Abstract Background This study evaluated health-related quality of life (HRQOL) using patient-reported outcomes in subjects with mucinous appendiceal neoplasms who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as part of a randomized trial comparing mitomycin with oxaliplatin. Methods In this prospective multicenter...
Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Abstract Background The presence of micrometastases is a source of recurrence after surgical resection of colorectal liver metastases (CRLM). The KRAS mutation is common in colorectal cancer, however the correlation between KRAS status and micrometastases has not been thoroughly clarified. Methods We enrolled a cohort of 251 consecutive CRLM patients who...
Tue Nov 12, 2019 02:00
Abstract Background Among numerous systemic inflammatory biomarkers, it remains unclear which is the most prognostic for patients with stage II/III colon cancer. We aimed to compare the prognostic significance of systemic inflammatory biomarkers among patients with stage II/III colon cancer. Methods We included 1303 patients with stage II/III colon cancer...
Tue Nov 12, 2019 02:00
Abstract Background Adjuvant radiation is generally not recommended for colon cancer but may be considered in certain clinical scenarios [advanced local disease (pT4) and/or positive margins]. Guidelines in this area are lacking; thus we analyzed the National Cancer Database (NCDB) for patterns of care in this regard and any predictors for outcome. Methods ...
Tue Nov 12, 2019 02:00
Abstract Background While platinum-based chemotherapy represents the standard treatment for advanced grade 3 (G3) neuroendocrine neoplasms (NENs) according to the European Neuroendocrine Tumor Society guidelines, the role of radical-intended surgery in these patients, as well as the use of adjuvant chemotherapy, are still controversial. The aim of the present work is to describe, in a retrospective series of gastroenteropancreatic neuroendocrine...
Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Abstract Surfactin is a promising microbial lipopeptide with wide applications in food, environmental, agricultural, and pharmaceutical fields. However, its high cost caused by low productivity largely limits the commercial application. In this study, genome shuffling was employed to improve surfactin production in Bacillus velezensis strain LM3403 via recursive protoplast fusion. RT-qPCR analysis was employed to evaluate the transcriptional variance of surfactin synthase genes...
Tue Nov 12, 2019 02:00
Abstract Purpose This is a rare case of a post-traumatic rectus abdominis muscle tear in an adolescent female diagnosed by ultrasonography (US). Conservative management is also described. Methods A 14-year-old female presented to a chiropractic clinic with extreme pain and tenderness in the right lower quadrant (RLQ) after post-plyometric power kneel box...
Tue Nov 12, 2019 02:00
Abstract In this study, the potential of date seed extracts to induce growth inhibition and apoptosis in HepG2 and HeLa cells was investigated. Analysis of the phytochemical compound content of the two Tunisian minor date seed extracts named Arechti and Korkobbi was determined. Moreover, their antioxidant properties are assessed through different assays including DPPH, ABTS, FRAP, TBARS, and phosphomolybdenum methods. Whereas, the cytotoxic effect was evaluated and apoptosis induction...
Tue Nov 12, 2019 02:00
Abstract Subcutaneous white adipose tissue is capable of becoming thermogenic in a process that is referred to as “beiging.” Beiging is associated with activation of the uncoupling protein, UCP1, and is known to be important for preventing adipose hypertrophy and development of insulin resistance. Polychlorinated biphenyls (PCBs) accumulate in fat, and it is hypothesized that disruption of adipogenesis and adipocyte function by PCBs may be causative in the development of obesity...
Tue Nov 12, 2019 02:00
Abstract Colloidal phosphorus (CP) as an additional route of P mobilization in soil solution has gained much attention. A batch experiment was conducted to investigate the effect of sheep manure-derived biochar (SMB) on CP release from various land uses (paddy, vegetable, tea, and citrus) at a rate of 0% as a control treatment (CK), 1% as a low (L) level, 2% as a middle (M) level, and 4% as a high (H) level of SMB application. The CP and MRPcoll in the solution increased from 30.58...
Tue Nov 12, 2019 02:00
Abstract Preparation of the value-added products from e-waste resources is an important step in the recycling process. The present paper aims to propose a methodology for the recovery of In from scrap LCD panel via preparation of InBO3 nanostructure. Discarded LCD panel was subjected to a recycling process through crushing, milling, and oxalic acid leaching to prepare In2(C2O4)3·6H2O. Through the leaching process, B(OH)3 from glass part (alumina borosilicate) has been leached out...
Tue Nov 12, 2019 02:00
Abstract Glyphosate is a broad-spectrum, non-selective, post-emergence herbicide that controls weeds by inhibiting their ability to synthesize amino acids. It is characterized by high persistence and adsorption to soil, with its dissipation to be highly correlated to the climatic conditions. After its degradation in soil, aminomethylphosphonic acid (AMPA) is the sole and major metabolite produced, characterized also by high persistence and adsorption. Both substances have the potential...
Tue Nov 12, 2019 02:00
Abstract In energy economics literature, we found few studies on the association between environmental quality energy consumption and financial development. The current study is an attempt to contribute in literature by examining the link between carbon dioxide (CO2) emissions, financial development, energy consumption, and economic growth, in South East Asian economies for the period 1980–2017 using annual time series data. For empirical analysis, Bound tests for cointegration...
Tue Nov 12, 2019 02:00
Abstract Arsenic (As) and copper (Cu) are ubiquitous pollutants that pose a threat to the environment. Our aim is to study the underlying mechanisms by which As and Cu act on the chicken gizzard. In order to detect ionic disorders in chicken gizzard under chronic treatment with As3+ and/or Cu2+ and whether they can induce oxidative damage as well as immune disorders, 30 mg/kg arsenic trioxide (As2O3) and/or 300 mg/kg copper sulfate (CuSO4) were added to the chicken’s basal diet....
Tue Nov 12, 2019 02:00
Abstract Green algae are dominant primary producers in aquatic environments. Thus, assessing the influences of pollutants such as nanoparticles on the algae is of high ecological significance. In the current study, cadmium selenide nanoparticles (CdSe NPs) were synthesized using the hydrothermal method and their characteristics were determined by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FT-IR) techniques. Subsequently,...
Tue Nov 12, 2019 02:00
Abstract The occurrence, seasonal variation and emission of nine widely used phosphorus flame retardants (PFRs) were investigated in a wastewater treatment plant (WWTP) located in Guangzhou, China, over 1 year. Results showed that PFRs were widely detected in wastewater and sewage sludge. Tris(2-chloroisopropyl) phosphate (TCIPP) was the most dominant PFRs in influent, effluent, and sludge. Significant seasonal variation of total PFRs in the influent was observed (p < 0.05)....
Tue Nov 12, 2019 02:00
Abstract Although banned from production for decades, PCBs remain a significant risk to human health. A primary target of concern is the developing brain. Epidemiological studies link PCB exposures in utero or during infancy to increased risk of neuropsychiatric deficits in children. Nonclinical studies of legacy congeners found in PCB mixtures synthesized prior to the ban on PCB production suggest that non-dioxin-like (NDL) congeners are predominantly responsible for the developmental...
Tue Nov 12, 2019 02:00
Abstract The widespread use of thiram has raised concerns for health and its toxic effects, but the underlying toxicity mechanism on platelets and bones is poorly defined. Here, we found a significant increase in the number of platelets in chickens with the thiram intake, due to the increased expression of thrombopoietin mRNA in the dysfunction liver. Furthermore, the decreased vascular distribution and cell death of chondrocytes in the...
Tue Nov 12, 2019 02:00
Abstract Cake formed by flocs is a crucial factor to affect membrane fouling during coagulation-ultrafiltration process. To investigate the role of floc properties on cake, cake characteristics under various coagulant dosage conditions were calculated by scanning electron microscope (SEM) imaging. Results found that one SEM image with × 5000 magnification could accurately estimate cake porosity with relative error lower than 5.00% for all conditions, whereas more SEM images with...
Tue Nov 12, 2019 02:00
Zusammenfassung Das maligne Melanom ist ein aggressiver Hauttumor, der aus melanozytären Zellen hervorgeht und mit invasivem Wachstum und frühzeitiger Metastasierung assoziiert ist. Neben endogenen Risikofaktoren wie hellem Hauttyp oder genetischer Disposition zur Ausbildung multipler Nävi ist als exogener Risikofaktor v. a. die Exposition gegen ultraviolettes Licht bedeutsam. Die Primärtherapie umfasst die vollständige Exzision des Primarius mit leitliniengerechtem Sicherheitsabstand...
Tue Nov 12, 2019 02:00
Abstract Background Ultrasound (US) is used in the initial evaluation and surveillance of urinary tract dilation in children. Urinary tract dilation is diagnosed in 1–2% of all pregnancies during routine prenatal sonography with technological advances in US imaging. Urinary tract dilation classification systems, including the 2014 multidisciplinary consensus, assess anterior–posterior renal pelvic diameter and calyceal dilation. There...
Tue Nov 12, 2019 02:00
Abstract Fossil spores of coprophilous fungi preserved in lake and bog sediments are well-established palaeoecological tracers for the local history of pastoralism and other animal husbandry. However, applications in Africa are limited by the lack of information on the exact relationship between human activity and fungi growing on large-herbivore dung. Here we use 25 small crater-lake basins in western Uganda, which cover the complete regional gradient of natural vegetation and...
Tue Nov 12, 2019 02:00
Zusammenfassung Die Kehlkopfentfernung (Laryngektomie) bietet für Patienten mit fortgeschrittenen Larynx- und Hypopharynxkarzinomen ohne Fernmetastasen einen kurativen Ansatz. Insbesondere bei Vorliegen eines cT4a-Karzinoms ist die Laryngektomie der primären Radio(chemo)therapie prognostisch (retrospektiv) überlegen. Weitere wichtige Indikationen für eine Laryngektomie stellen eine tumorbedingte Larynxdysfunktion wie Schluckunfähigkeit bzw. Aspirationsneigung und ein Rezidiv nach...
Tue Nov 12, 2019 02:00
Zusammenfassung Hintergrund Die Tonsillektomie zählt zu den häufigen Eingriffen in Deutschland, deren Anzahl durch demografische Veränderungen, das Aufkommen der Tonsillotomie und der Leitlinie zur Tonsillitistherapie beeinflusst sein könnte. Ziel Die Zahl der jährlich in den Bundesländern ausgeführten Tonsillektomien, Adenotonsillektomien und Tonsillotomien...
Tue Nov 12, 2019 02:00
Zusammenfassung Der Artikel geht zunächst auf die Rahmenbedingungen ein, die für die Durchführung der Facharztprüfung in den Weiterbildungsordnungen der Landesärztekammern festgelegt sind. Es werden konkrete Vorschläge unterbreitet, wie sich der Weiterbildungsassistent bei der Auswahl der von ihm zu bearbeitenden Fachliteratur und der Zeiteinteilung des von ihm zu bewältigenden Lernstoffs verhalten kann. Zur Ausgestaltung günstiger Umgebungsbedingungen in den letzten Stunden vor...
Tue Nov 12, 2019 02:00
Abstract Purpose The physical examination and pelvic imaging with MRI are often used in the pre-operative evaluation of pelvic organ prolapse. The objective of this study was to compare grading of prolapse on defecography phase of dynamic magnetic resonance imaging (dMRI) with physical examination (PE) grading using both the Pelvic Organ Prolapse Quantification (POP-Q) staging and Baden–Walker (BW) grading systems in the evaluation of...
Tue Nov 12, 2019 02:00
Abstract Purpose To evaluate the reproducibility of hepatic MRE under various combinations of settings of field strength, pulse sequence, scan interval, and reader in non-alcoholic fatty liver disease (NAFLD) patients. Methods Adult NAFLD patients were prospectively enrolled for serial hepatic MRE with 1.5 T using 2D GRE sequence and 3.0 T using 2D SE-EPI...
Tue Nov 12, 2019 02:00
Abstract The pelvic floor is composed of a network of muscles, ligaments, and fasciae, which provide active and passive support for the pelvic organs. Impairment of these pelvic floor elements can result in a variety of functional abnormalities and single or multicompartment organ prolapse. Knowledge of normal pelvic floor anatomy can aid the radiologist in understanding the complex nature of pelvic floor dysfunction and is important for comprehensive image interpretation. This...
Tue Nov 12, 2019 02:00
Abstract Introduction The corticotropin-releasing hormone (CRH) system, its receptors corticotropin-releasing hormone receptor 1 (CRHR1) and 2 (CRHR2), and its corresponding binding protein corticotropin-releasing hormone-binding protein (CRHBP) as well as the urocortin proteins—structural homologues to CRH, which are included in this peptide family—have become interesting oncological targets recently. Carcinogenesis of various human tumors...
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Abstract Introduction In patients undergoing thoracoabdominal aorta repair, spinal cord ischemia (SCI) remains one of the most common and important complications resulting in transient paraparesis through to permanent flaccid paraplegia. In this manuscript, after a brief introduction to spinal cord ischemia complication and its prevention in thoracoabdominal endovascular aortic repair (TEVAR), we propose a new clinical protocol potentially...
Tue Nov 12, 2019 02:00
Tue Nov 12, 2019 02:00
Abstract An age-associated increase in chronic, low-grade sterile inflammation termed “inflammaging” is a characteristic feature of mammalian aging that shows a strong association with occurrence of various age-associated diseases. However, the mechanism(s) responsible for inflammaging and its causal role in aging and age-related diseases are not well understood. Age-associated accumulation of damage-associated molecular patterns (DAMPs) is an important trigger in inflammation...
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Abstract Background Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria continues to evolve. There is a significant overlap between HAE-nC1 INH and idiopathic nonhistaminergic angioedema, ultimately this may be found to be the same condition. Characterization of cohorts suspected...
Tue Nov 12, 2019 02:00
Abstract Intravascular dissemination of tumor cells is the accepted mechanism of cancer metastasis. However, the phenomenon of angiotropism, pericyte mimicry (PM), and extravascular migratory metastasis (EVMM) has questioned the concept that tumor cells metastasize exclusively via circulation within vascular channels. This new paradigm of cancer spread and metastasis suggests that metastatic cells employ embryonic mechanisms for attachment to the abluminal surfaces of blood vessels...
Tue Nov 12, 2019 02:00
Abstract Allogeneic hematopoietic stem cell transplantation (allo-SCT) has been considered as a potentially curative treatment option for refractory or relapsed diffuse large B cell lymphoma (DLBCL) patients. However, there is little information available, especially for Japanese patients and in cord blood transplantation (CBT). We aimed to determine treatment outcomes of allo-SCT for DLBCL in the Kyoto Stem Cell Transplantation Group, a multi-institutional joint research group....
Tue Nov 12, 2019 02:00
Abstract Objective The aim of this study was to assess the treatment results of 90Y radiation synovectomy for chronic exudative synovitis of knee joints. Methods The retrospective data consist of 394 consecutive knee radiation synovectomies performed using 6 mCi (222 MBq) of 90Y. The assessment included 3-point custom pain and joint mobility scale, evaluation...
Tue Nov 12, 2019 02:00
Abstract Background Current guidelines have unsatisfied performance in predicting severe outcomes after Clostridium difficile infection (CDI). Our objectives were to develop a risk prediction model for 30-day mortality and to examine its performance among inpatients with CDI. Methods This retrospective cohort study was conducted at China Medical...
Tue Nov 12, 2019 02:00
Abstract Background The Asia Pacific Society of Infection Control (APSIC) launched the APSIC Guidelines for the Prevention of Surgical Site Infections in 2018. This document describes the guidelines and recommendations for the setting prevention of surgical site infections (SSIs). It aims to highlight practical recommendations in a concise format designed to assist healthcare facilities at Asia Pacific region in achieving high standards...
Tue Nov 12, 2019 02:00
Abstract Background Much effort has been made over the last two decades to educate and train healthcare professionals working on antimicrobial resistance in French hospitals. However, little has been done in France to assess perceptions, attitudes and knowledge regarding multidrug resistant organisms (MDROs) and, more globally, these have never been evaluated in a large-scale population of medical and non-medical healthcare workers...
Tue Nov 12, 2019 02:00
Abstract Salterns are extreme environments, where the high salt concentration is the main limitation to microbial growth, along with solar radiation, temperature and pH. These selective pressures might lead to the acquisition of unique genetic adaptations that can manifest in the production of interesting natural products. The present study aimed at obtaining the culturable microbial diversity from two Portuguese salterns located in different geographic regions. A total of 190...
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Abstract Bacillus subtilis currently encompasses four subspecies, Bacillus subtilis subsp. subtilis, Bacillus subtilis subsp. inaquosorum, Bacillus subtilis subsp. spizizenii and Bacillus subtilis subsp. stercoris. Several studies based on genomic comparisons have suggested these subspecies should be promoted to species status. Previously, one of the main reasons for leaving them as subspecies was the lack of distinguishing phenotypes. In this study, we used comparative genomics...
Tue Nov 12, 2019 02:00
Abstract Zygosaccharomyces seidelii, a new species in the genus Zygosaccharomyces is described. The description of the species is based on a single strain that was isolated from flowers collected on the Maldives. On this occasion, the description of yeast species from single strains was revisited. Sequence analysis of the D1/D2 domain of the nuclear large subunit rRNA gene revealed that Z. seidelii is closely related to Z. gambellarensis. Both species differ by 2.6% (one indel...
Tue Nov 12, 2019 02:00
Abstract Enzyme engineering has been widely employed to tailor the substrate specificity and enantioselectivity of enzymes. In this study, we mutated Trp288, an unconserved residue in the small binding pocket of an acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD). Trp288 mutants showed substrate specificity expansion towards bulky-bulky ketones and enantioselectivity alteration which was highly dependent on the substrate substituent length. In aliphatic ketone...
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Abstract There is a renewed interest in acetone-butanol-ethanol (ABE) fermentation from renewable substrates for the sustainable and environment-friendly production of biofuel and platform chemicals. However, the ABE fermentation is associated with several challenges due to the presence of heterogeneous components in the renewable substrates and the intrinsic characteristics of ABE fermentation process. Hence, there is a need to select optimal substrates and modify their characteristics...
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Abstract Microalgae are versatile sources of bioproducts, a solution for many environmental problems. However, and despite its importance, one of the main problems in large-scale cultures—the presence of contaminants—is rarely systematically approached. Contamination, or the presence of undesirable organisms in a culture, is deleterious for the culture and frequently leads to culture crashes. To avoid contamination, closed systems can be used; however, for very large-scale open...
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Abstract Aspergillus flavus is the main cause of postharvest agricultural commodity loss. In this study, puroindoline A (PINA) protein was expressed in Escherichia coli, purified, and its antifungal properties against A. flavus were characterized. Sodium dodecyl sulfate polyacrylamide gel electrophoresis showed that the molecular weight of the recombinant PINA protein was approximately 44 kDa. PINA exerted a powerful antifungal effect against A. flavus at 42.42 μg/mL on potato...
Tue Nov 12, 2019 02:00
Abstract The liver is an important digestive gland, and acute liver failure results in high mortality. Probiotics are considered potential adjuvant therapies for liver disease. This study aimed to investigate the beneficial effects of Lactobacillus helveticus R0052 on acute liver injury and the underlying mechanisms. Sprague-Dawley rats were gavaged with L. helveticus R0052 suspensions (3 × 109 CFU) for 1 week. Subsequently, acute liver injury was induced by intraperitoneal d-galactosamine...
Tue Nov 12, 2019 02:00
Abstract α-Glucosidase, Agl2, from Xanthomonas campestris was successfully overexpressed in Escherichia coli BL21(DE3) cells and purified with Ni columns. The enzyme exhibits glycosylation abilities towards a wide range of phenolic substrates, including phenol, vanillin, and ethyl vanillin, with maltose as the glycosyl donor. The catalytic properties of the purified enzyme were further investigated. It was observed that the synthesized glycosides started to degrade with prolonged...
Tue Nov 12, 2019 02:00
Abstract (2R,3S)-isocitric acid has long been used only as a specific biochemical reagent. However, there is ever increasing evidence that it can also be used as an original promising substance for prevention and treatment of some diseases. The review considers the results of longtime research in our laboratory and the data of other researchers related to microbial synthesis of (2R,3S)-isocitric acid, derivation and selection of active microbial producers, development of their...
Tue Nov 12, 2019 02:00
Abstract The present paper describes the generation of derivatives from the hybrid peptide called Ent35-MccV, active against Gram-positive and Gram-negative bacteria. This peptide has a triple glycine hinge region between enterocin CRL35 and microcin V. In order to obtain variants of Ent35-MccV with greater biotechnological potential, a saturation mutagenesis was carried out in the hinge region. As a result, we obtained a bank of E. coli strains expressing different mutated hybrid...
Tue Nov 12, 2019 02:00
Abstract A metagenome from an enrichment culture of a hydrothermal vent sample taken at Vulcano Island (Italy) was sequenced and an endoglucanase-encoding gene (vul_cel5A) was identified in a previous work. Vul_Cel5A with maximal activity at 115 °C was characterized as the most heat-active endoglucanase to date. Based on metagenome sequences, genomes were binned and bin4 included vul_cel5A as well as a putative GH1 β-glycosidase-encoding gene (vul_bgl1A) with highest identities...
Tue Nov 12, 2019 02:00
Abstract Mycobacterium tuberculosis is able to transition into a dormant state, causing a latent state of tuberculosis. Dormant mycobacteria acquire phenotypic resistance to all known antibacterial drugs; they are also able to maintain vitality in the host for decades and become active, causing the active form of the disease. In order to cure latent tuberculosis, new approaches should be developed. Earlier, we discovered accumulation in significant concentrations of porphyrins...
Tue Nov 12, 2019 02:00
Abstract FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by Streptomyces hygroscopicus. The problem of low yield and high impurities (mainly FK523) limits the industrialized production of FK520. In this study, the FK520 yield was significantly improved by strain mutagenesis and genetic engineering. First, a FK520 high-producing strain SFK-6-33 (2432.2 mg/L) was obtained from SFK-36 (1588.4 mg/L) through ultraviolet radiation mutation coupled...
Tue Nov 12, 2019 02:00
Abstract 1-Deoxynojirimycin (DNJ), a representative iminopyranose, is widely used in anti-diabetic, antioxidant, anti-inflammatory, and anti-obesity applications. It naturally exists in plants, insects, and the culture broth of some microbes as a secondary metabolite product. However, the content of DNJ in plants and insects is relatively low, which is an obstacle to investigating DNJ in terms of structure–function relationships and restricts large-scale industrial production....
Tue Nov 12, 2019 02:00
Abstract The highly toxic nerve agent sarin (o-isopropyl methyl-phosphonofluoridate, GB) has been used in several armed conflicts and terror attacks in recent decades. Due to its inherent high sensitivity, liquid chromatography–mass spectrometry (LC–MS/MS) has the potential to detect ultratrace levels of fluoride-regenerated G and V agents after appropriate chemical derivatization. A new method for the retrospective determination of exposure to sarin was developed. The method is...
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Abstract Background Adapting screening strategy to colorectal cancer (CRC) risk may improve efficiency for all stakeholders however limited tools for such risk stratification exist. Colorectal cancers usually evolve from advanced neoplasms that are present for years. We applied the National Cancer Institute (NCI) CRC Risk Assessment Tool, which calculates future risk of CRC, to determine whether it could be used to predict current...
Tue Nov 12, 2019 02:00
Abstract Background There are differences in the quality of care among breast cancer patients. Narrowing the quality differences could be achieved by increasing the utilization rate of indicators. Here we explored key indicators that can improve the quality of care and factors that may affect the use of these indicators. Methods A total of 3669...
Tue Nov 12, 2019 02:00
Abstract Background The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambiguous or inconclusive diagnosis by endometrial biopsies and imaging. Methods A retrospective study was performed selecting...
Tue Nov 12, 2019 02:00
Abstract Background This study aimed to assess the effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing treatment with immune checkpoint inhibitors (ICIs). Methods The medical records of 234 patients treated with ICIs for any type of solid cancer between February 2012 and May 2018 at the Seoul St. Mary’s Hospital...
Tue Nov 12, 2019 02:00
Abstract Background The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratification of patients for targeted therapy are still lacking. The DETECT studies explore the utility of CTC phenotype for treatment decisions in patients with HER2 negative MBC. Associated with this concept is a...
Tue Nov 12, 2019 02:00
Abstract Background The evasion of apoptosis is a hallmark of cancer. Understanding this process holistically and overcoming apoptosis resistance is a goal of many research teams in order to develop better treatment options for cancer patients. Efforts are also ongoing to personalize the treatment of patients. Strategies to confirm the therapeutic efficacy of current treatments or indeed to identify potential novel additional options...
Tue Nov 12, 2019 02:00
Abstract Background Anaplastic thyroid cancer (ATC) is considered to be a rare type of thyroid cancer but takes up the most important proportion of thyroid cancer-related deaths. Therefore, the development of molecular targeted therapy is an exciting strategy in the management of ATC. Methods miR-155 and SOCS1 expression were measured by qRT-PCR...
Tue Nov 12, 2019 02:00
Abstract Background The features and survival of stage IV breast cancer patients with different metastatic sites are poorly understood. This study aims to examine the clinicopathological features and survival of stage IV breast cancer patients according to different metastatic sites. Methods Using the Surveillance, Epidemiology, and End Results...
Tue Nov 12, 2019 02:00
Abstract Background Myxofibrosarcoma (MFS) is most often found on the limbs of aged male people, but extremely uncommon in the liver. Case presentation A 52-year-old female patient with a liver mass was diagnosed as a primary MFS. It had no obvious abdominal symptoms, and the tumor was resected with an extended margin. Three years after the...
Tue Nov 12, 2019 02:00
Abstract Background Circulating extracelluar vesicles (EVs) in epithelial ovarian cancer (EOC) patients emanate from multiple cells. These EVs are emerging as a new type of biomarker as they can be obtained by non-invasive approaches. The aim of this study was to investigate circulating EVs from EOC patients and healthy women to evaluate their biological function and potential as diagnostic biomarkers. ...
Tue Nov 12, 2019 02:00
Abstract Background The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2), a methyltransferase belonging to PRC2, plays important roles in epigenetic silencing and cell cycle regulation. EZH2 overexpression has been found in several malignant tumor tissues, while its expression...
Tue Nov 12, 2019 02:00
Abstract Background We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer. Methods We retrospectively analyzed 49 patients with resectable pancreatic cancer (surgery group, resection was performed for 38 cases;...
Tue Nov 12, 2019 02:00
Abstract Background SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far. Few patients with recurrent glioma have opportunity to undergo operation once again, so the recurrent glioma samples are scarce. This study tries to analyze SOX2 expression in paired primary and recurrent HGG, aims to better understand the transformation...
Tue Nov 12, 2019 02:00
Abstract Background It has been shown that bcl2, bcl-XL and mcl-1 protein levels are high in chronic lymphocytic leukemia cells, and resultantly, apoptosis does not occur chronic lymphocytic leukemia cells. Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein coupled receptor called apelin receptor. Studies have shown that ELA inhibits apoptosis by inhibiting apoptotic proteins and activating anti-apoptotic...
Tue Nov 12, 2019 02:00
Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma
Abstract Background Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum FGF19 as a novel tumor marker of HCC based on a sandwich enzyme-linked immunosorbent assay (ELISA). Methods The serum...
Tue Nov 12, 2019 02:00
Abstract Background Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characterization of CK7 negative breast cancer has not been addressed previously and similar studies on GATA3 negative tumors are limited. Methods ...
Tue Nov 12, 2019 02:00
Abstract Background Sheng Mai San (SMS) has been proven to exhibit cardio-protective effects. This study aimed to explore the molecular mechanisms of SMS on hyperglycaemia (HG)-induced apoptosis in H9C2 cells. Methods HG-induced H9C2 cells were established as the experimental model, and then treated with SMS at 25, 50, and 100 μg/mL. H9C2 cell...
Tue Nov 12, 2019 02:00
Abstract Background Dental caries is a biofilm-diet-dependent worldwide public health problem, and approaches against microorganisms in cariogenic biofilms are necessary. Methods The antimicrobial and antibiofilm activities of 12 Casearia sylvestris extracts (0.50 mg/mL) from different Brazilian biomes (Atlantic Forest, Cerrado, Caatinga, Pampa,...
Tue Nov 12, 2019 02:00
Abstract Background Heracleum moellendorffii roots (HM-R) have been long treated for inflammatory diseases such as arthritis, backache and fever. However, an anti-inflammatory effect and the specific mechanism of HM-R were not yet clear. In this study, we for the first time explored the anti-inflammatory of HM-R. Methods The cytotoxicity of...
Tue Nov 12, 2019 02:00
Abstract Background The present study aimed to investigate the prognostic significance of preoperative main pancreatic duct dilation and the neutrophil-to-lymphocyte ratio (PD-NLR) in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection. Methods Sixty-four consecutive PNETs of the head that underwent curative resection...
Tue Nov 12, 2019 02:00
Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules
Abstract Background Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. Methods In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and...
Tue Nov 12, 2019 02:00
Abstract Background Managing demand for services is a problem in many areas of healthcare, including specialist medical outpatient clinics. Some of these clinics have long waiting lists with variation in access for referred people. A model of triage and appointment allocation has been developed and tested that has reduced waiting times by about a third in community outpatient services. This study aims to determine whether the model...
Tue Nov 12, 2019 02:00
Abstract Background Evaluating hospital efficiency is a process to optimize resource utilization and allocation. This is vital due to hospitals being the largest financial cost in a health system. To limit avoidable uses of hospital resources, it is important to identify the sources of hospital inefficiencies and to put in place measures towards their reduction and elimination. Thus, the purpose of this research is to examine the...
Tue Nov 12, 2019 02:00
Abstract Background The exudative age-related macular degeneration (AMD) causes considerable healthcare costs for patients and healthcare system, which are expected to grow as the population ages. The objective of this study was to assess the incremental economic burden of exudative AMD by comparing total healthcare costs between the exudative AMD group and non-AMD group to understand economic burden related to exudative AMD. ...
Tue Nov 12, 2019 02:00
Abstract Background Cervical cancer is a major cause of morbidity and mortality among women yet access to treatment and care remains a huge challenge in Zimbabwe. The objective of this study was to investigate health system constraints affecting engagement into treatment and care by women with cervical cancer in Harare, Zimbabwe. Methods A sequential...
Tue Nov 12, 2019 02:00
Abstract Background In 2014 and 2015, biosimilars for the drugs filgrastim, infliximab, and insulin glargine were approved for use in Canada. The introduction of biosimilars in Canada could provide significant cost savings for the Canadian healthcare system over originator biologic drugs, however it is known that the use of biosimilars varies widely across the world. The aim of this study was to estimate the use of biosimilars in...
Tue Nov 12, 2019 02:00
Abstract Background In Saudi Arabia, healthcare industry is undergoing major expansions to meet the demand of rapidly growing healthcare needs. The aims of this study were; (1) to assess the pattern of smartphone use in healthcare facilities, and (2) to determine perception towards its use among healthcare workers. Method A cross-sectional survey...
Tue Nov 12, 2019 02:00
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