The ongoing SARS-CoV-2 outbreak marks the first time that large amounts of genome sequence data have been generated and made publicly available in near real-time. Early analyses of these data revealed low sequence variation, a finding that is consistent with a recently emerging outbreak, but which raises the question of whether such data are sufficiently informative for phylogenetic inferences of evolutionary rates and time scales. The phylodynamic threshold is a key concept that refers to the point...
Mon May 04, 2020 03:00
The zero-force evolutionary law (ZFEL) of McShea et al. states that independently evolving entities, with no forces or constraints acting on them, will tend to accumulate differences and therefore diverge from each other. McShea et al. quantified the law by assuming normality on an additive arithmetic scale and reflecting negative differences as absolute values, systematically augmenting perceived divergence. The appropriate analytical framework is not additive but proportional, where logarithmic...
Mon May 04, 2020 03:00
Bacteria typically reside in heterogeneous environments with various chemogradients where motile cells can gain an advantage over non-motile cells. Since motility is energetically costly, cells must optimize their swimming speed and behavior to maximize their fitness. Here we investigate how cheating strategies might evolve where slow or non-motile microbes exploit faster ones by sticking together and hitching a ride. Starting with physical and biological first-principles we computationally study...
Mon May 04, 2020 03:00
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