Δευτέρα 4 Μαΐου 2020

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
by Adil Doganay Duru, Renhua Sun, Eva B. Allerbring, Jesseka Chadderton, Nadir Kadri, Xiao Han, Kaliroi Peqini, Hannes Uchtenhagen, Chaithanya Madhurantakam, Sara Pellegrino, Tatyana Sandalova, Per-Åke Nygren, Stephen J. Turner, Adnane Achour Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that CD8+ T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated...
PLOS Pathogens: New Articles
12h
The intergenic small non-coding RNA <i>ittA</i> is required for optimal infectivity and tissue tropism in <i>Borrelia burgdorferi</i>
by Diana N. Medina-Pérez, Beau Wager, Erin Troy, Lihui Gao, Steven J. Norris, Tao Lin, Linden Hu, Jenny A. Hyde, Meghan Lybecker, Jon T. Skare Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse regulatory processes in bacteria, including virulence. One class of sRNAs, termed trans-acting sRNAs, can affect the stability and/or the translational efficiency of regulated transcripts. In this study, we utilized a collaborative approach that employed data...
PLOS Pathogens: New Articles
12h
Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease
by Laura A. Powell, Julie M. Fox, Nurgun Kose, Arthur S. Kim, Mahsa Majedi, Robin Bombardi, Robert H. Carnahan, James C. Slaughter, Thomas E. Morrison, Michael S. Diamond, James. E. Crowe Jr Ross River fever is a mosquito-transmitted viral disease that is endemic to Australia and the surrounding Pacific Islands. Ross River virus (RRV) belongs to the arthritogenic group of alphaviruses, which largely cause disease characterized by debilitating polyarthritis, rash, and fever. There is no specific...
PLOS Pathogens: New Articles
12h
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1
by Christina Paulus, Thomas Harwardt, Bernadette Walter, Andrea Marxreiter, Marion Zenger, Edith Reuschel, Michael M. Nevels Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are common targets of viral antagonism. The 72-kDa immediate-early protein 1 (IE1) is the principal antagonist of PML bodies encoded...
PLOS Pathogens: New Articles
12h
<i>Salmonella</i> typhimurium discreet-invasion of the murine gut absorptive epithelium
by Stefan A. Fattinger, Desirée Böck, Maria Letizia Di Martino, Sabrina Deuring, Pilar Samperio Ventayol, Viktor Ek, Markus Furter, Saskia Kreibich, Francesco Bosia, Anna A. Müller-Hauser, Bidong D. Nguyen, Manfred Rohde, Martin Pilhofer, Wolf-Dietrich Hardt, Mikael E. Sellin Salmonella enterica serovar Typhimurium (S.Tm) infections of cultured cell lines have given rise to the ruffle model for epithelial cell invasion. According to this model, the Type-Three-Secretion-System-1 (TTSS-1) effectors...
PLOS Pathogens: New Articles
12h
Structure and functional analysis of the <i>Legionella pneumophila</i> chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation
by Saima Rehman, Lubov S. Grigoryeva, Katherine H. Richardson, Paula Corsini, Richard C. White, Rosie Shaw, Theo J. Portlock, Benjamin Dorgan, Zeinab S. Zanjani, Arianna Fornili, Nicholas P. Cianciotto, James A. Garnett Chitinases are important enzymes that contribute to the generation of carbon and nitrogen from chitin, a long chain polymer of N-acetylglucosamine that is abundant in insects, fungi, invertebrates and fish. Although mammals do not produce chitin, chitinases have been identified...
PLOS Pathogens: New Articles
12h
EhC2B, a C2 domain-containing protein, promotes erythrophagocytosis in <i>Entamoeba histolytica</i> via actin nucleation
by Aashutosh Tripathi, Megha Jain, Mintu Chandra, Sameena Parveen, Rupali Yadav, Brett M. Collins, Sankar Maiti, Sunando Datta Remodelling of the actin cytoskeleton in response to external stimuli is obligatory for many cellular processes in the amoebic cell. A rapid and local rearrangement of the actin cytoskeleton is required for the development of the cellular protrusions during phagocytosis, trogocytosis, migration, and invasion. Here, we demonstrated that EhC2B, a C2 domain-containing protein,...
PLOS Pathogens: New Articles
12h
SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response
by Qinghe Li, Fei Wang, Qiao Wang, Na Zhang, Jumei Zheng, Maiqing Zheng, Ranran Liu, Huanxian Cui, Jie Wen, Guiping Zhao As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin 3-based ubiquitin ligase adaptor Speckle-type BTB–POZ protein (chSPOP) recognizes...
PLOS Pathogens: New Articles
12h

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