Πέμπτη 7 Νοεμβρίου 2019


Methodology for quantifying excitability of identified projection neurons in the dorsal horn of the spinal cord, specifically to study spinal cord stimulation paradigms
Publication date: Available online 6 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Trevor M. Smith, Dongchul Lee, Kerry Bradley, Stephen B. McMahonAbstractBackgroundUsing in and ex vivo preparations, electrophysiological methods help understand the excitability of biological tissue, particularly neurons, by providing microsecond temporal resolution. However, for in vivo recordings, in the context of extracellular recordings, it is often unclear precisely which type of neuron the...
Journal of Neuroscience Methods
Thu Nov 07, 2019 14:39
Adaptive Spike-Artifact Removal from Local Field Potentials Uncovers Prominent Beta and Gamma Band Neuronal Synchronization
Publication date: Available online 6 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo WomelsdorfAbstractBackgroundMany neurons synchronize their action potentials to the phase of local field potential (LFP) fluctuations in one or more frequency bands. Analyzing this spike-to-LFP synchronization is challenging, however, when neural spikes and LFP are generated in the same local circuit, because the spike’s action potential waveform leak...
Journal of Neuroscience Methods
Thu Nov 07, 2019 14:39
Management of seborrhoeic keratosis and actinic keratosis
Publication date: Available online 7 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P.A. Van Damme
Oral and Maxillofacial Surgery
Thu Nov 07, 2019 14:34
Does a learning curve exist for accuracy in three-dimensional planning for maxillary positioning in bimaxillary orthognathic surgery?
Publication date: Available online 7 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): F. Antonini, A.M. Borba, R.M. Pagnoncelli, M. Han, M.R. Markiewicz, M. MiloroAbstractThe purpose of this study was to investigate the influence of time, and experience, on the accuracy of maxillary repositioning in bimaxillary orthognathic surgery performed using virtual surgical planning (VSP). Patients who had undergone bimaxillary orthognathic surgery were reviewed. Maxillary...
Oral and Maxillofacial Surgery
Thu Nov 07, 2019 14:34
A comparison of airway interventions and gastrostomy tube placement in infants with Robin sequence
Publication date: Available online 6 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): K. El Ghoul, C.E. Calabrese, M.J. Koudstaal, C.M. ResnickAbstractThe purpose of this study was to evaluate feeding impairment following non-operative or operative management of airway obstruction in a large series of infants with Robin sequence (RS) by rate of G-tube placement. A retrospective study was conducted at Boston Children’s Hospital including 225 patients (47.1% female)...
Oral and Maxillofacial Surgery
Thu Nov 07, 2019 14:34
Antony Todd Young (15 August 1951–7 September 2019)
Journal of Medical Imaging and Radiation Oncology
Thu Nov 07, 2019 13:19
Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma
Condition:   Cutaneous Squamous Cell CarcinomaIntervention:   Drug: CemiplimabSponsor:   Regeneron PharmaceuticalsNot yet recruiting
ClinicalTrials
Thu Nov 07, 2019 14:28
Nutrition and Pharmacological Algorithm for Oncology Patients Study
Conditions:   Oncologic Complications;   Quality of Life;   Nutrition Poor;   Head and Neck Cancer;   Lung Cancer;   Pancreatic CancerInterventions:   Drug: Dexamethasone;   Drug: Dronabinol;   Drug: Mirtazapine;   Behavioral: Nutrition InterventionSponsor:   Montefiore Medical CenterNot yet recruiting
ClinicalTrials
Thu Nov 07, 2019 14:28
To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD8233 After Multiple Dose Administration in Subjects With Type 2 Diabetes.
Conditions:   Dyslipidemia;   Type 2 DiabetesInterventions:   Drug: AZD8233 subcutaneous injection;   Drug: PlaceboSponsors:   AstraZeneca;   ParexelNot yet recruiting
ClinicalTrials
Thu Nov 07, 2019 14:28
The Effect of High vs. Moderate Protein Consumption on Human Health
Conditions:   Weight Loss;   Metabolism and Nutrition Disorder;   ObesityInterventions:   Dietary Supplement: VLCD-Active;   Other: Maintenance-Active;   Dietary Supplement: VLCD-Control;   Other: Maintenance-ControlSponsors:   University of Copenhagen;   US National Cattlemen´s Association;   Danish Agriculture and Food CounselRecruiting
ClinicalTrials
Thu Nov 07, 2019 14:28
Transluminal balloon angioplasty for cerebral vasospasm after spontaneous subarachnoid hemorrhage: A single-center experience
Publication date: Available online 6 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Hannes Schacht, Jan Küchler, Tobias Boppel, Jan Leppert, Claudia Ditz, Peter Schramm, Alexander NeumannAbstractObjectivesAfter spontaneous subarachnoid hemorrhage (sSAH), cerebral vasospasm (CVS) is a common complication, potentially resulting in infarction mainly responsible for a poor outcome. Intra-arterial vasodilators lead to transient increase of brain perfusion, but only transluminal balloon...
Clinical Neurology and Neurosurgery
Thu Nov 07, 2019 14:24
Neurotoxicity of antibodies in cancer therapy: A review
Publication date: Available online 6 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Erika Horta, Connie Bongiorno, Mustapha Ezzeddine, Elizabeth C. NeilAbstractThe objective of this manuscript is to identify the neurological side effect profile associated with different classes of antibodies used in cancer pharmacotherapy and to estimate the frequency in which these neurotoxicity occurs. A systematic review of the literature was conducted using OVID MEDLINE and EMBASE databases...
Clinical Neurology and Neurosurgery
Thu Nov 07, 2019 14:24
A new leptoceratopsid dinosaur from Maastrichtian-aged deposits of the Sustut Basin, northern British Columbia, Canada
A partial dinosaur skeleton from the Sustut Basin of northern British Columbia, Canada, previously described as an indeterminate neornithischian, is here reinterpreted as a leptoceratopsid ceratopsian, Ferrisaurus sustutensis, gen. et. sp. nov. The skeleton includes parts of the pectoral girdles, left forelimb, left hindlimb, and right pes. It can be distinguished from other named leptoceratopsids based on the proportions of the ulna and pedal phalanges. This is the first unique dinosaur species...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Classifying Oryza sativa accessions into Indica and Japonica using logistic regression model with phenotypic data
In Oryza sativa, indica and japonica are pivotal subpopulations, and other subpopulations such as aus and aromatic are considered to be derived from indica or japonica. In this regard, Oryza sativa accessions are frequently viewed from the indica/japonica perspective. This study introduces a computational method for indica/japonica classification by applying phenotypic variables to the logistic regression model (LRM). The population used in this study included 413 Oryza sativa accessions, of which...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Scythes, sickles and other blades: defining the diversity of pectoral fin morphotypes in Pachycormiformes
The traditional terminology of ‘scythe’ or ‘sickle’ shaped is observed to be flawed as an effective descriptor for pectoral fin shape in pachycormids. The diversity of pachycormid pectoral fin shapes is assessed across the 14 recognised genera that preserve complete pectoral fins, and improved terms are defined to more effectively describe their form, supported by anatomical observation and aspect ratio analysis of individual fins, and corroborated by landmark analysis. Three clear and distinct pectoral...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Vector distribution and transmission risk of the Zika virus in South and Central America
Background Zika is of great medical relevance due to its rapid geographical spread in 2015 and 2016 in South America and its serious implications, for example, certain birth defects. Recent epidemics urgently require a better understanding of geographic patterns of the Zika virus transmission risk. This study aims to map the Zika virus transmission risk in South and Central America. We applied the maximum entropy approach, which is common for species distribution modelling, but is now also widely...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Effect of different ergonomic supports on muscle activity of dentists during posterior composite restoration
Background The aim of this study was to evaluate the effect of different ergonomic supports on the muscle activity of two trunk muscles while a group of dentists performed a common dental procedure on a phantom head, divided into three tasks. Methods A one-way repeated measures study (ANOVA) was conducted on a group of 36 dentists. The middle trapezius and lumbar erector spinae muscles were measured with and without the use of different ergonomic supports (ergonomic stool, magnification...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Combining data from different sampling methods to study the development of an alien crab Chionoecetes opilio invasion in the remote and pristine Arctic Kara Sea
Data obtained using three different types of sampling gear is compared and combined to assess the size composition and density of a non-indigenous snow crab population Chionoecetes opilio in the previously free of alien species Kara Sea benthos. The Sigsbee trawl has small mesh and catches even recently settled crabs. The large bottom trawl is able to catch large crabs, but does not retain younger crabs, due to its large mesh. Video sampling allows the observation of larger crabs, although some smaller...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Zooplankton communities in the Drake Passage through environmental boundaries: a snapshot of 2010, early spring
Background Spatial distribution of zooplankton communities influenced by various environmental factors is always important for understanding pelagic ecosystems. The area of the Drake Passage (Southern Ocean) is of particular interest owing to the high spatial and temporal variability of hydrological parameters affecting marine fauna. This study provides a survey of zooplankton composition and spatial distribution along a transect in the Drake Passage sampled during the 31th Cruise...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Chronic trace metals effects of mine tailings on estuarine assemblages revealed by environmental DNA
Mine tailing disasters have occurred worldwide and contemporary release of tailings of large proportions raise concerns of the chronic impacts that trace metals may have on the aquatic biodiversity. Environmental metabarcoding (eDNA) offers an as yet poorly explored opportunity for biological monitoring of impacted aquatic ecosystems from mine tailings and contaminated sediments. eDNA has been increasingly recognized to be an effective method to detect previously unrecognized small-sized Metazoan...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Idiosyncratic changes in spring arrival dates of Pacific Northwest migratory birds
Shifts in the timing of bird migration have been associated with climatic change and species traits. However, climatic change does not affect all species or geographic locations equally. Climate in the Pacific Northwest has shifted during the last century with mean temperatures increasing by 1 °C but little change in total annual precipitation. Few long-term data on migration phenology of birds are available in the Pacific Northwest. We analyzed trends in spring arrival dates from a site in the Oregon...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Competing endogenous RNA (ceRNA) hypothetic model based on comprehensive analysis of long non-coding RNA expression in lung adenocarcinoma
Background Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer with high malignancy and bad prognosis, consisted of lung adenocarcinomas (LUAD) and lung squamous cell carcinomas (LUSC) chiefly. Multiple studies have indicated that competing endogenous RNA (ceRNA) network centered long noncoding RNAs (lncRNAs) can regulate gene expression and the progression of various cancers. However, the research about lncRNAs-mediated ceRNA network in LUAD is still lacking. Methods ...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
The urban-rural disparity in the prevalence and risk factors of hypertension among the elderly in China—a cross-sectional study
Introduction This study aimed to assess the prevalence of hypertension and to explore the disparities of its risk factors among urban and rural elderly. Method Data of hypertensive patients were collected from the China Health and Retirement Longitudinal Study (CHARLS) 2015. Stratified sample households were selected from 450 villages or communities of 150 counties from 28 provinces. Multivariable logistic regression...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Genome-wide analysis of transcription factors related to anthocyanin biosynthesis in carmine radish (Raphanus sativus L.) fleshy roots
Carmine radish produced in Chongqing is famous for containing a natural red pigment (red radish pigment). However, the anthocyanin biosynthesis transcriptome and the expression of anthocyanin biosynthesis-related genes in carmine radish have not been fully investigated. Uncovering the mechanism of anthocyanin biosynthesis in the ‘Hongxin 1’ carmine radish cultivar has become a dominant research topic in this field. In this study, a local carmine radish cultivar named ‘Hongxin 1’ containing a highly...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Genome-wide identification and characterization of the MADS-box gene family in Salix suchowensis
MADS-box genes encode transcription factors that participate in various plant growth and development processes, particularly floral organogenesis. To date, MADS-box genes have been reported in many species, the completion of the sequence of the willow genome provides us with the opportunity to conduct a comprehensive analysis of the willow MADS-box gene family. Here, we identified 60 willow MADS-box genes using bioinformatics-based methods and classified them into 22 M-type (11 Mα, seven Mβ and four...
PeerJ Computer Science
Thu Nov 07, 2019 02:00
Dr. Alice Ettinger: Pioneer of fluoroscopy and exceptional teacher
Publication date: Available online 6 November 2019Source: Clinical ImagingAuthor(s): Kirti Magudia
Clinical Imaging
Thu Nov 07, 2019 14:06
Paid Worker and Unfamiliar Partner Communication Training: A Scoping Review
Publication date: Available online 6 November 2019Source: Journal of Communication DisordersAuthor(s): Alexandra Tessier, Emma Power, Claire CroteauAbstractBackgroundCommunication partner training could be employed to train people working in the community to facilitate interaction with individuals who live with a variety of communication disorders. However, current evidence syntheses are limited to a single disorder (e.g., aphasia) and focus on a variety of familiar and unfamiliar communication partners....
Journal of Communication Disorders (open access)
Thu Nov 07, 2019 13:59
Procedural learning in language: Introduction to special issue
Publication date: Available online 6 November 2019Source: Journal of Communication DisordersAuthor(s): Jean K. Gordon
Journal of Communication Disorders (open access)
Thu Nov 07, 2019 13:59
Editorial Board
Publication date: November–December 2019Source: Journal of Communication Disorders, Volume 82Author(s):
Journal of Communication Disorders (open access)
Thu Nov 07, 2019 13:59
Obituary for Paul Townsend Plastic and Reconstructive Surgeon
Publication date: Available online 6 November 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s):
British Association of Plastic Surgeons
Thu Nov 07, 2019 13:49
Table of Contents
Publication date: October 2019Source: Clinical Therapeutics, Volume 41, Issue 10Author(s):
Clinical Therapeutics
Thu Nov 07, 2019 13:48
Editorial Board
Publication date: October 2019Source: Clinical Therapeutics, Volume 41, Issue 10Author(s):
Clinical Therapeutics
Thu Nov 07, 2019 13:48
Sex Related Differences in Peri-operative Mortality after Elective Repair of an Asymptomatic Abdominal Aortic Aneurysm in the Netherlands: a Retrospective Analysis of 2013 to 2018
Publication date: Available online 6 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Reza Indrakusuma, Hamid Jalalzadeh, Anco C. Vahl, Mark J.W. Koelemay, Ron BalmObjectiveThe aim was to compare peri-operative (30 day and/or in hospital) mortality between women and men in the Netherlands after elective repair of an asymptomatic abdominal aortic aneurysm (AAA).MethodsThis was a retrospective study using data from the Dutch Surgical Aneurysm Audit (DSAA), a mandatory...
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Thu Nov 07, 2019 13:48
Short Term Success of Treatments to Salvage Thrombosed or Failing Synthetic Arteriovenous Grafts in End Stage Renal Disease: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials
Publication date: Available online 6 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Georgios K. Nikolopoulos, Anneza I. Yiallourou, Christos Argyriou, Stefanos Bonovas, Georgios S. Georgiadis, Miltos K. LazaridesObjectiveThere is currently uncertainty regarding the ideal treatment to salvage thrombosed or failing synthetic arteriovenous grafts (AVGs) in patients with end stage renal disease. Therefore, a systematic review up to December 2018 and network meta-analysis...
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Thu Nov 07, 2019 13:48
Cerumen impaction was composed of abnormal exfoliation of keratinocytes that was correlated with infection
Publication date: Available online 7 November 2019Source: American Journal of OtolaryngologyAuthor(s): Shoude Zhang, Mao Jin, Guojin Zhou, Yuejiao ZhangAbstractObjectiveThis study investigated the exact composition and tried to be helpful in explaining the etiologic mechanism of cerumen impaction in the external auditory canal (EAC).MethodsA hundred impacted cerumen samples and 15 normal cerumen samples were collected by manual removal and divided into 2 groups. All samples were examined via microbial...
American Journal of Otolaryngology
Thu Nov 07, 2019 13:39
Risk factors for post-tonsillectomy hemorrhage in adult population: Does smoking history have an impact?
Publication date: Available online 6 November 2019Source: American Journal of OtolaryngologyAuthor(s): Nurullah Seyhun, Senem Kurt Dizdar, Alican Çoktur, Merve Ekici Bektaş, Onuralp Albuz, Zeynep Nur Erol, Suat Turgut
American Journal of Otolaryngology
Thu Nov 07, 2019 13:39
Erratum
Audiol Neurotol
Audiology and neurotology
Thu Nov 07, 2019 11:14
Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides
Insulin resistance is present in most, but not all, obese and elderly patients and even in some young and lean persons. It is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and probably obesity-associated cancers.…
The New England Journal of Medicine: Search Results in Genetics
Thu Nov 07, 2019 02:00
Health, Social Reform, and Medical Schools — The Training of American Physicians and the Dissenting Tradition
In February 2019, the medical school yearbook page of Virginia Governor Ralph Northam ignited a national controversy. The 1984 document contained an incendiary photograph of two people, one wearing Ku Klux Klan robes, the other in blackface. The image recalled the ugly past of American medical…
The New England Journal of Medicine: Search Results in Health Policy and Reform
Thu Nov 07, 2019 02:00

A Good Physician — On Complacency and Communication
In the fall of 1997, my medical school roommate lent me her copy of Anne Fadiman’s The Spirit Catches You and You Fall Down. I stayed awake for two nights, fascinated and appalled by the misunderstanding between the young Hmong patient’s family and her American physicians. Taking the cautionary…
The New England Journal of Medicine: Search Results in Health Policy and Reform
Thu Nov 07, 2019 02:00
The U.S. Insulin Crisis — Rationing a Lifesaving Medication Discovered in the 1920s
On January 23, 1922, insulin was successfully injected into a 14-year-old boy with severe type 1 diabetes mellitus. Type 1 diabetes had been considered a universally fatal disease, with mortality approaching 100% within months after diagnosis. For their discovery of insulin, Frederick Banting and…
The New England Journal of Medicine: Search Results in Health Policy and Reform
Thu Nov 07, 2019 02:00
Ketamine reverses the impaired fear memory extinction and accompanied depressive-like behaviors in adolescent mice
Publication date: Available online 6 November 2019Source: Behavioural Brain ResearchAuthor(s): Mei-Dan Wei, Yu-Hang Wang, Kun Lu, Bi-Jun Lv, Yan Wang, Wen-Ying ChenAbstractPost-traumatic stress disorder (PTSD) is a chronic and disabling condition arising after exposure to a severe traumatic event, which affects approximately eight percent of the population. The underlying neurobiology of PTSD, however, has only been partially understood. The exploration of fear memory and its extinction has been...
Behavioural Brain Research
Thu Nov 07, 2019 12:52
Deaths Associated with Emicizumab in Patients with Hemophilia A
To the Editor: Emicizumab was recently licensed for the prophylactic treatment of hemophilia A in patients in whom antibodies (inhibitors) have not developed against the product they were using to treat or prevent bleeding episodes. Since the licensing of emicizumab in such patients, deaths have…
The New England Journal of Medicine: Search Results in Hematology\Oncology
Thu Nov 07, 2019 02:00
A Bleeding Toe
Figure 1.
The New England Journal of Medicine: Search Results in Hematology\Oncology
Thu Nov 07, 2019 02:00
Comparative Effectiveness of Sleep Apnea Screening Instruments During Inpatient Rehabilitation Following Moderate to Severe TBI
Publication date: Available online 6 November 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Risa Nakase-Richardson, Daniel J. Schwartz, Leah Drasher-Phillips, Jessica M. Ketchum, Karel Calero, Marie N. Dahdah, Kimberley R. Monden, Kathleen Bell, Ulysses Magalang, Jeanne Hoffman, John Whyte, Jennifer Bogner, Jamie M. ZeitzerAbstractObjectiveTo determine the diagnostic sensitivity and specificity and comparative effectiveness of traditional sleep apnea screening tools in traumatic...
Archives of Physical Medicine and Rehabilitation
Thu Nov 07, 2019 12:33
Corrigendum to ‘SPiQE: An automated analytical tool for detecting and characterising fasciculations in amyotrophic lateral sclerosis’ [Clin. Neurophysiol. 130 (2019) 1083–1090]
Publication date: Available online 6 November 2019Source: Clinical NeurophysiologyAuthor(s): J. Bashford, A. Wickham, R. Iniesta, E. Drakakis, M. Boutelle, K. Mills, C. Shaw
Clinical Neurophysiology
Thu Nov 07, 2019 12:27
40 years Western blotting: A scientific birthday toast
Publication date: Available online 6 November 2019Source: Journal of ProteomicsAuthor(s): Christian P. MoritzAbstractThe Western blot technique was first published 40 years ago. Since then, it has been mentioned in the titles, abstracts, and keywords of more than 400,000 PubMed-listed publications. This anniversary represents an opportunity to look back to its origins, to address the question as to whether the technique is outdated and heading toward being replaced, and to point out current improvements....
ScienceDirect Publication: Journal of Proteomics
Thu Nov 07, 2019 12:20
Proteomic characterization of <em>Mycobacterium tuberculosis</em> reveals potential targets of bostrycin
Publication date: Available online 6 November 2019Source: Journal of ProteomicsAuthor(s): Peibo Yuan, Lei He, Dongni Chen, Yunhao Sun, Zhenhuang Ge, Dong Shen, Yongjun LuAbstractTuberculosis (TB) is caused by bacterial pathogen Mycobacterium tuberculosis (Mtb) and remains a major health problem worldwide. The increasing prevalence of drug-resistant Mtb strains and the extended duration of anti-TB regimens have created an urgent need for new anti-tuberculosis antibiotics with novel targets or inhibitory...
ScienceDirect Publication: Journal of Proteomics
Thu Nov 07, 2019 12:20
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents
New England Journal of Medicine, Ahead of Print.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:02
The U.S. Insulin Crisis — Rationing a Lifesaving Medication Discovered in the 1920s
New England Journal of Medicine, Volume 381, Issue 19, Page 1793-1795, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest
New England Journal of Medicine, Volume 381, Issue 19, Page 1831-1842, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Deaths Associated with Emicizumab in Patients with Hemophilia A
New England Journal of Medicine, Volume 381, Issue 19, Page 1878-1879, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Double Trouble
New England Journal of Medicine, Volume 381, Issue 19, Page 1854-1860, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Warm Autoimmune Hemolytic Anemia
New England Journal of Medicine, Volume 381, Issue 19, Page 1881-1882, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Teplizumab in Relatives at Risk for Type 1 Diabetes
New England Journal of Medicine, Volume 381, Issue 19, Page 1879-1881, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
The “All of Us” Research Program
New England Journal of Medicine, Volume 381, Issue 19, Page 1883-1885, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
A Bleeding Toe
New England Journal of Medicine, Volume 381, Issue 19, Page 1853-1853, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Acute Severe Hypertension
New England Journal of Medicine, Volume 381, Issue 19, Page 1843-1852, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Total Penis, Scrotum, and Lower Abdominal Wall Transplantation
New England Journal of Medicine, Volume 381, Issue 19, Page 1876-1878, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00

A Good Physician — On Complacency and Communication
New England Journal of Medicine, Volume 381, Issue 19, Page 1798-1799, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides
New England Journal of Medicine, Volume 381, Issue 19, Page 1866-1869, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Liver Fluke
New England Journal of Medicine, Volume 381, Issue 19, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Pheochromocytoma and Paraganglioma
New England Journal of Medicine, Volume 381, Issue 19, Page 1882-1883, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Health, Social Reform, and Medical Schools — The Training of American Physicians and the Dissenting Tradition
New England Journal of Medicine, Volume 381, Issue 19, Page 1870-1875, November 2019.
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
Wed Nov 06, 2019 12:00
Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease
Abstract This study aims to investigate the levels of SLIT3 in gingival crevicular fluid (GCF) of healthy and periodontal disease subjects, and their correlations to periodontal disease. A total of 45 periodontal patients and 45 periodontally healthy volunteers were enrolled. The clinical parameters, radiographic bone loss and the levels of SLIT3, receptor activator of NF‐κB ligand (RANKL) and osteoprotegerin (OPG) in GCF were measured. The prevalences of Porphyromonas gingivalis, Treponema denticola...
Oral Diseases
Wed Nov 06, 2019 21:05
Thalamic Abscess in a Newly Diagnosed Diabetic Patient
Brain abscesses are commonly located in the cerebral cortex and cerebellum; however, solitary thalamic lesions are rare. Recent cases report dental pathology as a common source, potentially compounded by immunocompromise. Here, we report a newly diagnosed diabetic male with poor dentition presenting with evidence of meningitis wherein thalamic abscess was discovered.
Case Reports in Infectious Diseases
Thu Nov 07, 2019 11:05
27PArtemisia absinthium nanoparticles induce apoptosis in breast cancer cells via inhibiting vesicular trafficking related proteins
AbstractBackgroundThe limitations of the currently available anti-breast cancer agents like they exert side effects can be overcome by combining two approaches together i.e. loading of herbal drugs into the nanoparticles.MethodsKeeping in mind the tumor micro environment, double triggered (temperature and pH responsive) polymeric nanoparticles (NPs) were prepared and characterized by TEM, DLS and IR. The cytotoxicity of the different part extracts of A. absinthium was evaluated on the breast cancer...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
35PPatterns of N-cadherin (N-cad) and vimentin (Vim) expression as a sign of epithelial-mesenchymal transition (EMT) in prostate cancer (PCa)
AbstractBackgroundEMT is a mechanism of metastatic spread and therapy resistance. Agents targeting mesenchymal markers up-regulated during EMT, like N-cad (ADH-1, biflorin, synthetic peptide H-SWTLYTPSGQSK-NH2, mAbs) and Vim (withaferin-A, FiVe1, simvastatin, DNA aptamer NAS-24, mAbs) have shown promising results in preclinical studies. Aim: to evaluate the expression of N-cad and Vim in PCa.MethodsPCa samples from 48 patients were stained immunohistochemically on consequent sections with rabbit...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
99PLikelihood of targeted therapy recommendations for advanced solid tumours
AbstractBackgroundAdvanced therapy-refractory cancer diseases have a poor prognosis and constitute a major challenge for adequate treatment strategies. In this analysis, we aimed to show the potential and the likelihood of targeted therapy recommendations in patients with different types of advanced solid tumors for whom no standard treatment was available.MethodsIn this single center, real-world retrospective analysis of our precision medicine platform, we describe the likelihood of targeted therapy...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
Translational Research Index
ABCB7: 95P
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
114PSignal: The home page of mutational signatures
AbstractBackgroundThe somatic mutations found through sequencing a whole tumour genome are the aggregate outcome of one or multiple mutational processes. Each of these processes leaves a characteristic imprint, or mutational signature, on the genome. The final mutational profile is determined by the pattern of exposure of each of these mutational processes. Deconstructing the signature composition of a tumour’s mutational profile provides insights into the biological processes that drive it. The...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
22PFeasibility of precision cancer medicine in advanced gynaecologic cancers
AbstractBackgroundAdvanced gynecologic cancers have a poor prognosis and constitute a major challenge for adequate treatment strategies. By analyzing and targeting molecular alterations, precision cancer medicine (PCM) may be a viable option for the treatment of advanced gynecologic cancers.MethodsIn this single center, real-world retrospective analysis of our PCM platform, we describe the molecular profiling of 72 patients diagnosed with different types of metastasized BTC. Tumor samples of the...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
98PComparison of whole exome sequencing and FoundationOne Heme sequencing panel as tools for precision oncology in paediatric patients with difficult-to-treat solid tumours
AbstractBackgroundThe necessary condition for the application of precision oncology approach into the routine is a detailed molecular characterization of the tumour. In our study, we explored clinical applicability of both whole exome sequencing (WES) and FoundationOne Heme (F1Heme) panel (Foundation Medicine, Inc., MA, USA) as comprehensive genomic profiling tools in a cohort of 35 children with difficult-to-treat solid tumours.MethodsWES (both somatic and germline) in children with high-risk solid...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
47PThe properties of mitochondria in glioma stem cells
AbstractBackgroundMitochondria have a key role in cell survival, signaling, metabolism, and homeostasis. However, whether their biological properties affected by differentiation status of cells are not well known. This study aimed to compare structural and functional differences of mitochondria between differentiated cancer cells and undifferentiated cancer stem cells.MethodsGlioma stem cells (GSCs) were cultured in stem cell culture conditions to maintain their stem cell properties or serum culture...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
115PDetection of actionable variants in various cancer types reveals value of whole-genome sequencing over in-silico whole-exome and hotspot panel sequencing
AbstractBackgroundDeclining costs of next-generation sequencing technologies has led to their more widespread use for the identification of targetable mutations. Nonetheless, while multigene panels are being assimilated into clinical practice, the use of whole-exome and whole-genome sequencing (WES and WGS) remains limited, as its added value is unclear in the clinic.MethodsIn our study, we have used the Cancer Genome Interpreter (CGI) to identify the actionable variants that are detected by WGS...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
34PThe importance of p53 signaling pathway in the evolution of gastric cancer
AbstractBackgroundAlthough p53 pathway was previously explored in human carcinogenesis, the clinical implication of this gene is still unknown. The aim of this paper was to explore the particularities of TP53gene, at molecular and protein level, in gastric cancer.MethodsIn 197 surgical specimens provided from patients with gastric carcinomas, consecutive cases with curative resection, without preoperative therapy, the clinicopathological parameters were correlated with immunohistochemical (IHC) expression...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
64PRole of RNF144B in triple negative breast cancer proliferation
AbstractBackgroundBreast cancer (BC) is one of the leading causes of deaths in females worldwide. BC is classified into three distinct groups: hormone receptor positive (ER+/PR+), hormone negative/HER2 positive and triple negative breast cancer (TNBC). Patients with hormone positive (HR+) and HER2 positive(HER2+) cancers show a better prognosis and survival rate. However, due to a lack of biomarkers TNBC has the worst prognosis and approximately 70% of women with metastatic TNBC die within 5years....
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
109PAssociation of rs363293 single nucleotide polymorphism in promoter region of miRNA-143/145 with susceptibility to colorectal cancer and with patients’ outcome
AbstractBackgroundmiRNA-143 and miRNA-145 are known as suppressors of tumor cell proliferation and migration, and in triggering of apoptosis. Both miRNAs have been shown to be down-regulated in colorectal cancer (CRC). miRNA-143 and miRNA-145 are encoded from gene cluster on chromosome 5q32 and probably originate from the same primary RNA. The aim of the present study was to determine the possible association of gene variant in promoter region of miRNA-143/145 with risk of CRC in a Bulgarian population...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
62PIdentification of tamoxifen-resistant microRNA expression profiles in breast cancer: En route to precision medicine through establishing new biomarkers
AbstractBackgroundBreast cancer (BC) is found approximately at 1 million of new cases annually, and mortality reaches 400 thousand. Acquired resistance to tamoxifen limits adjuvant therapy`s potential to combat BC. Notably, up to 50% of ER+ BC cases fail to respond tamoxifen therapy. Elucidating molecular mechanisms of tamoxifen resistance development and transfer is important to develop novel therapies. New biomarkers indicating tamoxifen resistance are also to be found for proper development of...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00

97PCommunity-driven development of a modified progression-free survival ratio for precision oncology trials
AbstractBackgroundThe success of a cancer therapy in an individual patient can be estimated by calculating the progression-free survival (PFS) ratio. First conceived by Daniel Von Hoff more than two decades ago, it is now increasingly being used in precision oncology trials. Here, the PFS ratio is defined as the PFS under a molecularly guided therapy (PFS2) divided by the PFS under the last systemic therapy before molecular tumour profiling (PFS1). A significant therapy response is usually defined...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
23PA new quercetin glycoside enhances TNBC immunological profile through TP53/miR-155/MICA/ULBP2
AbstractBackgroundTriple-negative breast cancer (TNBC) patients are the least fortunate in terms of prognosis and treatment. Yet, the advent of immunotherapy has opened the gateway for several hopes. The most prominent immuno-oncological strategy is the utilization of the adaptive immune system through immune checkpoint inhibitors. But unfortunately evidence of resistance has shown up in TNBC patients. Consequently, as an alternative approach researchers have thought about employing the innate arm...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
46PPrevalence of homologous recombination deficiency (HRD)-related signatures indicates that a wider range of prostate cancer patients may benefit from PARP-inhibitor therapy
AbstractBackgroundProstate cancers with mutations in genes involved in homologous recombination (HR), most commonly BRCA2, respond favorably to PARP-inhibition and platinum-based chemotherapy. Currently targeted sequencing of key HR genes serves as an indicator of homologous recombination deficiency (HRD) in prostate cancer. It is well known, however, that other mechanisms, such as suppression of expression, rare mutations of HR-related genes can also cause HRD.MethodsHRD levels can be estimated...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
101PClinical application of routine comprehensive tumour molecular profiling in the management of cancer patients
AbstractBackgroundAlong with the extension of the FDA approved molecular matched therapies, the evidence is building to support molecular profile-based off-label drug prescription or inclusion in a clinical trial. We report the findings from our real-world comprehensive molecular tumor profiling (CMTP) practice to assess how CMTP extends treatment options within and beyond standards of care.MethodsPts with a confirmed diagnosis of advanced cancers are eligible. DNA was extracted from either archival...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
33PCombination of mTOR inhibition and paclitaxel as a personalised strategy in the context of MYC-amplified high-grade serous ovarian cancer
AbstractBackgroundThe extreme genomic heterogeneity of high-grade serous ovarian carcinoma (HGSOC) is a major barrier to precision medicine approaches. We have developed mutational signature analysis from shallow whole genome sequencing (sWGS) for molecular stratification and therapeutic prediction. PARP inhibitor therapy has significant survival advantage for women with germline BRCA1/2 mutations, but treatments and predictive biomarkers for women without homologous recombination deficiency have...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
6OComprehensive genomic profiling and outcomes among metastatic melanoma patients (pts) treated with first-line cancer immunotherapy (CIT) in a real-world setting
AbstractBackgroundDistinctive genomic subtypes (BRAF-mutated [BRAFmut], NRASmut, NF1mut, and triple wild type [wt]) have been identified in melanoma, but little is known about their distribution and association with outcomes outside of clinical trials. By linking longitudinal electronic health records (EHR) and comprehensive genomic profiling we aim to describe characteristics and outcomes among CIT-treated pts in a real-world setting.MethodsMetastatic melanoma pts in the de-identified Flatiron Health...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
Drug Index
Abiraterone acetate: 9P
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
89PDistribution of somatic mutations in PIK3CA gene in breast colorectal and colorectal Czech cancer patients - selected colorectal cancer patients with angiogenesis inhibitors treatment
AbstractBackgroundMutation profiling of tumours for treatment options is reality in many types of cancer and biomarkers eg. KRAS, EGFR are well established in personalised medicine. Phosphatidyl 3-kinases (PI3K) are a family of lipid kinases involved in many cellular processes, including cell growth, proliferation, differentiation, motility, and survival. Mutation of PIK3CA gene has been implicated in the pathogenesis of several cancers, but their prognostic/predictive/therapeutic implications are...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
60PEvaluation of mouse polyclonal antibody against nNav1.5 to recognize nNav1.5 protein in human breast cancer cells using fluorescence immunostaining
AbstractBackgroundNeonatal splice variant of Nav1.5 (nNav1.5) is a known tumor-associated antigen (TAA), re-expressed in adult aggressive breast cancer/tumor biopsies positive for lymph node metastasis. Accurate assessment of nNav1.5 protein in breast cancer cells/tissue is important in validating its potential value as a prognostic or predictive marker. Mouse polyclonal antibody (pAb) against nNav1.5 has been obtained. Herein, the ability of the pAb to selectively recognize nNav1.5 protein was evaluated...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
38PAnti-breast cancer activity of 7-α-hydroxyfrullanolide triggered G2/M arrest and apoptotic induction of triple negative breast cancer cell line, revealed by proteomics
AbstractBackgroundBreast cancer (BCa) affects women’s health worldwide. BCa subtype could be classified by presenting of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Knowing of BCa subtype would be benefit for chemotherapeutic treatments guidance. Triple negative breast cancer (TNBC) is a subtype of BCa that lacks of all those receptors and being poor response by currently targeted chemotherapies. The anti-cancer activities of 7-α-hydroxyfrullanolide (GM2)...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
108PTargeted proximity ligation assays combined with sequencing for robust detection of translocations in FFPE samples
AbstractBackgroundStructural variants in DNA such as translocations are increasingly found as key oncogenic events in tumors, and detection is clinically relevant for therapy choice in many conditions. Despite developments in targeted and whole genome gene sequencing, the robust detection of structural variants remains a challenge, especially in FFPE specimens.MethodsTargeted proximity ligation assays selectively amplify and sequence entire genes based on the crosslinking of physically proximal sequences,...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
112PA Bayesian framework to quantify survival uncertainty
AbstractBackgroundExisting survival models do not model uncertainty in personalized (per-patient) prediction of survival, which is useful for treatment planning of cancers. Moreover, their restrictive modeling assumptions limit their accuracy of personalized survival estimation. For example, the Cox proportional hazard (CPH) model assumes a constant effect of each input feature on survival rate over time along with a linear combination of features. The multi-task logistic regression (MTLR) allows...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
21PThe different prognostic impact of age according to individual molecular subtypes in breast cancer
AbstractBackgroundYoung age at diagnosis has been considered a poor prognostic factor. However, considering young age itself as an independent poor prognostic factor for all breast cancers is unwarranted. We analyzed the different prognostic effects of age as a prognostic factor according to molecular subtype.MethodsWe retrieved data from 1,410 patients with primary breast cancer at the breast cancer center between 2007 and 2011. We classified each molecular subtype in three age cohorts including...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
37PPlasma ctDNA RAS mutation analysis by digital polymerase chain reaction in patients with inoperable pancreatic cancer
AbstractBackgroundPancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and high mortality worldwide. Despite the emergence of new therapeutic approaches for the treatment of inoperable PDAC, reliable prognostic/predictive biomarkers are lacking. PDAC harbours mutations in the KRAS gene in 80-90% of patients. The aim of the present study is the detection and quantification of RAS mutations in the ctDNA of patients with inoperable PDAC by BEAMing digital polymerase chain reaction...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
96PAssessments of cancer-free lymph nodes for the prediction of disease progression
AbstractBackgroundHistological changes in the cancer-free lymph nodes (LNs) can add to the risk prediction of developing distant metastasis for LN-positive breast cancer patients. As Whole Slide Images (WSI) demonstrated suitability for detection of LN metastasis with high accuracy based on Convolutional Neural Networks (CNN), we extended the assessments to cancer-free LNs to determine whether early signs of disease progression could be identified.MethodsClinico-pathological data, including level...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
110PPan-cancer analysis for oncogenes and mechanisms of their upregulation
AbstractBackgroundEach tumor has a unique molecular portrait, nevertheless, there are also a number of genetic and epigenetic aberrations that are inherent to the groups of epithelial tumors of different localizations. Our research was aimed at the identification of genes with significantly increased expression (potential oncogenes) in multiple cancer types and determination of mechanisms of their upregulation.MethodsBioinformatics analysis was performed using our CrossHub tool and The Cancer Genome...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
45PCirculating tumour associated cells in esophageal cancers are resistance educated per previous chemo treatments
AbstractBackgroundInnate and acquired chemoresistance to anticancer therapies are a well-known phenomenon in Esophageal Squamous Cell Carcinomas (ESCC). There are presently no viable approaches for real-time monitoring of resistance in ESCC. We used a novel method for chemo-interrogation (CI) by harvesting sufficient number of Circulating-Tumor Associated Cells (C-TACs) which are defined as apoptosis-resistant cells of tumorigenic origin and are positive for Epithelial Cell Adhesion Molecule (EpCAM)...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00
67PCirculating tumour cells mRNA in treatment strategy for melanoma
AbstractBackgroundCirculating tumor cells may reflect the genetic events happening in tumor site what is especially advantageous in case of inability to make biopsy and for monitoring of disease progression and / or treatment effectiveness. Decreasing of distinct mRNA expression levels may indicate positive changes in disease course (for example, decreasing aggressiveness, and risk of metastases).Methods30 plasma samples of melanoma patients of 3-4 grades and 30 plasma samples of melanoma patients...
Annals of Oncology - current issue
Thu Nov 07, 2019 02:00

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