and cell suspension...
Wed Oct 30, 2019 00:00
Sara Ataei, Kaveh Ardalani, Maryam Mehrpooya, Mojdeh MohammadiJournal of Reports in Pharmaceutical Sciences 2019 8(2):284-288Background: Drug-drug interaction (DDI) is a complication that results from the combined use of two or more drugs. DDIs can create problems and increase drug toxicity. In some DDIs, a drug can reduce the effectiveness of other drugs. The treatment regimen of hematologic malignancies includes various medicines. Patients may have another disease and receive other medicines in...
Wed Oct 30, 2019 00:00
Elham Tabatabaie, Kahin Shahanipour, Ali Noori, Parisa S Samani, Mohammad AdibnejadJournal of Reports in Pharmaceutical Sciences 2019 8(2):128-132Introduction: Type 1 diabetes mellitus is believed to be caused by decline of insulin secretion because of destruction of the pancreatic β cell, which is characterized with symptoms such as hyperglycemia, polyuria, polydipsia, weight loss, and other symptoms. Due to the lack of sufficient data about protective effect of L-carnitine, chromium, and vitamin...
Wed Oct 30, 2019 00:00
Yuri I Poltavets, Vasilisa V Zavarzina, Sergey L Kuznetsov, Anna A Krasheninnikova, Danil O Dronov, Nadezhda V Gukasova, Valentina G Shuvatova, Vadim Yu BalabanyanJournal of Reports in Pharmaceutical Sciences 2019 8(2):253-261Background: Poly(lactic-co-glycolic acid) (PLGA) particles with small vector molecules are used for targeted delivery of anticancer agents. To be effective, they must be small, noncytotoxic, sterile, and stable. Aim: The aim of this study was to prepare docetaxel-loaded folate-modified...
Wed Oct 30, 2019 00:00
Azadeh Mesripour, Sepide Sajadian, Valiollah HajhashemiJournal of Reports in Pharmaceutical Sciences 2019 8(2):133-138Background: Vitamin B6 is a cofactor for various enzymes that are involved in neurotransmitter production. It has been shown that vitamin B6 administration reduces immobility time in mice forced swimming test (FST), which suggests potential antidepressant activity in humans. The aim of this study was to observe the possible involvement of the noradrenergic system in the antidepressant...
Wed Oct 30, 2019 00:00
Ashima Nagpal, Monika ChauhanJournal of Reports in Pharmaceutical Sciences 2019 8(2):115-123Background: With an aim to design a validated two-dimensional quantitative structure–activity relationship (2D QSAR) model, a probe was executed on a series of reported c-Jun NH2-terminal kinase-1 (JNK1) inhibitors, exhibiting selectivity toward JNKs (and not other members of MAPK family). Objective: The present work focused on obtaining valuable insights from the structural architecture of the selected compounds...
Wed Oct 30, 2019 00:00
Arockiya Anita Margret, Muppliyan Kalaiyarasan, Arockiya Avila Jerley, Theboral JeevarajJournal of Reports in Pharmaceutical Sciences 2019 8(2):139-148Back ground: Arthrospira platensis encompasses vital nutrients and is commercialized globally. It comprises of imperative resource that has the potential to combat neurological deformities caused due to stress and anxiety. Objective: This work evaluates the neuroprotective effect of spirulina cultivated on nitrogen enriched medium and compares it with...
Wed Oct 30, 2019 00:00
Somayeh Taymouri, Abolfazl Mostafavi, Mohamad JavanmardiJournal of Reports in Pharmaceutical Sciences 2019 8(2):236-244Objective: The objective of this study was to design, evaluate and optimize effervescent tablets containing bismuth sub-citrate with sufficient hardness and friability in treatment of peptic ulcer. Materials and Methods: Effervescent tablets were prepared by direct compression method and were optimized using irregular factorial design. Amount of citric acid, sodium bicarbonate to...
Wed Oct 30, 2019 00:00
Shahram Khademvatan, Alborz Eskandari, Batool Sadeghi Nejad, Shahla NajafiJournal of Reports in Pharmaceutical Sciences 2019 8(2):149-154Background and Objectives: Leishmaniasis is the main health problem and affects millions of people, especially in developing countries. On the other hand, there is no immunoprophylaxis (vaccination) accessible for the treatment of Leishmania infections and commercial drugs are unsatisfactory. Therefore, there is an effort to find alternative herbal remedies. The...
Wed Oct 30, 2019 00:00
Maryam Kouchak, Saeed Rezaee, Nasrin Moshabeh, Somayeh HandaliJournal of Reports in Pharmaceutical Sciences 2019 8(2):270-276Background: Lidocaine and prilocaine are amide-type local anesthetic agents that are expectedly adequate to create a rapid pharmacological effect immediately after using transdermal delivery system. Objective: The aim of this study was to investigate the effect of hydrophilic and hydrophobic materials on drug release from different polymeric films containing lidocaine and prilocaine....
Wed Oct 30, 2019 00:00
Maliheh Abdollahi, Hamid Beyzaei, Seyed Hadi Hashemi, Behzad GhasemiJournal of Reports in Pharmaceutical Sciences 2019 8(2):155-160Background: Vibrio fluvialis is an emerging zoonotic pathogen that its antibiotic-resistant strains are rapidly expanding. Discovering new antibacterial agents is one way to control it.Aims and Objectives: In this research, inhibitory potentials of glycine, magnesium oxide nanoparticles (NPs), and some synthesized thiazole, imidazolidine-2-thione, and tetrahydropyrimidine-2-thione...
Wed Oct 30, 2019 00:00
Volodymyr Mykolayovuch Shvets, Alexei Yuriyevich Voskoboynik, Galina Grigorievna Berest, Sergiy Ivanovych Kovalenko, Maxim Vyacheslavovich Agibailov, Oleg Konstantynovuch Kulchitskiy, Nataliya Olegivna Kulchitska, Vadim Vyacheslavovich DavydovJournal of Reports in Pharmaceutical Sciences 2019 8(2):295-297Background: The organism of an old human as well as an experimental animal has decreased adaptive abilities and increased sensitivity to the effect of adverse environmental factors. We point out...
Wed Oct 30, 2019 00:00
Mohamed G Ibrahim, Fardous F El-Senduny, Magdy M Youssef, Diaaeldin M Elimam, Fatma M Abdel Bar, Farid A BadriaJournal of Reports in Pharmaceutical Sciences 2019 8(2):161-171Background: Breast cancer remains the most potent threat to women’s life worldwide. So far, no ideal drug for treatment of breast cancer, all available drugs exhibit severe side effects, poor therapeutic index, and high cost. Objective: Therefore, this study aimed to investigate the potential use of the natural pentacyclic triterpenoids...
Wed Oct 30, 2019 00:00
Forouzan Khodaei, Hossein Kholghipour, Masood Hosseinzadeh, Marzieh RashediniaJournal of Reports in Pharmaceutical Sciences 2019 8(2):217-223Introduction: Sodium benzoate (SB), as a chemical preservative, is used in many kinds of foodstuff. Some studies reported toxicity effects of SB in food products and suggested to limit its usage. The aim of this study was to evaluate the effects of oral administration of SB on antioxidant enzymes and lipid peroxidation in the liver and kidney of mice. Materials...
Wed Oct 30, 2019 00:00
Chukwuemeka Paul Azubuike, Uloma Ubani-Ukoma, Shadrack Joel Madu, Oluwateniola Yomi-Faseun, Suliat YusufJournal of Reports in Pharmaceutical Sciences 2019 8(2):172-180Aims: The study sought to characterize the physicochemical properties and assess the binding properties of pregelatinized starch (PGSb) derived from Borassus aethiopum shoot at various concentrations in paracetamol (PCM) tablet formulation. Methods and Materials: PGSb was obtained by suspending 100g of the native starch (NS) in 100ml...
Wed Oct 30, 2019 00:00
Sijani Prahastuti, Meilinah Hidayat, Stella Tinia Hasiana, Wahyu Widowati, Annisa Amalia, Rismawati Laila Qodariah, Rizal Rizal, Hanna Sari W Kusuma, Zakiyatul KhoiriyahJournal of Reports in Pharmaceutical Sciences 2019 8(2):229-235Background: People with diabetes mellitus in Indonesia are predicted to increase until 2035. High glucose in body (hyperglycemia) leads to increased fibronectin synthesis. Fibronectin that gets accumulated in glomerulus (mesangial cells), at the end, will lead to diabetic...
Wed Oct 30, 2019 00:00
Cyrus Jalili, Shiva Roshankhah, Amir Jalali, Mohammad Reza SalahshoorJournal of Reports in Pharmaceutical Sciences 2019 8(2):181-187Background: Mercuric chloride (MC) is the chemical composition of mercury and chlorine with many side effects such as oxidative stress referring to mercury toxicity. Royal jelly (RJ) as a honey bee secretion has antioxidant activities. This study was designed to evaluate the effects of RJ against the parameters of hepatic damage in male rats induced by MC toxicity. Materials...
Wed Oct 30, 2019 00:00
Olusola I Aremu, Kokonne E Ekere, Yetunde C Isimi, Victoria C Nwaogu, Olawale G Agbaje, Olubunmi J Olayemi, Musiliu O Adedokun, Martins O EmejeJournal of Reports in Pharmaceutical Sciences 2019 8(2):245-252Background: Neem seed is very vital because of its rich lipid content and bitter constituents. Aims: This study was designed to provide a scientific rationale for the preparation and use of Neem seed oil as suppositories using dika fat (DF), and macrogol (MG), as bases. Materials and Methods: The...
Wed Oct 30, 2019 00:00
Israel O Okoro, Helen E Kadiri, Eferhire AganbiJournal of Reports in Pharmaceutical Sciences 2019 8(2):188-194The phytochemical screening, antioxidant, and nephroprotective effects of methanol and acetone extracts of cassava (Manihot esculenta Crantz) leaves were comparatively investigated using standard procedures. Fifty-four male Wistar rats (albino) were divided into nine groups of six rats each. Group 1 = negative control (normal untreated rats + normal saline); group 2 = positive control (rats...
Wed Oct 30, 2019 00:00
Leila Hosseinzadeh, Navid Mahmoudian, Farahnaz Ahmadi, Hadi AdibiJournal of Reports in Pharmaceutical Sciences 2019 8(2):262-269A green and efficient one-pot, four-component synthesis of 4-phenyl-4,5-dihydropyranopyrazolone derivatives 5a–5l is described in ethanol-water with activated potassium carbonate and evaluation of anticancer activity on cancer cell lines and apoptosis mechanism is also investigated. This method provides several advantages such as environmental friendliness, shorter reaction...
Wed Oct 30, 2019 00:00
Rafik Bensegueni, Mounia Guergouri, Chawki Bensouici, Mustapha BencharifJournal of Reports in Pharmaceutical Sciences 2019 8(2):195-203In this study, five oximes were synthesized, characterized, and their antioxidant activity investigated experimentally and theoretically. Labeled OX1–OX5, our oximes were subjected to three antioxidant activity assays (1,1-diphenyl-2-picrylhydrazyl, cupric reducing antioxidant capacity test [CUPRAC], and ferric reducing antioxidant power test). The related results...
Wed Oct 30, 2019 00:00
HN Shivakumar, Ruchira S KotianJournal of Reports in Pharmaceutical Sciences 2019 8(2):277-283Background: Conventional route, the most common route of administration, has drawbacks such as hepatic first-pass metabolism, poor bioavailability, and ability to alter drug concentrations in the blood. These problems can be overcome by a controlled-release drug delivery system, which can be accomplished with the development of transdermal drug delivery system. Objective: The objective of this study was...
Wed Oct 30, 2019 00:00
Parnian Khosropour, Sayed-Ebrahim Sajjadi, Ardeshir Talebi, Mohsen MinaiyanJournal of Reports in Pharmaceutical Sciences 2019 8(2):204-210Background: Colitis is an inflammatory bowel disease, many causes are involved in its pathogenesis and development. Myrtus communis (M. communis) contains anti-inflammatory and antioxidant ingredients that are useful for the treatment of inflammatory disease. Objectives: The purpose of this study was to investigate the effect of M. communis hydroalcoholic extract...
Wed Oct 30, 2019 00:00
Mayur Ashok Chordiya, Hemant Hiraman Gangurde, Vikram Nirmal SanchetiJournal of Reports in Pharmaceutical Sciences 2019 8(2):289-294Quality by design (QbD) refers to a new approach to product development that could increase efficiencies, provide regulatory relief and flexibility, and offer important business benefits throughout the product life cycle. QbD is increasingly becoming an important and widely used technique in the pharmaceutical industry. QbD can be considered to be system-based approach...
Wed Oct 30, 2019 00:00
Sina Andalib, Mojtaba Ziaee, Faezeh Mozafari, Reza Hosseini, Mahdieh AnoushJournal of Reports in Pharmaceutical Sciences 2019 8(2):211-216Purpose: Alzheimer’s disease (AD) is a degenerative brain disorder and the major cause of dementia and cognitive deficits in the elderly. Riluzole modulates glutamate concentration and improves memory performance in aged rats and may be of benefit in AD. Donepezil is a cholinesterase inhibitor that is used for the treatment of mild-to-moderate AD. In this study,...
Wed Oct 30, 2019 00:00
Azam Moslehi, Tahereh Komeili-movahed, Mohammad MoslehiJournal of Reports in Pharmaceutical Sciences 2019 8(2):298-302Context: Both endoplasmic reticulum (ER) stress and oxidative stress are involved in pathophysiology of many diseases. Recently, a cross talk between ER stress and oxidative stress has been identified. Amygdalin is an active ingredient in the seeds of apricots, bitter almonds, peaches, and other rosaceous plants. Aim: This study was designed to evaluate the antioxidant effects of...
Wed Oct 30, 2019 00:00
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