Structural connectivity alterations in chronic and episodic migraine: A diffusion magnetic resonance imaging connectomics study. Cephalalgia. 2019 Nov 01;:333102419885392 Authors: Planchuelo-Gómez Á, García-Azorín D, Guerrero ÁL, Aja-Fernández S, Rodríguez M, de Luis-García R Abstract OBJECTIVE: To identify possible structural connectivity alterations in patients with episodic and chronic migraine using magnetic resonance imaging data. METHODS:...
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Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries. Cephalalgia. 2019 Nov 01;:333102419884943 Authors: Rubio-Beltran E, Chan KY, Danser AJ, MaassenVanDenBrink A, Edvinsson L Abstract BACKGROUND: Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, a neuropeptide...
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Validation of a 3d CBCT-based protocol for the follow-up of mandibular condyle remodeling. Dentomaxillofac Radiol. 2019 Nov 01;:20190364 Authors: Verhelst PJ, Shaheen E, de Faria Vasconcelos K, Van der Cruyssen F, Shujaat S, Coudyzer W, Salmon B, Swennen G, Politis C, Jacobs R Abstract OBJECTIVES: Three-dimensional models of mandibular condyles provide a way for condylar remodeling follow-up. The overall aim was to develop and validate a user-friendly...
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Related Articles[Mobile seizure monitoring in epilepsy patients]. Nervenarzt. 2019 Oct 31;: Authors: Schulze-Bonhage A, Böttcher S, Glasstetter M, Epitashvili N, Bruno E, Richardson M, V Laerhoven K, Dümpelmann M Abstract Wearables are receiving much attention from both epilepsy patients and treating physicians, for monitoring of seizure frequency and warning of seizures. They are also of interest for the detection of seizure-associated risks of patients,...
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Results of a multinational survey of diagnostic and management practices of thromboembolic pulmonary embolism in children. Thromb Res. 2019 Aug 14;183:98-105 Authors: Rajpurkar M, Williams S, Goldenberg NA, Van Ommen CH, Chan AKC, Thomas R, Biss T Abstract INTRODUCTION: The incidence of thromboembolic (TE)-pediatric pulmonary embolism (PPE) is increasing. We sought to evaluate current practice patterns and gaps in the management of TE-PPE. MATERIALS...
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Related ArticlesPopulation pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2019 Oct 30;: Authors: Jung SY, Yug JS, Clarke JM, Bauer TM, Keedy VL, Hwang S, Kim SJ, Chung EK, Lee JI Abstract PURPOSE: Vactosertib, a novel inhibitor of transforming growth factor-β type Ι receptor, is under development for the treatment of various cancers. The objective of this study...
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Related ArticlesA Phase II Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases: Clinical Trial Protocol. Neurosurgery. 2019 Nov 01;: Authors: Takami H, Nassiri F, Moraes FY, Zadeh G, Bernstein M, Conrad T, Berlin A, Laperriere N, Millar BA, Shultz DB, Kongkham P Abstract BACKGROUND: Brain metastases which require resection are treated with surgery followed by whole brain radiation therapy or postoperative cavity boost stereotactic...
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Related ArticlesDoes the Incidence of Treatment-Related Toxicity Plateau After Radiation Therapy: The Long-Term Impact of Integral Dose in Hodgkin's Lymphoma Survivors. Adv Radiat Oncol. 2019 Oct-Dec;4(4):699-705 Authors: Holtzman AL, Stahl JM, Zhu S, Morris CG, Hoppe BS, Kirwan JE, Mendenhall NP Abstract Background: Conventional radiation therapy (RT) has produced unprecedented cure rates in patients with Hodgkin's lymphoma (HL) but exposed large volumes...
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Related ArticlesProton therapy for non-small cell lung cancer: the road ahead. Transl Lung Cancer Res. 2019 Sep;8(Suppl 2):S202-S212 Authors: Brooks ED, Ning MS, Verma V, Zhu XR, Chang JY Abstract Proton therapy is an evolving radiotherapy modality with indication for numerous cancer types. With the benefits of reducing dose and sparing normal tissue, protons offer a clear physical and dosimetric advantage over photon radiotherapy for many patients....
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Related ArticlesPACIFIC: shifting tides in the treatment of locally advanced non-small cell lung cancer. Transl Lung Cancer Res. 2019 Sep;8(Suppl 2):S139-S146 Authors: Bang A, Schoenfeld JD, Sun AY Abstract The treatment paradigm of stage III, unresectable non-small cell lung cancer (NSCLC) has had few advancement since concurrent chemoradiotherapy was established as standard of care treatment. Despite modifications to radiotherapy, chemotherapy and...
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Related ArticlesThe current and future landscape of radiotherapy for lung cancer. Transl Lung Cancer Res. 2019 Sep;8(Suppl 2):S122-S123 Authors: Louie AV, Bahig H, Moghanaki D PMID: 31673515 [PubMed]
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Related ArticlesMajor problems, current characteristics and future career plans of obstetrics and gynecology residents in Turkey. Turk J Obstet Gynecol. 2019 Sep;16(3):187-192 Authors: Erkılınç S, Yassa M, Coşkun B, İnce O, Karateke A Abstract Objective: To evaluate the current problems and future career plans of obstetrics and gynecology residents in Turkey. Materials and Methods: In this cross-sectional study, a survey was conducted with 143...
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Related ArticlesPIK3CA-CDKN2A clonal evolution in metastatic breast cancer and multiple points cell-free DNA analysis. Cancer Cell Int. 2019;19:274 Authors: Palmieri M, Baldassarri M, Fava F, Fabbiani A, Campennì GM, Mencarelli MA, Tita R, Marsili S, Renieri A, Frullanti E Abstract Background: Daily experience tells us that breast cancer can be controlled using standard protocols up to the advent of a relapse. Now new frontiers in precision medicine...
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Related ArticlesSiRNA-Mediated RRM2 Gene Silencing Combined with Cisplatin in the Treatment of Epithelial Ovarian Cancer In Vivo: An Experimental Study of Nude Mice. Int J Med Sci. 2019;16(11):1510-1516 Authors: Xue T, Wang L, Li Y, Song H, Chu H, Yang H, Guo A, Jiao J Abstract Introduction: We aimed to explore small interfering (si)RNA silencing of ribonucleotide reductase M2 (RRM2) gene combined with cisplatin for the treatment of human ovarian cancer...
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Related ArticlesA multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Sci Data. 2019 Oct 31;6(1):253 Authors: Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF Abstract Patient-derived xenografts (PDXs) are an essential pre-clinical resource for investigating tumor biology. However, cellular heterogeneity within and across PDX tumors can strongly impact the interpretation...
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Related ArticlesEpigenetic EGFR gene repression confers sensitivity to therapeutic BRAFV600E blockade in colon neuroendocrine carcinomas. Clin Cancer Res. 2019 Oct 31;: Authors: Capdevila J, Arqués O, Hernandez Mora JR, Matito J, Caratu G, Mancuso FM, Landolfi S, Barriuso J, Jimenez-Fonseca P, Lopez Lopez C, Garcia-Carbonero R, Hernando J, Matos I, Paolo N, Hernández-Losa J, Esteller M, Martínez-Cardús A, Tabernero J, Vivancos A, Palmer HG Abstract PURPOSE:...
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Related ArticlesPan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade. Clin Cancer Res. 2019 Oct 31;: Authors: Stein JE, Lipson EJ, Cottrell TR, Forde PM, Anders RA, Cimino-Mathews A, Thompson ED, Allaf ME, Yarchoan M, Feliciano J, Wang H, Jaffee EM, Pardoll DM, Topalian SL, Taube JM Abstract PURPOSE: Pathologic response assessment of tumor specimens from patients receiving systemic treatment provide an early indication of therapeutic efficacy...
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Related ArticlesAggressive B-cell lymphoma: chasing the target. J Investig Med. 2019 Oct 30;: Authors: Walewski J Abstract One of the first achievements of molecular biology in lymphoma science was a discovery of cell of origin (COO) classification around 20 years ago with defining activated B-cell like (ABC) and germinal center B-cell like subtypes of diffuse large B-cell lymphoma (DLBCL) with the use of gene expression profiling. These categories were...
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Related Articles[Interventional radiology of liver tumors]. Presse Med. 2019 Oct 28;: Authors: Piron L, Cassinotto C, Guiu B Abstract Interventional radiology (IR) has considerably grown since the 90s and has currently a central position in the management of patients suffering from cancer. The aim of this paper is to describe the principle, indications, technique and results of three common hepatic oncologic IR procedures: preoperative portal vein embolization,...
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Related ArticlesNivolumab in chemotherapy-resistant cervical cancer: report of a vulvitis as a novel immune-related adverse event and molecular analysis of a persistent complete response. J Immunother Cancer. 2019 Oct 31;7(1):281 Authors: Baettig F, Vlajnic T, Vetter M, Glatz K, Hench J, Frank S, Bihl M, Lopez R, Dobbie M, Heinzelmann-Schwarz V, Montavon C Abstract BACKGROUND: Treatment options for advanced cervical cancer are limited and patients experiencing...
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Related ArticlesImmunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2019 Oct 30;20(21): Authors: Cristina V, Herrera-Gómez RG, Szturz P, Espeli V, Siano M Abstract Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage and has a dismal prognosis. Nearly 10 years after the approval of cetuximab, anti-PD1/PD-L1 checkpoint inhibitors are the first drugs that have shown...
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Abstract Raynaud’s phenomenon (RP) is a clinical disorder characterized by recurrent, reversible episodes of digital vasospasm. RP can be classified as primary (pRP) or secondary, depending on whether it occurs as a benign condition (not disease-associated) or is associated with other diseases, mainly of the connective tissues. In both cases, it can be triggered by environmental factors, as indicated by the increased incidence of pRP episodes following exposure to cold,...
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Vaccines, Vol. 7, Pages 172: Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits Vaccines doi: 10.3390/vaccines7040172 Authors: Li Wang Tian Xia Tiantian Guo Yi Ru Yanping Jiang Wen Cui Han Zhou Xinyuan Qiao Lijie Tang Yigang Xu Yijing Li Rabbit hemorrhagic disease virus (RHDV) is the causative agent of rabbit hemorrhagic disease (RHD). RHD, characterized by hemorrhaging,...
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Vaccines, Vol. 7, Pages 173: Significant Interference with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strain Replication in Small-Intestine Epithelial Cells Using an shRNA Expression Vector Vaccines doi: 10.3390/vaccines7040173 Authors: Da Shi Xiaobo Wang Hongyan Shi Jiyu Zhang Yuru Han Jianfei Chen Xin Zhang Jianbo Liu Jialin Zhang Zhaoyang Ji Zhaoyang Jing Li Feng Porcine epidemic diarrhea (PED) re-emerged in China in 2010 and is now widespread....
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Vaccines, Vol. 7, Pages 167: Succinate Coenzyme A Ligase Beta-Like Protein from Trichinella spiralis Suppresses the Immune Functions of Rat PBMCs in Vitro and Inhibits the Secretions of Interleukin-17 in Vivo Vaccines doi: 10.3390/vaccines7040167 Authors: Sun Li Naqvi Naqvi Chu Xu Song Li Yan : Succinate Coenzyme A ligase beta-like protein (SUCLA-β) is a subunit of Succinyl-coenzyme A synthetase, which is involved in substrate synergism, unusual...
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Vaccines, Vol. 7, Pages 174: Success and Limitation of Equine Influenza Vaccination: The First Incursion in a Decade of a Florida Clade 1 Equine Influenza Virus that Shakes Protection Despite High Vaccine Coverage Vaccines doi: 10.3390/vaccines7040174 Authors: Fougerolle Fortier Legrand Jourdan Marcillaud-Pitel Pronost Paillot Every year, several epizooties of equine influenza (EI) are reported worldwide. However, no EI case has been identified in France between...
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Viruses, Vol. 11, Pages 1019: Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors Viruses doi: 10.3390/v11111019 Authors: Gao Tai Wang Li Jiang Debnath Du Chen Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans;...
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Abstract Sym004 is an equimolar mixture of two monoclonal antibodies, futuximab and modotuximab, which non-competitively block the epidermal growth factor receptor (EGFR). Sym004 has been clinically tested for treatment of solid tumors. The present work characterizes the non-linear pharmacokinetics (PK) of Sym004 and its constituent antibodies and investigates two types of covariate models for interpreting the interindividual variability of Sym004 exposure. Sym004 serum concentration...
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Το τελευταίο «αντίο» στον Γιάννη Σπανό, ο οποίος άφησε την τελευταία του πνοή σε ηλικία 85 ετών την Πέμπτη (31/10), σκορπώντας την θλίψη.
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Τίποτα δεν μπορεί να συγκριθεί με μια νόστιμη μακαρονάδα.
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submitted by /u/GeneralReposti_Bot [link] [comments]
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Δικαιούχοι του επιδόματος μακροχρονίως ανέργων είναι Έλληνες υπήκοοι και οι υπήκοοι κρατών μελών της Ευρωπαϊκής Ένωσης που είναι ασφαλισμένοι κατά της ανεργίας - Το ύψος…
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H εγκυμοσύνη είναι πολύ ιδιαίτερη περίοδος για κάθε γυναίκα.
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Related ArticlesExpression of the checkpoint receptors LAG-3, TIM-3 and VISTA in peripheral T cell lymphomas. J Clin Pathol. 2019 Oct 31;: Authors: Murga-Zamalloa CA, Brown NA, Wilcox RA Abstract AIMS: Peripheral T cell lymphomas represent approximately 10%-15% of non-Hodgkin lymphomas and are characterised by an aggressive clinical courses and poor outcomes. Ligands provided by constituents of the tumour microenvironment engage receptors expressed by...
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Pathogens, Vol. 8, Pages 214: Rapid Discrimination of Methicillin-Resistant Staphylococcus aureus…Pathogens, Vol. 8, Pages 214: Rapid Discrimination of Methicillin-Resistant Staphylococcus aureus by MALDI-TOF MSPathogens, Vol. 8, Pages 214: Rapid Discrimination of Methicillin-Resistant Staphylococcus aureus by MALDI-TOF MS Pathogens doi: 10.3390/pathogens8040214 Authors: Kim Kim Chung Chung Han Kim Methicillin-resistant Staphylococcus aureus (MRSA) is a serious pathogen in clinical settings and early...
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Implantierbare Hörsysteme. HNO. 2019 Nov;67(11):816-817 Authors: Stöver T PMID: 31673745 [PubMed - in process]
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Related ArticlesOptic Nerve Crush Modulates Refractive Development of the C57BL/6 Mouse by Changing Multiple Ocular Dimensions. Brain Res. 2019 Oct 28;:146537 Authors: Gong X, Wu XH, Liu AL, Qian KW, Li YY, Ma YY, Huang F, Wang Q, Wu H, Zhou X, Qu J, Yuan F, Zhong YM, Yang XL, Weng SJ Abstract Higher visual centers could modulate visually-guided ocular growth, in addition to local mechanisms intrinsic to the eye. There is evidence that such central modulations...
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Related ArticlesFrom Knowing to Remembering: The Semantic-Episodic Distinction. Trends Cogn Sci. 2019 Oct 28;: Authors: Renoult L, Irish M, Moscovitch M, Rugg MD Abstract The distinction between episodic and semantic memory was first proposed in 1972 by Endel Tulving and is still of central importance in cognitive neuroscience. However, data obtained over the past 30 years or so support the idea that the frontiers between perception and knowledge and...
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Related ArticlesDo Not Forget to Pull the Graft! Eur J Vasc Endovasc Surg. 2019 Oct 28;: Authors: Schwein A, Georg Y PMID: 31672478 [PubMed - as supplied by publisher]
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