Authors: Webster HC, Andrusaite AT, Shergold AL, Milling SWF, Perona-Wright G Abstract The use of helminth infections as tools to understand the type 2 immune response is a well-established technique and important to many areas of immunological research. The phenotype and function of immune cell populations at the site of infection is a key determinant of pathogen clearance. However, infections with helminths such as the murine nematode Heligomosmoides polygryrus cause increased mucus production...
Wed Nov 06, 2019 00:00
CONCLUSION: HELIOS could provide accurate diagnostic results, this include not only positive/negative results, but also endpoint titer, common patterns. The application of this system can help to promote standardization of ANA detection. PMID: 31705859 [PubMed - as supplied by publisher] (Source: Journal of Immunological Methods)
Wed Nov 06, 2019 00:00
Authors: Rice HM, Rossi AP, Bradford MK, Elkins KL, De Pascalis R Abstract Methods used to prepare bone marrow-derived macrophages (BMDMs) may influence the outcomes of immunological assays in which they are used. Supernatant conditioned by growth of L929 cells has often been used to generate mouse macrophages from bone marrow in vitro but is subject to lot-to-lot variability. To reduce experimental variability and to standardize techniques across laboratories, we investigated recombinant...
Sat Nov 02, 2019 00:00
Publication date: Available online 11 November 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hidetoshi Igari, Kazutaka Yamagishi, Shingo Yamazaki, Shota Murata, Misuzu Yahaba, Shin Takayanagi, Yohei Kawasaki, Toshibumi TaniguchiAbstractThe Macrolides (MLs), clarithromycin and azithromycin, are key drugs for non-tuberculous mycobacteria (NTM) diseases treatment. A three antibiotics regimen including MLs, rifampicin (RFP) and ethambutol (EB) has been recommended for the treatment of NTM...
Tue Nov 12, 2019 17:04
Once again the UK has recorded its highest rate of drug related deaths—this is the seventh annual increase we have witnessed. The number of people dying is now at unprecedented levels, which has led...
Tue Nov 12, 2019 14:16
Mali is a vast and troubled country. Much of it is lawless Sahara desert, where UN peacekeepers have failed in recent years to root out jihadists and criminal gangs. To the south, where the Sahara...
Tue Nov 12, 2019 14:15
Patients arrive at a GP appointment with all manner of symptoms and varying degrees of unease, anxiety, pain, and fear. If we aim for patients to leave feeling better than when they came, they need...
Tue Nov 12, 2019 14:06
As I walk towards the sound of 1970s music, coloured disco lights spill out from the window. I clutch a quickly wrapped bottle of cold wine, snatched from the fridge as I left the house. But an early...
Tue Nov 12, 2019 14:05
The chief medical officer’s report on childhood obesity has helped to raise awareness of one of the most serious public health challenges of the 21st century.12 It describes evidence that shows that...
Tue Nov 12, 2019 13:36
A Nottinghamshire paediatrician has reported a severe immune reaction in a 16 year old boy who had been smoking e-cigarettes. The incident comes amid growing concerns at the safety of the products,...
Tue Nov 12, 2019 13:26
Abstract Racial/ethnic disparities in cancer outcomes have been well documented. Access to Pap testing may account for some of the variation in the racial and socioeconomic differences in cervical cancer outcomes. Literature exploring perceived access to care as it relates to women of color and low-income women is lacking. The goal of the study was to evaluate and characterize the relationship between what respondents believe about access to free/low-cost screening facilities and...
Tue Nov 12, 2019 02:00
Abstract Histone deacetylase (HDAC) inhibitors impair tumor cell proliferation and alter gene expression. However, the impact of these changes on anti-tumor immunity is poorly understood. Here, we showed that the class I HDAC inhibitor, entinostat (ENT), promoted the expression of immune-modulatory molecules, including MHCII, costimulatory ligands, and chemokines on murine breast tumor cells in vitro and in vivo. ENT also impaired tumor growth in vivo—an effect that was dependent...
Tue Nov 12, 2019 02:00
Abstract Hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) is usually considered an inflammation-related cancer associated with chronic inflammation triggered by exposure to HBV and tumor antigens. T-cell exhaustion is implicated in immunosuppression of chronic infections and tumors. Although immunotherapies that enhance immune responses by targeting programmed cell death-1(PD-1)/PD-L1 are being applied to malignancies, these treatments have shown limited response...
Tue Nov 12, 2019 02:00
Abstract Purpose Tumor-associated macrophages (TAMs) exist as heterogeneous subsets and have dichotomous roles in cancer-immune evasion. This study aims to assess the clinical effects of Galectin-9+ tumor-associated macrophages (Gal-9+TAMs) in muscle-invasive bladder cancer (MIBC). Experimental design We identified Gal-9+TAMs by immunohistochemistry (IHC)...
Tue Nov 12, 2019 02:00
Abstract Background Sebastes schlegelii are an important species of fish found in the coastal areas of the Korea with significant commercial importance. Most studies thus far have been primarily focused on environmental factors; behavioural patterns, aquaculture, diseases and limited genetic studies with little to none related to either microRNAs (miRNAs) or transposable elements (TE). ...
Tue Nov 12, 2019 02:00
Abstract Background Various kinds of transposable elements (TEs) constitute high proportions of eukaryotic genomes. Although most of these TEs are not actively mobile, genome stress can induce mobilization of dormant TEs. Transgenic plants undergo tissue culture and subsequent whole-plant regeneration, which can cause genomic stress and in turn induce mobilization of inactive TEs. ...
Tue Nov 12, 2019 02:00
Abstract Purpose In Japan, due to the increased incidence of cancer among the working population, it has become more important to support employees to achieve a balance between cancer treatment and work. This study aimed to clarify the predictors of resigning from employment after being diagnosed with cancer (post-cancer diagnosis [PCD] resignation) among Japanese employees. ...
02:00
Abstract Mps1/TTK plays an important role in development of many tumors. The purpose of the present study was designed to investigate the role of TTK in colon cancer. We analyzed TTK and colon cancer in the GEO database, colon cancer tissues and normal tissues were collected to verify the results by immunohistochemistry. We detected the TTK expression in the colon cancer cell lines, and overexpressed or silenced TTK expression in colon cancer cell lines. GEO database showed that...
02:00
The last decade has seen a transition in the surgical approach to lobectomy, from thoracotomy to minimally invasive surgery (MIS), for treating patients with early-stage non-small cell lung cancer (NSCLC) [1]. Growing evidence has demonstrated that MIS lobectomy, including video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS), is associated with fewer postoperative complications such as arrhythmias and pneumonia and shorter chest tube duration and length of hospital...
Mon Nov 11, 2019 00:00
Pulmonary high-grade neuroendocrine carcinoma includes the following two clinicopathological entities classified on the basis of their morphological and biological features: large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) [1,2]. LCNEC and SCLC share several histological features, including rosette formation, molding of nuclei, and lack of apparent glandular formation and keratinization [3,4]. LCNEC, diagnosed in approximately 3% of all patients with lung cancer, is generally...
Mon Nov 11, 2019 00:00
Title: Self-Testing for Cervical Cancer Increases Screening RatesCategory: Health NewsCreated: 11/8/2019 12:00:00 AMLast Editorial Review: 11/11/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Mon Nov 11, 2019 08:00
Publication date: Available online 11 November 2019Source: MethodsAuthor(s): Jennifer I. Brown, Brent D.G. Page, Adam FrankelAbstractProtein arginine N-methyltransferases (PRMTs) are a family of 9 enzymes that catalyze mono- or di-methylation of arginine residues using S-adenosyl-L-methionine (SAM). Arginine methylation is an important post-translational modification that can regulate the activity and structure of target proteins. Altered PRMT activity can lead to a variety of health issues including...
06:38
Authors: Liu R, Sun M, Zhang G, Lan Y, Yang Z Abstract Despite the presence of methods evaluating drug resistance during chemotherapies, techniques, which allow for monitoring the degree of drug resistance in early chemotherapeutic stage from single cells in their native microenvironment, are still absent. Herein, we report an analytical approach that combines single cell mass spectrometry (SCMS) based metabolomics with machine learning (ML) models to address the existing challenges. Metabolomic...
06:06
Authors: Li D, Li X, Shen B, Li P, Chen Y, Ding S, Chen W Abstract Platelet-derived growth factor-BB (PDGF-BB) is currently used as a biomarker protein for cancer early diagnosis and clinical treatment. Herein, we reported a robust and enzyme-free strategy based on aptamer recognition and proximity-induced entropy-driven circuits (AR-PEDC) for homogeneous and rapid detection of platelet-derived growth factor BB (PDGF-BB) without any washing steps or thermocycling. The proximity probes specifically...
06:06
In conclusion, this study suggests curcumin as a potent neuroprotective agent with potential for the treatment of HIE. The delayed application of curcumin further increases its clinical relevance. (Source: Frontiers in Physiology)
00:00
Publication date: Available online 12 November 2019Source: European UrologyAuthor(s): Guillaume Ploussard (Source: European Urology)
04:08
Publication date: Available online 11 November 2019Source: Preventive MedicineAuthor(s): Jennifer Leeman, Karen Glanz, Peggy Hannon, Jackilen ShannonAbstractThis editorial provides a high level overview of the articles included in this supplement. (Source: Preventive Medicine)
04:06
Financial hardship among rural cancer survivors: An analysis of the Medical Expenditure Panel Survey
This study examined contrasts in financial hardship among 1419 rural and urban cancer survivors using the 2011 Medical Expenditure Panel Survey supplement – The Effects of Cancer and Its Treatment on Finances. We combined four questions, creating a measure of material financial hardship, and examined one question on financial worry. We conducted multivariable logistic regression analyses, which produced odds ratios (OR) for factors associated with financial hardship and worry, and then generated...
04:06
Publication date: Available online 12 November 2019Source: Preventive MedicineAuthor(s): Susannah Gibbs, S. Marie Harvey, Linh Bui, Lisa Oakley, Jeff Luck, Jangho YoonAbstractWe evaluated the effect of the Affordable Care Act (ACA) Medicaid expansion on receipt of preventive reproductive services for women in Oregon. First, we compared service receipt among continuing Medicaid enrollees pre- and post-ACA. We then compared receipt among new post-ACA Medicaid enrollees to receipt by continuing enrollees...
04:06
ConclusionsAn 11-point modified frailty index as measured in NSQIP correlates with readmissions after colorectal resection in patients with colon and rectal cancer. (Source: The American Journal of Surgery)
03:37
ConclusionsThe development of a pelvic MRI curriculum for residents entering CGSO fellowships could enhance their clinical training in the multidisciplinary management of patients with rectal cancer. (Source: The American Journal of Surgery)
03:37
ConclusionsThere were no OS differences in patients undergoing MAST, XRT, or MXRT, suggesting breast conservation can be considered in patients with OBC. (Source: The American Journal of Surgery)
03:37
ConclusionsIORT is an effective treatment option for well-selected patients with early breast cancer and can be considered for patients with lobular histology. (Source: The American Journal of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
03:37
DiscussionIn case of TTE with PMDS, optimal surgical approach with orchiopexy and excision of Müllerian duct is necessary. Intraoperative aggressive dissection of vas deferens and testicular vessels should be avoided in TTE patients. They should be closely followed because of the increased risk of malignant transformation in the postoperative period.ConclucionAn investigation of transvers testicular ectopia should be performed in all nonpalpable undescended testis anomalies. (Source: International...
03:37
ConclusionPara-aortic surgical staging contributes significantly to individualize the radiation treatment of patients with LACC, particularly for those with positive PLN at PET/CT. Indication of surgical staging deserves particular attention when the PET/CT suggests positive LN in the common iliac region. (Source: European Journal of Surgical Oncology (EJSO))
03:37
ConclusionRadiological and pathological response in the breast to NACT does not accurately predict axillary response. The axilla and the breast should be viewed and assessed as two separate entities for treatment plans. (Source: European Journal of Surgical Oncology (EJSO))
03:37
ConclusionThis study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked. (Source: Respiratory Investigation)
03:09
Biologic drugs have revolutionized the treatment of certain hematologic, autoimmune, and malignant diseases, but they may place patients at risk for reactivation or acquisition of tuberculosis. This risk is highest with the tumor necrosis factor-alpha (TNF- α) inhibitors. Amongst this class of drugs, the monoclonal antibodies (infliximab, adalimumab, golimumab) and antibody fragment (certolizumab) carry an increased risk compared to the soluble receptor fusion molecule, etanercept. Treatment of latent...
03:08
ConclusionDiffusion-related parameters (D, ADC, MD, and MK) were able to significantly distinguish between low- and high-grade ccRCC. However, perfusion-related parameters (D* and f) were unable to separate high- and low-grade ccRCC. MD may be the most promising parameter for grading ccRCC in the clinic. (Source: Academic Radiology)
02:41
ConclusionLow-keV VMI reconstructions improve reliability of quantitative size measurements and diagnostic accuracy for the assessment of CRLM compared to standard linearly-blended images. (Source: Academic Radiology)
02:41
This study offers a new approach to analyzing how death gets discussed in medical interaction. Using a corpus of 90 video-recorded oncology visits and conversation analytic (CA) methods, this analysis reveals that when existing parameters are expanded to look at mentions of death outside of the end-of-life context, physicians do discuss death with their patients. Specifically, the most frequent way physicians invoke death is in a persuasive context during treatment recommendation discussions. When...
02:38
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Can Yi, Chao Huang, Huan Wang, Chen Wang, Lijuan Dong, Xiuli Gu, Xianhong Feng, Bifeng ChenAbstractCYP24A1, an essential gene in regulation of vitamin D, has been reported to play an important role in enhancing immune activity and inhibiting tumorigenesis. Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. To...
02:05
ConclusionsmiR-424-5p serves as an oncogene in CRC and circulating exosomal miR-424-5p is a novel potential diagnostic biomarker of CRC patients. (Source: Pathology Research and Practice)
02:05
ConclusionsFKBP9 may be a cancer promoter that enhances PCa progression, and the level of FKBP9 may be used as an independent precursor of PCa patients. (Source: Pathology Research and Practice)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
02:05
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Nenggang Zhang, Asis K. Sarkar, Debananda PatiAbstractSepin-1 is a small compound that inhibits enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, herein we have profiled the toxicity of Sepin-1 in Sprague-Dawley rats in a good laboratory practice (GLP) setting. The maximum tolerated dose (MTD) of Sepin-1...
02:05
ConclusionOverall, high level of LINC00261 in CCA predicts a poor prognosis, and promotes a metastasis via EMT process. Thus, LINC00261 could be a promising biomarker and therapeutic target for CCA, and in the high level of LINC00261 in CCA, E-cadherin or CDH1 might be an effective factor for tumor metastasis or poor prognosis. (Source: Pathology Research and Practice)
02:05
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Jie Mei, Bujie Xu, Leiyu Hao, Zhuang Xiao, Yan Liu, Ting Yan, Yichao ZhuAbstractRecent studies have reported that dishevelled-associated activator of morphogenesis 1 (DAAM1) is remarkably essential for mediating cell migration and invasion in breast cancer (BrCa). Nonetheless, the definite expression profile of DAAM1 in BrCa patients and the impact on metastasis of BrCa in vivo have not been explored...
02:05
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Pablo Igor Ribeiro Francoa, Arthur Perillo Rodrigues, Liliana Borges de Menezes Leite, Marina Pacheco MiguelAbstractCancer is a disease that affects millions of individuals worldwide and has a great impact on public health. Therefore, the study of tumor biology and an understanding of how the components of the tumor microenvironment behave and interact is extremely important for cancer research....
02:05
In conclusion, heterogeneous RICTOR overexpression is common in solid tumors and RICTOR IHC can be used as a screening tool to detect RICTOR amplification. (Source: Pathology Research and Practice)
02:05
In this study, we revealed that NLRP3 was elevated in CRC tissues and related to clinical factors, such as lymph node invasion and tumor-node-metastasis (TNM) stage. Moreover, NLRP3- positive patients had a poor prognosis. Furthermore, univariate and multivariate analysis revealed that NLRP3 expression was an independent prognostic factor for the survival of CRC patients. We investigated whether NLRP3 linked with the mTOR-S6K1 pathway. The expression of p-S6K1 was upregulated in CRC tissues and NLRP3...
02:05
CONCLUSION: This observational study highlights that head and neck specialists are not aware of, and are consequently not complying with, routine human immunodeficiency virus testing as recommended by the British HIV Association guidelines. PMID: 31708001 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
02:05
Publication date: Available online 11 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Yingao Zhang, Megan S. Grant, Wesley H. Stepp, Leslie H. ClarkAbstractThe development of brain and central nervous system (CNS) metastases from primary gynecologic cancers is an extremely uncommon but deadly process. Through this retrospective case series of patients treated at a single institution from 2004 to 2018, we aim to explore potential clinical patterns of this phenomenon with respect to primary...
01:39
Publication date: Available online 11 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Yuji Ohki, Hisako Yamada, Yusuke Taira, Wataru Kudaka, Yoichi Aoki (Source: Gynecologic Oncology Reports)
01:39
Endobronchial Small-cell Lung Cancer with Intraluminal Growth Pattern Showing "Finger-in-glove" Appearance. Intern Med. 2019 Nov 08;: Authors: Kitahara Y, Murakami Y, Nakai S, Hiramatsu T, Kishimoto Y, Nihashi F, Aono Y, Eifuku T, Uto T, Sato J, Imokawa S, Suda T Abstract Invasion of the endobronchial mucosa by cancer cells is frequently seen in small cell lung cancer (SCLC), but an intraluminal polypoid growth pattern is extremely rare. We herein describe the case of a 69-year-old...
00:55
Authors: Fukuda M, Miyake T, Matsubara A, Ikai N, Tanaka E, Namura T, Wada Y, Noujima M, Moritani S, Murakami K, Andoh A, Tani M, Kushima R Abstract A 72-year-old man was followed as an outpatient at our hospital for 6 years after surgery for small cell carcinoma of left adrenal gland origin. Follow-up abdominal computed tomography showed a 6-cm mass in the left lower mesentery. The patient underwent open laparotomy. The histological diagnosis was sclerosing mesenteritis. The previous specimens...
00:55
Authors: Ohara N, Kobayashi M, Ikeda Y, Hoshi T, Morita S, Kanefuji T, Yagi K, Suda T, Takada T, Hasegawa G, Sato Y, Hirano K, Kosugi SI Abstract A 70-year-old man with insulinoma-associated antigen-2 autoantibodies developed diabetes mellitus (DM) without ketoacidosis after starting nivolumab to treat advanced gastric cancer. He subsequently exhibited preserved insulin-secretion capacity for over one year. Immune-checkpoint inhibitors (ICIs) infrequently cause type 1 DM associated with...
00:55
(Source: BMJ News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
00:42
ConclusionThe major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer. (Source: Journal of the Formosan Medical Association)
00:42
Publication date: Available online 11 November 2019Source: Blood Cells, Molecules, and DiseasesAuthor(s): Jana Volejnikova, Petr Vojta, Helena Urbankova, Renata Mojzíkova, Monika Horvathova, Ivana Hochova, Jaroslav Cermak, Jan Blatny, Martina Sukova, Eva Bubanska, Jaroslava Feketeova, Daniela Prochazkova, Julia Horakova, Marian Hajduch, Dagmar PospisilovaAbstractDiamond-Blackfan anemia (DBA) is a rare congenital erythroid aplasia, underlied by haploinsufficient mutations in genes coding for ribosomal...
00:14
Publication date: Available online 11 November 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Shivani Shah-BeckerMost benign tumors of the larynx are epithelial in origin, with nearly 85% being laryngeal papilloma. Nonepithelial laryngeal tumors are uncommon and more than 50% of these are malignant. Therefore, benign nonepithelial solid tumors of the larynx are quite rare. The management of these tumors varies based on the site of origin, specific pathology, tumor...
00:06
ConclusionThis technique is a feasible treatment in patients aged over 70 years, providing good functional results, and acceptable oncologic outcome. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
00:06
ConclusionThis case draws attention to the unique clinical value of molecular testing in the diagnosis of MTC. The authors believe this case supports the consideration for molecular testing to prevent missed diagnoses in cases of rare benign-appearing disease. (Source: American Journal of Otolaryngology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
00:02
Cardio-oncology has developed as a new field due to the proliferation of novel cancer therapies that not only have improved outcomes for some types of cancer, but also may lead to various cardiovascular toxicities. Older therapies, such as anthracyclines, are associated with cardiomyopathy as a result of myocyte death at the time of treatment, followed by cardiac remodeling in the years following completion of therapy, and eventually lead to heart failure (HF). In 2019, data are limited on the prevention...
Tue Nov 12, 2019 01:00
This article has been corrected online. (Source: JAMA)
Tue Nov 12, 2019 01:00
An “electronic nose,” or eNose, accurately predicted whether patients with advanced non–small cell lung cancer would respond to anti–programmed cell death 1 (anti-PD-1) therapies in a recent observational study published in the Annals of Oncology. If the findings bear out in randomized clinical trials, the device could spare patients with cancer from receiving immunotherapies that won’t benefit them. (Source: JAMA)
Tue Nov 12, 2019 01:00
(Source: Annals of Surgical Oncology)
Tue Nov 12, 2019 00:00
ConclusionsOur model that included novel biomarkers of BUN-to-SCr ratio and glucose have a higher predictive performance of 30-day mortality and prolonged ICU stay following CDI than do the guidelines. (Source: Antimicrobial Resistance and Infection Control)
Tue Nov 12, 2019 00:00
Publication date: Available online 11 November 2019Source: Trends in Pharmacological SciencesAuthor(s): Bushu Dong, Alex M. Jaeger, Dennis J. ThieleThe ability of cancer cells to cope with stressful conditions is critical for their survival, proliferation, and metastasis. The heat shock transcription factor 1 (HSF1) protects cells from stresses such as chemicals, radiation, and temperature. These properties of HSF1 are exploited by a broad spectrum of cancers, which exhibit high levels of nuclear,...
Tue Nov 12, 2019 23:39
Publication date: Available online 12 November 2019Source: Pharmacological ResearchAuthor(s): Zhuojun Liu, Jia Liu, Tianming Zhang, Mingxia Shi, Xiaofang Chen, Yun Chen, Jian YuAbstractReceptor tyrosine kinase-like orphan receptor 1 (ROR1) is an onco-embryonic antigen presented on chronic lymphocytic leukemia (CLL), but not on normal adult tissues, which promotes CLL-cell survival. Here, ROR1 was identified as a new client of Heat Shock Protein 90 (HSP90) via a mass spectrometry-based screen for...
Tue Nov 12, 2019 23:39
Publication date: Available online 11 November 2019Source: International Journal of PharmaceuticsAuthor(s): Anirban Jana, Pankhuri Narula, Archana Chugh, Ritu KulshreshthaAbstractThe levels of microRNAs (miRNAs) are altered in various diseases including glioblastoma (GBM) and this alteration may have widespread effects on various hallmarks of cancer cells. MiR210 is overexpressed in GBM and functions as an oncogenic miRNA. Anti-miR210 therapy holds great promise but its efficient delivery remains...
Tue Nov 12, 2019 23:39
Synthesis of hyaluronic acid-based polymersomes for doxorubicin delivery to metastatic breast cancer
Publication date: Available online 11 November 2019Source: International Journal of PharmaceuticsAuthor(s): Mahsa Shahriari, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona AlibolandiAbstractIn the current research, the synthesis of polysaccharide-based polymersomes for targeted delivery of doxorubicin is reported. To this aim, doxorubicin was encapsulated in aqueous compartment of hyaluronan-polycaprolactone polymersomes via nanoprecipitation method. Then the therapeutic index of...
Tue Nov 12, 2019 23:39
ConclusionOur result indicated miR-195 suppresses cyclin D1 and Cdc42 to inhibit EC cell proliferation, and Cdc42 may via regulating both cyclin D1-dependent and independent pathways to control EC cell proliferation. (Source: Biomedicine and Pharmacotherapy)
Tue Nov 12, 2019 23:39
ConclusionThe effects of PLB in endocrine-resistant breast cancer cells is dependent on NQO1’s activity.Graphical Abstract (Source: Phytomedicine)
Tue Nov 12, 2019 23:38
Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization. (Source: Annals of Plastic Surgery)
Tue Nov 12, 2019 23:08
This study aims to determine if a disparity in BR utilization exists in women from Appalachia Kentucky. Methods A retrospective, population-based cohort study was conducted from January 1, 2006, to December 31, 2015. The Kentucky Cancer Registry was queried to identify population-level data for female patients diagnosed with breast cancer and treated with mastectomy. A multivariate logistic regression model controlling for patient, disease, and treatment characteristics was constructed to predict...
Tue Nov 12, 2019 23:08
This article describes ossification of the corresponding vascular pedicle after soft tissue transfer with the lateral upper arm free flap and microsurgical anastomosis in oral cancer treatment. Similar findings in the context of the lateral upper arm free flap have never been reported in the literature; however, it is important for surgeons to know that pedicle ossification can occur. This knowledge may be helpful to avoid erroneous diagnosis of the ossification as a sign of tumor relapse/recurrence...
Tue Nov 12, 2019 23:08
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Tue Nov 12, 2019 00:00
. (Source: Expert Opinion on Biological Therapy)
Tue Nov 12, 2019 00:00
(Source: Annals of Surgical Oncology)
Tue Nov 12, 2019 00:00
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Xue-Yan He, David Ng, Linda Van Aelst, Mikala EgebladStress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on...
Tue Nov 12, 2019 22:38
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Lisa N. Heppler, David A. FrankDespite the role of STAT3 as a known driver of oncogenesis, efforts to develop therapeutic STAT3 inhibitors have thus far been unsuccessful. In this issue of Cancer Cell, Bai et al. report a potent and selective STAT3 degrader capable of producing complete and long-lasting tumor regression in mouse xenograft models. (Source: Cancer Cell)MedWorm Message: If you are looking to buy something...
Tue Nov 12, 2019 22:38
Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Jessica L. Hopkins, Lee ZouIn this issue of Cancer Cell, Quereda and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes triple-negative breast cancer cells to PARP inhibitors and DNA-damaging chemotherapeutics by reducing expression of the genes in the DNA damage response pathway. (Source: Cancer Cell)
Tue Nov 12, 2019 22:38
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Anne Trinh, Kornelia PolyakImmunotherapy has been the most effective in tumors with high mutational burden. However, a recent study in Cell by Wolf et al. demonstrates that high intratumor heterogeneity (ITH) for cancer neoantigens paradoxically attenuates anti-tumor immune responses, suggesting a need to quantify ITH to improve patient selection for checkpoint blockade therapy. (Source: Cancer Cell)
Tue Nov 12, 2019 22:38
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Anthony M. Joshua, Ian F. TannockIn this issue of Cancer Cell, Pillarsetty and colleagues radiolabel the potential anticancer drug PU-H71 and use it with PET imaging to quantify the epichaperome protein complex in tumors and its inhibition by the drug. They thereby develop a companion diagnostic paradigm of probe-drug pairing to explore therapeutic potential. (Source: Cancer Cell)
Tue Nov 12, 2019 22:38
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Longchuan Bai, Haibin Zhou, Renqi Xu, Yujun Zhao, Krishnapriya Chinnaswamy, Donna McEachern, Jianyong Chen, Chao-Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Hui Jiang, Bo Wen, Praveen Kumar, Jennifer L. Meagher, Duxin Sun, Jeanne A. Stuckey, Shaomeng WangSummarySignal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Here we report the discovery of SD-36, a small-molecule...
Tue Nov 12, 2019 22:38
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S. AdusumilliCheckpoint blockade (CPB) therapy can elicit durable clinical responses by reactivating an exhausted immune response. However, response rates remain limited, likely secondary to a lack of a tumor-reactive immune infiltrate. Chimeric antigen receptor (CAR) T cells may provide the necessary tumor-targeting immune infiltrate and a highly specific...
Tue Nov 12, 2019 22:38
This study aimed to analyze AS prognostic factors in a large nationwide cohort of histologically confirmed cases, established through linkage of clinical data from the Netherlands Cancer Registry and pathology data from the Dutch pathology registry (PALGA). All cases were reviewed by an expert pathologist, showing a 16% discordance rate. Multivariable Cox regression survival analysis among 479 confirmed AS patients revealed remarkably poorer overall survival (OS) for primary AS compared to secondary...
Tue Nov 12, 2019 00:00
Authors: María Auxiliadora Olivares-Urbano Carmen Griñán-Lisón Sandra Ríos-Arrabal Francisco Artacho-Cordón Ana Isabel Torralbo Elena López-Ruiz Juan Antonio Marchal María Isabel Núñez Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated...
Tue Nov 12, 2019 00:00
Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and “leaky” tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented and hypo-perfused tumor vessels hamper the anti-tumor efficacy of immune cells and prevent the efficient diffusion of chemotherapeutic drugs. Therefore, tumor vascular normalization has emerged as a new treatment goal, aiming to provide a mature tumor...
Tue Nov 12, 2019 00:00
Metastatic non-small cell lung cancer (NSCLC) is associated with a limited survival when treated with palliative intent platinum-based chemotherapy alone. Recent advances in imaging and therapeutic strategy have identified a subset of patients with limited metastases who may benefit from early local ablative therapy with either surgery or radiotherapy, in addition to standard treatment. Stereotactic body radiotherapy (SBRT) is increasingly used in the treatment of extra-cranial oligometastatic NSCLC...
Tue Nov 12, 2019 00:00
Mounting evidence has demonstrated that a lot of miRNAs are overexpressed or downregulated in colorectal cancer (CRC) tissues and play a crucial role in tumorigenesis, invasion, and migration. The aim of our study was to screen new biomarkers related to CRC prognosis by bioinformatics analysis. By using the R language edgeR package for the differential analysis and standardization of miRNA expression profiles from The Cancer Genome Atlas (TCGA), 502 differentially expressed miRNAs (343 up-regulated,...
Tue Nov 12, 2019 00:00
The purpose of this study was to examine pazopanib/topotecan combination activity vs. pazopanib monotherapy on anaplastic thyroid cancer (ATC) cells. Proliferation analyses were performed on ATC cell lines administered for 72 h with pazopanib and topotecan alone and to their simultaneous combination. Pazopanib and topotecan produced a strong synergism on ATC cells, calculated by the combination index, increasing the intracellular concentrations of topotecan lactone measured by high-performance liquid...
Tue Nov 12, 2019 00:00
ConclusionsThe intervention was associated with increased patient knowledge. Data from this pilot have guided the development of a larger scale randomized clinical trial to improve decision quality in men with prostate cancer being treated in community settings. (Source: Cancer Medicine)
Tue Nov 12, 2019 00:00
ConclusionsThe cancer burden attributable to HPV in China is substantial. HPV vaccination and cervical screening should be prioritized. (Source: Cancer Medicine)
Tue Nov 12, 2019 00:00
In this report, we demonstrate potent anti‐myeloma effects of the TOPK inhibitor OTS514 for the fir st time. OTS514 induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from MM patient ‐derived peripheral blood mononuclear cells. In bone marrow cells from MM patients, OTS514 treatment exhibited preferential killing of the malignant CD138+ plasma cells compared with the CD138−...
Tue Nov 12, 2019 00:00
In this study, we show that different TKIs used for treatment of Chronic Myeloid Leukemia have opposing effects on platelet function, with large inter ‐individual differences. Thus, in patients with high risk for hemostatic or thrombotic complications, we suggest that treatment with TKIs should be individualized to minimize risks associated with long‐term treatment. AbstractSince their introduction, tyrosine kinase inhibitors (TKIs, eg, imatinib, nilotinib, dasatinib, bosutinib, ponatinib) have revolutionized...
Tue Nov 12, 2019 00:00
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