While identifying and cataloging unpublished studies from conference proceedings is generally recognized as a good practice during systematic reviews, controversy remains whether to include study results that ...
Thu Nov 07, 2019 02:00
Paediatric cancers account for a minor fraction of deaths and hence receive little attention from policymakers. In low-income countries, the absence of comprehensive national paediatric strategies results in a...
Thu Nov 07, 2019 02:00
Abstract Purpose The Spanish Society of Medical Oncology (SEOM, for its Spanish acronym) would like to attest to the relevance of training in Oncology as part of the undergraduate education in Medicine program and issue recommendations to improve said training, with the aim of responding better to the challenges that cancer poses to our society. Materials and methods ...
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With up to millions of nearly neutral polymorphisms now being routinely sampled in population-genomic surveys, it is possible to estimate the site-frequency spectrum of such sites with high precision. Each frequency class reflects a mixture of potentially unique demographic histories, which can be revealed using theory for the probability distributions of the starting and ending points of branch segments over all possible coalescence trees. Such distributions are completely independent of past population...
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Thu Nov 07, 2019 02:00
Summary This study was done to elucidate the influence of direct-acting antiviral (DAA) agents on the recurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related HCC (HCV-HCC) after curative therapies. HCV-HCC patients who received curative therapies and obtained a complete response were analyzed. From January 2017 to September 2017, 112 HCV-HCC patients received DAA and obtained a sustained virological response (SVR). From January 2006 to December...
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Summary Radiation-induced oral mucositis has a dismal outcome with limited treatment options. We conducted a phase I study to evaluate the safety and preliminary efficacy of epigallocatechin-3-gallate (EGCG) mouthwash when given along with radiation in head and neck cancer. Patients with pathologically confirmed head and neck cancer were eligible for this study. EGCG mouthwash was administered at the assigned dosage level (starting at 440 μmol/L, three times a day) in a standard...
Thu Nov 07, 2019 02:00
Summary In a previous study we reported on the synthesis of 1,4-naphthoquinone-sulfides by thiolation of 1,4-naphthohydroquinones with primary aryl and alkyl thiols using laccase as catalyst. These compounds were synthesized as Vitamin K3 analogues. Vitamin K3 (VK3; 2-methyl-1,4-naphthoquinone; menadione) is known to have potent anticancer activity. This investigation reports on the anticancer activity of these VK3 analogues against TK10 renal, UACC62 melanoma, MCF7 breast, HeLa...
Thu Nov 07, 2019 02:00
A 40-year-old man presented to the emergency department with fatigue that had progressively worsened over a period of 3 months. He had recently emigrated from Mexico, where he had worked on a farm and eaten raw watercress. Examination revealed pallor of the oral mucosa. Laboratory studies showed…
Thu Nov 07, 2019 02:00
A 52-year-old man presented to the outpatient clinic with a bleeding mass on his right great toe. Two months earlier, the patient had noticed a pink nodule that was approximately 5 mm in diameter on the dorsum of the toe. One month later, his toe was stepped on, after which the nodule grew rapidly…
Thu Nov 07, 2019 02:00
Related ArticlesNiemann-Pick Disease Type C Misdiagnosed as Cerebral Palsy: A Case Report. Ann Rehabil Med. 2019 Oct;43(5):621-624 Authors: Ko EJ, Sung IY, Yoo HW Abstract Niemann-Pick disease type C (NP-C) is a rare autosomal recessive neurovisceral lysosomal lipid storage disorder. The clinical manifestations of the disorder are variable. This report describes the case of a 27-month-old girl with NP-C whose condition had been misdiagnosed as spastic...
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Related ArticlesSignificance of Sufficient Neck Flexion During Magnetic Resonance Imaging in the Diagnosis of Hirayama Disease: Report of Two Cases. Ann Rehabil Med. 2019 Oct;43(5):615-620 Authors: No SW, Sung DH, Kim DH Abstract It is difficult to distinguish Hirayama disease (HD) from other mimicking disorders in adolescent patients with distal upper limb weakness. The prevailing theory of HD postulates that the lower cervical cord is susceptible to...
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Related ArticlesEffects of Different Modes of Upper Limb Training in Individuals With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Ann Rehabil Med. 2019 Oct;43(5):592-614 Authors: Kruapanich C, Tantisuwat A, Thaveeratitham P, Lertmaharit S, Ubolnuar N, Mathiyakom W Abstract OBJECTIVE: To determine effects of different modes of upper limb training on dyspnea and quality of life of individuals with chronic obstructive pulmonary...
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Related ArticlesEffectiveness of Family-Engaged Multidimensional Team Planning and Management for Recovery in Patients With Severe Stroke and Low Functional Status. Ann Rehabil Med. 2019 Oct;43(5):581-591 Authors: Hiragami F, Hiragami S, Inoue Y Abstract OBJECTIVE: To evaluate the effectiveness of family-engaged multidimensional team planning and management for patients with severe stroke and low functional status and to identify factors predictive of...
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Related ArticlesPost-operative Physical Performance Factors Associated With Gait Speed in Patients Surgically Treated for Hip Fracture: A Cross-Sectional Study. Ann Rehabil Med. 2019 Oct;43(5):570-580 Authors: Jeon YT, Kim BR, Han EY, Nam KW, Lee SY, Park YG, Suh MJ, Kim JH Abstract OBJECTIVE: To determine post-operative physical performance factors associated with gait speed in patients surgically treated for hip fracture. METHODS: Cross-sectional...
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Related ArticlesRelationship Between Performance Improvement in Activities of Daily Living and Energy Intake in Older Patients With Hip Fracture Undergoing Rehabilitation. Ann Rehabil Med. 2019 Oct;43(5):562-569 Authors: Umezawa H, Kokura Y, Abe S, Suzuki C, Nishida A, Uchiyama Y, Maeda K, Wakabayashi H, Momosaki R Abstract OBJECTIVE: To analyze whether sufficient energy intake (EI) improves performance of activities of daily living (ADL) in patients...
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Related ArticlesIntrathecal Baclofen Dosage for Long-Term Treatment of Patients With Spasticity Due to Traumatic Spinal Cord Injuries or Multiple Sclerosis. Ann Rehabil Med. 2019 Oct;43(5):555-561 Authors: Skoog B, Hedman B Abstract OBJECTIVE: To investigate dosage changes in intrathecal baclofen during long-term treatment of patients with severe leg spasticity. METHODS: We performed a retrospective chart review of 49 patients treated with an...
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Related ArticlesReliability and Validity of the Comprehensive Limb and Oral Apraxia Test: Standardization and Clinical Application in Korean Patients With Stroke. Ann Rehabil Med. 2019 Oct;43(5):544-554 Authors: Pyun SB, Hwang YM, Jo SY, Ha JW Abstract OBJECTIVE: To develop and standardize the Limb and Oral Apraxia Test (LOAT) for Korean patients and investigate its reliability, validity, and clinical usefulness for patients with stroke. METHODS:...
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Related ArticlesEffect of Decreased Skeletal Muscle Index and Hand Grip Strength on Functional Recovery in Subacute Ambulatory Stroke Patients. Ann Rehabil Med. 2019 10;43(5):535-543 Authors: Park JG, Lee KW, Kim SB, Lee JH, Kim YH Abstract OBJECTIVE: To investigate the effect of decreased Skeletal Muscle Index (SMI) and hand grip strength on functional recovery in subacute ambulatory stroke patients. METHODS: Subacute stroke patients who were...
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Purpose: Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic target for many cancers. Multiple non-selective CDK9 inhibitors have progressed clinically but were limited by a narrow therapeutic window. This work describes a novel, potent, and highly selective CDK9 inhibitor, AZD4573. Experimental Design: The anti-tumor activity of AZD4573 was determined across broad cancer cell line panels in vitro as well as cell line- and patient-derived xenograft models in...
Thu Nov 07, 2019 15:47
Purpose: Despite the therapeutic success of existing HER2 targeted therapies, tumors invariably relapse. This study aimed at identifying new mechanisms responsible for HER2 targeted therapies resistance. Experimental Design: We have used a platform of HER2 targeted therapies resistant cell lines and primary cultures of healthy and tumor associated fibroblast to identify new potential targets related to tumor escape from anti-HER2 therapies Results: We have shown that tumor associated fibroblasts...
Thu Nov 07, 2019 15:47
Purpose: Increased availability of next generation sequencing has allowed for the genomic characterization of a variety of pediatric tumors, although genomic determinants of response to treatment remain largely unknown. We sought to evaluate the genomic landscape and genomic determinants of clinical outcomes in rhabdomyosarcoma (RMS). Experimental Design: Of 29,067 patients who underwent genomic profiling at our institution using a 468-gene oncopanel with complete records, 87 had RMS, of whom 22...
Thu Nov 07, 2019 15:47
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 51-year-old man…
Thu Nov 07, 2019 02:00
Related ArticlesInhibition of tremulous jaw movements in rats by memantine-Δ9 -tetrahydrocannabinol combination: neuroanatomical correlates. Br J Pharmacol. 2019 Nov 06;: Authors: Ionov ID, Pushinskaya II, Frenkel DD, Gorev NP, Shpilevaya LA Abstract BACKGROUND AND PURPOSE: Memantine and marijuana smoking have been previously found to inhibit tremor in parkinsonian patients, however, the observed effects were relatively weak. The tremorolytic efficacy...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08914
Thu Nov 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09194
Thu Nov 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10195
Thu Nov 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05063
Thu Nov 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10316
Thu Nov 07, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06913
Thu Nov 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03226
Thu Nov 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04082
Thu Nov 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03946
Thu Nov 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03733
Thu Nov 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03556
Thu Nov 07, 2019 07:00
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