(Source: Cancer Management and Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 23:43
(Source: Cancer Management and Research)
Mon Nov 11, 2019 23:33
(Source: Cancer Management and Research)
Mon Nov 11, 2019 23:24
(Source: Cancer Management and Research)
Mon Nov 11, 2019 23:04
In Ethiopia, most cervical cancer patients present at advanced cancer stages, long time after they experience first symptoms. We investigated possible predictors of long time spans between symptom onset and pa... (Source: Infectious Agents and Cancer)
Mon Nov 11, 2019 01:00
(Source: Annals of Surgical Oncology)
Mon Nov 11, 2019 00:00
(Source: Annals of Surgical Oncology)
Mon Nov 11, 2019 00:00
ConclusionsDelays cause small but measurable effects overall, but the effect on survival does not differ among breast cancer phenotypes. Our data suggest that urgency between diagnosis and surgery or chemotherapy is similar for breast cancers of different subtypes. Although NACT is sometimes advocated solely to avoid treatment delays, this study does not suggest a greater surgical urgency for TNs compared with other breast cancer phenotypes. (Source: Annals of Surgical Oncology)
Mon Nov 11, 2019 00:00
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.9b12469 (Source: ACS Applied Materials and Interfaces)
Mon Nov 11, 2019 06:00
ACS NanoDOI: 10.1021/acsnano.9b05383 (Source: ACS Nano)
Mon Nov 11, 2019 06:00
ACS NanoDOI: 10.1021/acsnano.9b04303 (Source: ACS Nano)
Mon Nov 11, 2019 06:00
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.9b18472 (Source: ACS Applied Materials and Interfaces)
Mon Nov 11, 2019 06:00
The original version of this article unfortunately contained a mistake in Fig. 2. (Source: Journal of Molecular Neuroscience)
Mon Nov 11, 2019 00:00
Collectively, successful delivery of miR and chemotherapy by pH ‐responsive targeting nanoparticles modulates β‐catenin/multiple drug resistance/apoptosis/metastasis pathways and induces cancer cell death, mainly via apoptosis. These pH‐sensitive targeting nanoparticles carrying chemotherapy and gene therapeutics remarkably enhance anticancer efficacy in tumor‐bearing mice. Thus, these nanoparticles may provide a potential regimen for effective treatment of colorectal cancer. AbstractIrinotecan is...
Mon Nov 11, 2019 00:00
Abstract The CREB‐binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pathway genes played a role in survival of non‐small‐cell lung cancer (NSCLC). We tested this hypothesis using the genotyping data from the genome‐wide association study (GWAS) dataset from the Prostate, Lung, Colorectal, and Ovarian (PLCO)...
Tue Nov 12, 2019 11:53
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Mon Nov 11, 2019 00:00
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Thu Oct 31, 2019 00:00
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Tue Oct 29, 2019 00:00
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Fri Oct 25, 2019 00:00
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Fri Oct 25, 2019 00:00
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Tue Oct 22, 2019 00:00
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Tue Oct 22, 2019 00:00
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Tue Oct 22, 2019 00:00
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Mon Oct 21, 2019 00:00
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Mon Oct 21, 2019 00:00
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Wed Oct 16, 2019 00:00
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Wed Oct 16, 2019 00:00
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Wed Oct 16, 2019 00:00
Abstract Lung cancer is currently a leading cause of cancer-associated mortality worldwide. Despite the increasing evidences of variants that were associated with lung cancer risk, investigations of genetic factors and their roles in genetic susceptibility to lung cancer were limited. Here we systematically investigated the spectrum of pathogenic germline mutations in Chinese population with lung cancer. Genomic profiling of DNA was performed through next-generation sequencing...
Tue Nov 12, 2019 02:00
Abstract Background Ultrasound (US) is used in the initial evaluation and surveillance of urinary tract dilation in children. Urinary tract dilation is diagnosed in 1–2% of all pregnancies during routine prenatal sonography with technological advances in US imaging. Urinary tract dilation classification systems, including the 2014 multidisciplinary consensus, assess anterior–posterior renal pelvic diameter and calyceal dilation. There...
Tue Nov 12, 2019 02:00
Abstract Objective Long‐term childhood cancer survivors (CCS) are less likely to become parents than their peers of the same age. Previous research has suggested that besides fertility, this outcome is shaped by psychosocial factors such as emotional motives toward having a child. Drawing from a sample of CCS with survival times >25 years, we present the validation of a questionnaire assessing cancer‐specific reproductive motives and concerns. Methods We evaluated the cancer‐specific...
Tue Nov 12, 2019 11:09
Abstract Objective Compassion fatigue – that is, secondary traumatic stress (STS) and burnout – is a traumatic emotional state experienced by healthcare providers and expressed in a reduced capacity to be interested in and empathic to the suffering of others. Compassion fatigue may be related to grief over patients’ loss. We examined the relation between grief and compassion fatigue among psycho‐oncologists while exploring the impact of social acknowledgment on this association. We hypothesized...
Tue Nov 12, 2019 11:07
Abstract Purpose Despite cure, adolescents and young adults (AYA) who complete cancer treatment remain at risk for numerous physical and psychological late effects. However, engagement in recommended follow‐up care, knowledge of cancer treatment history and risks, and adoption of health promoting behaviors are often suboptimal. The pilot randomized controlled trial assessed the feasibility and acceptability of a text messaging intervention (THRIVE; Texting Health Resources to Inform, motiVate,...
Mon Nov 11, 2019 20:54
Abstract Objective Without an agreed‐upon set of characteristics that differentiate clinical from non‐clinical levels of fear of cancer recurrence (FCR), it is difficult to ensure that FCR severity is appropriately measured, and that those in need of intervention are identified. The objective of this study was to establish expert consensus on the defining features of clinical FCR. Method A three‐round Delphi was used to reach consensus on the defining features of clinical FCR. Sixty‐five...
Mon Nov 11, 2019 20:48
Abstract Objective Precision cancer medicine (PCM) aims at identifying tumor‐driving molecular characteristics to improve therapy. Despite early successes for some cancers, the approach faces manifold challenges. Patients undergoing extensive molecular diagnostics (MD) may hope for personal benefit although chances are small. In order to offer suitable support to this group, healthcare professionals need to gain insight into their experience. Thus, this study sought to explore the expectations...
Mon Nov 11, 2019 20:28
Abstract Objective Little attention has been paid to understanding how engaging in cancer‐related interpersonal exchanges via varying modes of communication influences psychological well‐being among young adults with cancer. This study explored the moderating role of communication mode on the relationship of relational processes of disclosure and responsiveness with psychological well‐being. Methods 61 young adults with cancer (M age = 34.59, SD = 4.82) completed a questionnaire about...
Mon Nov 11, 2019 19:03
Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this stu...
Mon Nov 11, 2019 02:00
Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...
Mon Nov 11, 2019 02:00
The 3'-termini of tRNA are the point of amino acid linkage and thus crucial for their function in delivering amino acids to the ribosome and other enzymes. Therefore, to provide tRNA functionality, cells have to ensure the integrity of the 3'-terminal CCA-tail, which is generated during maturation by the 3'-trailer processing machinery and maintained by the CCA-adding enzyme. We developed a new tRNA sequencing method which is specifically tailored to assess the 3'-termini of E. coli tRNA. Intriguingly,...
Tue Nov 12, 2019 20:00
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Xue-Yan He, David Ng, Linda Van Aelst, Mikala EgebladStress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on...
Tue Nov 12, 2019 17:23
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Longchuan Bai, Haibin Zhou, Renqi Xu, Yujun Zhao, Krishnapriya Chinnaswamy, Donna McEachern, Jianyong Chen, Chao-Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Hui Jiang, Bo Wen, Praveen Kumar, Jennifer L. Meagher, Duxin Sun, Jeanne A. Stuckey, Shaomeng WangSummarySignal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Here we report the discovery of SD-36, a small-molecule...
Tue Nov 12, 2019 17:23
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S. AdusumilliCheckpoint blockade (CPB) therapy can elicit durable clinical responses by reactivating an exhausted immune response. However, response rates remain limited, likely secondary to a lack of a tumor-reactive immune infiltrate. Chimeric antigen receptor (CAR) T cells may provide the necessary tumor-targeting immune infiltrate and a highly specific...
Tue Nov 12, 2019 17:23
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Anne Trinh, Kornelia PolyakImmunotherapy has been the most effective in tumors with high mutational burden. However, a recent study in Cell by Wolf et al. demonstrates that high intratumor heterogeneity (ITH) for cancer neoantigens paradoxically attenuates anti-tumor immune responses, suggesting a need to quantify ITH to improve patient selection for checkpoint blockade therapy.
Tue Nov 12, 2019 17:23
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Anthony M. Joshua, Ian F. TannockIn this issue of Cancer Cell, Pillarsetty and colleagues radiolabel the potential anticancer drug PU-H71 and use it with PET imaging to quantify the epichaperome protein complex in tumors and its inhibition by the drug. They thereby develop a companion diagnostic paradigm of probe-drug pairing to explore therapeutic potential.
Tue Nov 12, 2019 17:23
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Jessica L. Hopkins, Lee ZouIn this issue of Cancer Cell, Quereda and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes triple-negative breast cancer cells to PARP inhibitors and DNA-damaging chemotherapeutics by reducing expression of the genes in the DNA damage response pathway.
Tue Nov 12, 2019 17:23
Publication date: 11 November 2019Source: Cancer Cell, Volume 36, Issue 5Author(s): Lisa N. Heppler, David A. FrankDespite the role of STAT3 as a known driver of oncogenesis, efforts to develop therapeutic STAT3 inhibitors have thus far been unsuccessful. In this issue of Cancer Cell, Bai et al. report a potent and selective STAT3 degrader capable of producing complete and long-lasting tumor regression in mouse xenograft models.
Tue Nov 12, 2019 17:23
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): G. Bregni, T. Akin Telli, S. Camera, C. Baratelli, L. Shaza, A. Deleporte, L. Moretti, M.A. Bali, G. Liberale, A. Hendlisz, F. SclafaniAbstractBackgroundWhile the management of nonmetastatic and oligometastatic rectal cancer has rapidly evolved over the last few decades, many grey areas and highly debated topics remain that foster significant variation in clinical practice. We aimed to identify controversial...
Tue Nov 12, 2019 19:31
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): Isabel Heidegger, Igor Tsaur, Hendrik Borgmann, Christian Surcel, Alexander Kretschmer, Romain Mathieu, Pieter De Visschere, Massimo Valerio, Roderick C.N. van den Bergh, Piet Ost, Derya Tilki, Giorgio Gandaglia, Guillaume Ploussard, on behalf of the EAU-YAU Prostate Cancer Working PartyAbstractProstate cancer (PCa) remains the most common cancer in men. The proportion of all PCa attributable to high-risk...
Tue Nov 12, 2019 19:31
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): Eleonora Lai, Marco Puzzoni, Pina Ziranu, Andrea Pretta, Valentino Impera, Stefano Mariani, Nicole Liscia, Paolo Soro, Francesca Musio, Mara Persano, Clelia Donisi, Simona Tolu, Francesca Balconi, Annagrazia Pireddu, Laura Demurtas, Valeria Pusceddu, Silvia Camera, Francesco Sclafani, Mario ScartozziAbstractPancreatic ductal adenocarcinoma(PDAC) is associated with poor survival. Of all newly diagnosed patients,...
Tue Nov 12, 2019 19:31
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): Johanna Veldman, Lydia Visser, Anke van den Berg, Arjan DiepstraAbstractHodgkin lymphoma is a B cell derived malignancy characterized by a low number of tumor cells within an environment consisting of inflammatory cells. Recently, immune checkpoint blockade targeting the PD-1-PD-L1 axis has shown to be a great success in relapsed and refractory Hodgkin lymphoma patients. However, complete responses are scarce...
Tue Nov 12, 2019 19:31
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Efstathios Kastritis, Evangelos Terpos, Meletios A DimopoulosAbstractAutologous stem cell transplantation (ASCT) has been the mainstay of multiple myeloma (MM) treatment for approximately 30 years. Although the continuous introduction of novel agents in the armamentarium against MM has questioned its value, ASCT remains a backbone treatment for fit MM...
Tue Nov 12, 2019 19:31
Publication date: Available online 11 November 2019Source: Cancer Treatment ReviewsAuthor(s): Thomas Powles, Jill Walker, J. Andrew Williams, Joaquim BellmuntAbstractImmune checkpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway improve clinical outcomes in patients with locally advanced/metastatic urothelial carcinoma (UC). PD-L1 complementary or companion diagnostic assays are now available for anti–PD-1 and anti–PD-L1 antibodies and these...
Tue Nov 12, 2019 19:31
Publication date: Available online 12 November 2019Source: European Journal of Surgical OncologyAuthor(s): C. Morgan, T.D. Stringfellow, R. Rolph, T. Kovacs, A. Kothari, S.E. Pinder, H. Hamed, A.R. SeverAbstractIntroductionDetermining the extent of residual disease in the breast and axilla following neoadjuvant chemotherapy (NACT) is vital for surgical planning. Traditionally patients with incomplete radiological response in the breast after NACT undergo axillary node clearance, regardless of axillary...
Tue Nov 12, 2019 16:55
Publication date: Available online 11 November 2019Source: European Journal of Surgical OncologyAuthor(s): Marjolein De Cuypere, Pierre Lovinfosse, Frédéric Goffin, Christine Gennigens, Ramon Rovira Negre, Joan Duch Remon, Maxime Fastrez, Géraldine Gebhart, Jean Luc Squifflet, Mathieu Luyckx, Gabriel Charaf, Kurt Crener, Frédéric Buxant, Dario Bucella, Mathieu Jouret, Roland Hustinx, Frédéric KridelkaAbstractObjectiveExtended field chemoradiation is recommended for patients with locally advanced...
Tue Nov 12, 2019 16:55
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