Key PointsMethod for highly sensitive detection of phosphorylation in B cell subpopulations. B cell subpopulations show different phosphorylation levels upon BCR stimulation.
Mon May 04, 2020 23:00
Key PointsIslets are engineered with SA-PDL1 protein without impacting viability/function. SA-PDL1–engineered islets show indefinite survival in allogeneic hosts. Survival is associated with elevated intragraft Th2, Treg, and M2 transcripts.
Mon May 04, 2020 23:00
Key PointsSP-A is a collectin and plays a key role in innate immunity in the lung. SP-A modulates inflammation in airway epithelial cells from patients with asthma. SP-A modulates IL-13–induced inflammation through downstream IL-6/STAT3 signaling.
Mon May 04, 2020 23:00
Key PointsThe a3-subunit of V-ATPase acidifies cytotoxic granules in mouse CD8+ T lymphocytes. Neutralization of luminal pH leads to altered morphology of cytotoxic granules. Knockdown of a3-subunit disturbs trafficking of cytotoxic granules.
Mon May 04, 2020 23:00
Key Points5-HT2B agonists stimulate AhR transcriptional activation in human macrophages. Serotonin-induced expression of AhR target genes is 5-HT2B dependent in macrophages.
Mon May 04, 2020 23:00
Key PointsThe augmented ISG profile of RdRP mice develops largely postnatally. Elevated ISG expression is then maintained through adulthood. The ISG signature in adults requires persistent type I IFN signaling.
Mon May 04, 2020 23:00
Key PointsApoE was found in complex with C4d in RA patient SF. Deposited ApoE activates complement whereas ApoE in solution is inhibitory. Posttranslational modifications alter ApoE's capacity to bind FH and C4BP.
Mon May 04, 2020 23:00
Key PointsE4 is an enhancer element that regulates transcriptions of TCR genes. E4–/– mice have fewer CD27+CD45RBhigh V2+ T cells in peripheral organs. Attenuation of TCR signal impairs homeostasis of T cells in peripheral organs.
Mon May 04, 2020 23:00
Key PointsLack of Tfh cells renders the mice susceptible to C. rodentium infection. Tfh cell–dependent protective Abs are essential to control C. rodentium. Tfh cells regulate IgG1 response to C. rodentium infection.
Mon May 04, 2020 23:00
Key PointsGolgi morphology and Grasp55 expression are regulated during hematopoiesis. Hematopoiesis is not affected in Grasp55-deficient mice. Grasp55 regulates Myc-transformed leukemic cell survival.
Mon May 04, 2020 23:00
Key PointsLymphotoxin axis is not essential for formation of O-MALT in ectotherms and birds. Vertebrate O-MALT structures are enriched in neuroactive ligand/receptor genes. Mammalian PPs and LNs are enriched in genes involved in olfactory transduction.
Mon May 04, 2020 23:00
Key PointsVirulent and avirulent parasites significantly differ in their proteome profiles. Avirulent parasites fail to inhibit CD40 signaling. Avirulent parasite strain is a potential antileishmanial vaccine candidate.
Mon May 04, 2020 23:00
Key PointsTLR signaling pathway regulates expression of monocyte chemoattractant CCR2. IRAK-M is an important regulator of monocyte trafficking to the lung in fibrosis.
Mon May 04, 2020 23:00
Key PointsL. donovani induces histone lysine methyltransferases/demethylases in the host. L. donovani–induced epigenetic enzymes induce host M(IL-10) polarization. Knockdown of epigenetic enzymes inhibited parasite multiplication in infected host.
Mon May 04, 2020 23:00
Key PointsIRAK1 is hyperactivated in human preterm birth and in mouse and rhesus IUI models. IRAK1 deletion and inhibition reduces preterm birth. IRAK1 induces preterm birth by upregulating COX-2.
Mon May 04, 2020 23:00
Key PointsSTAT1-pS727 is required for SLE-associated AFC, GC, and autoantibody responses. STAT1-pS727 in B cells promotes autoimmune AFC, GC, and autoantibody responses. STAT1-pS727 is not required for foreign Ag– or gut microbiota–driven responses.
Mon May 04, 2020 23:00
Key PointsNovel TM lupus mouse strains develop spontaneous nephritis. In C1q deficiency, kidney complement activation likely occurred via the LP. In C3 deficiency, coagulation cascade contributed to kidney complement activation.
Mon May 04, 2020 23:00
The past decade has increased our understanding of how genome topology controls RAG endonuclease-mediated assembly of lymphocyte AgR genes. New technologies have illuminated how the large IgH, Ig, TCRα/, and TCRβ loci fold into compact structures that place their numerous V gene segments in similar three-dimensional proximity to their distal recombination center composed of RAG-bound (D)J gene segments. Many studies have shown that CTCF and cohesin protein–mediated chromosome looping have fundamental...
Mon May 04, 2020 23:00
Key PointsKupffer cells phagocytose both bacteria and CRP–VLDL complexes. High levels of CRP–VLDL complexes delay bacterial clearance. Pch disrupts CRP–VLDL complexes to improve bacterial clearance.
Mon May 04, 2020 23:00
Key PointsCMV coinfection promotes the generation of CD57+ CD4 Tmem in PLWH. CD2/LFA-3 costimulation enhances the functionality of CD57+ CD4 Tmem. IL-15 and TNF enhance chemoattraction of CD57+ CD4 Tmem to CX3CL1+ endothelial cells.
Mon May 04, 2020 23:00
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