Related ArticlesAge- and sex-specific plasticity in dopamine transporter function revealed by food restriction and exercise in a rat activity-based anorexia paradigm. J Pharmacol Exp Ther. 2019 Sep 03;: Authors: Gilman TL, Owens WA, George CM, Metzel L, Vitela M, Ferreira L, Bowman MA, Gould GG, Toney GM, Daws LC Abstract Eating disorders such as anorexia typically emerge during adolescence, are characterized by engagement in compulsive and detrimental...
Thu Sep 05, 2019 19:33
Abstract Purpose To optimize and validate a current (NRG [a newly constituted National Clinical Trials Network group through National Surgical Adjuvant Breast and Bowel Project [NSABP], the Radiation Therapy Oncology Group [RTOG] and the Gynecologic Oncology Group (GOG)]) nomogram for glioblastoma patients as part of continuous validation. Methods We identified...
Thu Sep 05, 2019 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01241
Thu Sep 05, 2019 07:00
ObjectivesSeveral recent large-scale studies have indicated a prospective association between job strain and coronary heart disease, stroke and diabetes. Job strain is also associated with poorer mental health, a risk factor for cardiometabolic disease. This study investigates the prospective relationships between change in job strain, poor mental health and cardiometabolic disease, and whether poor mental health is a potential mediator of the relationship between job strain and cardiometabolic disease.MethodsWe...
Thu Sep 05, 2019 19:00
ObjectivesOur objective was to monitor blood lead levels (BLLs) of miners and ore processors participating in a pilot programme to reduce lead poisoning and take-home exposures from artisanal small-scale gold mining. A medical surveillance programme was established to assess exposures as new methods aimed at reducing lead exposures from ore were introduced in a community in Nigeria where children experienced substantial lead-related morbidity and mortality.MethodsExtensive outreach and education...
Thu Sep 05, 2019 19:00
Community-acquired pneumonia (CAP) is an important cause of hospitalizations in adults. In the United States, Streptococcus pneumoniae is the most frequently identified bacterial pathogen responsible for CAP. Other etiologic pathogens of CAP vary based on the geographic region. Mycobacterium tuberculosis is an uncommon cause of CAP in the United States, while it is a principal cause in many African and Asian countries. Coinfection with Streptococcus pneumoniae and Mycobacterium tuberculosis is rare...
Thu Sep 05, 2019 19:05
The first few minutes after birth are critical in a child’s life. Clinicians generally follow the guidelines of the American Heart Association’s International Liaison Committee on Resuscitation when monitoring blood oxygenation during the first ten minutes post birth. This is usually performed “manually,” either with printed charts or simply by a quick reference into one’s memory. Masimo is now dragging this process into the 21st century by incorporating its new Pathway feature into the company’s...
Thu Sep 05, 2019 14:46
Engineers from Purdue University, University of Georgia, and University of Texas have combined forces to develop a glove that can be put over existing prosthetic hands to give them a more life-like feel and the ability to sense a variety of parameters. The glove is intended to improve a user’s ability to interact with others. The device is soft and supposedly feels similar to a human hand when touched. It can measure the pressure when shaking someone’s hand or grabbing objects, as well as...
Thu Sep 05, 2019 16:10
Edwards Lifesciences won FDA clearance to integrate its ForeSight brain tissue oxymetry sensors with the HemoSphere monitoring platform. While the clearance is really for a connecting cable, the capability allows anesthesiologists to monitor the oxygen saturation of the brain during surgeries and to correlate it with hemodynamic parameters in real-time. “Understanding the relationship between the heart and the brain can provide valuable patient insights to support decision making during a...
Thu Sep 05, 2019 16:53
The electrical activity of cardiomyocytes and other excitable cells such as neurons is studied using a number of techniques. To get details about the action potentials within the interior of the cell requires either forcefully pushing microelectrodes through the cellular barrier or using electroporation, a high voltage technique that makes temporary openings in the membranes. Sticking electrodes carefully through springy cell membranes is a hit and miss process and electroporation is only effective...
Thu Sep 05, 2019 20:01
Related Articles[Application of lean management in cost control of cerebral infarction single disease in stroke center]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 May;31(5):637-640 Authors: Qin C, Pan L, Chen Q, Lin Q, Zhang D Abstract OBJECTIVE: To explore the effect of lean management on cost control of single disease in patients with acute cerebral infarction (ACI) in stroke center. METHODS: A retrospective study was conducted. The patients...
Thu Sep 05, 2019 20:21
Abstract In the present work, a novel cordycepic pigment was successfully isolated and identified from Cordyceps militaris, as well as named as cordycepene (C14H17N1O4), according to the long unsaturated conjugated polyene structural characteristic. Cordycepene is sensitive to light, high temperature (≥ 60 °C), and acidic condition (pH ≤ 3), but possesses high stability against metal ions, and under alkaline and neutral conditions. Cordycepene shows a comparable DPPH (1,1-diphenyl-2-picrylhydrazyl)...
Thu Sep 05, 2019 03:00
This review of 190 patient photographs and computed tomography scans measured the distribution of nasal soft-tissue envelope thickness (STE) and evaluates whether 4 facial plastic surgery physicians were able to accurately predict STE thickness via visual assessment.
Thu Sep 05, 2019 03:00
Abstract Introduction Brain metastases are a significant source of morbidity and mortality for patients with lung cancer. Lung cancer can induce local and systemic immunosuppression, promoting tumor growth and dissemination. One mechanism of immunosuppression is tumor-induced expansion of programmed death-ligand 1 (PD-L1) expressing myeloid cells. Here, we investigate peripheral blood immune phenotype in NSCLC patients with or without...
Thu Sep 05, 2019 03:00
Publication date: Available online 4 September 2019Source: Human PathologyAuthor(s): Michael Torbenson, Kay WashingtonSummaryLiver disease has been recognized in various forms for centuries. Incredible advances, however, have been made especially in the last 50 years, driven by improvements in histology, the development of immunostains, the development of high resolution imaging methods, improved biopsy and resection methods, and the emergence of the molecular era. With these tools, pathologists...
Thu Sep 05, 2019 20:59
Publication date: Available online 5 September 2019Source: Human PathologyAuthor(s): M. Adelita Vizcaino, Abeer Z. Tabbarah, Laura Asnaghi, Azza Maktabi, Allen O. Eghrari, Divya Srikumaran, Charles G. Eberhart, Fausto J. RodriguezSummaryConjunctival squamous cell carcinoma (cSCC) and its precursors are among the most frequent ocular surface neoplasms worldwide. Copy gain of 8p11.22 and ADAM3A overexpression have been recently identified in invasive cSCC. We sought to study copy number gains using...
Thu Sep 05, 2019 20:59
Publication date: Available online 5 September 2019Source: Human PathologyAuthor(s): Steven H. Swerdlow, James R. CookSummaryThe last century and a half has seen first the recognition of lymphomas, and then the publication of one lymphoma classification after another often together with highly critical comments about preceding classifications or a welcome that was less than warm. The introduction of HUMAN PATHOLOGY in 1970 came just before one of the very acrimonious periods in lymphoma classification,...
Thu Sep 05, 2019 20:59
The complex three-dimensional organization of genomes in the cell nucleus arises from a wide range of architectural features including DNA loops, chromatin domains, and higher-order compartments. Although these features are universally present in most cell types and tissues, recent single-cell biochemistry and imaging approaches have demonstrated stochasticity in transcription and high variability of chromatin architecture in individual cells. We review the occurrence, mechanistic basis, and functional...
Thu Sep 05, 2019 20:39
Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. The presence of colibactin-producing bacteria correlates with the frequency and severity of colorectal cancer in humans. However, because colibactin has not been isolated or structurally characterized, studying the physiological effects of colibactin-producing bacteria in the human gut has been difficult. We used a combination of genetics, isotope labeling, tandem mass spectrometry, and chemical...
Thu Sep 05, 2019 20:39
Advances in synthetic biology have led to an arsenal of proof-of-principle bacterial circuits that can be leveraged for applications ranging from therapeutics to bioproduction. A unifying challenge for most applications is the presence of selective pressures that lead to high mutation rates for engineered bacteria. A common strategy is to develop cloning technologies aimed at increasing the fixation time for deleterious mutations in single cells. We adopt a complementary approach that is guided by...
Thu Sep 05, 2019 20:39
The construction of atomically precise carbon nanostructures holds promise for developing materials for scientific study and nanotechnology applications. Here, we show that graphene origami is an efficient way to convert graphene into atomically precise, complex nanostructures. By scanning tunneling microscope manipulation at low temperature, we repeatedly fold and unfold graphene nanoislands (GNIs) along an arbitrarily chosen direction. A bilayer graphene stack featuring a tunable twist angle and...
Thu Sep 05, 2019 20:39
Lack of therapeutic efficacy of an antibody to {alpha}4{beta}7 in SIVmac251-infected rhesus macaques
Sustained virologic control of human immunodeficiency virus type 1 (HIV-1) infection after discontinuation of antiretroviral therapy (ART) is a major goal of the HIV-1 cure field. A recent study reported that administration of an antibody against α4β7 induced durable virologic control after ART discontinuation in 100% of rhesus macaques infected with an attenuated strain of simian immunodeficiency virus (SIV) containing a stop codon in nef. We performed similar studies in 50 rhesus macaques infected...
Thu Sep 05, 2019 20:39
Particles placed inside an Abelian (commutative) gauge field can acquire different phases when traveling along the same path in opposite directions, as is evident from the Aharonov-Bohm effect. Such behaviors can get significantly enriched for a non-Abelian gauge field, where even the ordering of different paths cannot be switched. So far, real-space realizations of gauge fields have been limited to Abelian ones. We report an experimental synthesis of non-Abelian gauge fields in real space and the...
Thu Sep 05, 2019 20:39
Binary pulsars are affected by general relativity (GR), causing the spin axis of each pulsar to precess. We present polarimetric radio observations of the pulsar PSR J1906+0746 that demonstrate the validity of the geometrical model of pulsar polarization. We reconstruct the (sky-projected) polarization emission map over the pulsar’s magnetic pole and predict the disappearance of the detectable emission by 2028. Two tests of GR are performed using this system, including the spin precession for strongly...
Thu Sep 05, 2019 20:39
The impacts of human and natural disturbances on coral reefs are typically quantified through visible damage (e.g., reduced coral coverage as a result of bleaching events), but changes in environmental conditions may also cause damage in less visible ways. Despite the current paradigm, which suggests consistent, highly synchronized spawning events, corals that reproduce by broadcast spawning are particularly vulnerable because their reproductive phenology is governed by environmental cues. Here,...
Thu Sep 05, 2019 20:39
Thu Sep 05, 2019 20:39
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