Related ArticlesEvidence of Vowel Discrimination Provided by the Acoustic Change Complex. Ear Hear. 2019 Oct 31;: Authors: Cheek D, Cone B Abstract OBJECTIVES: The objectives of this study were to measure the effects of level and vowel contrast on the latencies and amplitudes of acoustic change complex (ACC) in the mature auditory system. This was done to establish how the ACC in healthy young adults is affected by these stimulus parameters that could...
Thu Nov 07, 2019 21:06
Related ArticlesGamma-Band Oscillations Preferential for Nociception can be Recorded in the Human Insula. Cereb Cortex. 2018 10 01;28(10):3650-3664 Authors: Liberati G, Klöcker A, Algoet M, Mulders D, Maia Safronova M, Ferrao Santos S, Ribeiro Vaz JG, Raftopoulos C, Mouraux A Abstract Transient nociceptive stimuli elicit robust phase-locked local field potentials (LFPs) in the human insula. However, these responses are not preferential for nociception,...
Thu Nov 07, 2019 21:06
Related ArticlesTreatment characteristics for nonmetastatic castration-resistant prostate cancer in the United States, Europe and Japan. Future Oncol. 2019 Nov 05;: Authors: Shah R, Botteman M, Waldeck R Abstract Aim: We conducted this study to describe nonmetastatic castration-resistant prostate cancer (nmCRPC) patient characteristics and treatment patterns in the US, Europe and Japan. Materials & methods: Descriptive analyses were conducted using...
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma. Oncotarget. 2019 Oct 29;10(59):6398-6399 Authors: Xiang ZL, Zhao XM, Zhang L, Yang P, Fan J, Tang ZY, Zeng ZC Abstract [This corrects the article DOI: 10.18632/oncotarget.13531.].PMID: 31695850 [PubMed - in process]
Thu Nov 07, 2019 21:05
Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection.
Related ArticlesCorrection: Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget. 2019 Oct 29;10(59):6397 Authors: Vicente D, Patino M, Marcus R, Lillemoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP Abstract [This corrects the article DOI: 10.18632/oncotarget.26549.].PMID: 31695849 [PubMed - in process]
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: MiR-451 as a new tumor marker for gastric cancer. Oncotarget. 2019 Oct 29;10(59):6396 Authors: Shen Y, Gong JM, Zhou LL, Sheng JH Abstract [This corrects the article DOI: 10.18632/oncotarget.17239.].PMID: 31695848 [PubMed - in process]
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer. Oncotarget. 2019 Oct 29;10(59):6393-6395 Authors: Gravina GL, Mancini A, Colapietro A, Marampon F, Sferra R, Pompili S, Biordi LA, Iorio R, Flati V, Argueta C, Landesman Y, Kauffman M, Shacham S, Festuccia C Abstract [This corrects the article DOI: 10.18632/oncotarget.22760.].PMID: 31695847 [PubMed...
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition. Oncotarget. 2019 Oct 29;10(59):6391-6392 Authors: Terzo EA, Lim AR, Chytil A, Chiang YC, Farmer L, Gessner KH, Walker CL, Jansen VM, Rathmell WK Abstract [This corrects the article DOI: 10.18632/oncotarget.26567.].PMID: 31695846 [PubMed - in process]
Thu Nov 07, 2019 21:05
Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts. Oncotarget. 2019 Oct 29;10(59):6378-6390 Authors: Mangialardi EM, Chen K, Salmon B, Vacher J, Salmena L Abstract Inositol Polyphosphate 4-Phosphatase, Type II (INPP4B) is a tumour suppressor in breast, ovarian, prostate, thyroid and other cancers, attributed to its ability to reduce oncogenic Akt-signaling. However, emerging studies show that INPP4B also...
Thu Nov 07, 2019 21:05
Related ArticlesImportance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination. Oncotarget. 2019 Oct 29;10(59):6362-6377 Authors: Sanders AJ, Owen S, Morgan LD, Ruge F, Collins RJ, Ye L, Mason MD, Jiang WG Abstract Activated Leukocyte Cell Adhesion Molecule (ALCAM) has been linked to the progression of numerous human cancers, where it appears to play a complex role. The current study aims...
Thu Nov 07, 2019 21:05
Related ArticlesTissue ACE phenotyping in prostate cancer. Oncotarget. 2019 Oct 29;10(59):6349-6361 Authors: Danilov SM, Kadrev AV, Kurilova OV, Tikhomirova VE, Kryukova OV, Mamedov VN, Kamalov DM, Danilova NV, Okhobotov DA, Gayfullin NM, Evdokimov VV, Alekseev BJ, Kost OA, Samokhodskaya LM, Kamalov AA Abstract Epithelial cells of prostate express significant level of ACE and, as a result, seminal fluid has 50-fold more ACE than plasma. The substitution...
Thu Nov 07, 2019 21:05
Related ArticlesDynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases. Oncotarget. 2019 Oct 29;10(59):6334-6348 Authors: Uzunalli G, Dieterly AM, Kemet CM, Weng HY, Soepriatna AH, Goergen CJ, Shinde AB, Wendt MK, Lyle LT Abstract Invasion of the brain by non-small cell lung cancer (NSCLC) results in a shift of the blood-brain barrier (BBB) to the insufficiently characterized blood-tumor barrier...
Thu Nov 07, 2019 21:05
Related ArticlesThe multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo. Oncotarget. 2019 Oct 29;10(59):6323-6333 Authors: Flynn SM, Lesperance J, Macias A, Phanhthilath N, Paul MR, Kim JW, Tamayo P, Zage PE Abstract Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk...
Thu Nov 07, 2019 21:05
Related ArticlesCentral nervous system-specific efficacy of CDK4/6 inhibitors in randomized controlled trials for metastatic breast cancer. Oncotarget. 2019 Oct 29;10(59):6317-6322 Authors: Nguyen LV, Searle K, Jerzak KJ Abstract Importance: Metastatic breast cancer with central nervous system (CNS) metastases carries a poor prognosis. Recently, CDK4/6 inhibitors have demonstrated a progression free survival (PFS) and overall survival benefit when combined...
Thu Nov 07, 2019 21:05
Related ArticlesImproved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery. Oncotarget. 2019 Oct 29;10(59):6308-6316 Authors: Juhl K, Christensen A, Rubek N, Karnov KKS, von Buchwald C, Kjaer A Abstract Pancreatic cancer remains one of the deadliest cancers. The five-year survival rates have been reported as 3%. Radical surgical tumor resection is critical...
Thu Nov 07, 2019 21:05
Related ArticlesRandomized phase 3 open label study of quality of life of patients on Pemetrexed versus Erlotinib as maintenance therapy for advanced non squamous non EGFR mutated non small cell lung cancer. Oncotarget. 2019 Oct 29;10(59):6297-6307 Authors: Patil V, Joshi A, Noronha V, Agarwala V, Chougule A, Kanan S, Bhattacharjee A, Chandrasekharan A, Pande N, Simha V, Goud S, More S, Kumar R, Mahajan A, Janu A, Purandare N, Prabhash K Abstract Background:...
Thu Nov 07, 2019 21:05
Related ArticlesA negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10. Oncotarget. 2019 Oct 29;10(59):6288-6296 Authors: Luo Z, Zhang M, Cui R, Tili E, Kim T, Lee TJ, Peng Y, Croce C Abstract TP53 is a critical tumor suppressor. In approximately 50% of human cancers the TP53 gene is either lost or mutated. The expression level of TP53 in the cells is tightly controlled by a fine-tune machinery, mainly through the Mdm2-mediated...
Thu Nov 07, 2019 21:05
Related ArticlesOvercoming heterogenity in imatinib-resistant gastrointestinal stromal tumor. Oncotarget. 2019 Oct 29;10(59):6286-6287 Authors: Serrano C, Fletcher JA PMID: 31695836 [PubMed]
Thu Nov 07, 2019 21:05
Related ArticlesThe positivity rate of 68Gallium-PSMA-11 ligand PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6124-6137 Authors: Hoffmann MA, Buchholz HG, Wieler HJ, Höfner T, Müller-Hübenthal J, Trampert L, Schreckenberger M Abstract Background: The aim of the present study is to analyze the efficacy of 68Gallium (Ga)-PSMA-11 PET/CT for detecting and localizing recurrent...
Thu Nov 07, 2019 21:05
Related ArticlesA-to-I RNA editing in leukemia stem cells - set ADAR1 on the radar. Oncotarget. 2019 Oct 22;10(58):6047-6048 Authors: Jiang Q, Diep R, Jamieson C PMID: 31692993 [PubMed]
Thu Nov 07, 2019 21:05
Related ArticlesKallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein. Oncotarget. 2019 Oct 22;10(58):6062-6078 Authors: Chen H, Sells E, Pandey R, Abril ER, Hsu CH, Krouse RS, Nagle RB, Pampalakis G, Sotiropoulou G, Ignatenko NA Abstract Kallikrein-related peptidase 6 (KLK6) overexpression is commonly observed in primary tumors of colorectal cancer (CRC) patients and has been associated with tumor aggressiveness,...
Thu Nov 07, 2019 21:05
Related ArticlesIntegrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients. Oncotarget. 2019 Oct 22;10(58):6184-6203 Authors: Sugita BM, Pereira SR, de Almeida RC, Gill M, Mahajan A, Duttargi A, Kirolikar S, Fadda P, de Lima RS, Urban CA, Makambi K, Madhavan S, Boca SM, Gusev Y, Cavalli IJ, Ribeiro EMSF, Cavalli LR Abstract Triple negative breast cancer (TNBC), a clinically aggressive breast cancer...
Thu Nov 07, 2019 21:05
Related ArticlesEffect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells. Oncotarget. 2019 Oct 22;10(58):6111-6123 Authors: Kawase T, Nakazawa T, Eguchi T, Tsuzuki H, Ueno Y, Amano Y, Suzuki T, Mori M, Yoshida T Abstract Therapeutic effects of FLT3 inhibitors have been reported in acute myeloid leukemia (AML) with constitutively activating FLT3 mutations,...
Thu Nov 07, 2019 21:05
Related ArticlesAdoptive cellular immunotherapy for refractory childhood cancers: a single center experience. Oncotarget. 2019 Oct 22;10(58):6138-6151 Authors: Merker M, Meister MT, Heinze A, Jarisch A, Sörensen J, Huenecke S, Bremm M, Cappel C, Klingebiel T, Bader P, Rettinger E Abstract Prognosis of refractory childhood cancers despite multimodal treatment strategies remains poor. Here, we report a single center experience encountered in 18 patients...
Thu Nov 07, 2019 21:05
Related ArticlesHyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019 Oct 22;10(58):6096-6110 Authors: Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR Abstract There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease...
Thu Nov 07, 2019 21:05
The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts.
Related ArticlesThe phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts. Oncotarget. 2019 Oct 22;10(58):6269-6282 Authors: Visochek L, Atias D, Spektor I, Castiel A, Golan T, Cohen-Armon M Abstract Recent reports demonstrate an exclusive eradication of a variety of human cancer cells by the modified phenanthridine PJ34. Their eradication during mitosis is attributed to PJ34 preventing NuMA clustering in the...
Thu Nov 07, 2019 21:05
Related ArticlesDifferential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures. Oncotarget. 2019 Oct 22;10(58):6168-6183 Authors: Shaikh I, Ansari A, Ayachit G, Gandhi M, Sharma P, Bhairappanavar S, Joshi CG, Das J Abstract Head and neck cancer is the sixth most common cancer worldwide, with tobacco as the leading cause. However, it is increasing in non-tobacco users also, hence limiting our understanding...
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway. Oncotarget. 2019 Oct 22;10(58):6283-6284 Authors: Ouyang Z, Guo X, Chen X, Liu B, Zhang Q, Yin Z, Zhai Z, Qu X, Liu X, Peng D, Shen Y, Liu T, Zhang Q Abstract [This corrects the article DOI: 10.18632/oncotarget.22930.].PMID: 31692899 [PubMed - in process]
Thu Nov 07, 2019 21:05
Related ArticlesBiodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. Oncotarget. 2019 Oct 22;10(58):6234-6244 Authors: Boswell CA, Yadav DB, Mundo EE, Yu SF, Lacap JA, Fourie-O'Donohue A, Kozak KR, Ferl GZ, Zhang C, Ho J, Ulufatu S, Khawli LA, Lin K Abstract TENB2, a transmembrane proteoglycan protein, is a promising target for antibody drug conjugate (ADC) therapy due to overexpression...
Thu Nov 07, 2019 21:05
Related ArticlesExtramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A. Oncotarget. 2019 Oct 22;10(58):6152-6167 Authors: Pourmaleki M, Young JH, Socci ND, Chiang S, Edelweiss M, Li Y, Zhang M, Roshal L, Chi DS, Busam KJ, Mellinghoff IK, Hollmann TJ Abstract Extramammary Paget disease (EMPD) is a rare cutaneous adenocarcinoma of the anogenital region most...
Thu Nov 07, 2019 21:05
Related ArticlesCorrection: Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC. Oncotarget. 2019 Oct 22;10(58):6285 Authors: Wang Z, Ma B, Li H, Xiao X, Zhou W, Liu F, Zhang B, Zhu M, Yang Q, Zeng Y, Sun Y, Sun S, Wang Y, Zhang Y, Weng H, Chen L, Ye M, An X, Liu J Abstract [This corrects the article DOI: 10.18632/oncotarget.6312.].PMID: 31692885 [PubMed - in process]
Thu Nov 07, 2019 21:05
Related ArticlesPreclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma. Oncotarget. 2019 Oct 22;10(58):6049-6061 Authors: Dührsen L, Hartfuß S, Hirsch D, Geiger S, Maire CL, Sedlacik J, Guenther C, Westphal M, Lamszus K, Hermann FG, Schmidt NO Abstract Glioblastoma are highly invasive and associated with limited therapeutic options and a grim prognosis. Using...
Thu Nov 07, 2019 21:05
Related ArticlesEsophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition. Oncotarget. 2019 Oct 22;10(58):6245-6259 Authors: Guha M, Srinivasan S, Sheehan MM, Kijima T, Ruthel G, Whelan K, Tanaka K, Klein-Szanto A, Chandramouleeswaran PM, Nakagawa H, Avadhani NG Abstract Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis....
Thu Nov 07, 2019 21:05
Related ArticlesMultiplatform profiling of pancreatic neuroendocrine tumors: Correlative analyses of clinicopathologic factors and identification of co-occurring pathogenic alterations. Oncotarget. 2019 Oct 22;10(58):6260-6268 Authors: Gong J, Blais EM, Bender JR, Guan M, Placencio-Hickok V, Petricoin EF, Pishvaian MJ, Gregory G, Tuli R, Hendifar AE Abstract Background: Multi-omic profiling of pancreatic neuroendocrine tumors (PanNETs) was performed...
Thu Nov 07, 2019 21:05
Related ArticlesPreferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide. Oncotarget. 2019 Oct 22;10(58):6219-6233 Authors: Hadji A, Schmitt GK, Schnorenberg MR, Roach L, Hickey CM, Leak LB, Tirrell MV, LaBelle JL Abstract BCL-2 family proteins are central regulators of apoptosis and represent prime therapeutic targets for overcoming cell death resistance in malignancies. However, plasticity of anti-apoptotic members, such as MCL-1, often...
Thu Nov 07, 2019 21:05
Related ArticlesThe predictive capability of immunohistochemistry and DNA sequencing for determining TP53 functional mutation status: a comparative study of 41 glioblastoma patients. Oncotarget. 2019 Oct 22;10(58):6204-6218 Authors: Roshandel AK, Busch CM, Mullekom JV, Cuoco JA, Rogers CM, Apfel LS, Marvin EA, Sontheimer HW, Umans RA Abstract Tumor protein 53 (p53) regulates fundamental pathways of cellular growth and differentiation. Aberrant p53 expression...
Thu Nov 07, 2019 21:05
Related ArticlesTargeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells. Oncotarget. 2019 Oct 22;10(58):6079-6095 Authors: Naidoo C, Kruger CA, Abrahamse H Abstract Metastatic Melanoma (MM) is a deadly form of skin cancer and many photodynamic therapy (PDT) studies have noted limitations in relation to effective photosensitizer (PS) drug uptake in tumors. The focus of this study was to develop a PS multicomponent nanoparticle...
Thu Nov 07, 2019 21:05
162 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/11/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Nov 07, 2019 21:04
Related ArticlesVaricella zoster presenting as cranial polyneuropathy. Am J Emerg Med. 2019 03;37(3):564.e5-564.e6 Authors: Niesvizky-Kogan I, Greca I, Gambhir HS Abstract Cranial polyneuropathy is commonly caused by Lyme disease. We discuss the case of a man who presented with cranial nerve deficits causing dysphagia, dysphonia and facial weakness. This diagnostic dilemma stemmed from a workup that ruled out Lyme and vascular causes leading to an expanded...
Thu Nov 07, 2019 21:04
Related ArticlesPrevalence and risk factors of smell dysfunction - a comparison between five German population-based studies. Rhinology. 2019 Nov 04;: Authors: Stögbauer J, Wirkner K, Engel C, Moebus S, Pundt N, Teismann H, Löffler M, Hummel T, Beule AG, Berger K Abstract BACKGROUND: The prevalence of olfactory impairment increases with age and is known to be an early sign of different neurodegenerative diseases. Only few population-based studies examined...
Thu Nov 07, 2019 21:01
Related ArticlesNanotechnology platforms for cancer immunotherapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Nov 07;:e1590 Authors: Yang Z, Ma Y, Zhao H, Yuan Y, Kim BYS Abstract Various cancer therapies have advanced remarkably over the past decade. Unlike the direct therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the host's immune system to detect specific cancer cells for efficient elimination. Nanoparticles...
Thu Nov 07, 2019 21:00
Related ArticlesMyocardial dysfunction in long-term breast cancer survivors treated at ages 40-50 years. Eur J Heart Fail. 2019 Nov 06;: Authors: Jacobse JN, Steggink LC, Sonke GS, Schaapveld M, Hummel YM, Steenbruggen TG, Lefrandt JD, Nuver J, Crijns APG, Aleman BMP, van der Meer P, Gietema JA, van Leeuwen FE Abstract AIMS: Anthracyclines increase heart failure (HF) risk, but the long-term prevalence of myocardial dysfunction in young breast cancer...
Thu Nov 07, 2019 21:00
Related ArticlesSurgery for Metastatic Melanoma: an Evolving Concept. Curr Oncol Rep. 2019 Nov 06;21(11):98 Authors: Testori AAE, Blankenstein SA, van Akkooi ACJ Abstract PURPOSE OF REVIEW: This review describes the evolving role of surgery in stage III and IV melanoma. RECENT FINDINGS: Surgery has been the first option to cure melanoma patients at initial diagnosis of metastatic spread: a complete surgical excision of the disease either in...
Thu Nov 07, 2019 21:00
Related ArticlesTracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer. EJNMMI Radiopharm Chem. 2019 Nov 06;4(1):29 Authors: Wierstra P, Sandker G, Aarntzen E, Gotthardt M, Adema G, Bussink J, Raavé R, Heskamp S Abstract Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the treatment of several types of cancer. Unfortunately, not all patients respond to therapy while severe immune-related...
Thu Nov 07, 2019 21:00
Related ArticlesThe Role and Necessity of Sentinel Lymph Node Biopsy for Invasive Melanoma. Front Med (Lausanne). 2019;6:231 Authors: Nakamura Y Abstract Sentinel lymph node biopsy (SLNB) is a widely accepted procedure for melanoma staging and treatment. The development of lymphatic mapping and SLNB, which was first introduced in 1992, has enabled surgeons to detect microscopic nodal metastases and stage-negative regional nodal basins with low morbidity....
Thu Nov 07, 2019 21:00
Related ArticlesRecent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment. Front Bioeng Biotechnol. 2019;7:293 Authors: Li Z, Chen Y, Yang Y, Yu Y, Zhang Y, Zhu D, Yu X, Ouyang X, Xie Z, Zhao Y, Li L Abstract Conventional chemotherapy for cancer treatment is usually compromised by shortcomings such as insufficient therapeutic outcome and undesired side effects. The past decade has witnessed the rapid...
Thu Nov 07, 2019 21:00
Related ArticlesOrgan Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Front Oncol. 2019;9:999 Authors: Stelmes JJ, Gregoire V, Poorten VV, Golusiñski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts AS, Fortpied C, Simon C Abstract Dysphagia represents...
Thu Nov 07, 2019 21:00
Related ArticlesPatterns of Radiotherapy Utilization for Lung Cancer Patients with Brain Metastases: A Population-based Analysis. Cureus. 2019 Sep 07;11(9):e5591 Authors: Schlijper R, Fraser IM, Regan J, Lefresne S, Ho C, Olson RA Abstract INTRODUCTION: Brain metastases occur in 15%-20% of lung cancer patients. Recently, studies have suggested that whole-brain radiotherapy (WBRT) may not prolong survival for a subset of patients, and is associated with...
Thu Nov 07, 2019 21:00
Related ArticlesSystemic Therapy for Advanced Hepatocellular Carcinoma: An Update of a Rapidly Evolving Field. J Clin Exp Hepatol. 2019 Sep-Oct;9(5):588-596 Authors: Doycheva I, Thuluvath PJ Abstract Hepatocellular carcinoma (HCC) incidence and mortality have shown an unfavorable upward trend over the last two decades, especially in developed countries. More than one-sixth of the patients have advanced HCC at presentation. Systemic therapy remains the...
Thu Nov 07, 2019 21:00
Related ArticlesmiR-223 overexpression inhibits doxorubicin-induced autophagy by targeting FOXO3a and reverses chemoresistance in hepatocellular carcinoma cells. Cell Death Dis. 2019 Nov 06;10(11):843 Authors: Zhou Y, Chen E, Tang Y, Mao J, Shen J, Zheng X, Xie S, Zhang S, Wu Y, Liu H, Zhi X, Ma T, Ni H, Chen J, Chai K, Chen W Abstract Doxorubicin is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed...
Thu Nov 07, 2019 21:00
Related ArticlesCost-effectiveness analysis (CEA) of IMRT plus C12 boost vs IMRT only in adenoid cystic carcinoma (ACC) of the head and neck. Radiat Oncol. 2019 Nov 06;14(1):194 Authors: Jensen AD, Debus J Abstract BACKGROUND: Particle therapy provides steep dose gradients to facilitate dose escalation in challenging anatomical sites which has been shown not only to improve local control but also overall survival in patients with ACC. Cost-effectiveness...
Thu Nov 07, 2019 21:00
Related ArticlesThe Prognostic Role of CD8+ T Lymphocytes in Childhood Adrenocortical Carcinomas Compared to Ki-67, PD-1, PD-L1, and the Weiss Score. Cancers (Basel). 2019 Nov 05;11(11): Authors: Parise IZS, Parise GA, Noronha L, Surakhy M, Woiski TD, Silva DB, Costa TEB, Del-Valle MHCP, Komechen H, Rosati R, Ribeiro MG, Nascimento ML, Souza JA, Andrade DP, Paraizo MM, Galvão MMR, Barbosa JRS, Barbosa ML, Custódio GC, Figueiredo MMO, Fabro ALMR, Bond G, Volante M, Lalli...
Thu Nov 07, 2019 21:00
Related ArticlesAssociation between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study. Biosci Rep. 2019 Oct 11;: Authors: Zhang S, Lin J, Jiang J, Chen Y, Tang W, Liu L Abstract Polymorphisms in one-carbon metabolism genes may influence the susceptibility to hepatocellular carcinoma (HCC). In this study, we studied MTHFR tagging polymorphisms in 584 HCC cases and 923 controls....
Thu Nov 07, 2019 21:00
Related ArticlesLDeform: Longitudinal Deformation Analysis for Adaptive Radiotherapy of Lung Cancer. Med Phys. 2019 Nov 06;: Authors: Nadeem S, Zhang P, Rimner A, Sonke JJ, Deasy JO, Tannenbaum A Abstract PURPOSE: Conventional radiotherapy for large lung tumors is given over several weeks, during which the tumor typically regresses in a highly non-uniform and variable manner. Adaptive radiotherapy would ideally follow these shape changes, but we need...
Thu Nov 07, 2019 21:00
Related ArticlesHigh preoperative serum prealbumin predicts long-term survival in resected esophageal squamous cell cancer. Cancer Manag Res. 2019;11:7997-8003 Authors: Wei J, Jin M, Shao Y, Ning Z, Huang J Abstract Purpose: The current study aimed to explore the prognostic role of preoperative prealbumin in resectedesophageal squamous cell carcinoma (ESCC). Methods: A total of 1374 resected ESCC patients were retrospectively reviewed. Serum...
Thu Nov 07, 2019 21:00
Related ArticlesDie Advanced Practice Nurse (APN) in der gynäkologischen Onkologie. Pflege. 2019 Nov 06;:1-11 Authors: Kobleder A, Mayer H, Senn B Abstract The Advanced Practice Nurse (APN) in gynaecological oncology - development of an evidence-based concept Abstract. Background: The role of an Advanced Practice Nurse (APN) is suggested to provide supportive care for women with gynaecological cancer throughout the caring process. In Austria and Switzerland,...
Thu Nov 07, 2019 21:00
Related ArticlesThe Current Status and Future of Andrology: A Consensus Report from the Cairo Workshop Group. Andrology. 2019 Nov 06;: Authors: Barratt C, Mortimer D, Amer M, Baldi E, De Jonge C, Fawzy M, Jørgensen N, Krausz C, Mahran A, MartinsdaSilva S, Mortimer S, Pacey A, Publicover S Abstract BACKGROUND: In attempting to formulate potential WHO guidelines for the diagnosis of male infertility, the Evidence Synthesis Group noted a paucity of high...
Thu Nov 07, 2019 21:00
Related ArticlesA utility approach to individualized optimal dose selection using biomarkers. Biom J. 2019 Nov 06;: Authors: Li P, Taylor JMG, Kong S, Jolly S, Schipper MJ Abstract In many settings, including oncology, increasing the dose of treatment results in both increased efficacy and toxicity. With the increasing availability of validated biomarkers and prediction models, there is the potential for individualized dosing based on patient specific...
Thu Nov 07, 2019 21:00
Related ArticlesSpirulina extract enriched for Braun-type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis. Phytother Res. 2019 Nov 05;: Authors: Kefayat A, Ghahremani F, Safavi A, Hajiaghababa A, Moshtaghian J Abstract Spirulina platensis extracts have exhibited considerable anti-cancer effects. To investigate the efficacy of the Spirulina extract enriched for Braun-type lipoprotein (Immulina®) for breast cancer treatment,...
Thu Nov 07, 2019 21:00
Related ArticlesA review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices. Biomed Chromatogr. 2019 Nov 06;:e4732 Authors: Knikman JE, Rosing H, Guchelaar HJ, Cats A, Beijnen JH Abstract The bioanalysis of the oral anticancer drug capecitabine and its metabolites has been investigated extensively over the past years. This paper reviews methods for the bioanalysis of capecitabine...
Thu Nov 07, 2019 21:00
Related ArticlesCD19 chimeric antigen receptor-T cells in B-cell leukemia and lymphoma: current status and perspectives. Leukemia. 2019 Nov 05;: Authors: Mohty M, Gautier J, Malard F, Aljurf M, Bazarbachi A, Chabannon C, Kharfan-Dabaja MA, Savani BN, Huang H, Kenderian S, Nagler A, Perales MA Abstract The approval of tisagenlecleucel and axicabtagene ciloleucel represents a breakthrough in the field of immune and cellular therapy for hematologic malignancies....
Thu Nov 07, 2019 21:00
Related ArticlesAn engineered antibody fragment targeting mutant β-catenin via Major Histocompatibility Complex I neoantigen presentation. J Biol Chem. 2019 Nov 05;: Authors: Miller MS, Douglass J, Hwang MS, Skora AD, Murphy M, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB Abstract Mutations in CTNNB1, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin. Peptides...
Thu Nov 07, 2019 21:00
Related ArticlesHealth-related quality of life and its socio-economic and cultural predictors among advanced cancer patients: evidence from the APPROACH cross-sectional survey in Hyderabad-India. BMC Palliat Care. 2019 Nov 05;18(1):94 Authors: Jacob J, Palat G, Verghese N, Chandran P, Rapelli V, Kumari S, Malhotra C, Teo I, Finkelstein E, Ozdemir S Abstract BACKGROUND: Patients with advanced cancer often experience poor health-related quality-of-life...
Thu Nov 07, 2019 21:00
Related ArticlesModel genotype-phenotype mappings and the algorithmic structure of evolution. J R Soc Interface. 2019 Nov 29;16(160):20190332 Authors: Nichol D, Robertson-Tessi M, Anderson ARA, Jeavons P Abstract Cancers are complex dynamic systems that undergo evolution and selection. Personalized medicine approaches in the clinic increasingly rely on predictions of tumour response to one or more therapies; these predictions are complicated by the inevitable...
Thu Nov 07, 2019 21:00
Related ArticlesNotch signalling in T cell homeostasis and differentiation. Open Biol. 2019 Nov 29;9(11):190187 Authors: Brandstadter JD, Maillard I Abstract The evolutionarily conserved Notch signalling pathway regulates the differentiation and function of mature T lymphocytes with major context-dependent consequences in host defence, autoimmunity and alloimmunity. The emerging effects of Notch signalling in T cell responses build upon a more established...
Thu Nov 07, 2019 21:00
Related ArticlesA Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography. Plast Reconstr Surg. 2019 Nov;144(5):1197-1201 Authors: Granoff MD, Johnson AR, Lee BT, Padera TP, Bouta EM, Singhal D Abstract Lymphedema arises from impaired lymphatic function. Quantification of lymphatic contractility has previously been shown using a custom-built near-infrared imaging system. However, to broaden the clinical use of...
Thu Nov 07, 2019 21:00
Related ArticlesValue assessment of immuno-oncology in the treatment of rare tumors in the era of accelerated conditional approvals. Future Oncol. 2019 Nov 05;: Authors: Lanitis T, Ambavane A, Zheng Y, Schlichting M, Phatak H Abstract Aim: To conduct a value assessment of an immuno-oncology (IO) therapy for a rare cancer and evaluate whether existing frameworks consider challenges associated with valuing IOs for rare cancers. Materials & methods:...
Thu Nov 07, 2019 21:00
Related ArticlesConsidering abuse liability and neurocognitive effects of cannabis and cannabis-derived products when assessing analgesic efficacy: a comprehensive review of randomized-controlled studies. Am J Drug Alcohol Abuse. 2019 Nov 05;:1-16 Authors: Cooper ZD, Abrams D Abstract Background: Pain is the most frequent indication for which medical cannabis treatment is sought.Objectives: The clinical potential of cannabis and cannabis-derived products...
Thu Nov 07, 2019 21:00
Related ArticlesCircumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases. Saudi J Ophthalmol. 2019 Jul-Sep;33(3):219-228 Authors: Dalvin LA, Lim LS, Chang M, Udyaver S, Mazloumi M, Vichitvejpaisal P, Su GL, Florakis E, Mashayekhi A, Shields JA, Shields CL Abstract Purpose: To investigate features and outcomes of circumscribed choroidal hemangioma by patient age. Methods: Retrospective review of circumscribed...
Thu Nov 07, 2019 21:00
Related ArticlesCarbon ion and proton beam irradiation of a normal human TK6 lymphoblastoid cell line within a magnetic field of 1.0 tesla. Cancer Manag Res. 2019;11:8327-8335 Authors: Yudhistiara B, Weber KJ, Huber PE, Ruehle A, Brons S, Haering P, Debus J, Hauswald H Abstract Background: Considering the increasing simultaneous application of magnetic resonance imaging (MRI) for more precise photon radiotherapy, it will be likely for particle radiotherapy...
Thu Nov 07, 2019 21:00
Related ArticlesDurvalumab for stage III non-small-cell lung cancer patients: clinical evidence and real-world experience. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619885530 Authors: Botticella A, Mezquita L, Le Pechoux C, Planchard D Abstract Stage III non-small cell lung cancer (NSCLC) has a dismal prognosis, with only 15-20% of patients alive at 5 years after concomitant chemo-radiotherapy, which represents the standard treatment. Targeting immune-checkpoint...
Thu Nov 07, 2019 21:00
Related ArticlesImplementation of the Smoking Treatment and Recovery (STAR) program: healthy cancer survivorship through integrated tobacco control. J Cancer Surviv. 2019 Nov 04;: Authors: Taylor KL, Fallon S, Subramaniam D, Davis K, To C, Lobo T, Tercyak KP, Friberg J, Tynan M, Russell E, Ahmed W, Ponder MC, Cusaac L, Thompson J, Gardner K, Kim C, Weiner LM Abstract PURPOSE: It is well-established that persistent tobacco use among patients with cancer...
Thu Nov 07, 2019 21:00
Related ArticlesPreclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma. Cancer Immunol Immunother. 2019 Nov 04;: Authors: Xu Y, Morales AJ, Cargill MJ, Towlerton AMH, Coffey DG, Warren EH, Tykodi SS Abstract 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but...
Thu Nov 07, 2019 21:00
Related ArticlesTumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol. 2019 Nov 04;: Authors: Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar...
Thu Nov 07, 2019 21:00
Related ArticlesScoping review protocol documenting cancer outcomes and inequalities for adults living with intellectual and/or developmental disabilities. BMJ Open. 2019 Nov 03;9(11):e032772 Authors: Stirling M, Linton J, Ouellette-Kuntz H, Shooshtari S, Hallet J, Kelly C, Dawe D, Kristjanson M, Decker K, Mahar A Abstract INTRODUCTION: There is increasing attention on the cancer burden for adults with intellectual and developmental disabilities (IDD)....
Thu Nov 07, 2019 21:00
Related ArticlesRadiotherapy Trial Set-up in the UK: Identifying Inefficiencies and Potential Solutions. Clin Oncol (R Coll Radiol). 2019 Nov 01;: Authors: Hanna CR, Lynskey DM, Wadsley J, Appleyard SE, Anwar S, Miles E, Gower J, Hall E, Coles CE, Hanna GG Abstract AIMS: Radiotherapy clinical trials are integral to the development of new treatments to improve the outcomes of patients with cancer. A collaborative study by the National Cancer Research...
Thu Nov 07, 2019 21:00
Related ArticlesBRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease. Acta Neuropathol Commun. 2019 Nov 04;7(1):168 Authors: Picarsic J, Pysher T, Zhou H, Fluchel M, Pettit T, Whitehead M, Surrey LF, Harding B, Goldstein G, Fellig Y, Weintraub M, Mobley BC, Sharples PM, Sulis ML, Diamond EL, Jaffe R, Shekdar K, Santi M Abstract ...
Thu Nov 07, 2019 21:00
Related ArticlesAXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Mol Cancer. 2019 Nov 04;18(1):153 Authors: Zhu C, Wei Y, Wei X Abstract Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling pathway is associated with tumour...
Thu Nov 07, 2019 21:00
Related ArticlesA New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer. Cancers (Basel). 2019 Nov 01;11(11): Authors: Chiu HW, Yeh YL, Ho SY, Wu YH, Wang BJ, Huang WJ, Ho YS, Wang YJ, Chen LC, Tu SH Abstract Radiation therapy (RT) is one of the main treatments for triple-negative breast cancer (TNBC). However, many patients experience RT...
Thu Nov 07, 2019 21:00
Related ArticlesHyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis. Cancers (Basel). 2019 Nov 01;11(11): Authors: Kim JY, Lee KH, Kang J, Borcoman E, Saada-Bouzid E, Kronbichler A, Hong SH, de Rezende LFM, Ogino S, Keum N, Song M, Luchini C, van der Vliet HJ, Shin JI, Gamerith G Abstract Hyperprogressive disease (HPD) is a recently acknowledged pattern of rapid tumor progression after the...
Thu Nov 07, 2019 21:00
Related ArticlesBlood outgrowth endothelial cells overexpressing eNOS mitigate pulmonary hypertension in rats: a unique carrier cell enabling autologous cell-based gene therapy. Transl Res. 2019 08;210:1-7 Authors: Somani A, Nair SL, Milbauer LC, Zhu G, Sajja S, Solovey A, Chen Y, Hebbel RP Abstract We have investigated a unique cell type, blood outgrowth endothelial cells (BOEC), as a cell-based gene therapy approach to pulmonary hypertension. BOEC...
Thu Nov 07, 2019 21:00
Thu Nov 07, 2019 14:44
Related ArticlesNon-synergistic synergies of muscle activation: an apparent oxymoron. J Physiol. 2019 Nov 06;: Authors: Lacquaniti F, Sylos-Labini F, Zago M PMID: 31691968 [PubMed - as supplied by publisher]
Thu Nov 07, 2019 20:59
Related ArticlesPhysiological basis of brief vigorous exercise to improve health. J Physiol. 2019 Nov 06;: Authors: Gibala MJ, Little JP Abstract This review considers the physiological basis of brief vigorous exercise to improve health, with a focus on cardiorespiratory fitness (CRF) and glycemic control, and the potential underlying mechanisms involved. We defined 'brief' as a protocol lasting ≤15 min including warm-up, cool-down, and recovery, and...
Thu Nov 07, 2019 20:59
Related ArticlesComplications arising from transfemoral, percutaneous implantation of an indwelling port-catheter system for hepatic infusion chemotherapy: Case series of the management and salvage of the system. Int J Surg Case Rep. 2019 Oct 18;65:78-82 Authors: Ueda M, Sai K, Sonoda T, Tanaka M, Shibaoka Y Abstract INTRODUCTION: Regional hepatic arterial infusion of chemotherapy is performed for unresectable liver tumors via percutaneously implanted...
Thu Nov 07, 2019 20:57
Related ArticlesTranscatheter embolization of the esophagomediastinal fistula with N-butyl cyanoacrylate glue: A case report. Int J Surg Case Rep. 2019 Oct 29;65:73-77 Authors: Bae SH Abstract INTRODUCTION: Acute mediastinitis with esophageal perforation is a very fatal condition and must be treated promptly. Esophagomediastinal fistula is a rare complication of acute mediastinitis with esophageal perforation. There are many treatment options such as...
Thu Nov 07, 2019 20:57
Related ArticlesObscure gastrointestinal bleeding localization using preoperative super-selective mesenteric angiography and intraoperative methylene blue injection: A case report and literature review. Int J Surg Case Rep. 2019 Nov 01;65:69-72 Authors: Bhuller SB, Lieser M, Ismail N, Woods B Abstract INTRODUCTION: Currently available diagnostic tests for localizing the source of gastrointestinal bleeding include esophagogastroduodenoscopy, colonoscopy,...
Thu Nov 07, 2019 20:57
Related ArticlesPlacenta percreta causing spontaneous uterine rupture and intrauterine fetal death in an unscared uterus: A case report. Int J Surg Case Rep. 2019 Nov 01;65:65-68 Authors: Enebe JT, Ofor IJ, Okafor II Abstract INTRODUCTION: Placenta percreta is a rare; a life-threatening disorder of placentation and one of the components of the placenta accreta spectrum. It can lead to uterine rupture, an obstetric catastrophe that can be associated with...
Thu Nov 07, 2019 20:57
Related ArticlesUnusual case of papillary thyroid carcinoma mimicking paraganglioma in a 16-year-old girl. Int J Surg Case Rep. 2019 Oct 23;65:61-64 Authors: Ahmad S Abstract BACKGROUND: Papillary thyroid carcinoma is a common neoplasm arising from follicular cells of the thyroid. Differentiating the neck mass between thyroid paraganglioma and papillary thyroid carcinoma is often difficult. CASE REPORT: We report a 16-year-old girl with painless...
Thu Nov 07, 2019 20:57
Related ArticlesDiaphragmatic lipoma; A benign condition necessitating an aggressive management. Int J Surg Case Rep. 2019 Oct 23;65:57-60 Authors: Baram A, Kakamad FH, Salih KAH, Rashid DF, Essa RA Abstract INTRODUCTION: Primary diaphragmatic lipoma (PDL) is a very rare condition. The aim of this paper is to report a case of diaphragmatic lipoma presenting as a case of diaphratmatic hernia with a brief literature review. A 73-year-old female presented...
Thu Nov 07, 2019 20:57
Related ArticlesA case of severe flail chest with several dislocated sterno-chondral fractures. Int J Surg Case Rep. 2019 Oct 28;65:52-56 Authors: El-Akkawi AI, de Paoli FV, Andersen G, Højsgaard A, Christensen TD Abstract INTRODUCTION: Flail chest is diagnosed clinically by the presence of paradox movement of a segment of the thoracic wall during spontaneous breathing. Radiographic finding confirming a clinical flail chest are fractures of three or...
Thu Nov 07, 2019 20:57
Related ArticlesResurfacing shoulder hemi arthroplasty in ballistic injuries. A case report. Int J Surg Case Rep. 2019 Oct 22;65:48-51 Authors: Amri K, Chefi MA, Znagui T, Rafrafi A, Saadi S, Nouisri L Abstract INTRODUCTION: Ballistic traumatology of the shoulder joint is uncommon. Usually, it is associated to comminuted fractures of the upper humerus. Total shoulder arthroplasty has been proposed to restore a good function. The indication of resurfacing...
Thu Nov 07, 2019 20:57
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