This study demonstrated that sleep deficiency can increase esophageal acid exposure not only in GERD patients but also in healthy controls. Moreover, healthy controls may develop abnormal esophageal acid exposure after sleep deficiency. Thus, sleep deficiency appears to be an important underlying mechanism for abnormal esophageal acid exposure and as a result should be addressed in GERD patients. Abstract Background Studies have demonstrated a bi‐directional relationship between sleep deficiency...
Thu Nov 07, 2019 19:02
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01992H, PaperZiyu Wang, Ningning Wang, Hang Gao, Yiwu Quan, Huangxian Ju, Yixiang ChengThree-component conjugated polymers with strong donor-acceptor (D-A) type could be synthesized by Pd-catalyzed Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)-1,2-diphenylethene (M-1) with 9-octyl-3,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole (M-2) and 4,6-bis((E)-4-bromostyryl)-2,2-difluoro-5-phenyl-2H-1l3,3,2l4-dioxaborinine...
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01954E, PaperWen Liu, Liuqin Huang, Rachel Komorek, Pubudupinipa Handakumbura, Yadong Zhou, Dehong Hu, Mark H Engelhard, Hongchen Jiang, Xiao-Ying Yu, Christer Jansson, Zihua ZhuThe rhizosphere is arguably the most complex microbial habitat on earth, comprising an integrated network of plant roots, soil and a highly diverse microbial community (the rhizosphere microbiome)1. Understanding, predicting...The content of this RSS Feed (c) The Royal Society...
Thu Nov 07, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01473J, MinireviewSteven Wilson, Christine Olsen, Elsa LundanesNano liquid chromatography (nanoLC), with columns having an inner diameter (ID) of ≤ 100 µm, can provide enhanced sensitivity and enable analysis of limited samples. NanoLC has become an established...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Nov 07, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01539F, PaperCairui Huang, Congcong Shen, Ling Jin, Deyu Qu, Xiaosong Hu, Yawei Lin, Hongwei CaiA new quantitative analysis method is proposed, aiming at the difficulty in accurately determining the trace content of free acid in lithium-ion battery electrolytes in the past 30 years. The...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Nov 07, 2019 02:00
Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN90105A, Retraction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tarun Mistri, Rabiul Alam, Rahul Bhowmick, Sushil Kumar Mandal, Malay Dolai, Anisur Rahman Khuda-Bukhsh, Mahammad AliTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Nov 07, 2019 02:00
Abstract As the key organism for enhanced biological phosphorus removal, Accumulibacter has shown high intragenus diversity based on the phylogeny of polyphosphate kinase1 gene (ppk1) and many clade-specific features related to performance of wastewater treatment. However, the widely used molecular approaches are deficient or cost-inefficient in providing a comprehensive and quantitative population-level profile for Accumulibacter in complex community. In this study, we introduced...
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Abstract The successful production of recombinant enzymes by tobacco transplastomic plants must maintain compatibility of the heterologous enzyme with chloroplast metabolism and its long-time enzyme stability. Based on previous reports, it has been taken for granted that following biolistic-transformation, homoplasticity could be obtained from the initially heteroplastic state following successive rounds of selection in the presence of the selection agent. However, several studies...
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Abstract Discovering sugar metabolism genes is of great interest for lignocellulosic biorefinery. Xylose isomerases (XIs) were commonly screened from metagenomes derived from bovine rumen, soil, and other sources. However, so far, XIs and other sugar-utilizing enzymes have not been discovered from fecal metagenomes. In this study, environmental DNA from the fecal samples collected from yellow cattle (Bos taurus) was sequenced and analyzed. In the whole 14.26 Gbp clean data, 92...
Thu Nov 07, 2019 02:00
Abstract Current advances on gut microbiota have broadened our view on host-microbiota interactions. As a microbiota-targeted approach, the use of antibiotics has been widely adopted to explore the role of gut microbiota in vivo. Antibiotics can change the microbial composition, resulting in varied effects, depending on the antibiotic class, dosage, and duration. Antibiotic intervention in early life leads to life-long phenotype alterations, including obesity. Antibiotic-induced...
Thu Nov 07, 2019 02:00
Abstract Imatinib resistance remains the biggest hurdle for the treatment of chronic myeloid leukemia (CML), with the underlying mechanisms not fully understood. In this study, we found that miR328 significantly and strikingly decreased among other miRNA candidates during the induction of imatinib resistance. Overexpression of miR328 sensitized resistant cells to imatinib via post-transcriptionally decreasing ABCG2 expression, while miR328 knockdown conferred imatinib resistance...
Thu Nov 07, 2019 02:00
Abstract Purpose Intrahepatic cholangiocarcinoma (ICC) is associated with a poor prognosis with surgical resection offering the best chance for long-term survival and potential cure. However, in up to 36% of patients who undergo surgery, more extensive disease is found at time of operation requiring cancellation of surgery. PET/MR is a novel hybrid technology that might improve local and whole-body staging in ICC patients, potentially...
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Abstract Purpose Subthalamotomy using magnetic resonance–guided focused ultrasound (MRgFUS) has become a potential treatment option for the cardinal features of Parkinson’s disease (PD). The purpose of this study was to evaluate the effects of MRgFUS-subthalamotomy on brain metabolism using different scale levels. Methods We studied resting-state glucose...
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Abstract Objectives To evaluate the impact of morphological information derived from contrast-enhanced CT in the characterization of incidental focal colonic uptake in 18F-FDG PET/CT examinations. Methods A total of 125 patients (female: n = 53, male: n = 72) that underwent colonoscopy secondary to contrast-enhanced, full-dose PET/CT without special bowel...
Thu Nov 07, 2019 02:00
Abstract Purpose Evidence to date has failed to reveal unique female determinants of cardiovascular disease. However, a strong association was recently observed between increased metabolic activity in the amygdala, a neural centre involved in the processing of emotions, and impaired myocardial function in women, but not in men. Given the stronger immune responses in females, we sought to retrospectively investigate the interaction between...
Thu Nov 07, 2019 02:00
Periodontitis and peri‐implantitis are multifactorial diseases characterized by alveolar bone destruction mediated by the host response to a microbial challenge. Alveolar bone resorption mediated by epigenetics could be one of the mechanisms responsible for this destruction of alveolar bone. The relationship between epigenetic modifications and bone metabolism has been thoroughly investigated in bone remodeling, cancer, and rheumatoid arthritis, but evidence is low regarding the relationship between...
Thu Nov 07, 2019 19:39
Abstract Ischemia-reperfusion injury is an organ failure caused by hypoxia and reperfusion, which is closely associated with oxidative stress and inflammation. In this study, we investigated whether nobiletin had protective effects on inflammatory parameters, oxidative damage, iNOS-eNOS expressions, and histopathological structure of renal tissue in rats with renal ischemia-reperfusion injury. For this purpose, 24 rats were divided into...
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Abstract Many studies have demonstrated an association between cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). Moreover, CMV infection is more common in patients with severe or steroid-refractory IBD. However, it is not clarified whether CMV worsens IBD or if it is merely a surrogate marker for IBD. Here, we used the dextran sodium sulfate (DSS)-induced colitis model to investigate if CMV infection exacerbates colitis. The mice were injected intraperitoneally...
Thu Nov 07, 2019 02:00
Abstract Salidroside, an active component of Rhodiola rosea, reduces inflammation and neuronal damage after middle cerebral artery occlusion (MCAO) with reperfusion, partly by inhibiting cerebral complement C3 activation. However, the mechanisms of this inhibition are not fully understood. In this study, we investigated which cerebral cells might contribute to the inhibition of complement by salidroside and the consequences of this inhibition....
Thu Nov 07, 2019 02:00
Abstract Rationale The neuropeptide galanin has been implicated in a wide range of pathological conditions in which frontal and temporal structures are compromised. It works through three subtypes of G-protein-coupled receptors. One of these, the galanin receptor 1 (Gal-R1) subtype, is densely expressed in the ventral hippocampus (vHC) and ventral prefrontal cortex (vPFC); two brain structures that have similar actions on behavioral control....
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Abstract Rationale Women with cocaine use disorder have worse treatment outcomes compared with men. Sex differences in cocaine addiction may be driven by differences in neurobiology or stress reactivity. Oxytocin is a potential therapeutic for stress reduction in substance use disorders, but no studies have examined the effect of oxytocin on neural response to drug cues in individuals with cocaine use disorders or potential sex differences...
Thu Nov 07, 2019 02:00
Abstract Background We aimed to explore insomnia symptoms among 2299 children and adolescents after an earthquake and their bidirectional relationship to somatic complaints and posttraumatic stress disorder (PTSD). Methods The Patient Health Questionnaire-15 scale, the Children’s Revised Impact of Event Scale, and three questions evaluating insomnia symptoms...
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Abstract Upper tract urothelial carcinoma (UTUC) is a common and lethal malignancy. Patients diagnosed with this illness often face invasive workups, morbid therapies, and prolonged post-operative surveillance. UTUC represents approximately 5–10% of urothelial malignancies in the United States and affect 4600–7800 new patients annually. Various environmental exposures as well as smoking have been implicated in the development of UTUC. The diagnosis and workup of UTUC relies on...
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Abstract Background Gadoxetate disodium (Eovist®, Bayer Healthcare, Wayne, NJ) is the preferred MR contrast agent for pediatric hepatobiliary imaging. A known limitation of this contrast agent is transient severe respiratory artifacts during arterial phase imaging, and some adult studies have raised caution against its use for evaluation of arterial enhancing lesions. The reported rate of transient severe breathing motion is 5–22% in adult...
Thu Nov 07, 2019 02:00
Abstract This article reviews the anatomy and magnetic resonance imaging (MRI) appearance of the penis. The recommended technique for MRI of the penis is outlined, with discussion of the benefits and drawbacks to imaging the penis after artificial erection. Common penile pathologies are reviewed, with a summary of their clinical features, MRI appearance, and treatment. The ability to demonstrate the erectile bodies and vasculature helps to evaluate vascular pathologies such as...
Thu Nov 07, 2019 02:00
Abstract Postmenopausal endometriosis is an important clinical entity which is likely under-recognized and in which the Radiologist can play a valuable role. In this review, we describe the clinical presentation and management of postmenopausal endometriosis, appraising the literature and providing case examples. Persons with postmenopausal endometriosis may present with symptoms including pelvic pain or dyschezia, but endometriosis may also be an asymptomatic, incidental finding....
Thu Nov 07, 2019 02:00
Abstract Multiparametric magnetic resonance (MR) imaging of the prostate is an excellent tool to detect clinically significant prostate cancer, and it has widely been incorporated into clinical practice due to its excellent tissue contrast and image resolution. The aims of this article are to describe the prostate MR imaging technique for detection of clinically significant prostate cancer according to PI-RADS v2.1, as well as alternative sequences and basic aspects of patient...
Thu Nov 07, 2019 02:00
Thu Nov 07, 2019 02:00
Cholesteatoma is a destructive, erosive growth of keratinizing squamous epithelium in the middle ear cleft. Following treatment with a canal wall-up (CWU) tympanomastoidectomy, surveillance of residual and rec...
Thu Nov 07, 2019 02:00
There is evidence to suggest that rates of hearing loss are increasing more rapidly than the capacity of traditional audiometry resources for screening. A novel innovation in tablet, self-administered portable...
Thu Nov 07, 2019 02:00
Surgical Infections, Ahead of Print.
Thu Nov 07, 2019 10:00
Surgical Infections, Ahead of Print.
Thu Nov 07, 2019 10:00
Soft Robotics, Ahead of Print.
Thu Nov 07, 2019 10:00
The relation between socioeconomic position (SEP) and obesity measured by body mass index (BMI) has been extensively reviewed, but there is less research on the association between SEP and body composition. Fa...
Thu Nov 07, 2019 02:00
While Internet- and mobile-based interventions (IMIs) might possess the potential to increase access to evidence-based therapies for post-traumatic stress disorder (PTSD), comprehensive knowledge on active int...
Thu Nov 07, 2019 02:00
Experimental designs for evaluating knowledge translation (KT) interventions can provide strong estimates of effectiveness but offer limited insight into how the intervention worked. Consequently, process evaluat...
Thu Nov 07, 2019 02:00
While identifying and cataloging unpublished studies from conference proceedings is generally recognized as a good practice during systematic reviews, controversy remains whether to include study results that ...
Thu Nov 07, 2019 02:00
Paediatric cancers account for a minor fraction of deaths and hence receive little attention from policymakers. In low-income countries, the absence of comprehensive national paediatric strategies results in a...
Thu Nov 07, 2019 02:00
Cancer Biotherapy and Radiopharmaceuticals, Volume 34, Issue 9, Page 581-588, November 2019.
Thu Nov 07, 2019 10:00
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