Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution. We report here a case of possibly undocumented ventricular arrhythmia in a sickle cell anemia patient diagnosed with Plasmodium falciparum malaria and treated with intravenous artesunate. The patient suffered from wide complex tachycardia after treatment with artesunate 170 mg (2.4 mg/kg) i.v. bolus, tachycardia was managed with amiodarone (150 mg...
09:05
Abstract Objectives To evaluate the impact of previous coronary artery bypass grafting (CABG) on early safety at 30 days and 1‐year mortality in patients receiving transcatheter aortic valve replacement (TAVR). Background The use of TAVR in patients with previous CABG suffering from severe aortic stenosis has increased in the last years. Methods Consecutive TAVR patients were stratified according to previous CABG versus no previous cardiac surgery (control). All‐cause 1‐year mortality...
Tue Nov 12, 2019 17:03
Abstract Background There is little data on the impact of chronic thrombocytopenia (CTP) on outcomes after transcatheter aortic valve repair (TAVR). Most studies are from single centers and mostly focused on postprocedure thrombocytopenia. Objectives This study sought to report on the impact of CTP (>1 year) on in‐hospital outcomes and healthcare resource utilization after TAVR. Methods From the National Inpatient Sample (NIS) between 2012 and 2015, we identified patients with...
Tue Nov 12, 2019 16:55
Abstract Objective To evaluate the feasibility, safety, and effectiveness of a novel, absorbable atrial septal defect (ASD) closure device made of poly‐l‐lactic acid (PLLA) in a swine model of ASD and for the first time in humans. Methods A preclinical safety study was conducted using a swine model of ASD. In a clinical setting, five pediatric patients underwent ASD closure with the PLLA device with fluoroscopic and transthoracic echocardiography guidance. The procedural results and clinical...
Tue Nov 12, 2019 16:41
Abstract Background Coronary collaterals are often seen supplying retrograde flow to an acutely occluded arterial territory. Whether this early collateralization offers prognostic benefit is not well established. Methods We analyzed data from all patients presenting to our regional cardiac unit with acute ST‐elevation myocardial infarction requiring immediate angiography (years 1999–2017). Data on all patients is entered prospectively into a bespoke tailored database prior to knowledge...
Tue Nov 12, 2019 15:58
Abstract Objectives We sought to assess the national trends in the utilization and outcomes of percutaneous coronary interventions (PCI) in patients with cirrhosis. Background Contemporary data on PCI in patients with liver cirrhosis are limited. Methods The National‐Inpatient‐Sample was used to identify patients who underwent PCI between 2003 and 2016. We examined the annual PCI rate, and compared the in‐hospital morbidity, mortality, resource utilization, and cost following PCI...
Tue Nov 12, 2019 15:15
Abstract Background Out of hospital cardiac arrest (OHCA) is common and associated with low survival rates. Guidelines propose a fast work‐up after OHCA including coronary angiography (CA) but little is known about the actual outcome of those patients who undergo immediate CA after OHCA with suspected cardiac origin. Aim The aim of this retrospective single‐center study was to evaluate the short‐term outcomes and predictors of in‐hospital mortality in patients who underwent immediate CA...
Tue Nov 12, 2019 15:11
Abstract Introduction Percutaneous femoral access is the preferred access route for transcatheter aortic valve replacement (TAVR). The majority of experienced TAVR centers use two 6F Perclose ProGlide™ devices to close the primary vascular access site, deployed prior to upsizing sheath size with closure completed at the end of the case (the “preclose” approach). A strategy of utilizing a single Perclose device to preclose may have advantages including fewer complications, complexity, and cost,...
Tue Nov 12, 2019 15:10
Abstrct Objectives The aim of this study was to evaluate the long‐term clinical safety and efficacy of drug‐coated balloon (DCB) in the treatment of in‐stent restenosis (ISR). Background There is a long‐term safety issue in peripheral arterial disease patients treated with paclitaxel‐coated balloon, this has also raised concerns on DCB in coronary intervention. Methods Nine randomized controlled trials (RCTs) and nine observational studies (OSs) were included with a total of 3,782...
Tue Nov 12, 2019 15:07
Abstract We report a case of antegrade transcatheter occlusion of a paravalvular leak (PVL) after bioprosthetic pulmonary valve replacement in a 31‐year‐old patient with tetralogy of Fallot. The leak resulted in severe pulmonary regurgitation with right ventricle volume overload. This case is the first‐ever report of a successful percutaneous closure of PVL using the Occlutech paravalvular leak device.
Tue Nov 12, 2019 14:50
Abstract Objective The SCAFFOLD trial evaluated the GORE® Carotid Stent (GCS), a novel, mesh‐covered device and evaluated outcomes at 1 year. Background SCAFFOLD was a prospective, multicenter, single‐arm clinical trial in patients with severe carotid artery stenosis (angiographically defined as symptomatic ≥50% or asymptomatic ≥80%) at increased risk for adverse events from carotid endarterectomy. Interim 30‐day analysis demonstrated low rates of death/stroke/myocardial infarction (DSMI;...
Mon Nov 11, 2019 20:48
Abstract Objectives The United Kingdom and Ireland Implanters' registry is a multicenter registry which reports on real‐world experience with new transcatheter heart valves. Background The Evolut PRO (Medtronic, Minneapolis, MN) transcatheter aortic valve is a self‐expanding transcatheter aortic valve with an outer pericardial wrap, designed to minimize paravalvular regurgitation. Methods Between July 2017 and December 2018, clinical, procedural, and 30‐day outcome data were prospectively...
Mon Nov 11, 2019 20:18
Abstract Background Prior randomized controlled trials (RCT) evaluating the optimal antithrombotic therapies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) have not been powered to evaluate ischemic outcomes. We compared double therapy with oral anticoagulation (OAC) and a P2Y12 inhibitor to triple therapy with an OAC + dual antiplatelet therapy in patients with AF requiring PCI. Methods Using PRISMA guidelines, we searched for RCTs including...
Mon Nov 11, 2019 20:14
ConclusionsOur findings suggest that exosomes derived from GEM-resistant pancreatic cancer stem cells mediate the horizontal transfer of drug-resistant traits to GEM-sensitive pancreatic cancer cells by delivering miR-210. (Source: Cellular Oncology)
Tue Nov 12, 2019 00:00
We report on a female patient who presented with severe intellectual disability and autistic behavior, dysmorphic features, orodental anomalies, and bilateral calcification of basal ganglia. Using a high-density oligonucleotide microarray, we have identified a de novo duplication of 11q13.1q22.1 involving the dosage sensitive genes FGF3 and FGF4, genes related to autosomal dominant disorders KMT5B, GAL, SPTBN2, and LRP5, susceptibility loci SCZD2, SLEH1, and SHANK2, mitochondrial genes NDUFV1, NDUFS8,...
Tue Nov 12, 2019 17:28
Bendamustine is a cytostatic drug with a unique structure, combining the features of purine nucleoside analogs and alkylating agents. In patients with chronic lymphocytic leukemia (CLL) it is commonly used in combination with rituximab (BR protocol) both in the first-line as well as subsequent lines of therapy, and in clinical trials it is often combined with new targeted therapies. Therefore, the data on its real-life safety and efficacy are of clinical significance. As the Polish Lymphoma Research...
Tue Nov 12, 2019 10:45
Objective: Colorectal cancer (CRC) remains a major cause of cancer-related death worldwide. Proteasome 26S subunit ATPase 2 (PSMC2) plays vital roles in regulating cell cycle and transcription and has been confirmed to be a gene potentially associated with some human tumors. However, the expression correlation and molecular mechanism of PSMC2 in CRC are still unclear. This study aimed to investigate the role of PSMC2 in malignant behaviors in CRC. Methods: The high protein levels of PSMC2 in CRC...
Tue Nov 12, 2019 10:13
Abstract Adequate implant stability is an essential requirement. The introduction of the Penguin resonance frequency analysis raises some questions regarding its reliability, reproducibility, and repeatability as well as how it compares to the older Osstell device. Purpose To assess the newer Penguin implant stability coefficient (ISQ) device (vs the Osstell device). Materials and methods A total of 120 implants were used, divided into four groups (A, B, C, and D) (according to design)...
Tue Nov 12, 2019 14:10
AbstractBackgroundIn the United States, surveillance of norovirus gastroenteritis is largely restricted to outbreaks, limiting our knowledge of the contribution of sporadic illness to the overall impact on reported outbreaks. Understanding norovirus transmission dynamics is vital for improving preventive measures, including norovirus vaccine development.MethodsWe analyzed seasonal patterns and genotypic distribution between sporadic pediatric norovirus cases and reported norovirus outbreaks in middle...
02:00
AbstractBackgroundBedaquiline and delamanid are newly available drugs for treating multidrug-resistant tuberculosis (MDR TB); however, there is limited data guiding their use and no comparison studies.MethodsWe conducted a prospective observational study among patients with MDR TB in Georgia receiving a bedaquiline or delamanid-based treatment regimen. Monthly sputum cultures, minimal inhibitory concentration testing, and adverse event monitoring were performed. Primary outcomes were culture conversion...
Tue Nov 12, 2019 02:00
AbstractBackgroundGuidelines recommend adding intravenous (IV) metronidazole to oral vancomycin for fulminant Clostridioides difficile infection (CDI). This study compared dual therapy with IV metronidazole and oral vancomycin versus vancomycin monotherapy. It assessed prevalence of use and effectiveness of dual therapy in non-fulminant and fulminant CDI.MethodsThis was a two-center retrospective study conducted from 2010 to 2018. Adult inpatients were included if they had a positive C. difficile...
Tue Nov 12, 2019 02:00
AbstractBackgroundRates of early syphilis in US women are steadily increasing but predictors of infection in this group are not clearly defined.MethodsThis retrospective analysis focused on women enrolled in the US CFAR Network of Integrated Clinical Systems cohort between January 2005 and December 2016 with syphilis testing performed. The primary outcome of incident syphilis infection was defined serologically as a newly positive test with positive confirmatory testing after a negative test or a...
Tue Nov 12, 2019 02:00
AbstractBACKGROUNDCDC guidelines recommend 240 mg gentamicin plus 2g azithromycin for the treatment of gonorrhea in cephalosporin-allergic patients. The efficacy of gentamicin alone in the treatment of pharyngeal gonorrhea is uncertain.METHODSBetween September 2018 – March 2019, we enrolled men who have sex with men (MSM) with NAAT-diagnosed pharyngeal gonorrhea in a single-arm, unblinded clinical trial. Men received a single 360mg intramuscular (IM) dose of gentamicin and underwent test-of-cure...
Tue Nov 12, 2019 02:00
AbstractAntimicrobial resistance has become one of the greatest threats to public health, with rising resistance to carbapenems being a particular concern due to the lack of effective and safe alternative treatment options. Carbapenem-resistant gram-negative bacteria of clinical relevance include the Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and more recently, Stenotrophomonas maltophilia. Colistin and tigecycline have been used as first-line agents for the treatment of...
02:00
AbstractCarbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of...
02:00
AbstractHistorically, the regulatory requirements of the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for developing new antibiotics have not addressed pathogen-focused indications for drug approval. The design of the necessary randomized controlled trials traditionally involves the enrollment of patients with site-specific infections caused by susceptible as well as resistant pathogens. Cefiderocol has undergone a streamlined clinical development program to address...
02:00
AbstractCarbapenem-resistant gram-negative bacteria including Enterobacteriaceae as well as nonfermenters, such as Pseudomonas aeruginosa and Acinetobacter baumannii, have emerged as significant global clinical threats. Although new agents have recently been approved, none are active across the entire range of resistance mechanisms presented by carbapenem-resistant gram-negative bacteria. Cefiderocol, a novel siderophore cephalosporin, has been shown in large surveillance programs and independent...
02:00
AbstractThe emergence of antimicrobial resistance is a significant public health issue worldwide, particularly for healthcare-associated infections caused by carbapenem-resistant gram-negative pathogens. Cefiderocol is a novel siderophore cephalosporin targeting gram-negative bacteria, including strains with carbapenem resistance. The structural characteristics of cefiderocol show similarity to both ceftazidime and cefepime, which enable cefiderocol to withstand hydrolysis by β-lactamases. The unique...
02:00
AbstractIron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for pathogenic bacteria. However, bacteria have developed various mechanisms to sequester or scavenge iron from the host environment. Iron can be taken up by means of active transport systems that consist of bacterial small molecule siderophores, outer membrane...
02:00
AbstractCefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a “Trojan horse” active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.
02:00
AbstractCefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent in vitro activity and in vivo efficacy against most gram-negative bacteria, including carbapenem-resistant strains of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia. In phase 1 studies, cefiderocol demonstrated linear pharmacokinetics, primarily urinary excretion, an elimination half-life of 2–3 hours, and a protein binding of 58% in human plasma. Cefiderocol is...
02:00
Authors: Antaki C, Chinn D, Walton C, Finlay WML, Sempik J Abstract How do health and social care professionals deal with undecipherable talk produced by adults with intellectual disabilities (ID)? Some of their practices are familiar from the other-initiated repair canon. But some practices seem designed for, or at least responsive to, the needs of the institutional task at hand, rather than those of difficult-to-understand conversational partners. One such practice is to reduce the likelihood...
Mon Nov 11, 2019 00:00
This study describes the phonological skills of Finnish-speaking children at 3;6 and compares them with early lexicon size at 2;0 and lexical ability at 3;6 (N = 67). The children's phonological development was measured using The Finnish Phonology Test. Lexical development was evaluated using the Finnish, long-form version of the Communicative Development Inventory at 2;0 and the Boston naming test at 3;6 At 3;6, all children mastered the vowels and diphthongs fully, and most of the children also...
Tue Oct 29, 2019 00:00
Authors: D'Ortenzio S, Volpato F Abstract In this paper, we analyse how Italian-speaking children with cochlear implants produce subject and object questions introduced by who and which+NP. The aim of the study is to analyse whether a correlation exists between the accuracy of the responses of an elicitation task of wh-questions and clinical variables (i.e. age of hearing aid fitting; age of cochlear implantation; duration of hearing experience) in a group of children with cochlear implants,...
Tue Oct 29, 2019 00:00
Authors: Overby M, Belardi K, Schreiber J Abstract Canonical babbling and volubility are common indicators of infant vocal development. If either indicator falls below values found in typical infants, it may be an early signal of a developmental disorder. The aim of this retrospective investigation was to examine home videos for the frequency of canonical babbles, age of canonical babbling onset, and overall volubility of eight infants later diagnosed with childhood apraxia of speech and...
Tue Oct 29, 2019 00:00
Condition: Esophageal AdenocarcinomaInterventions: Drug: Durvalumab 50 MG/ML; Drug: TremelimumabSponsors: University of Cologne; AstraZenecaRecruiting
Mon Nov 11, 2019 19:00
Condition: Chronic Rhinosinusitis Without Nasal PolypsIntervention: Device: Vibration TherapySponsors: SynDermix AG; ISS AGNot yet recruiting
Mon Nov 11, 2019 19:00
Condition: Primary Axillary HyperhidrosisInterventions: Drug: WO3970; Drug: Qbrexza® (glycopyrronium) cloth, 2.4%, for topical useSponsors: Dr. August Wolff GmbH & Co. KG Arzneimittel; Therapeutics, Inc.Not yet recruiting
Mon Nov 11, 2019 19:00
Condition: Concussion, MildIntervention: Device: Top Spin 360Sponsors: Western University, Canada; TopSpin Technologies LtdNot yet recruiting
Mon Nov 11, 2019 19:00
Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Yenisleidy de las Mercedes Zulueta Díaz, Karen Menghi, Maria Laura Guerrero, Natalia Nocelli, María Laura FananiAbstractL-ascorbic acid alkyl esters (ASCn) are lipophilic forms of vitamin C, which act as skin permeation enhancers. We investigated the physical changes induced by incorporating ASCn into stratum corneum (SC) lipid membranes and correlated this with the mechanism proposed in the literature...
Tue Nov 12, 2019 17:16
Objectives: No consensus exists on a standardized critical care content outline for medical student education. The aim of this research is to develop a national undergraduate medical education critical care content outline. Design: The authors used a Delphi process to reach expert consensus on a content outline that identified the core critical care knowledge topics and procedural skills that medical students should learn prior to entering residency. Over three iterative rounds, the expert...
Mon Nov 11, 2019 02:00
Objectives: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response to infection utilizing an aptamer-based multiplexed proteomics approach to identify novel serum protein changes that might help distinguish between pediatric sepsis and infection-negative...
Mon Nov 11, 2019 02:00
Objectives: Thyroid storm represents a rare but life-threatening endocrine emergency. Only rare data are available on its management and the outcome of the most severe forms requiring ICU admission. We aimed to describe the clinical manifestations, management and in-ICU and 6-month survival rates of patients with those most severe thyroid storm forms requiring ICU admission. Design: Retrospective, multicenter, national study over an 18-year period (2000–2017). Setting: Thirty-one French...
Mon Nov 11, 2019 02:00
Purpose of review Visual snow is considered a disorder of central visual processing resulting in a perturbed perception of constant bilateral whole-visual field flickering or pixelation. When associated with additional visual symptoms, it is referred to as visual snow syndrome. Its pathophysiology remains elusive. This review highlights the visual snow literature focusing on recent clinical studies that add to our understanding of its clinical picture, pathophysiology, and treatment. Recent...
Sat Nov 09, 2019 02:00
Tue Nov 12, 2019 03:00
Abstract Purpose of Narrative To enlighten the audience and suggest potential gaps and areas of future interest for further exploration and discussion related to wound care in developing regions of the world. Recent Findings Beyond limited case reports and a relative handful of typical epidemiological studies and clinical trials, there exist little significant...
Tue Nov 12, 2019 02:00
Abstract Purpose of Review Commercialization of an automated epidermal harvesting device (CelluTome™, Kinetic Concepts Inc., San Antonio, TX) in the last 6 years has led to numerous publications describing a growing number of clinical applications. The current article reviews this literature while summarizing outcomes. Recent Findings A total of 20 published...
Tue Nov 12, 2019 02:00
Diagnostics, Vol. 9, Pages 187: Otolaryngologists and the Early Diagnosis of Mucopolysaccharidoses: A Cross-Sectional Study Diagnostics doi: 10.3390/diagnostics9040187 Authors: Danielle de Araujo Torres Anneliese Lopes Barth Mariana Pires de Mello Valente Paulo Pires de Mello Dafne Dain Gandelman Horovitz Mucopolysaccharidoses (MPS) are a group of inborn errors of metabolism with an aggressive and usually fatal course. Therefore, early treatment is essential because the involvement...
02:00
Diagnostics, Vol. 9, Pages 186: Visceral Origin: An Underestimated Source of Neck Pain. A Systematic Scoping Review Diagnostics doi: 10.3390/diagnostics9040186 Authors: Ángel Oliva-Pascual-Vaca Carlos González-González Jesús Oliva-Pascual-Vaca Fernando Piña-Pozo Alejandro Ferragut-Garcías Juan Carlos Fernández-Domínguez Alberto Marcos Heredia-Rizo The diagnosis of neck pain is challenging. Many visceral disorders are known to cause it, and clinical practice guidelines...
Tue Nov 12, 2019 02:00
Background and Aim. Aspartate aminotransferase-to-platelet ratio index (APRI) is widely used in the assessment of fibrosis and cirrhosis, especially in patients with chronic hepatitis. However, the prognostic value of APRI in patients with chronic hepatitis with regard to the prediction of hepatocellular carcinoma (HCC) occurrence remains controversial. The objective of this meta-analysis is to investigate the association between APRI and HCC risk on the basis of cohort studies. Methods. We systematically...
03:05
Diseases, Vol. 7, Pages 58: Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far? Diseases doi: 10.3390/diseases7040058 Authors: Hiroshi Fukui Accumulating evidence supports that gut dysbiosis may relate to various liver diseases. Alcoholics with high intestinal permeability had a decrease in the abundance of Ruminnococcus. Intestinal dysmotility, increased gastric pH, and altered immune responses in addition to environmental and genetic factors are likely to cause alcohol-associated...
Tue Nov 12, 2019 02:00
Publication date: January 2020Source: DNA Repair, Volume 85Author(s): Brian Ruis, Amy Molan, Taylor Takasugi, Eric A. HendricksonAbstractThe repair of DNA double-stranded breaks (DSBs) is an essential function performed by the Classical Non-Homologous End-Joining (C-NHEJ) pathway in higher eukaryotes. C-NHEJ, in fact, does double duty as it is also required for the repair of the intermediates formed during lymphoid B- and T-cell recombination. Consequently, the failure to properly repair DSBs leads...
Tue Nov 12, 2019 17:20
Publication date: Available online 11 November 2019Source: DNA RepairAuthor(s): Polina S. Loshchenova, Svetlana V. Sergeeva, Dmitry V. Limonov, Zhigang Guo, Grigory L. DianovAbstractBase excision repair (BER) is the major repair pathway that removes DNA single strand breaks (SSBs) arising spontaneously due to the inherent instability of DNA. Unrepaired SSBs promote cell-cycle delay, which facilitates DNA repair prior to replication. On the other hand, in response to persistent DNA strand breaks,...
Tue Nov 12, 2019 17:20
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