Related ArticlesA commentary on "Cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery, Health Economic Evaluation" (Int J Surg 2019; Oct 8. pii: S1743-9191(19)30264-X [Epub ahead of print]). What is the real impact of a Quality Improvement (QI) Programme for emergency abdominal surgery in quality of life? Int J Surg. 2019 Nov 02;: Authors: Iuamoto LR, Meyer A PMID: 31689558 [PubMed - as supplied...
Thu Nov 07, 2019 20:57
Related ArticlesA Commentary on "A novel hybrid fixation versus dual plating for both-bone forearm fractures in older children: A prospective comparative study" (Int. J. Surg. 2019;70:19-24). Int J Surg. 2019 Nov 02;: Authors: Wang X, Cai L PMID: 31689557 [PubMed - as supplied by publisher]
Thu Nov 07, 2019 20:57
Related ArticlesA Commentary on "Robotic versus laparoscopic liver resection in complex cases of left lateral sectionectomy" (Int J Surg 2019; 67: 54-60). Int J Surg. 2019 Nov 02;: Authors: Zhang W PMID: 31689556 [PubMed - as supplied by publisher]
Thu Nov 07, 2019 20:57
Related ArticlesSuctioning versus traditional minimally invasive percutaneous nephrolithotomy to treat renal staghorn calculi: a case-matched comparative study. Int J Surg. 2019 Nov 02;: Authors: Zhu Z, Cui Y, Zeng H, Li Y, He C, Chen J, Zeng F, Li Y, Chen Z, Chen H Abstract BACKGROUND: Staghorn calculi remain a treatment challenge for urologists. The aim of the study was to compare the treatment outcomes of suctioning minimally invasive percutaneous...
Thu Nov 07, 2019 20:57
Related ArticlesReply letter to: "A Commentary on "Minimally invasive percutaneous nephrolithotomy versus retrograde intrarenal surgery in surgical management of upper urinary stones - A systematic review with meta-analysis" (Int J Surg 2019;71:1-11)". Int J Surg. 2019 Nov 02;: Authors: Jiao B, Luo Z, Zhang G, Lai S PMID: 31689554 [PubMed - as supplied by publisher]
Thu Nov 07, 2019 20:57
Related ArticlesEvidence of a Vestibular Origin for Crossed-Sternocleidomastoid Muscle Responses to Air-Conducted Sound. Ear Hear. 2019 Oct 31;: Authors: Taylor RL, Winton RW, Rosengren SM, Argaet EC, Welgampola MS Abstract OBJECTIVES: Small, excitatory surface potentials can sometimes be recorded from the contralateral sternocleidomastoid muscle (SCM) following monaural acoustic stimulation. Little is known about the physiological properties of these...
Thu Nov 07, 2019 20:54
Related ArticlesThe Medial Canthus Reference Electrode Is not Electrically Indifferent to the Ocular Vestibular Evoked Myogenic Potential. Otol Neurotol. 2018 12;39(10):e1069-e1077 Authors: Piker EG, Jacobson GP, Makowiec KF, Atabek PM, Krolewicz S Abstract OBJECTIVE: To determine whether a reference electrode placed over the contralateral medical canthus is electrically indifferent to the ocular vestibular evoked myogenic potential (oVEMP). ...
Thu Nov 07, 2019 20:54
Related ArticlesAn update on potentials and promises of T cell co-signaling molecules in transplantation. J Cell Physiol. 2019 Nov 06;: Authors: Mardomi A, Mohammadi N, Khosroshahi HT, Abediankenari S Abstract The promising outcomes of immune-checkpoint based immunotherapies in cancer have provided a proportional perspective ahead of exploiting similar approaches in allotransplantation. Belatacept (CTLA-4-Ig) is an example of costimulation blockers successfully...
Thu Nov 07, 2019 20:54
Related ArticlesVibration of osteoblastic cells using a novel motion-control platform does not acutely alter cytosolic calcium, but desensitizes subsequent responses to extracellular ATP. J Cell Physiol. 2019 Nov 06;: Authors: Lorusso D, Nikolov HN, Holdsworth DW, Dixon SJ Abstract Low-magnitude high-frequency mechanical vibration induces biological responses in many tissues. Like many cell types, osteoblasts respond rapidly to certain forms of mechanostimulation,...
Thu Nov 07, 2019 20:54
Related ArticlesPCBP2 promotes the development of glioma by regulating FHL3/TGF-β/Smad signaling pathway. J Cell Physiol. 2019 Nov 06;: Authors: Mao J, Sun Z, Cui Y, Du N, Guo H, Wei J, Hao Z, Zheng L Abstract The purpose of this study was to investigate the role of Poly (C)-binding protein 2 (PCBP2) and the related signaling pathway in glioma progression. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were...
Thu Nov 07, 2019 20:54
Related ArticlesThe landscape of immune checkpoint inhibitor plus chemotherapy versus immunotherapy for advanced non-small-cell lung cancer: A systematic review and meta-analysis. J Cell Physiol. 2019 Nov 06;: Authors: Wang C, Qiao W, Jiang Y, Zhu M, Shao J, Wang T, Liu D, Li W Abstract BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide and the prognosis remains poor. The recent introduction of the immune checkpoint inhibitor...
Thu Nov 07, 2019 20:54
Related ArticlesMesenchymal stem cells as carrier of the therapeutic agent in the gene therapy of blood disorders. J Cell Physiol. 2019 Nov 06;: Authors: Shomali N, Gharibi T, Vahedi G, Mohammed RN, Mohammadi H, Salimifard S, Marofi F Abstract Nonhematopoietic stem cells as a delivery platform of therapeutic useful genes have attracted widespread attention in recent years, owing to gained a long lifespan, easy separation, high proliferation, and high...
Thu Nov 07, 2019 20:54
Related ArticlesPosttranscriptional regulation of MMP-9 by HuR contributes to IL-1β-induced pterygium fibroblast migration and invasion. J Cell Physiol. 2019 Nov 06;: Authors: Cui YH, Feng QY, Liu Q, Li HY, Song XL, Hu ZX, Xu ZY, Li JH, Li MJ, Zheng WL, Li ZJ, Pan HW Abstract Inflammation is considered to be critical in the pterygium progression and recurrence. However, the underlying molecular mechanism is not well understood. Herein, we investigated...
Thu Nov 07, 2019 20:54
Related ArticlesAstrocyte elevated gene 1 (AEG-1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma. J Cell Physiol. 2019 Nov 06;: Authors: Zhu HD, Liu L, Deng H, Li ZB, Sheng JQ, He XX, Tian DA, Li PY Abstract Astrocyte elevated gene 1 (AEG-1) is overexpressed in hepatocellular carcinoma (HCC) and is strongly associated with tumor metastasis. Anoikis resistance and autophagy may play an important role in the...
Thu Nov 07, 2019 20:54
Related ArticlesSignatures of altered DNA methylation gene expression after central and peripheral nerve injury. J Cell Physiol. 2019 Nov 06;: Authors: Shi G, Zhou X, Wang X, Zhang X, Zhang P, Feng S Abstract Nerve damage can lead to movement and sensory dysfunction, with high morbidity and disability rates causing severe burdens on patients, families, and society. DNA methylation is a kind of epigenetics, and a great number of previous studies have...
Thu Nov 07, 2019 20:54
Related ArticlesRecurrence of benign phonotraumatic vocal fold lesions after microlaryngoscopy. Laryngoscope. 2019 Nov 06;: Authors: Lee M, Sulica L Abstract OBJECTIVES: To determine recurrence rates for benign phonotraumatic vocal fold lesions after microlaryngoscopic surgery. STUDY DESIGN: Retrospective review. METHODS: Records of adults who underwent microlaryngoscopy between 2006 and 2017 for vocal fold cysts, midfold masses, polyps,...
Thu Nov 07, 2019 20:53
Abstract Following the submission of application EFSA‐GMO‐RX‐013 under Regulation (EC) No 1829/2003 from Syngenta Crop Protection NV/SA, the EFSA Panel on Genetically Modified Organisms (GMO) was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect‐resistant genetically modified maize MIR604, for food and feed uses, excluding cultivation within the EU. The data received in the context of this renewal application...
Thu Nov 07, 2019 20:51
Abstract Following the submission of application EFSA‐GMO‐RX‐015 under Regulation (EC) No 1829/2003 from Bayer Agriculture BVBA, the EFSA Panel on Genetically Modified Organisms (GMO Panel) was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect‐resistant genetically modified maize MON 89034, for food and feed uses, excluding cultivation within the EU. The data received in the context of this renewal application...
Thu Nov 07, 2019 16:50
Abstract Maize MON 87427 × MON 89034 × MIR162 × MON 87411 (four‐event stack maize) was produced by conventional crossing to combine four single events: MON 87427, MON 89034, MIR162 and MON 87411. The genetically modified organism (GMO) Panel previously assessed the four single maize events and four of the subcombinations and did not identify safety concerns. No new data on the single maize events or the four subcombinations that could lead to modification of the original conclusions on their safety...
Thu Nov 07, 2019 16:49
Abstract ECONASE® XT is an enzyme based on endo‐1,4‐β‐xylanase produced by a genetically modified strain of Trichoderma reesei ■■■■■. The additive is currently authorised for use in chickens for fattening or reared for laying, turkeys for fattening or reared for breeding, laying hens, weaned piglets, pigs for fattening and minor poultry species. This scientific opinion concerns the renewal of the authorisation of the additive when used in weaned piglets, chickens for fattening, chickens reared for...
Thu Nov 07, 2019 16:01
Abstract The European Commission asked EFSA for an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a l‐lysine monohydrochloride (HCl, minimum 98.5%) and of a concentrated liquid l‐lysine (base, minimum 50%) produced by genetically modified strains of Corynebacterium glutamicum (NRRL‐B‐67439 or NRRL B‐67535). They are intended to be used in feed or water for drinking for all animal species and categories. Neither viable cells of the production...
Thu Nov 07, 2019 16:00
Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a feed additive turkeys for fattening, turkeys reared for breeding and minor poultry species. The additive is a preparation of 6‐phytase produced by a genetically modified strain of Komagataella phaffii and has been previously assessed by the...
Thu Nov 07, 2019 16:00
Related ArticlesSolution equilibrium, structural and cytotoxicity studies on Ru(η6-p-cymene) and copper complexes of pyrazolyl thiosemicarbazones. J Inorg Biochem. 2019 Oct 22;202:110883 Authors: Dömötör O, Kiss MA, Gál GT, May NV, Spengler G, Nové M, Gašparović AČ, Frank É, Enyedy ÉA Abstract Solution chemical properties of two bidentate pyrazolyl thiosemicarbazones 2-((3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinecarbothioamide (Me-pyrTSC),...
Thu Nov 07, 2019 20:50
Related ArticlesIntramolecular platinum migration on a peptide in gas phase during collision-induced dissociation. J Inorg Biochem. 2019 Sep 13;202:110858 Authors: Du Z, Qu Y, Farrell NP Abstract We report the migration of platinum ligand unit {Pt(en)}2 (en = ethylenediamine) on a short peptide during collision-induced dissociation fragmentation combined with the characterization of the same species by 2D [1H,15N] HSQC (Heteronuclear Single Quantum Coherence)...
Thu Nov 07, 2019 20:50
Related ArticlesPt(II) and Pd(II) complexes with a thiazoline derivative ligand: Synthesis, structural characterization, antiproliferative activity and evaluation of pro-apoptotic ability in tumor cell lines HT-29 and U-937. J Inorg Biochem. 2019 Oct 22;202:110870 Authors: Fernández-Delgado E, de la Cruz-Martínez F, Galán C, Franco L, Espino J, Viñuelas-Zahínos E, Luna-Giles F, Bejarano I Abstract Eluding apoptosis represents the hallmark of tumoral...
Thu Nov 07, 2019 20:50
Related ArticlesNew polynuclear 1,5-naphthyridine-silver(I) complexes as potential antimicrobial agents: The key role of the nature of donor coordinated to the metal center. J Inorg Biochem. 2019 Oct 23;203:110872 Authors: Đurić S, Vojnovic S, Pavic A, Mojicevic M, Wadepohl H, Savić ND, Popsavin M, Nikodinovic-Runic J, Djuran MI, Glišić BĐ Abstract New polynuclear silver(I) complexes with 1,5-naphthyridine (1,5-naph), [Ag(NO3)(1,5-naph)]n (Ag1), [Ag(CF3COO)(1,5-naph)]n...
Thu Nov 07, 2019 20:50
Related ArticlesIdentification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents. J Inorg Biochem. 2019 Oct 29;203:110909 Authors: Peng W, Hegazy AM, Jiang N, Chen X, Qi HX, Zhao XD, Pu J, Ye RR, Li RT Abstract Glioma stem cells (GSCs) are thought to be responsible for the recurrence and invasion of glioblastoma multiform (GBM), which have been evaluated and exploited as the therapeutic target...
Thu Nov 07, 2019 20:50
Related ArticlesBeta-lactam allergy in Chinese patients and factors predicting genuine allergy. World Allergy Organ J. 2019 Aug;12(8):100048 Authors: Li PH, Siew LQC, Thomas I, Watts TJ, Ue KL, Rutkowski K, Lau CS Abstract Introduction: Beta-lactams (BL) are the most frequently reported drug allergy, but the vast majority of patients are found not to be genuinely allergic after evaluation. Few studies have investigated the clinical predictors of...
Thu Nov 07, 2019 20:50
Related ArticlesAngioedema and prescribing of omalizumab for chronic urticaria in countries with limited financial resources. World Allergy Organ J. 2019 Nov;12(11):100079 Authors: Popov TA, Church MK, Christoff G, Maurer M PMID: 31687062 [PubMed]
Thu Nov 07, 2019 20:50
Related ArticlesThe regulatory role of HIF-1 in tubular epithelial cells in response to kidney injury. Histol Histopathol. 2019 Nov 06;:18182 Authors: Qiu Y, Huang X, He W Abstract The high sensitivity to changes in oxygen tension makes kidney vulnerable to hypoxia. Both acute kidney injury and chronic kidney disease are almost always accompanied by hypoxia. Tubular epithelial cells (TECs), the dominant intrinsic cells in kidney tissue, are believed...
Thu Nov 07, 2019 20:48
Related ArticlesEwing's sarcoma of the cervix: A case report and review of literature. Histol Histopathol. 2019 Nov 05;:18181 Authors: Zhang Y, Nong W, Ren Y, Jiang J, Zhang H, Meng L, Li Q, Zhang Q, Wang X, Wang Y, Liu C, Li F Abstract Ewing's sarcoma (ES) is a small cell malignant tumor that occurs in the bone of children or adolescents. ES can also occur in extraskeletal organs, such as the pancreas, thyroid, liver, proximal phalanx, and, rarely,...
Thu Nov 07, 2019 20:48
Non-immersive video games are currently being used as technological rehabilitation tools for individuals with Parkinson’s disease (PD). The aim of this feasibility study was to evaluate the effectiveness of th...
Wed Nov 06, 2019 02:00
ABSTRACT Soft tissue myoepithelial tumors are very rare mesenchymal tumors that are currently categorized as miscellaneous neoplasms with uncertain differentiation. Although the molecular pathogenesis of soft tissue myoepithelial tumors remains unclear, EWSR1 gene fusions with a variety of partner genes are regarded as one of the major pathogenic driver events in these tumors. We herein present a case of a deep soft tissue malignant myoepithelial tumor arising in the thigh with multiple pulmonary...
Thu Nov 07, 2019 18:17
The cover image is based on the Original Article A basal‐enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model by Xiying Fan, Glen Bjerke, Rui Yi et al., https://doi.org/10.1002/mc.23112.
Thu Nov 07, 2019 14:55
To the Editor The basis of an elective neck dissection was given by Weiss et al using a mathematical model, wherein whenever the risk of nodal metastasis was more than 20%, outcomes were poorer and called for a neck dissection.
Thu Nov 07, 2019 02:00
This case series assesses the rate of and risk factors for occult contralateral nodal disease in patients with human papillomavirus−related base of tongue oropharyngeal squamous cell carcinoma undergoing transoral surgery and bilateral neck dissection.
Thu Nov 07, 2019 02:00
A female neonate was born with stridor and respiratory distress, which required intubation. Laryngoscopy and bronchoscopy revealed a large laryngeal mass that was soft and fluctuant on palpation. What is your diagnosis?
Thu Nov 07, 2019 02:00
This cost-effectiveness analysis examines the cost-effectiveness of stapedectomy vs hearing aid use for the treatment of otosclerosis.
Thu Nov 07, 2019 02:00
In this Viewpoint, Ehab Hanna, MD, president of the American Head and Neck Society, gives the 2019 annual meeting address.
Thu Nov 07, 2019 02:00
The management of otosclerosis is viewed by many as the sine qua non of an otologic practice. From the elegant otopathologic descriptions by Ádám Politzer in the 19th century to surgical breakthroughs by Julius Lempert and John Shea Jr in the mid-20th century, otosclerosis and its surgical management have inspired generations of students, researchers, and surgeons alike. The allure of stapedectomy may be, in part, the elegant tightrope walk to fix hearing loss along with the anticipation of a surgeon...
Thu Nov 07, 2019 02:00
Abstract Introduction: Warthin tumors are the second most common benign tumors of the parotid gland. We examined the clinical features of Warthin tumors in our hospital, and analyzed the consistency within the literatures. Objective: The aim of this study is to analyze the clinical features of Warthin tumors in our 10-year experience of 118 Warthin tumors undergoing surgery at a single institute. Methods: From December 2006 to December 2016, 110 patients who underwent surgical treatment for Warthin...
Thu Nov 07, 2019 20:18
Abstract Introduction: Radiologic evaluation is mandatory to assess the type of endoscopic approach concerning sinonasal pathology and reconstruction of fractured defects before any treatment modalities are instituted related to medial wall of the orbit. Objective: The goal was to provide improved understanding of the lamina papyracea variations and the relationship with the orbital morphometry. Methods: This retrospective study was performed using computed tomography scans of 200 orbits and results...
Thu Nov 07, 2019 20:18
Abstract Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss, there is no report, till date, about the association of glutamate metabotropic receptor 7 polymorphisms with sensorineural hearing loss at different ages. Objective: To test the association between the single nucleotide polymorphisms rs11928865...
Thu Nov 07, 2019 20:18
Abstract Introduction: The most common cause of septoplasty failure is inferior turbinate hypertrophy that is not treated properly. Several techniques have been described to date: total or partial turbinectomy, submucosal resection (surgical or with a microdebrider), with turbinate outfracture being some of those. Objective: In this study, we compared the pre- and postoperative lower turbinate volumes using computed tomography in patients who had undergone septoplasty and compensatory lower turbinate...
Thu Nov 07, 2019 20:18
Abstract Introduction: Despite recent advancement in the prediction of cochlear implant outcome, the benefit of bilateral procedures compared to bimodal stimulation and how we predict speech perception outcomes of sequential bilateral cochlear implant based on bimodal auditory performance in children remain unclear. Objectives: This investigation was performed: (1) to determine the benefit of sequential bilateral cochlear implant and (2) to identify the associated factors for the outcome of sequential...
Thu Nov 07, 2019 20:18
Abstract Introduction: Systemic inflammatory biomarkers are promising predictive and prognostic factors for solid cancers. The neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio are used to predict inflammation and used as biomarker in several malignancies. Objective: The purpose of this study was to demonstrate the diagnostic, predictive and prognostic role of neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio in patients with laryngeal neoplasms. Methods: A...
Thu Nov 07, 2019 20:18
Abstract Introduction: There is still no general method for discriminating between benign and malignant leukoplakia and identifying vocal fold leukoplakia. Objective: To evaluate the reliability of a morphological classification and the correlation between morphological types and pathological grades of vocal fold leukoplakia. Methods: A total of 375 patients with vocal fold leukoplakia between 2009 and 2015 were retrospectively reviewed. Two observers divided the vocal fold leukoplakia into flat...
Thu Nov 07, 2019 20:18
Abstract Introduction: Bone-anchored hearing aids are currently well-established solutions for treatment of hearing-impaired patients. Objective: To evaluate the surgery of the Baha® Attract system, healing process and soft tissue condition after the processor activation. Methods: 125 patients implanted with the Baha® Attract system during a 3 year period in a single ENT department were analysed. Evaluated parameters comprised: details of surgery, healing process and soft tissue condition at the...
Thu Nov 07, 2019 20:18
Abstract Introduction: The treatment of laryngeal squamous cell carcinoma needs accurate risk stratification, in order to choose the most suitable therapy. The prognostic significance of resection margin is still highly debated, considering the contradictory results obtained in several studies regarding the survival rate of patients with a positive resection margin. Objective: To evaluate the prognostic role of resection margin in terms of survival and risk of recurrence of primary tumour through...
Thu Nov 07, 2019 20:18
Abstract Introduction: Tinnitus is a subjective auditory symptom usually associated with a sound, even in the absence of external sound sources. Its diagnosis is complex, and some of the forms of measurement alone or in combination, include self-assessment questionnaires, such as the tinnitus handicap inventory, the visual analog scale and/or pitch and loudness matching. Objective: To analyze the correlation among three tinnitus measurement methods: tinnitus handicap inventory, visual analog scale...
Thu Nov 07, 2019 20:18
Abstract Introduction: The fine-needle cytology is being used as a first line of investigation in the diagnosis of head and neck swellings, as it is simple, cost effective and less invasive as compared to biopsy. Objective: The aims of this study were to evaluate the results of the fine-needle non-aspiration cytology of cervical lymphadenopathy and to study the factors influencing the rate of non-diagnosis results. Methods: This retrospective study was conducted on selected patients with cervical...
Thu Nov 07, 2019 20:18
Abstract Introduction: The post-laryngectomy state is characterized by several alterations in lung function. A reliable estimation of lung function can be very useful in laryngectomees to prevent postoperative complications and to evaluate the results of the treatment. Objective: Characterize the presence of respiratory functional disorders and the functional pattern of laryngectomees through the use of an extratracheal device. Methods: This transversal study included 50 patients submitted to...
Thu Nov 07, 2019 20:18
Abstract Introduction: Random noise stimulation was reported as the more effective and safer type of electrical stimulation techniques in relieving tinnitus symptoms. The multisite protocol of transcranial random noise stimulation has shown additional favorable effects. Objective: Here we will discuss the role of applying eight sessions of multisite transcranial random noise stimulation in decreasing tinnitus loudness and annoyance without exerting additional adverse effects. Methods: Twenty-nine...
Thu Nov 07, 2019 20:18
Abstract Introduction: The side effects of antithyroid drugs are well known. Antineutrophil cytoplasmic antibody-associated vasculitis is a severe adverse reaction. Most studies evaluating antineutrophil cytoplasmic antibodies related to antithyroid drugs have been carried out with patients treated with propylthiouracil, but less information is available for methimazole. Furthermore, most studies that investigated antineutrophil cytoplasmic antibodies related to antithyroid drugs were conducted...
Thu Nov 07, 2019 20:18
Abstract Introduction: Possible associations between Zika virus infection and hearing loss were observed during the epidemic in the Americas. Objective: To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired Zika virus infection. Methods: Bibliographic research conducted in March/2018-April/2019 at the main available databases. Article selection, data extraction and quality evaluation were carried out by two independent reviewers....
Thu Nov 07, 2019 20:18
Abstract Introduction: Possible associations between Zika virus infection and hearing loss were observed during the epidemic in the Americas. Objective: To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired Zika virus infection. Methods: Bibliographic research conducted in March/2018-April/2019 at the main available databases. Article selection, data extraction and quality evaluation were carried out by two independent reviewers....
Thu Nov 07, 2019 20:18
Abstract Introduction: Possible associations between Zika virus infection and hearing loss were observed during the epidemic in the Americas. Objective: To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired Zika virus infection. Methods: Bibliographic research conducted in March/2018-April/2019 at the main available databases. Article selection, data extraction and quality evaluation were carried out by two independent reviewers....
Thu Nov 07, 2019 20:18
Abstract Introduction: Possible associations between Zika virus infection and hearing loss were observed during the epidemic in the Americas. Objective: To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired Zika virus infection. Methods: Bibliographic research conducted in March/2018-April/2019 at the main available databases. Article selection, data extraction and quality evaluation were carried out by two independent reviewers....
Thu Nov 07, 2019 20:18
Abstract Introduction: Possible associations between Zika virus infection and hearing loss were observed during the epidemic in the Americas. Objective: To describe the auditory alterations, pathogenesis and recommendations for follow-up in individuals with prenatal or acquired Zika virus infection. Methods: Bibliographic research conducted in March/2018-April/2019 at the main available databases. Article selection, data extraction and quality evaluation were carried out by two independent reviewers....
Thu Nov 07, 2019 20:18
A microfluidic assembly method based on microfluidic chip and capillary device was developed for deftly manipulating microfluid that can be employed to create multi‐compartmental particles. he ingenious microfluidic chip design endows the particles with regulable internal structure. The high degree of control afforded by the capillary device achieves the ideal particle geometry. By adjusting the microstructure of the chip, the diameter of the capillary, the gap length between the two microfluidic...
Thu Nov 07, 2019 20:09
Autoxidation of benzaldehyde in the presence of uranium results in the in situ generation of organic peroxide and the isolation of novel nanotubular uranyl peroxide phases. Owing to the constant low‐level production of peroxide, the uranium phase is formed in remarkably high yield and uniform structure. Abstract Current synthetic pathways for uranyl peroxide materials introduce high initial concentrations of aqueous H2O2 that decline over time. Alternatively, in situ generation of organic peroxide...
Thu Nov 07, 2019 20:09
Site‐selective functionalization of C–H bonds in small complex molecules is a long‐standing challenge in organic chemistry. Herein, we report a broadly‐applicable and site‐selective aromatic C–H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two‐step C–H 18F‐fluorination of a series of marketed small‐molecule drugs.
Thu Nov 07, 2019 15:46
Oxylipins are key lipid mediators of important brain processes, including pain, sleep, oxidative stress and inflammation. For the first‐time, an in‐depth profile of up to 52 oxylipins can be obtained from the brains of awake moving animals using in vivo solid‐phase microextraction (SPME) chemical biopsy tool in combination with liquid chromatography – high resolution mass spectrometry. Among these, 23 oxylipins are detectable in the majority of healthy wildtype samples. This new approach successfully...
Thu Nov 07, 2019 15:34
C−H(is) functionalization: The first example of chemoselective C‐2 alkylation of histidine‐containing peptides through a mild Minisci‐type reaction is described. This new approach enables the rapid exploration of chemical diversity around this underexplored residue and provides a novel opportunity for the labelling and conjugation of peptides. Abstract The late‐stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling...
Thu Nov 07, 2019 14:56
The milling ball is the catalyst: In a mechanochemical Suzuki polymerization of 4‐bromo‐ or 4‐iodophenylboronic acid yielding poly(para‐phenylene) the classical Pd catalysts could be replaced by solid Pd milling balls, enabling outstanding degrees of polymerization. Abstract The milling ball is the catalyst. We introduce a palladium‐catalyzed reaction inside a ball mill, which makes catalyst powders, ligands, and solvents obsolete. We present a facile and highly sustainable synthesis concept...
Thu Nov 07, 2019 14:54
Conversion of carbon monoxide to high value‐added ethylene with high selectivity by traditional syngas conversion process is always challenging because of the limitation of Anderson‐Schulz‐Flory distribution. Herein we report a direct electrocatalytic process for highly selective ethylene production from CO reduction with water over the Cu catalysts at room temperature and ambient pressure. An unprecedented 52.7% Faradaic efficiency of ethylene formation from CO electroreduction has been achieved...
Thu Nov 07, 2019 14:40
With the goal of imposing shape and structure on supramolecular gels, we combine a low molecular weight gelator (LMWG) with the polymer gelator (PG) calcium alginate in a hybrid hydrogel. By imposing temporal and thermal control of the orthogonal gelation methods, the system either forms an extended inter‐penetrating network or core‐shell structured gel beads – a rare example of a supramolecular gel formulated inside discrete gel spheres. The self‐assembled LMWG retains its unique properties within...
Thu Nov 07, 2019 14:09
The iridium half‐sandwich complex [Ir(η 5 :κ 1 ‐C 5 Me 4 CH 2 py)(2‐phenylpyridine)]PF 6 is highly cytotoxic: ca. 15‐250x more potent than clinically used cisplatin in several cancer cell lines tested. Unequivocal determination of the intracellular fate of the compound is mandatory to rationalize its potency and improve metallodrug design. We have developed a correlative 3D cryo X‐ray imaging approach to specifically localize the iridium distribution within the whole hydrated cell at...
Thu Nov 07, 2019 13:10
Exclusively intramolecular: The conformationally induced activation of the amide bond, the idea behind the “CyClick” strategy, is exploited for the macrocyclization of peptides and precludes the formation of dimers or oligomers via intermolecular reactions. This method is tolerant to variety of peptide aldehydes and has been applied for the synthesis of 12‐ to 23‐membered rings. Abstract Here, we report a novel “CyClick” strategy for the macrocyclization of peptides that works in an exclusively...
Thu Nov 07, 2019 12:52
On the water front: The injection control technique forms a capillary‐water‐like state in a reduced graphene oxide (rGO) foam solar absorber resulting in high performance solar steam generation. The water production rate reached 2.40 kg m−2 h−1. Abstract Solar‐driven interfacial water evaporation yield is severely limited by the low efficiency of solar thermal energy. Herein, the injection control technique (ICT) achieves a capillary water state in rGO foam and effectively adjusts the water...
Thu Nov 07, 2019 12:49
Strong N−X⋅⋅⋅−O−N+ (X=I, Br) halogen bonds, by using oxygen as halogen bond acceptor, are obtained from N‐halosaccharins and aromatic N‐oxides. The donor–acceptor‐dependent tunable X⋅⋅⋅O distances are investigated by using computational methods, solution NMR spectroscopy, and X‐ray diffraction analysis. Abstract A study of the strong N−X⋅⋅⋅−O−N+ (X=I, Br) halogen bonding interactions reports 2×27 donor×acceptor complexes of N‐halosaccharins and pyridine N‐oxides (PyNO). DFT calculations were...
Thu Nov 07, 2019 12:48
Separation into rich and poor: The formation of supramolecular nanofibrils from amphiphilic amino acids and short peptides follows a nucleation–elongation mechanism mediated by liquid–liquid phase separation. The initial formation of solute‐poor and solute‐rich liquid droplets is entropy driven, while the transition of liquid droplets to nanofibrils is dominated by enthalpic interactions. Abstract The transition of peptides and proteins from the solution phase into fibrillar structures is a...
Thu Nov 07, 2019 12:46
Zr‐MOF membranes for hydrogen separation have been developed and tuned. The MOF membranes have shown great selectivity towards hydrogen, which is due to the molecular sieving effect when the bulkier ligands were used to narrow down the pore apertures of the MOFs. Abstract The effect of organic ligands on the separation performance of Zr based metal–organic framework (Zr‐MOF) membranes was investigated. A series of Zr‐MOF membranes with different ligand chemistry and functionality were synthesized...
Thu Nov 07, 2019 12:46
A long‐standing secret unveiled: The mammalian lectin responsible for the recognition of the core fucose on N‐glycans is Dectin‐1, a known anti‐β‐glucan lectin. Dectin‐1 recognizes aromatic amino acids adjacent to the N‐terminal asparagine at the glycosylation site as well as a core fucose. This heterovalent interaction is the origin of the efficacy and unique recognition pattern of Dectin‐1. Abstract The core fucose, a major modification of N‐glycans, is implicated in immune regulation, such...
Thu Nov 07, 2019 12:45
Alkyne‐directed chemo‐ and enantioselectivity: Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14‐C23 of pladienolide D in half the steps previously required. Abstract Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic...
Thu Nov 07, 2019 12:44
Molecule‐engineered 3D electrode: A self‐supported electrode of Fe3O4 nanoarrays grown on Ti mesh with grafted Co corroles shows improved activity, durability, and atom efficiency for oxygen electrolysis at neutral pH. A high‐performance neutral Zn‐air battery using this electrode is reported, the first molecule‐based metal‐air battery. Abstract Electrodes for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are required in energy conversion and storage technologies. An assembly...
Thu Nov 07, 2019 12:44
Squaring up: A continuous‐flow approach has been developed to photoisomerize 1,2‐azaborines to cis‐1,2‐aminoborylated cyclobutanes and analogues bearing quaternary carbon centers. Further derivatizations at the borylated position led to a series of 2‐functionalized aminocyclobutanes. FG=functional group. Abstract We provide a seminal example of the utility of the 1,2‐azaborine motif as a 4C+1N+1B synthon in organic synthesis. Specifically, conditions for the practically scalable photoisomerization...
Thu Nov 07, 2019 12:43
Affairs of state: Aliphatic polyesters prepared from ethylene oxide and maleic anhydride undergo reversible transformation between amorphous and crystalline states through cis–trans isomerization of the C=C bonds in the polymer backbone without any change in either the molecular weight or dispersity of the polymer. A similar transformation was also observed with chiral unsaturated polyesters. Abstract An aliphatic polyester has been prepared from ethylene oxide and maleic anhydride that undergoes...
Thu Nov 07, 2019 12:28
Connecting the dots: Energy transfer (ET) from carbon dots embedded in crystalline Mn‐containing open‐framework matrices results in high‐efficiency red room‐temperature phosphorescence (RTP) emissions. Varying the carbon dot precursors and the heteroatom coordination geometries enables the emissions to be tuned from red to green/yellow. Abstract High‐efficiency red room‐temperature phosphorescence (RTP) emissions have been achieved by embedding carbon dots (CDs) in crystalline Mn‐containing...
Thu Nov 07, 2019 12:27
An azobenzene setup was used to examine London dispersion in conjunction with solvent interactions between linear alkyl chains. 1H NOESY NMR analysis indicated additional long‐range interactions with the opposite phenyl core in the Z‐isomer. This work provides rare insight into the stabilizing contributions of highly flexible groups in an intra‐ as well as an intermolecular setting. Abstract Interactions on the molecular level control structure as well as function. Especially interfaces between...
Thu Nov 07, 2019 12:25
Short, DNA‐based fluorophore labels that transiently and repeatedly bind to DNA‐labeled antibodies enable super‐resolution STED imaging. Compared to covalent labels, dynamic labels constantly exchange between target‐bound and free states, which bypasses photobleaching and subsequently increases image quality and information content. Abstract Photobleaching is a major challenge in fluorescence microscopy, in particular if high excitation light intensities are used. Signal‐to‐noise and spatial...
Thu Nov 07, 2019 12:24
White magic: White phosphorus can be selectively activated and functionalized at a low‐valent α‐diimine‐cobalt complex. Treatment of the resulting pentaphosphido complexes (P5) with cyanide ions releases rare cyanodiphosphan‐1‐ide anions (P2) and forms an anionic cobalt complex with a triphosphido ligand (P3). Abstract The activation of white phosphorus (P4) by transition‐metal complexes has been studied for several decades, but the functionalization and release of the resulting (organo)phosphorus...
Thu Nov 07, 2019 12:22
Biopsies from blood samples: In this minireview, the development of sensors for non‐invasive cancer diagnosis and management, an approach referred to as “liquid biopsy”, is discussed. This application has very demanding performance requirements as high sensitivity and specificity are needed to detect bloodborne nucleic acids in patient samples. Electrochemical and spectroscopic approaches that demonstrate potential for this important biomedical problem are discussed. Abstract Circulating tumour...
Thu Nov 07, 2019 12:22
Getting into shape: This Minireview gives a summary of the latest progress in characterizing and modeling the equilibrium shape of metal nanoparticles (NPs) in reactive environments through the combination of state‐of‐the‐art in situ environmental transmission electron microscopy (ETEM) experiments and the multiscale structure reconstruction (MSR) model. Abstract The shape of metal nanoparticles (NPs) is one of the key factors determining their catalytic reactivity. Recent in situ TEM observations...
Thu Nov 07, 2019 12:21
Nitride spinel: At 47 GPa and 1800 K phenakite‐type BeP2N4 was transformed into the spinel‐type form of BeP2N4 using a laser‐heated diamond anvil cell. Its crystal structure was investigated using pressure‐dependent in situ synchrotron XRD measurements and its isothermal bulk modulus was determined to >300 GPa, which renders spinel‐type BeP2N4 an ultraincompressible material. Abstract Owing to its outstanding elastic properties, the nitride spinel γ‐Si3N4 is of considered interest for materials...
Thu Nov 07, 2019 12:18
We demonstrate controlled charge trapping and release, accompanied by multiple color changes in a metallo‐organic bilayer. The dual functionality of the metallo‐organic materials provides a fundamental insight into the metal‐mediated electron transport pathways.The electrochemical processes are accompanied by distinct, four color–to–color transitions: red, transparent, orange, and brown. The bilayer consists of two elements: (i) a nanoscale gate consisting of a layer of well‐defined polypyridyl ruthenium...
Thu Nov 07, 2019 11:35
The discovery of biologically active small molecules requires sifting through large amounts of data to identify unique or unusual arrangements of atoms. Here, we develop, test and evaluate an atom‐based sort to identify novel features of secondary metabolites and demonstrate its use to evaluate novelty in marine microbial and sponge extracts. This study outlines an important ongoing advance towards the translation of autonomous systems to identify, and ultimately elucidate, atomic novelty within...
Wed Nov 06, 2019 21:04
Abstract Agenesis of the corpus callosum (ACC) is a common prenatally‐detected brain anomaly. Recently, an association between mutations in the DCC Netrin 1 receptor (DCC) gene and ACC, with or without mirror movements, has been demonstrated. In this manuscript, we present a family with a novel heterozygous frameshift mutation in DCC, review the available literature, and discuss the challenges involved in the genetic counseling for recently discovered disorders with paucity of medical information....
Thu Nov 07, 2019 14:10
Abstract RASopathies are a group of phenotypically overlapping disorders that arise from dysregulation of the RAS/MAPK pathway. These disorders include Noonan syndrome, Costello syndrome, cardiofaciocutaneous syndrome, and neurofibromatosis‐Type 1. While somatic mutations in the three human Ras genes (KRAS, HRAS, and NRAS) are a common finding in a variety of cancers, germline mutations in each of the these genes cause developmental RASopathy phenotypes with mutations in specific genes typically...
Thu Nov 07, 2019 14:00
Ischemic strokes can cause havoc in the brain, but early and properly directed treatment can mitigate a lot of damage. While there are a number of options to unclog blocked arteries, the potential to provide additional drug therapy remains mostly unexplored because of the difficulty in getting medications past the blood-brain barrier. Now, researchers at the University of Manchester are reporting that they were able to pass liposomes across the tiny tears in the vasculature that occur...
Thu Nov 07, 2019 19:45
Philips is releasing a new vital signs monitor designed to offer advanced warning on worsening patient status within general care clinical environments. The EarlyVue VS30 is a newly FDA cleared device featuring Philips’ Early Warning Scoring technology that spots tell-tale signs of degradation in patient health, and notifies clinicians sometimes even hours before the onset of symptomatic deterioration. The technology allows for earlier intervention and the prevention of serious events. ...
Thu Nov 07, 2019 18:13
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