ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00437
Tue Nov 12, 2019 07:00
ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00310
Tue Nov 12, 2019 07:00
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00318
Tue Nov 12, 2019 07:00
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00701
Tue Nov 12, 2019 07:00
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00336
Tue Nov 12, 2019 07:00
Abstract Purpose The physical examination and pelvic imaging with MRI are often used in the pre-operative evaluation of pelvic organ prolapse. The objective of this study was to compare grading of prolapse on defecography phase of dynamic magnetic resonance imaging (dMRI) with physical examination (PE) grading using both the Pelvic Organ Prolapse Quantification (POP-Q) staging and Baden–Walker (BW) grading systems in the evaluation of...
Tue Nov 12, 2019 02:00
Abstract Purpose To evaluate the reproducibility of hepatic MRE under various combinations of settings of field strength, pulse sequence, scan interval, and reader in non-alcoholic fatty liver disease (NAFLD) patients. Methods Adult NAFLD patients were prospectively enrolled for serial hepatic MRE with 1.5 T using 2D GRE sequence and 3.0 T using 2D SE-EPI...
Tue Nov 12, 2019 02:00
Abstract The pelvic floor is composed of a network of muscles, ligaments, and fasciae, which provide active and passive support for the pelvic organs. Impairment of these pelvic floor elements can result in a variety of functional abnormalities and single or multicompartment organ prolapse. Knowledge of normal pelvic floor anatomy can aid the radiologist in understanding the complex nature of pelvic floor dysfunction and is important for comprehensive image interpretation. This...
Tue Nov 12, 2019 02:00
Abstract In forensic practice, autopsies are regularly carried out in cases of suspected medical malpractice to determine whether a treatment resulted in death. Intraoperative deaths, as well as deaths shortly after an operation, can be particularly suspicious as iatrogenic. We report a case of a 75-year-old woman with a complaint of intermittent angina pectoris who underwent cardiac catheterization. Intra-interventionally, coronary artery dissection occurred and was stabilized...
Tue Nov 12, 2019 02:00
Abstract The examination of strangulation is one of the most challenging causes of death diagnoses encountered in forensic pathology. The injuries are often subtle and difficult to detect, especially in cases that lack superficial marks. Fractures of the laryngeal skeleton are commonly regarded as evidence of strangulation but these can be too subtle to be detected during autopsy. Micro-CT is a novel imaging technique that achieves a spatial resolution 1 μm or less which lends...
Tue Nov 12, 2019 02:00
Abstract Body fluid identification in crime scene investigations aids in reconstruction of crime scenes. Several studies have identified and reported differentially methylated sites (DMSs) and regions (DMRs) which differ between forensically relevant tissues (tDMRs) and body fluids. Diverse factors affect methylation patterns such as the environment, diets, lifestyle, disease, ethnicity, genetic variation, amongst others. Thus, it is important to analyse the stability of markers...
Tue Nov 12, 2019 02:00
Abstract We immunohistochemically examined the intrathrombotic dynamics of autophagy during thrombogenesis using murine deep vein thrombosis (DVT) models. To perform the immunohistochemical analyses, we used anti-LC3 antibody and anti-p62 antibody for detecting the intrathrombotic autophagic functions. We estimated dynamics of the intrathrombotic autophagy as LC3+ cell number (×1000, five fields) with the thrombus ages (each group n = 5). The number of LC3+ cells was once decreased...
Tue Nov 12, 2019 02:00
Abstract In a case of a fatal traffic accident, a suspicious finding was identified in the muscular tissue of the left thigh by whole-body postmortem computed tomography. To better interpret the finding, the lower extremities were investigated by magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS). MRI revealed the presence of an evenly distributed intramuscular fluid and 1H-MRS of a volume within the fluid detected concentrations of acetate and...
Tue Nov 12, 2019 02:00
Abstract We evaluated whether the number of contributors to mixed DNA samples can be estimated by analyzing the D-loop of mitochondrial DNA using massively parallel sequencing. The A- (positions 16,209–16,400) and B- (positions 30–284) amplicons in hypervariable regions 1 and 2, respectively, were sequenced using MiSeq with 2 × 251 cycles. Sequence extraction and trimming were performed using CLC Genomics Workbench 11 and the number of observed haplotypes was counted for each amplicon...
Tue Nov 12, 2019 02:00
Abstract Genotyping by targeting short tandem repeats (STRs) has been widely used in forensic applications. However, most commercial kits detect autosomal STRs or Y-STRs alone, which waste both time and opportunity. The AGCU Expressmarker 16 + 22Y Kit includes 16 autosomal and 22 Y-chromosomal STR loci and is designed for the forensic science field and obtaining quicker results. Here, we conducted the validation study according to Scientific Working Group on DNA Analysis Methods...
Tue Nov 12, 2019 02:00
Abstract Magnetic resonance imaging is currently being studied extensively, but it is still far from being the frequently recommended radiological method for age estimation. In this study, we used magnetic resonance imaging (MRI) of distal radius ossification to obtain data for age estimation. Wrist MRI scans from 338 individuals, aged 10–29 years, were examined retrospectively using the staging system of Schmidt et al. and the extension of the stages as described by Timme et al....
Tue Nov 12, 2019 02:00
Abstract Introduction In this paper, we studied the effect over time of agomelatine, an antidepressant drug administered in patient with major depressive disorder, through item response theory (IRT), taking into account a strong placebo effect and missing not at random. We also assessed the informativeness of the HAMD-17 scale’s item. Materials and Methods ...
Tue Nov 12, 2019 02:00
MacromoleculesDOI: 10.1021/acs.macromol.9b01802
Tue Nov 12, 2019 07:00
MacromoleculesDOI: 10.1021/acs.macromol.9b01367
Tue Nov 12, 2019 07:00
MacromoleculesDOI: 10.1021/acs.macromol.9b01546
Tue Nov 12, 2019 07:00
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