In this report, we demonstrate potent anti‐myeloma effects of the TOPK inhibitor OTS514 for the fir st time. OTS514 induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from MM patient ‐derived peripheral blood mononuclear cells. In bone marrow cells from MM patients, OTS514 treatment exhibited preferential killing of the malignant CD138+ plasma cells compared with the CD138−...
Tue Nov 12, 2019 00:00
In this study, we show that different TKIs used for treatment of Chronic Myeloid Leukemia have opposing effects on platelet function, with large inter ‐individual differences. Thus, in patients with high risk for hemostatic or thrombotic complications, we suggest that treatment with TKIs should be individualized to minimize risks associated with long‐term treatment. AbstractSince their introduction, tyrosine kinase inhibitors (TKIs, eg, imatinib, nilotinib, dasatinib, bosutinib, ponatinib) have revolutionized...
Tue Nov 12, 2019 00:00
Publication date: Available online 11 November 2019Source: Neuroscience LettersAuthor(s): Bingjie Qin, Yuxing Li, Xiaohu Liu, Denghui Gong, Weihong ZhengAbstarctChemotherapy-induced peripheral neuropathy (CIPN) has a adverse impact to the living quality of cancer patients. This side effect of CIPN limit the dose of drug used in many chemotherapies, such as vincristine (VCR). The activation of microglia in the spinal dorsal horn is involved in the occurrence and development of neuropathic pain induced...
Tue Nov 12, 2019 20:36
Publication date: Available online 11 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Pratiksha Saxena, Pramod K. Sharma, Priyank PurohitAbstractThe most enthralling and versatile class of drugs called the Non-steroidal anti-inflammatory (NSAIDs) showed its therapeutic utility in inflammation, beginning from the era of classic drug ‘Aspirin’. NSAIDs and their well-established action based on inhibiting the COX-1 and COX-2 enzyme leads to blockage of prostaglandin pathway....
Tue Nov 12, 2019 20:05
Authors: Çulha G, Kaya T, Gülbol Duran G, Urhan Küçük M, Doğramacı AÇ, Tiyekli Çelik D Abstract Leishmaniasis is a parasitic disease that is transmitted to humans by the bites of infected female phlebotomine sandflies. In the diagnosis of cutaneous leishmaniasis (CL), in the smear samples, the demonstration of the parasite by microscope remains a gold standard method. However, it becomes difficult to diagnose the parasite since the number of amastigotes in chronic cases with a lesion of...
Tue Nov 12, 2019 20:01
AbstractCancer classification is one of the crucial tasks in medical field. The gene expression of cells helps in identifying the cancer. The high dimensionality of gene expression data hinders the classification performance of any machine learning models. Therefore, we propose, in this paper a methodology to classify cancer using gene expression data. We employ a bio-inspired algorithm called binary bat algorithm for feature selection and extreme learning machine for classification purpose. We also...
Tue Nov 12, 2019 00:00
CONCLUSIONS Hence, we concluded that the overexpression of LINC-PINT may exhibit inhibitory effects on the progression of cardiomyopathy and retinopathy among patients with type 2 diabetes. PMID: 31711064 [PubMed - in process] (Source: Medical Science Monitor)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 19:21
CONCLUSIONS Application of Traditional Chinese Medicine prolonged progression-free survival and enhanced therapeutic effect in NSCLC patients harboring EGFR mutations receiving EGFR-TKI treatment. Meanwhile, adjunctive Chinese medicine combining EGFR-TKI in NSCLC with EGFR mutations caused no adverse effects. PMID: 31704907 [PubMed - in process] (Source: Medical Science Monitor)
Tue Nov 12, 2019 19:21
CONCLUSIONS Nomogram 1 can assist in preoperative prediction of survival time in ATC patients, whereas nomogram 2 can provide additional outcome-related information. PMID: 31705799 [PubMed - in process] (Source: Medical Science Monitor)
Tue Nov 12, 2019 19:21
CONCLUSIONS In summary, this study demonstrated that wogonin acts as an ovary cancer cell proliferation inhibiting agent through activation of apoptosis. Wogonin, therefore, can be investigated further for the development of ovary cancer treatment. PMID: 31707402 [PubMed - in process] (Source: Medical Science Monitor)
Tue Nov 12, 2019 19:21
Authors: Amer NA Abstract [No Abstract Available]. PMID: 31707419 [PubMed - in process] (Source: Saudi Medical Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 19:00
Publication date: Available online 11 November 2019Source: Biosensors and BioelectronicsAuthor(s): Leixia Meng, Ke Xiao, Xiaohua Zhang, Cuicui Du, Jinhua ChenAbstractDNA methylation catalyzed by M.SssI methyltransferases (MTase) has important roles in gene expression and other cellular activities, and relates to some diseases, especially cancers. Therefore, it is important to develop a sensitive sensing platform for M.SssI MTase activity assay. Here, taking zeolitic imidazolate framework-8 (ZIF-8)...
Tue Nov 12, 2019 17:02
Publication date: Available online 11 November 2019Source: Biosensors and BioelectronicsAuthor(s): Parham Ghassemi, Xiang Ren, Brittni M. Foster, Bethany A. Kerr, Masoud AgahAbstractCirculating tumor cells (CTCs) in blood can provide valuable information when detecting, diagnosing, and monitoring cancer. This paper describes a system that consists of a constriction-based microfluidic sensor with embedded electrodes that can detect and enumerate cancer cells in blood. The biosensor measures impedance...
Tue Nov 12, 2019 17:02
Colitis-associated cancer (CAC) is the most serious outcome of inflammatory bowel disease, which has an alteration of commensal intestinal microbiota. However, the role of intestinal microbiota on CAC progression is not well-understood. Fecal microbiota transplantation (FMT) was used for treating murine azoxymethane–dextran sodium sulfate (AOM-DSS) model of CAC. Composition of gut microbiota during FMT treatment was analyzed. RT-PCR and ELISA were used to detect the inflammatory factors, and immunofluorescence...
Tue Nov 12, 2019 00:00
Volume 47, Issue 1, December 2019, Page 4194-4201 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Tue Nov 12, 2019 00:00
Authors: Mahé I, Meyer G, Sanchez O, groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE PMID: 31703829 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 16:11
ConclusionsTargeted therapy showed remarkable efficacy in ASC patients harboring sensitiveEGFR mutations, comparable to adenocarcinoma. The application of the third-generation TKI provided an option to prolong survival. (Source: Molecular Diagnosis and Therapy)
Tue Nov 12, 2019 00:00
AbstractIntravascular dissemination of tumor cells is the accepted mechanism of cancer metastasis. However, the phenomenon of angiotropism, pericyte mimicry (PM), and extravascular migratory metastasis (EVMM) has questioned the concept that tumor cells metastasize exclusively via circulation within vascular channels. This new paradigm of cancer spread and metastasis suggests that metastatic cells employ embryonic mechanisms for attachment to the abluminal surfaces of blood vessels (angiotropism)...
Tue Nov 12, 2019 00:00
Publication date: Available online 12 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Wonwoong Lee, Jinhee Um, Boram Hwang, Yong Chan Lee, Bong Chul Chung, Jongki HongAbstractBile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Moreover, the progression of gastric cancer, could change...
Tue Nov 12, 2019 15:38
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Nguyen Thi Thuy My, Tran Thi Hong Hanh, Pham Thi Cham, Nguyen Xuan Cuong, Tran Thu Huong, Tran Hong Quang, Nguyen Hoai Nam, Chau Van MinhAbstract•Two new ent-labdane diterpenoid glucosides, andropaniosides A and B, along with five known analogs, andrographiside, neoandrographolide, andropanoside, 14-deoxy-11,12-didehydroandrographiside, and 19-O-β-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol were isolated...
Tue Nov 12, 2019 15:37
Publication date: Available online 11 November 2019Source: European Polymer JournalAuthor(s): Fuhua Xin, Meng Wei, Shengling Jiang, Yanjing Gao, Jun Nie, Yuejiao Wu, Fang SunAbstractThree kinds of hydrophilic photocleavage o-nitrobenzyl acrylate-modified nanogels with different particle size and narrow particle size distribution (1.8-0.24) were designed and synthesized by reversible addition-fragmentation chain transfer radical (RAFT) polymerization based on methoxy polyethylene glycol methacrylate...
Tue Nov 12, 2019 15:37
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC07683B, Feature ArticleZhen Chen, Haoqiang Lai, Liyuan Hou, Tianfeng Chen Organo-seleno compounds (org-Se) have been widely used in antitumor, antivirus, antiinflammation, antioxidation and other biological fields. As such, they have made an important contribution in overcoming various kinds of diseases... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Tue Nov 12, 2019 15:35
We present our shared vision for change from leading scientists from academic, government, nonprofit, and industrial sectors and chemical and pharmaceutical safety applications. This call to action builds upon a 2017 workshop on “Advances and Roadblocks for Use of Genomics in Cancer Risk Assessment.” The authors propose a path for implementation of innovative cancer risk assessment including incorporating genomic signatures to assess mechanistic relevance of carcinogenicity and enhanced use of genomics...
Tue Nov 12, 2019 15:08
Publication date: Available online 12 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): D. Hariharan, P. Thangamuniyandi, A. Jegatha Christy, R. Vasantharaja, P. Selvakumar, S. Sagadevan, A. Pugazhendhi, L.C. NehruAbstractTitanium dioxide (TiO2) nanoparticles (NPs) have been doped with varying amounts (0.005, 0.010 and 0.015 M) of silver nanoparticles (AgNPs) using hydrothermal method. Further, in this work, a green approach was followed for the formation of Ag@TiO2...
Tue Nov 12, 2019 14:35
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 13:13
No abstract available (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 13:13
Objective: The aim of this study was to determine outcomes of primary tumor resection in metastatic neuroendocrine tumors across all primary tumor sites. Background: Primary tumor resection (PTR) may offer a survival benefit in metastatic gastrointestinal neuroendocrine tumors (GI-NETs); however, few studies have examined the effect of primary site and grade on resection and survival. Methods: This is a retrospective study of patients with metastatic GI-NETs at presentation between 2005 and...
Tue Nov 12, 2019 13:13
Conclusions: S-LYMPHA is a simple method, which decreases incidence of LE dramatically. It should be considered as an adjunct procedure to ALND for all patients during initial surgery. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Objective: Here, we assess the ability of metabolic tumor volume (MTV) as measured by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) to evaluate neoadjuvant chemotherapy response for patients with locally advanced esophageal cancer (EC). Background: Optimal methods to evaluate treatment response for EC patients have not yet been established. Although previous studies have reported the value of standardized uptake value (SUV), the accuracy of predicting...
Tue Nov 12, 2019 13:13
Objective: The aim of this study was to evaluate the benefit of anatomical resection (AR) in lung metastasectomy (LM) of colorectal cancer (CRC) harboring KRAS mutations Summary Background Data: KRAS mutations are related to high aggressiveness in the lung metastasis of CRC. It is unknown whether AR can lead to better outcomes than can non-AR (NAR) in KRAS patients. Methods: We retrospectively reviewed the data from 574 consecutive patients who underwent a LM for CRC. We focused on patients...
Tue Nov 12, 2019 13:13
Objective: First, to assess the impact of the number of examined lymph nodes (ELNs) on staging and survival after distal pancreatectomy (DP) for pancreatic adenocarcinoma (PDAC). Second, to identify the minimum number of ELNs (MNELNs) ensuring an accurate detection of nodal involvement. Third, to reappraise the role of lymph node (LN) parameters, including N-status and lymph node ratio (LNR). Background: In contrast with pancreatoduodenectomy, information on LN staging and the MNELN required...
Tue Nov 12, 2019 13:13
Objective: To investigate cancer- and noncancer-specific mortality following lobectomy by minimally invasive surgery (MIS) versus open thoracotomy in elderly patients with nonsmall cell lung cancer (NSCLC). Background: Two-thirds of patients with NSCLC are ≥65 years of age. As age increases, the risk of competing events, such as noncancer death, also increases. Methods: Elderly patients (≥65 yrs of age) who have undergone curative-intent lobectomy for stage I-III NSCLC without induction therapy...
Tue Nov 12, 2019 13:13
Conclusions: High-quality TME for patients with rectal adenocarcinoma of the mid and low rectum can be equally achieved by transanal or robotic approaches in skilled hands, but attention should be paid to the distal margin. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Conclusion: Patients selected to receive MIPD for cancer have equivalent short-term and oncologic outcomes, when compared with patients who undergo OPD. (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
Conclusions: In the CRITICS trial, hospitals with a high annual volume of gastric cancer surgery were associated with higher overall and DFS. These findings emphasize the value of centralizing gastric cancer surgeries in the Western world. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Conclusions and Relevance: Few hospitals would meet TVP volume thresholds for complex cancer resections with little difference in outcomes between ILV, IHV, and HV hospitals. While a policy to regionalize complex surgical care may have merit, it could also compromise patient autonomy and limit access to care if patients are unable or unwilling to travel. (Source: Annals of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media...
Tue Nov 12, 2019 13:13
Objective: To study the effect of postoperative complications (POC) on overall survival (OS) and disease-free survival (DFS) after surgical resection of colorectal liver metastases (CRLM). Summary Background Data: Morbidity rates after liver resection can reach 45%. The negative impact of POC on oncologic outcomes has been reported in various types of cancer, especially colorectal. However, data on the consequences of POC after CRLM resection on long-term survival are scarce. Methods: Eligible...
Tue Nov 12, 2019 13:13
Conclusion: An international consensus definition for the rectum is the point of the sigmoid take-off as visualized on imaging. The sigmoid take-off can be identified as the mesocolon elongates as the ventral and horizontal course of the sigmoid on axial and sagittal views respectively on cross-sectional imaging. Routine application of this landmark during multidisciplinary team discussion for all patients will enable greater consistency in tumour localisation. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Conclusions: Laparoscopic distal gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer shows benefits in terms of lower complication rate, faster recovery, and less pain compared with open surgery. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Conclusions: The long-term survival after MIE compares well with OE and may even be better. Thus, MIE can be recommended as a standard surgical approach for esophageal cancer. (Source: Annals of Surgery)
Tue Nov 12, 2019 13:13
Conclusions: Using novel algorithms, the addition of a dedicated team of surgical quality officers to the surgical innovation evaluation process improved both the efficiency and the safety associated with introducing new devices and procedures into practice. (Source: Annals of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 13:13
ConclusionsA low-preoperative PNI was significantly associated with a poor prognosis in oldest-old colorectal cancer patients. Perioperative nutritional support may be important for prolonging the survival. (Source: Surgery Today)
Tue Nov 12, 2019 00:00
AbstractDNA methylation is an epigenetic mechanism involved in the development of primary osteoarthritis (OA). The association between DNA methyltransferases (DNMTs) genes polymorphisms and diseases in which DNA methylation plays a role in their pathogenesis has been described (e.g., cancer); however, its relationship with OA has not been investigated. The aim of this study was to analyze the association betweenDNMT1,DNMT3A, andDNMT3B polymorphisms with radiologic primary knee OA in Mexican mestizo...
Tue Nov 12, 2019 00:00
Cell Death & Disease, Published online: 12 November 2019; doi:10.1038/s41419-019-2096-xCorrection: miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via downregulating histone H4K20 trimethylation through directly targeting SUV420H2 (Source: Cell death and disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 00:00
In this study, we systematically identified translated smORFs derived from lncRNAs and explored their potential pathological functions in cancer to improve our comprehensive understanding of the building blocks of living systems (Source: Frontiers in Genetics)
Tue Nov 12, 2019 00:00
There has been increasing attention on immune-oncology for its impressive clinical benefits in many different malignancies. However, due to molecular and genetic heterogeneity of tumors, the activities of traditional clinical and pathological criteria are far from satisfactory. Immune-based strategies have re-ignited hopes for the treatment and prevention of breast cancer. Prognostic or predictive biomarkers, associated with tumor immune microenvironment, may have great prospects in guiding patient...
Tue Nov 12, 2019 00:00
In this study, Mutagen X was removed from aqueous media by a thermally reduced graphene oxide bonded on the surface of amino-functionalized sand particles.MethodA Box-Behnken design was applied to optimize the adsorption process. Characterization of the adsorbent and graphene oxide was accomplished using scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Raman analysis. The effects of...
Tue Nov 12, 2019 00:00
In this study, we investigate the atomistic details of Keap1-Nrf2 inhibitors by in-depth modeling techniques, including molecular dynamics (MD) simulations, and the path-based free energy method of umbrella sampling (US). The protein–protein interaction (PPI) of Keap1-Nrf2 is implicated in several neurodegenerative diseases like cancer, diabetes, and cardiomyopathy. A better understanding of the five sub-pocket binding sites for Nrf2 (ETGE and DLG motifs) inside the Kelch domain would expedite the...
Tue Nov 12, 2019 00:00
In this study, ficifolidione derivatives with alkyl groups such as methyl, n-pentyl, and n-heptyl group—instead of the isobutyl group at the C-4 position—were synthesized to evaluate their cytotoxicity against the human promyelocytic leukaemia cell line HL60 and their insecticidal activity against mosquito larvae. The biological activities of their corresponding 4-epimers were also evaluated. As a result, the conversion of the isobutyl group to another alkyl group did not significantly influence...
Tue Nov 12, 2019 00:00
Here, we report a case of chronic empyema with bronchopleural fistula and destroyed lung in which bronchial occlusion with N ‐butyl‐2‐cyanoacrylate and lipiodol resulted in the improvement of respiratory distress and recurrent pneumonia. A 72 ‐year‐old Japanese man who had undergone resection of a left upper lung carcinoma developed chronic empyema with bronchopleural fistula and destroyed lung 12 years after surgery. Open‐window thoracotomy and bronchial occlusion with an endoscopic Watanabe spigot...
Tue Nov 12, 2019 00:00
(Source: Clinical Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 12:35
Corrigendum to "About the French prohibition of textured breast implants: Is it justified or over-cautious? The EUSOMA, ESSO/BRESSO position" [Breast 46 (August 2019) 95-96]. Breast. 2019 Dec;48:103 Authors: Cardoso MJ, Biganzoli L, Rubio IT, Leidenius M, Curigliano G, Cutuli B, Marotti L, Kovacs T, Wyld L PMID: 31706464 [PubMed - in process] (Source: Breast)
Tue Nov 12, 2019 11:47
Corrigendum to "EUSOMA position regarding breast implant associated anaplastic large cell lymphoma (BIA-ALCL) and the use of textured implants" [Breast 44 (April 2019) 90-93]. Breast. 2019 Dec;48:102 Authors: Cardoso MJ, Wyld L, Rubio IT, Leidenius M, Curigliano G, Cutuli B, Marotti L, Biganzoli L PMID: 31706463 [PubMed - in process] (Source: Breast)
Tue Nov 12, 2019 11:47
Conclusion: Taken together, AFPE that acts at a low micromolar range against breast cancer cells may be considered as a promising candidate for anticancer therapy. (Source: Current Nutrition and Food Science)
Tue Nov 12, 2019 11:15
Conclusion: The present study confirms that the process of roasting coffee beans is a significant factor in the formation of acrylamide in Arabic coffee powders and beverages. (Source: Current Nutrition and Food Science)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 11:15
Conclusion: These findings suggest that a pro-inflammatory diet is a risk factor for prostate cancer and also can have the impact on body composition. (Source: Current Nutrition and Food Science)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 11:15
Cervical dysplastic lesions called cervical intraepithelial neoplasias (CINs) need be treated to prevent cervical cancer. Currently available surgical procedures are effective, but the development of noninvasive treatment is warranted. In human papillomavirus transgenic mice engineered to express human papillomavirus type 16 E6 and E7, short-term treatment with 17 β-estradiol induces CINs that progress to cervical cancer if the treatment is continued. In the present study, this mouse model was used...
Tue Nov 12, 2019 00:00
Authors: Ahmadi M, Mohammadi M, Ali-Hassanzadeh M, Zare M, Gharesi-Fard B Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as a new immune regulator at the feto-maternal interface. Although the phenotypes and functions of these cells were primarily studied in pathological conditions such as cancers and infections, new evidence has underscored their beneficial roles in homeostasis and physiological circumstances such as normal pregnancy. In this regard, studies have shown an...
Tue Nov 12, 2019 10:09
ConclusionVictims in the gothic vampire novels from the nineteenth century could very likely be inspired by real-life acute leukaemia patients. (Source: Irish Journal of Medical Science)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 00:00
The original article unfortunately contained a mistake. The corresponding author ’s name should be corrected as “Yingsheng Cheng”. (Source: Journal of Medical Systems)
Tue Nov 12, 2019 00:00
High-risk human papillomavirus (HR-HPV) testing is more sensitive than cytology for the detection of cervical cancer and its precursors. However, limited and inconsistent data are available about the efficacy ... (Source: BMC Infectious Diseases)
Mon Nov 11, 2019 01:00
Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing...
Tue Nov 12, 2019 09:12
Conclusion: We report a case of an encapsulated follicular variant of papillary thyroid carcinoma with unexpected metastasis to the lung 9 years after thyroid surgery in a patient who was initially diagnosed as follicular adenoma. A careful close follow-up with re-examination of the histopathology specimen may be needed in patients who were diagnosed with benign thyroid follicular tumors. (Source: Frontiers in Endocrinology)
Tue Nov 12, 2019 00:00
All individuals presenting with an extratympanic paraganglioma of the head and neck should undergo genetic testing. (Source: ENTtoday - TRIO Best Practices)
Mon Nov 11, 2019 22:23
Conclusions/interpretationOur study indicates that incident diabetes in adults has an element of autoimmune aetiology. Thus, there might be a reason to re-evaluate the present subclassification of diabetes in adulthood. (Source: Diabetologia)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 00:00
Publication date: Available online 10 November 2019Source: Seminars in Cancer BiologyAuthor(s): Jessica Burns, Christopher P Wilding, Robin L Jones, Paul H HuangAbstractSarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made over the past...
Tue Nov 12, 2019 08:17
(Source: OncoTargets and Therapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 02:35
Recurrence and distant metastases were main reasons of unfavorable outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) after surgery. The aim of this study was to describe the patterns, timing, and predictors of recurrence or metastasis in PDAC patients after curative surgery. Patients with PDAC who underwent radical pancreatectomy were included. Associations between clinicopathological and radiological characteristics and specific pattern of progression were investigated. Least absolute...
Tue Nov 12, 2019 00:00
Conclusion: The stromal-immune score-based gene signature represents a prognosis stratification tool in gastric cancer. (Source: Frontiers in Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 00:00
Authors: Katja Seipel Karin Schmitter Ulrike Bacher Thomas Pabst Amplification and overexpression of the myeloid cell leukemia differentiation protein MCL1 and the murine double minute protein MDM2 have been reported in various human tumors as well as hematological malignancies including acute myeloid leukemia (AML). While MCL1 is an anti-apoptotic member of the BCL-2 family proteins, MDM2 is an important cellular inhibitor of the p53 tumor suppressor. The key oncogene in AML is...
Tue Nov 12, 2019 00:00
Oncogenic activation of RAS isoforms leads tumor initiation and progression in many types of cancers and is gaining increasing interest as target for novel therapeutic strategies. In sharp contrast with other types of cancer, the importance of RAS in breast tumorigenesis has long been undermined by the low frequency of its oncogenic mutation in human breast lesions. Nevertheless, a wealth of studies over the last years have revealed how the engagement of RAS function might be mandatory downstream...
Tue Nov 12, 2019 00:00
ConclusionsOur findings suggest that exosomes derived from GEM-resistant pancreatic cancer stem cells mediate the horizontal transfer of drug-resistant traits to GEM-sensitive pancreatic cancer cells by delivering miR-210. (Source: Cellular Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Nov 12, 2019 00:00
(Source: Frontiers in Oncology)
Tue Nov 12, 2019 00:00
Conclusion: DNA repair inhibitor treatments are efficient in the platinum resistant model, MDA-MB-231. The combination with carboplatin improves survival. The association of carboplatin with olaparib is associated with high liver toxicity, which is not observed with AsiDNA. AsiDNA could delay resistance to carboplatin without increasing its toxicity. (Source: Frontiers in Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media...
Tue Nov 12, 2019 00:00
Conclusions: The incidence and incidence-based mortality of extranodal DLBCL had been increasing for decades, followed by a promising downward trend in recent years. These findings may help scientists identify disease-related risk factors and better manage the disease. The prediction signature cloud identifies high-risk patients who should receive effective therapies to prevent the fatal nature of this disease, and low-risk patients to reduce over-treatment. (Source: Frontiers in Oncology)MedWorm...
Tue Nov 12, 2019 00:00
Conclusions: The results obtained from these 5 cases demonstrate impressive tumor control from the combination of SBRT and checkpoint inhibitors in patients with large tumors of advanced HCC. Further prospective trials are warranted. (Source: Frontiers in Oncology)
Tue Nov 12, 2019 00:00
In conclusion, this article summarize the prognostic value of Cx43 and offer a clinical evidence for the notion that Cx43 is generally a tumor suppressor and beneficial for the patients' survival time. (Source: Frontiers in Oncology)
Tue Nov 12, 2019 00:00
Cancer immunotherapy including adoptive T cell therapy (ACT) is widely used in the clinic and is highly beneficial for patients with hematological malignancies; however, it remains a challenge to develop effective immunotherapy strategies for the treatment of solid cancers, due to the inefficiency of the immune response and the immunosuppressive tumor microenvironment (TME). Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulate a systemic antigen-specific...
Tue Nov 12, 2019 00:00
Casein kinase 1 delta (CK1δ) has a tumor-promoting role in different cancers and it is genetically amplified in a portion of human epithelial ovarian cancer (EOC). CK1δ is involved in pleiotropic cellular functions such as cell proliferation, DNA damage, and migration. We specifically knocked down CK1δ by short hairpin RNA (shRNA) in human ovarian cancer cells and we performed proliferation, chemosensitivity, as well as in vitro and in vivo migration assays. CK1δ knocked-down cells displayed reduced...
Tue Nov 12, 2019 00:00
AbstractReproducible patient positioning is essential for precision in radiation therapy (RT) delivery. We tested the hypothesis that a structured daily pre-treatment stretching regimen is both feasible and effective for minimizing variability in positioning, as measured by sacral slope angles (SSA). Eight female subjects undergoing pelvic radiotherapy performed a structured daily hip exercise regimen (extension and external rotation) immediately prior to both simulation imaging and daily treatment,...
Tue Nov 12, 2019 00:00
Conclusion: The current data provide novel and natural multi-kinase inhibitors with competitive regulation of the mutant proteins; K-Ras and B-Raf and sustained MAPK signaling without any detectable toxic effect in normal cells. (Source: Frontiers in Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Nov 12, 2019 00:00
AbstractPatients with advanced stage ovarian clear cell carcinoma (OCCC) have a poor prognosis due to resistance to conventional platinum chemotherapy. Recent studies have demonstrated that PI3K/AKT/mTOR and ERK1/2 signaling pathways are involved in this chemoresistance. Progranulin (PGRN) overexpression contributes to cisplatin resistance of epithelial ovarian cancer cell lines. Also, PGRN expression is regulated by AKT/mTOR and ERK1/2 signaling pathways in different cell types. Thus, the present...
Tue Nov 12, 2019 00:00
Gastric cancer (GC), with high heterogeneity, can be mainly classified into intestinal type and diffuse type according to the Lauren classification system. Although a number of differences were reported between these two types, no study on the Lauren subtype-specific multi-gene signature for evaluation of GC prognosis has been conducted, and the molecular mechanism underlying its poor prognosis has still remained elusive. Therefore, this study aimed to explore subtype-specific multi-gene signature...
Tue Nov 12, 2019 00:00
Conclusions: The complete response observed here illustrate the role of molecular profiling in complicate clinical situation of rare head and neck cancer and the potential benefit of BRAF-targeted therapy in ameloblastoma carrying BRAF V600E mutation. (Source: Frontiers in Oncology)
Tue Nov 12, 2019 00:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου