Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01964B, PaperYangyang Li, Yuqiu Wang Yuqiu Wang, Cuicui Fu, Yan Wu, Haiyan Cao, Wenbin Shi, Young Mee JungA simple enzyme-free method based on surface-enhanced Raman scattering (SERS) was developed for the first time to detect H2O2 in food by etching a self-assembled film of silver nanoparticles (Ag...The content of this RSS Feed (c) The Royal Society of Chemistry
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Abstract Background Fine needle aspiration cytology (FNAC) assisted with scrotal ultrasonography is the best preoperative diagnostic modality for palpable epididymal nodules. It also aids in their successive remedial approach as well as serves semi‐therapeutically in cystic lesions. The objectives of this study are to recognize the spectrum of pathological conditions giving rise to epididymal nodules, then to compare them with corresponding ultrasound images, and to evaluate the histological...
Thu Nov 07, 2019 16:37
Abstract Although endoscopic biopsy of a rectal submucosal nodule may be nondiagnostic, endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) can be an important tool to make diagnosis. We report a case of a female patient who had an EUS‐FNA of a submucosal nodule after a nondiagnostic rectal biopsy. The original diagnosis was erroneously rendered as concerning for necrotic neoplasm. The correct diagnosis of Solesta‐induced foreign body reaction was made on reviewing the slides once the...
Thu Nov 07, 2019 16:30
Abstract Neuroendocrine carcinoma (NEC) in the extrahepatic bile duct is extremely rare and clinically aggressive. Cytological examination of bile and/or bile duct brushing specimens plays an important role in the diagnosis of carcinoma of the extrahepatic bile duct, but only a few articles have described the cytological features of NEC in this area. Thus, we retrospectively analyzed the cytological features of NEC in bile and/or bile duct brushing specimens. Patients with a histopathological diagnosis...
Thu Nov 07, 2019 16:24
Particle therapy provides steep dose gradients to facilitate dose escalation in challenging anatomical sites which has been shown not only to improve local control but also overall survival in patients with AC...
Wed Nov 06, 2019 02:00
Publication date: Available online 6 November 2019Source: Cancer EpidemiologyAuthor(s): Raffaella Mormile
Thu Nov 07, 2019 19:20
Abstract Despite advances in medical technology, the parathyroid glands are still damaged during thyroid surgery. Our previous studies exploring methods for locating the parathyroid glands using autofluorescence have limitations, such as turning off the surgical light or requiring additional matching between the autofluorescence image and real‐surgical field‐of‐view. We developed a probe‐type parathyroid autofluorescence detector using a phase‐sensitive process and optical filtering to overcome...
Thu Nov 07, 2019 18:23
Insulin resistance is present in most, but not all, obese and elderly patients and even in some young and lean persons. It is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and probably obesity-associated cancers.…
Thu Nov 07, 2019 02:00
Abstract Purpose To explore the temporal profile of the peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced nasopharyngeal carcinoma (LANPC) and the potential prognostic value of its dynamic changes. Methods Complete blood count of 112 patients from a previous phase II study were retrospectively collected at the timepoints of...
Thu Nov 07, 2019 02:00
Publication date: Available online 6 November 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Benjamin Palla, Michael Miloro
Thu Nov 07, 2019 18:40
Publication date: Available online 6 November 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Kevin C. Lee, Keyur Naik, Steven Halepas, Sidney B. Eisig, Elie M. Ferneini
Thu Nov 07, 2019 18:40
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Jordan Lam, Darrin J. Lee, Azeem OladunjoyeBackgroundResidual hematoma after operative management of acute subdural hematoma contributes to reoperation and is cited as a reason for deferment of less invasive drainage strategies. Although local antithrombolytic therapy has been studied in intracerebral hemorrhage and chronic subdural hematoma, to date there are no reports of recombinant tissue plasminogen activator for...
Thu Nov 07, 2019 18:39
Publication date: Available online 6 November 2019Source: Journal of VoiceAuthor(s): Luise Marques da Rocha, Mara Behlau, Luciano Dias de Mattos SouzaSummaryObjectiveTo identify the progression of voice disorders and their risk factors in teachers.DesignLongitudinal quantitative study conducted in municipal schools.MethodOf the 575 teachers who participated in the baseline study, 469 were re-evaluated after 3 years of the initial study. Out of these, 152 reported having a voice disorder at baseline...
Thu Nov 07, 2019 18:39
Publication date: Available online 6 November 2019Source: Acta HistochemicaAuthor(s): Irit Allon, Michael Abba, Ilana Kaplan, Alejandro Livoff, Amram Zaguri, Oded Nahlieli, Marilena VeredAbstractAcantholytic squamous cell carcinoma (ASCC) is an uncommon variant of squamous cell carcinoma (SCC). It is characterized by a combination of typical SCC and pseudoglandular structures, dyskeratotic cells and prominent acantholysis.The purpose of this study was to analyze the histochemical and immunohistochemical...
Thu Nov 07, 2019 18:30
Publication date: Available online 6 November 2019Source: Acta HistochemicaAuthor(s): Praveenkumar Sugumaran, Vishnusekar Narayanan, Daling Zhu, Meetha Medhora, Elizabeth R. Jacobs, Yamini Chandramohan, Vimalraj Selvaraj, Anuradha DhanasekaranAbstractHypoxia reoxygenation (HR) injury perturbs structural and functional syncytium in lung tissues. It is commonly implicated in conditions such as stroke, lung transplant or severe pneumonia. In the present study, we investigated the cytoprotective action...
Thu Nov 07, 2019 18:30
Abstract Objectives The aim of the present study was to clarify the association between the degree of development of pregnancy parturition scars (PPSs) and the total number of pregnancies and parturitions (TNPPs) on the basis of new identification standards for PPS in the preauricular area. Materials and Methods Preauricular grooves were macroscopically observed on the pelves of 103 early modern males and 295 females (62 early modern females; 233 present‐day females). Three categories of...
Thu Nov 07, 2019 18:15
Background. Cancer cells undergo various rewiring of metabolism and dysfunction of epigenetic modification to support their biosynthetic needs. Although the major features of metabolic reprogramming have been elucidated, the global metabolic genes linking epigenetics were overlooked in pan-cancer. Objectives. Identifying the critical metabolic signatures with differential expressions which contributes to the epigenetic alternations across cancer types is an urgent issue for providing the potential...
Thu Nov 07, 2019 18:05
This study is to identify the circular RNA (circRNA) expression profile that is functionally related to pancreatic islet β-cell autophagy and their potential regulation mechanisms in type 2 diabetes mellitus (T2DM). T2DM rat model was constructed by administration of high-fat and high-sugar diet. β-cells were isolated from islets by flow cytometry. CircRNA expression profile in β-cells was detected by circRNA microarrays, and the differentially expressed circRNAs were identified and validated by...
Thu Nov 07, 2019 18:05
This study aims to achieve high-level soluble expression and characterization of a thermostable industrially important enzyme, i.e., beta-glucosidase (BglA; EC: 3.2.1.21), from Clostridium thermocellum (C. thermocellum) by cloning in an Escherichia coli (E. coli) expression system. BglA was expressed as a partially soluble component of total cellular protein (TCP) having a molecular weight of ∼53 kDa with 50% of it as soluble fraction. Purification in two steps, namely, heat inactivation and Ni-chromatography,...
Thu Nov 07, 2019 18:05
Background. By weekly monitoring of China’s influenza situation, Chinese National Influenza Center observed that the 2017-18 season was predominated by influenza B virus (IBV)/Yamagata. No studies regarding hospitalizations in adults with IBV infections have been performed. We aimed to describe the clinical characteristics of hospitalized patients with IBV infection in northern China. Methods. In this multicenter and retrospective study, we reviewed all consecutive adult patients with confirmed IBV...
Thu Nov 07, 2019 18:05
The mechanisms underlying severe liver injury after brain-dead (BD) donor liver transplantation (BDDLT) remain unclear. In this study, we aimed to explore the roles of lncRNAs and circRNAs in liver injury after BDDLT. Rat liver injury was detected in the sham, BD, control, and BDDLT groups. We examined the expression profiles of lncRNAs and circRNAs in the livers of the BDDLT and control group using microarray analysis. The main functions of the differentially expressed genes were analyzed by gene...
Thu Nov 07, 2019 15:30
Objectives. To explore the differences of immune disorders in peripheral blood between patients with early-onset Parkinson’s disease (EOPD) and late-onset Parkinson’s disease (LOPD). Methods. We retrospectively reviewed medical records of Parkinson’s disease (PD) patients and healthy controls between June 2002 and July 2017. At last, we included 117 PD patients who were divided into EOPD and LOPD according to whether onset age of PD was after 50 and 99 controls divided into E-Control (match for EOPD)...
Thu Nov 07, 2019 14:05
Ankle joint kinematics is mainly stabilized by the morphology of the talar dome and the articular surface of tibiofibular mortise as well as the medial and lateral ligament complexes. Because of this the bicondylar geometry of talus dome is believed to be crucial for ankle implant design. However, little data exist describing the precise anatomy of the talar dome and the talocrural joint axis. The aim of this study is to document the anatomy of the talar dome and the axis of the talocrural joint...
Thu Nov 07, 2019 14:05
Background. Both percutaneous Achilles tendon lengthening by triple hemisection and the traditional open Z-lengthening are effective methods for Achilles tendon contracture. This study aims to evaluate the efficacy and safety of this new therapeutic method, which is based on the percutaneous sliding technique with three hemi-cuts in the tendon, as compared with the traditional open Z-lengthening. Methods. Retrospective analysis of the Achilles tendon contracture cases in our hospital between January...
Thu Nov 07, 2019 12:05
Purpose. The clinical features and laboratory results of dengue-infected adult patients admitted to the hospital during the 2017 outbreak were analyzed in this study. Method. This is a cross-sectional study. 2922 patients aged 18 years or more with dengue fever in National Hospital for Tropical Diseases (NHTD) in the North and Hospital for Tropical Disease (HTD) in the South of Vietnam were recruited in this study. Result. Patients were admitted in the hospital around the year and concentrated from...
Thu Nov 07, 2019 11:05
Aim. This study evaluated whether specific actual performance could accurately predict body function levels and upper limb use in the real-life functioning of poststroke hemiparesis patients to aid in choosing the most appropriate rehabilitation exercises. Methods. We measured the time taken for poststroke patients to move small objects with the paralyzed hand and investigated how the measurement could estimate upper extremity motor impairment and hand usage during activities of daily living (ADL)....
Thu Nov 07, 2019 10:05
This paper aims to investigate the function of structural maintenance of chromosome 4 (SMC4) in the progression of hepatocellular carcinoma (HCC) under hypoxic condition. In this study, we found that suppression of SMC4 could inhibit proliferation and migration of HCC cells through inducing G1 phase arrest and affecting process of epithelial-mesenchymal transition (EMT) under hypoxic condition. Moreover, we demonstrated that SMC4 was transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1)...
Thu Nov 07, 2019 10:05
Publication date: Available online 7 November 2019Source: Gait & PostureAuthor(s): Kyong Jin Shin, Jinse Park, Samyeol Ha, Kang Min Park, Sung Eun Kim, Byung In Lee, Dong A Lee, Hee-Tae Kim, Ji-Yeon Yoon
Thu Nov 07, 2019 18:14
Publication date: Available online 7 November 2019Source: Gait & PostureAuthor(s): J Riis, F Eika, AW Blomkvist, MT Rahbek, KD Eikhof, MD Hansen, M Søndergaard, J Ryg, S Andersen, MG JorgensenAbstractBackgroundMaintaining balance is important throughout life. The Nintendo Wii Balance Board (WBB) can give reliable quantitative measures of postural balance, but reference data are lacking. Furthermore, one-leg standing balance across the adult lifespan is not fully described. The aim of the study...
Thu Nov 07, 2019 18:14
Nature Chemistry, Published online: 07 November 2019; doi:10.1038/s41557-019-0377-8Very few consumers are aware that chemistry and synthetic chemicals are indispensable in making everyday goods because the products that people buy — such as cell phones, cars and processed foods — are typically far removed from the raw chemicals used in their production.
Thu Nov 07, 2019 02:00
Publication date: Available online 6 November 2019Source: Medical HypothesesAuthor(s): Katharina Angerpointner, Stefanie Weber, Karen Tschech, Hannah Schubert, Tanja Herbst, Antonio Ernstberger, Maximilian KerschbaumAbstractBackgroundPosttraumatic stress disorder (PTSD) can arise as a reaction to a traumatic experience. While many data concerning PTSD in severely injured patients are available, little is known about this disease in slightly injured patients after road traffic accidents. It is rather...
Thu Nov 07, 2019 18:09
Publication date: Available online 6 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Jang-Ching ChouAbstractAn implant driver and tether system is described as a metal driver body and handle, a shaft for accepting a tether, and a distal end flange. The tether can be made of a soft material, such as silicone, and includes a retaining aperture, an elongated body, and a finger-securing aperture. During use, the tether is attached to the driver body by slipping the distal end flange...
Thu Nov 07, 2019 18:02
Cancers, Vol. 11, Pages 1749: PAC-5 Gene Expression Signature for Predicting Prognosis of Patients with Pancreatic Adenocarcinoma Cancers doi: 10.3390/cancers11111749 Authors: Kim Jo Jang Nguyen Yun Ko Shin Lee Kang Ha Choi Kim Pancreatic adenocarcinoma (PAC) is one of the most aggressive malignancies. Intratumoural molecular heterogeneity impedes improvement of the overall survival rate. Current pathological staging system is not sufficient...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1750: Post-Surgery Circulating Tumor Cells and AXL Overexpression as New Poor Prognostic Biomarkers in Resected Lung Adenocarcinoma Cancers doi: 10.3390/cancers11111750 Authors: de Miguel-Pérez Bayarri-Lara Ortega Russo Moyano Rodriguez Alvarez-Cubero Maza Serrano Lorente Rolfo Serrano Background: The prognosis of early stage non-small cell lung cancer (NSCLC) is quite disappointing and the benefits of adjuvant therapy are...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1748: [18F] Clofarabine for PET Imaging of Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11111748 Authors: Sergeeva Kepe Zhang Miller-Atkins Keynon Iyer Sexton Awadallah Xin Saunthararajah Chan Lee Clinical diagnosis of hepatocellular carcinoma (HCC) relies heavily on radiological imaging. However, information pertaining to liver cancer treatment such as the proliferation status is lacking. Imaging tumor proliferation...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1747: HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway Cancers doi: 10.3390/cancers11111747 Authors: Marie-Elodie Spaety Alexandre Gries Amandine Badie Aina Venkatasamy Benoit Romain Christophe Orvain Kazuyoshi Yanagihara Koji Okamoto Alain C. Jung Georg Mellitzer Sébastien Pfeffer Christian Gaiddon Gastric cancer (GC) remains a health issue due to the low efficiency of therapies,...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1743: WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage Cancers doi: 10.3390/cancers11111743 Authors: Mathilde Rikje Willemijn de Jong Myra Langendonk Bart Reitsma Pien Herbers Marcel Nijland Gerwin Huls Anke van den Berg Emanuele Ammatuna Lydia Visser Tom van Meerten Genomically unstable cancers are dependent on specific cell cycle checkpoints to maintain viability and prevent apoptosis....
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1745: Targeting Epithelial Mesenchymal Plasticity in Pancreatic Cancer: A Compendium of Preclinical Discovery in a Heterogeneous Disease Cancers doi: 10.3390/cancers11111745 Authors: James H. Monkman Erik W. Thompson Shivashankar H. Nagaraj Pancreatic Ductal Adenocarcinoma (PDAC) is a particularly insidious and aggressive disease that causes significant mortality worldwide. The direct correlation between PDAC incidence, disease progression, and mortality...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1744: Coexisting Germline CHEK2 and Somatic BRAFV600E Mutations in Papillary Thyroid Cancer and Their Association with Clinicopathological Features and Disease Course Cancers doi: 10.3390/cancers11111744 Authors: Danuta Gąsior-Perczak Artur Kowalik Agnieszka Walczyk Monika Siołek Krzysztof Gruszczyński Iwona Pałyga Estera Mikina Tomasz Trybek Janusz Kopczyński Ryszard Mężyk Stanisław Góźdź Aldona Kowalska BRAFV600E is the most...
Thu Nov 07, 2019 02:00
Cancers, Vol. 11, Pages 1746: Network Meta-Analysis of Efficacy and Safety of Chemotherapy and Target Therapy in the First-Line Setting of Advanced Pancreatic Cancer Cancers doi: 10.3390/cancers11111746 Authors: Kun-I Lin Jia-Lian Yang Yu-Chao Lin Che-Yi Chou Jin-Hua Chen Chin-Chuan Hung Both gemcitabine and fluoropyrimidine are recommended backbones in the first-line treatment of pancreatic ductal adenocarcinoma (PDAC). To compare the efficacy and safety of these two...
Thu Nov 07, 2019 02:00
Key points •Thermal and hypoxic stress commonly coexist in environmental, occupational and clinical settings, yet how the brain tolerates these multi‐stressor environments is unknown •Core cooling by 1.0 °C reduced cerebral blood flow (CBF) by 20 – 30% and cerebral oxygen delivery (CDO2) by 12 – 19% at sea level and high altitude, whereas core heating by 1.5 °C did not reliably reduce CBF or CDO2 •Oxygen content in arterial blood was fully restored with acclimatization to 4330 m, but concurrent...
Thu Nov 07, 2019 14:23
Key points Increased insulin action is an important component of the health benefits of exercise, but its regulation is complex and not fully elucidated. Previous studies of insulin‐stimulated GLUT4 translocation to the skeletal muscle membrane found insufficient increases to explain the increases in glucose uptake. By determination of leg glucose uptake and interstitial muscle glucose concentration we calculated insulin‐induced muscle membrane permeability to glucose 4 h after one‐legged knee‐extensor...
Thu Nov 07, 2019 12:24
Background: Pectoralis major flap reconstruction is often associated with large unappealing scars in head-neck surgery. We recently established an alternative harvesting technique that improves aesthetic outcome. Objectives: The objective of this study was to demonstrate a modified surgical technique that harvests the pectoralis major muscle as an island flap and focuses on minimizing incision lines and applying a muscle-sparing approach. Methods: A retrospective analysis covering the period 2008–2018...
Thu Nov 07, 2019 17:07
Τη μοναξιά των χρηστών του Twitter προσπάθησε να εντοπίσει ομάδα ερευνητών της ιατρικής σχολής του Πολιτειακού Πανεπιστημίου Penn σε έρευνα που δημοσιεύθηκε στο BMJ Open. Τα ευρήματα θα μπορούσαν να οδηγήσουν σε ευκολότερο εντοπισμό των χρηστών που αισθάνονται μόνοι ακόμα κι αν δεν αναφέρονται στις αναρτήσεις τους στο πρόβλημα αυτό και να τους χορηγηθεί η απαραίτητη στήριξη. Εφαρμόζοντας μοντέλα γλωσσολογικών αναλύσεων στα tweets, οι ερευνητές βρήκαν ότι οι χρήστες που έκαναν αναρτήσεις για τη μοναξιά...
Thu Nov 07, 2019 15:30
Τα ηλεκτρονικά τσιγάρα ενδέχεται να έχουν βλαπτικές επιπτώσεις στο καρδιαγγειακό σύστημα των χρηστών και μάλλον είναι πρόωρο να θεωρηθούν «ασφαλής εναλλακτική» στο τσιγάρο, σύμφωνα με έρευνα που δημοσιεύθηκε στην επιθεώρηση της Ευρωπαϊκής Εταιρείας Καρδιολογίας (ESC) Cardiovascular Research. «Τα ηλεκτρονικά τσιγάρα περιέχουν νικοτίνη, μικροσωματίδια, μέταλλα και αρώματα, δεν πρόκειται απλώς για αβλαβή καπνό», υπογραμμίζει ο Δρ Λόρεν Γουόλντ του Πανεπιστημίου του Οχάιο, βασικός συντάκτης της έρευνας....
Thu Nov 07, 2019 14:40
Το 2016, μία γυναίκα από το Μεντεγίν της Κολομβίας ταξίδεψε στη Βοστόνη ούτως ώστε οι ερευνητές να εξετάσουν τον εγκέφαλό της, να αναλύσουν το αίμα της και να μελετήσουν το γονιδίωμά της. Η 73χρονη ήταν φορέας μίας σπάνιας γονιδιακής μετάλλαξης η οποία είχε προκαλέσει σε πολλά μέλη της οικογένειάς της άνοια κατά τη μέση ηλικία. Η ίδια είχε αποφύγει τη νόσο. Οι ερευνητές αναφέρουν πως μία άλλη σπάνια μετάλλαξη την προστάτευσε χωρίς όμως να μπορούν να αποδείξουν πως αυτή η μετάλλαξη από μόνη της απέτρεψε...
Thu Nov 07, 2019 10:10
Μια νέα μελέτη που δημοσιεύθηκε στο Journal of Nutrition Education and Behavior βρήκε ότι τα μοναχοπαίδια είχαν πιο ανθυγιεινές συνήθειες διατροφής και επιλογές ροφημάτων και χαμηλότερη βαθμολογία στον Δείκτη Υγιεινής Διατροφής (2010), σε σχέση με τα παιδιά που έχουν αδέλφια. Φάνηκε, επίσης, ότι η σημαντικά χαμηλότερη βαθμολογία αφορούσε όλες τις ημέρες της εβδομάδας και τα Σαββατοκύριακα, υποδεικνύοντας σε γενικές γραμμές ότι υπάρχουν τόσο ατομικές όσο και συλλογικές διαφορές στα διατροφικά μοτίβα...
Thu Nov 07, 2019 09:30
Όταν αποτυγχάνουμε κατά 15% σε μία δοκιμασία, η διαδικασία της μάθησης βελτιστοποιείται, σύμφωνα με έρευνα η οποία κατέληξε ότι το ποσοστό αυτό συνιστά την «χρυσή τομή» σε μία μαθησιακή εμπειρία. Η συγκεκριμένη μελέτη, που διεξήχθη από το Πανεπιστήμιο της Αριζόνα και δημοσιεύτηκε στο Nature Communications, αναδεικνύει ότι όταν δίνουμε 15% λάθος απαντήσεις ή εναλλακτικά όταν απαντάμε σωστά κατά 85%, η διαδικασία της μάθησης βελτιστοποιείται. Οι ερευνητές εκπαίδευσαν υπολογιστές να εκτελούν απλές...
Thu Nov 07, 2019 09:20
Τον βιολογικό μηχανισμό μέσω του οποίου μία γενετική μετάλλαξη προστατεύει από τον σακχαρώδη διαβήτη τύπου 2, εντόπισε ερευνητική ομάδα με επικεφαλής ερευνητές από τα Πανεπιστήμια του Ελσίνκι και της Οξφόρδης. Στη μελέτη που δημοσιεύθηκε στο Nature Genetics, διαπιστώνεται πως οι αλλαγές σε ένα γονίδιο μειώνουν τον κίνδυνο σακχαρώδους διαβήτη τύπου 2 ενισχύοντας την έκκριση ινσουλίνης από το πάγκρεας. Ο γενετικός παράγοντας αυτός αποτελεί μία παραλλαγή του γονιδίου SLC30A8 το οποίο κωδικοποιεί μία...
Thu Nov 07, 2019 09:00
Σημαντικά μειωμένο κίνδυνο εμφάνισης καρκίνου έχουν όσοι υποβάλλονται σε βαριατρική χειρουργική επέμβαση – δηλαδή σε επεμβάσεις τροποποίησης του στομάχου με σκοπό την δραστική μείωση της κατανάλωσης τροφής . Σε αυτό το συμπέρασμα κατέληξε μελέτη που παρουσιάστηκε στην ετήσια συνάντηση της Αμερικανικής Εταιρείας για τις Μεταβολικές και Βαριατρικές Χειρουργικές επεμβάσεις και την Εταιρία της Παχυσαρκίας. Η Δρ. Camila Ortiz Gomez και οι συνεργάτες της εξέτασαν την επίδραση της βαριατρικής χειρουργικής...
Thu Nov 07, 2019 08:25
Τα συμπληρώματα βιοτίνης που λαμβάνονται συχνά για την ενίσχυση των μαλλιών, του δέρματος και των νυχιών, μπορούν να αλλοιώσουν τα αποτελέσματα κάποιων σημαντικών εργαστηριακών εξετάσεων, προειδοποιεί ο Εθνικός Οργανισμός Τροφίμων και Φαρμάκων της Αμερικής (FDA). Οι ειδικοί διατυπώνουν την ανησυχία τους σχετικά με την παρεμβολή της βιοτίνης – ευρύτερα γνωστής ως βιταμίνη B7 – στα αποτελέσματα των ιατρικών εξετάσεων, καθώς ενδέχεται να προκαλεί ψευδώς χαμηλές ενδείξεις για τα επίπεδα τροπονίνης,...
Thu Nov 07, 2019 08:03
Abstract Dysphagia in patients with multiple sclerosis (MS) is associated with significant morbidity and has profound impact on the quality of life (QoL). This study aimed to analyze the dysphagia prevalence, attitudes, and dysphagia-related QoL in patients with MS, not at relapse. A prospective study of 108 consecutively recruited patients. The patients were asked to report dysphagia and completed a general dysphagia questionnaire (the Eating Assessment Tool-10, EAT-10), a disease-specific...
Thu Nov 07, 2019 02:00
Publication date: Available online 7 November 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): S. Smarrito
Thu Nov 07, 2019 17:23
Publication date: Available online 7 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Yilin Yao, Xuemin Shen, Linjun Shi, Guoyao Tang, Lan WuAbstractOral leukoplakia (OL), a predominantly white change to the oral mucosa, is the most common potentially malignant lesion. Elimination of this condition, especially the high risk OL, is advisable, even necessary as an attempt to avoid malignant transformation. Here we presented three cases of OL successfully treated by photodynamic...
Thu Nov 07, 2019 17:17
Publication date: Available online 6 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Magda Rogéria Pereira Viana, Igor Martins Alves Melo, Breno Pupin, Leandro José Raniero, Renata de Azevedo CanevariAbstractBackgroundThe expressive increase in the incidence of Cervical Cancer in the female population worldwide has been an issue that deserves attention from the scientific community. Several studies have already proven the intrinsic relationship of its development with the molecular...
Thu Nov 07, 2019 17:17
Publication date: Available online 7 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Di Wang, Haiyue Jiang, Qinghua Yang, Xia Liu, Leren He, Bo Pan, Lin LinAbstractObjectiveTo explore correlations between post-treatment outcomes of non-surgical correction for cryptotia and treatment time and other influence factors.MethodsForty-seven consecutive patients with 64 cryptotias were treated with the adjusted external stretching device and followed up over 12 months....
Thu Nov 07, 2019 17:10
Publication date: Available online 6 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Laís Ferreira, Maria Clara da Silva Valadão, Piotr H. Skarzynski, Milaine Dominici Sanfins, Eliara Pinto Vieira BiaggioAbstractObjectiveTo investigate the effect of congenital toxoplasmosis (CTP) on the Frequency-Following Response (FFR) in infants.Study Design11 infants diagnosed with CTP and 12 healthy infants with no risk indicators for hearing impairment, aged 29 to 90 days...
Thu Nov 07, 2019 17:10
Publication date: Available online 6 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Breanne L. Schiffer, Sara Stern, Albert ParkAbstractObjectiveOptimize the diagnosis of pediatric Sjögren’s syndrome in children who present with parotitis.MethodsTwenty children presented to a pediatric otolaryngology or rheumatology clinic with recurrent parotitis. Presenting symptoms, serologies, sialendoscopy findings, and minor salivary gland biopsy pathology results were...
Thu Nov 07, 2019 17:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Jie Pan, Ruixian Peng, Nuo Cheng, Fengyuan Chen, Bin GaoAbstractObjectiveA large number of studies have explored the function of LNK in hematologic system disease, while that in solid tumors has been rarely investigated. In the present study, we attempted to explore the expression level of LNK in colorectal cancer (CRC) as well as the potential relationship between them.Materials and methodsThe expression...
Thu Nov 07, 2019 17:05
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Tian Wei, Xie Xiaojun, Cao PeilongAbstractBreast cancer is a leading cause of cancer death among women worldwide. Doxorubicin (DOX) is a broad-spectrum anti-breast cancer agent, but its clinical use is restricted due to irreversible tissue toxicity. Thereby, new therapeutic approaches are urgently required to promote the sensitivity of breast cancer cells to DOX. Magnoflorine (Mag), a quaternary alkaloid...
Thu Nov 07, 2019 17:05
To describe the genetic variants in the ARSA gene in Sri Lankan patients with metachromatic leukodystrophy (MLD). As the variant profile of MLD in the Sri Lankan population is currently unknown.
Wed Nov 06, 2019 02:00
This study aims to examine the predisposing factors influencing occupational injuries among frontline construction workers in Ghana. A cross-sectional survey was carried out with 634 frontline construction wor...
Wed Nov 06, 2019 02:00
Blood transfusion saves millions of lives. But, the need and the actual number of donations are not balanced in Ethiopia. The actual reason is not clearly assessed; however, level of knowledge and attitude may...
Wed Nov 06, 2019 02:00
Though gradual improvements are exist; Ethiopia’s learning outcomes are still low in primary schools. Academic achievement of school age children can be affected by several factors such as nutritional status, ...
Wed Nov 06, 2019 02:00
This pilot study aimed to compare the commercial Unyvero ITI multiplex PCR application (U-ITI, Curetis GmbH) with conventional culturing concerning (a) detection of pathogens, (b) time to detection of pathogen...
Wed Nov 06, 2019 02:00
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): M. Todd Greene, Heather M. Gilmartin, Sanjay SaintBackgroundPsychological safety is a critical factor in team learning that positively impacts patient safety. We sought to examine the influence of psychological safety on using recommended health care–associated infection (HAI) prevention practices within US hospitals.MethodsWe mailed surveys to infection preventionists in a random sample of nearly...
Thu Nov 07, 2019 16:48
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): Stephanie Huffman, Carly Webb, Sean P. SpinaBackgroundMany health care workers are using smartphones and wearable devices without an enforced cleaning standard to prevent the spread of bacteria to patients. To our, no real-world trials have been performed to date, examining bacterial elimination on these devices in a hospital setting. The primary objective was to determine if ultraviolet wavelength...
Thu Nov 07, 2019 16:48
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): Matthew W.H. Wong, Yan Zhu Xu, Jeffrey Bone, Jocelyn A. SrigleyBackgroundPatient and visitor hand hygiene has the potential to prevent health care–associated infections, but there are few data on the efficacy of interventions to improve patient/visitor hand hygiene.ObjectiveTo determine whether conventional and front-line ownership (FLO) patient/visitor hand hygiene interventions improve patient/visitor...
Thu Nov 07, 2019 16:48
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): Christina Davidson, Jordan Enns, Carrie Dempster, Suzanne Lundeen, Catherine EppesBackgroundThis study investigated cesarean delivery surgical site infection (SSI) rates before and after implementation of a SSI care bundle.MethodsA SSI bundle for cesareans was introduced in our hospital in April 2014 to reduce the SSI rate. The practices were divided into bundle elements that reflected preoperative,...
Thu Nov 07, 2019 16:48
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): Emily Walits, Gopi Patel, Selina Lavache, Rose-Marie Faotto, Adam Pobliner, Sheron Wilson, Sarah SchaeferCandida auris is an emerging, multidrug-resistant yeast that is considered a threat to patients and health care facilities worldwide. As the incidence of C auris increases, the management of patients with C auris will expand beyond acute care hospitals and long-term care facilities. We discuss...
Thu Nov 07, 2019 16:48
Publication date: Available online 7 November 2019Source: American Journal of Infection ControlAuthor(s): Laia Castellà, Nieves Sopena, David Rodriguez-Montserrat, Sergio Alonso-Fernández, Jose María Cavanilles, Miquel Iborra, Ana Ciercoles, Ana Pulido, Montserrat Gimenez, Jose Antonio Hernandez Hermoso, Irma CasasBackgroundThis study examines the incidence, characteristics, and risk factors of surgical site infections (SSIs) after spine surgery and evaluates the efficacy of a preventive intervention.MethodsThis...
Thu Nov 07, 2019 16:48
Abstract In the recent past, the sirtuins have been under intense investigation for their roles in biology and disease, including cancer. The sirtuin SIRT6 is comparatively a lesser studied member of this family of seven proteins. Like certain other sirtuins, SIRT6 isemerging to have an oncogenic function as well as tumor suppressor roles in cancer. Limited studies have been conducted assessing the role and functional significance of SIRT6 in melanoma and non‐melanoma skin cancers. In this review,...
Thu Nov 07, 2019 14:34
Abstract Periodontitis is a disease caused by periodontopathogens and is characterized by periodontal inflammation and alveolar bone resorption. As has been proven, host immune responses incite the development and progression of periodontitis. The present study sought to establish B10 cell functions and mechanisms in regulating host immunity during periodontitis. Periodontopathogen-specific B10 cells were purified and then injected into recipients to create the adoptive transfer...
Thu Nov 07, 2019 02:00
Thu Nov 07, 2019 15:58
Zusammenfassung Hintergrund Die Beiträge der diesjährigen ASCO-Konferenz zur Therapie von rezidivierenden und metastasierenden Kopf-Hals-Karzinomen (R/M-HNSCC) legen wie in den Vorjahren einen Fokus auf medikamentöse Ansätze. Zwei vorgestellte Phase-III-Studien, TPExtreme und Keynote-048, werden voraussichtlich die Erstlinientherapie von rezidivierenden und metastasierenden Kopf-Hals-Tumoren weitreichend beeinflussen. ...
Thu Nov 07, 2019 02:00
Zusammenfassung Beim diesjährigen Kongress der Amerikanischen Gesellschaft für Onkologie (ASCO, American Society for Clinical Oncology) fanden sich unter der Stichwortsuche „HPV-associated head and neck cancer“ 920 Treffer – 74 % der Treffer zum Stichwort humane Papillomaviren (HPV). Dies zeigt die Relevanz des Themas: Das Spektrum reichte von der Validierung und Trennung der Prognosegruppen von Patienten mit einem HPV-assoziierten Oropharynxkarzinom (OPSCC) nach TNM 8 über die...
Thu Nov 07, 2019 02:00
The palmaris brevis muscle reveals a distinct number of fiber bundles, each containing numerous muscle spindles. It shows no tendon‐associated neuronal elements but some surrounding Pacinian bodies. Abstract The palmaris brevis muscle contains numerous muscle spindles to control changes of the muscle length but is devoid of tendon‐associated neuronal elements (e.g. Golgi tendon organs or Ruffini‐like corpuscles) controlling changes in muscle strength. Pacinian bodies, frequently seen in the palm...
Thu Nov 07, 2019 14:58
Publication date: Available online 7 November 2019Source: Medical Image AnalysisAuthor(s): Sarah E. Gerard, Jacob Herrmann, David W. Kaczka, Guido Musch, Ana Fernandez-Bustamante, Joseph M. ReinhardtAbstractSegmentation of lungs with acute respiratory distress syndrome (ARDS) is a challenging task due to diffuse opacification in dependent regions which results in little to no contrast at the lung boundary. For segmentation of severely injured lungs, local intensity and texture information, as well...
Thu Nov 07, 2019 15:52
Publication date: Available online 6 November 2019Source: Medical Image AnalysisAuthor(s): Mariana Nogueira, Mathieu De Craene, Sergio Sanchez-Martinez, Devyani Chowdhury, Bart Bijnens, Gemma PiellaAbstractAlternative stress echocardiography protocols such as handgrip exercise are potentially more favorable towards large-scale screening scenarios than those currently adopted in clinical practice. However, these are still underexplored because the maximal exercise levels are not easily quantified...
Thu Nov 07, 2019 15:52
Publication date: Available online 6 November 2019Source: Acta Otorrinolaringológica EspañolaAuthor(s): María Costales, Marta Diñeiro, Guadalupe A. Cifuentes, Raquel Capín, Andrea Otero, Mónica Viejo-Díaz, Ana Plasencia, Faustino Núñez, Justo Ramón Gómez, José Luis Llorente, Juan Cadiñanos, Rubén CabanillasResumenIntroducciónLa hipoacusia neurosensorial (HNS) es el déficit sensorial más prevalente en nuestro medio. La secuenciación genómica de nueva generación (NGS) permite obtener un diagnóstico...
Thu Nov 07, 2019 15:37
Abstract Purpose Emergence delirium (ED) is common in children after sevoflurane anesthesia and should be prevented for patient safety. A prospective, double-blind, randomized, controlled study was performed to compare the efficacy of minimal dosage of midazolam versus dexmedetomidine to prevent ED in children undergoing tonsillectomy. Methods Seventy children...
Thu Nov 07, 2019 02:00
Abstract Introduction The gold standard for measuring the partial pressure of carbon dioxide remains arterial blood gas (ABG) analysis. For patients with cystic fibrosis undergoing general anesthesia or polysomnography studies, continuous non-invasive carbon dioxide monitoring may be required. The current study compares end-tidal (ETCO2), transcutaneous (TCCO2), and capillary blood gas carbon dioxide (Cap-CO2) monitoring with the partial...
Thu Nov 07, 2019 02:00
Abstract Recent national guidelines recommend genetic risk assessment for all patients diagnosed with pancreatic cancer, yet individuals with pancreatic cancer obtain genetic testing at suboptimal rates. Both patient and provider factors play a role in adherence to genetic testing recommendations. The purpose of this study was to understand health care provider perspectives of caring for patients with inherited pancreatic cancer risk. The study was a cross-sectional mixed method...
Thu Nov 07, 2019 02:00
Publication date: Available online 6 November 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Birte J. Wolff, Cara J. Joyce, Lindsey A. McAlarnen, Cynthia A. Brincat, Elizabeth R. Mueller, Colleen M. FitzgeraldAbstractIntroductionPhysical therapy has been shown to be effective for women with overactive bladder (OAB). We report on our experience with pelvic floor physical therapy (PFPT) with or without myofascial release as treatment for women with symptoms of urinary urgency or urge...
Thu Nov 07, 2019 15:32
Despite improved management, overall survival rates at hospital discharge among patients with out-of-hospital cardiac arrests do not exceed 20%, and neurologic outcomes remain poor. Even though controversies persist, targeted temperature management at 32 to 36°C remains recommended in patients with…
Thu Nov 07, 2019 02:00
Dengue is a pandemic-prone viral disease, the incidence of which has increased by a factor of 30 over the past 50 years. Nearly half of the world’s population lives in dengue-endemic areas in more than 100 countries worldwide, where approximately 390 million cases of dengue virus infection are…
Wed Nov 06, 2019 02:00
Publication date: Available online 7 November 2019Source: Seminars in OncologyAuthor(s): Alessio Cortellini, Sebastiano Buti, Veronica Agostinelli, Melissa BersanelliABSTRACTThe correlation between clinical outcomes and treatment-related adverse events (AEs) has always been a debated topic in clinical oncology. Despite toxicities pharmacodynamics effects, the misunderstanding has always been around the corner: AEs themselves could lead to morbidity and mortality; on the other hand, the choice of...
Thu Nov 07, 2019 15:13
Publication date: Available online 6 November 2019Source: Seminars in OncologyAuthor(s): Ashley M. Hopkins, Ganessan Kichenadasse, Ross A. McKinnon, Andrew Rowland, Michael J. SorichAbstractBackgroundBaseline tumor size (BTS) was recently indicated as prognostic of overall survival (OS) in patients advanced melanoma treated with pembrolizumab. We review the association between BTS and OS/progression-free survival (PFS) in patients with a diagnosis of advanced non–small-cell lung cancer (NSCLC) treated...
Thu Nov 07, 2019 15:13
Publication date: Available online 6 November 2019Source: Seminars in OncologyAuthor(s): Ondrej Uher, Veronika Caisova, Per Hansen, Jan Kopecky, Jindrich Chmelar, Zhengping Zhuang, Jan Zenka, Karel PacakAbstractThere is no doubt that immunotherapy lies in the spotlight of current cancer research and clinical trials. However, there are still limitations in the treatment response in certain types of tumors largely due to the presence of the complex network of immunomodulatory and immunosuppressive...
Thu Nov 07, 2019 15:13
Publication date: Available online 6 November 2019Source: Seminars in OncologyAuthor(s): Cinzia Solinas, Pushpamali De Silva, Dominique Bron, Karen Willard-Gallo, Dario SangioloAbstractTargeting inhibitory immune checkpoint molecules has dramatically changed treatment paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing immune response or to induce an efficient immune response against tumors has emerged as a research priority. In this work, we focus on a novel...
Thu Nov 07, 2019 15:13
Publication date: Available online 7 November 2019Source: Allergology InternationalAuthor(s): Yoko Osawa, Yumi Ito, Noboru Takahashi, Chizuru Sugimoto, Yoko Kohno, Shigehito Mori, Taiyo Morikawa, Yukinori Kato, Masayuki Okamoto, Masafumi Kanno, Tetsuji Takabayashi, Shigeharu FujiedaAbstractBackgroundOral allergy syndrome (OAS) is an immediate allergy caused by a cross-reaction of highly homologous common antigens (pan-allergens) contained in fruits/vegetables and pollen.MethodsA questionnaire was...
Thu Nov 07, 2019 15:06
Thu Nov 07, 2019 12:33
between the studies assessed for
Thu Nov 07, 2019 02:00
Publication date: Available online 6 November 2019Source: Academic RadiologyAuthor(s): Luke Oakden-RaynerRationale and ObjectivesMedical artificial intelligence systems are dependent on well characterized large-scale datasets. Recently released public datasets have been of great interest to the field, but pose specific challenges due to the disconnect they cause between data generation and data usage, potentially limiting the utility of these datasets.Materials and MethodsWe visually explore two...
Thu Nov 07, 2019 14:53
Publication date: Available online 6 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Martin T. Tyler, Craig S. Miller, Peter B. Lockhart, Lauren L. Patton
Thu Nov 07, 2019 14:49
Abstract Checkpoint inhibitors (CPI) have significantly changed the therapeutic landscape of oncology. We adopted a non-invasive metabolomic approach to understand immunotherapy response and failure in 28 urological cancer patients. In total, 134 metabolites were quantified in patient sera before the first, second, and third CPI doses. Modeling the association between metabolites and CPI response and patient characteristics revealed that one predictive metabolite class (n = 9/10)...
Thu Nov 07, 2019 02:00
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