Inflammatory response to the anti PD-L1 drug, atezolizumab, masquerades as breast implant rupture

First-in-human 18 F-SiFA lin -TATE PET/CT for NET imaging and theranostics

Al 18 F-NOTA-octreotide and 18 F-SiFA lin -TATE: two ‘new kids on the block’ in somatostatin receptor imaging

Al 18 F-NOTA-octreotide: first comparison with 68 Ga-DOTATATE in a neuroendocrine tumour patient

Radiation-induced myocardial damage indicated by focal defect on 123 I-MIBG SPECT

Scan preparation for patients with type I diabetes treated with continuous sub-cutaneous insulin infusion (CSII) pumps

Current experts’ views on precision nuclear medicine imaging of phaeochromocytoma and paraganglioma Abstract The EANM/SNMMI 2019 guidelines for radionuclide imaging of phaeochromocytoma and paraganglioma (PPGL) describe the current experts’ views on molecular imaging in the era of precision medicine, and contain all of the information needed by nuclear physicians for performing, interpreting, and reporting the results of imaging investigations. This editorial, from a clinician’s perspective, describes the first-choice radiopharmaceutical for a particular clinical setting as an important element of the revised guidelines. It also gives new evidence-based data showing the steadily growing role of nuclear imaging in PPGL phenotyping and assessment of their clinical characteristics and outcomes.

Molecular imaging of impulse control disorders in Parkinson’s disease

EANM commitment towards involvement and engagement of patients and the public: learning from the UK experience

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [ 11 C]PBR28 HRRT PET study Abstract Purpose The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [11C]PBR28. Methods [11C]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19–80 years; BMI range 17.6–36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (VT) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts. Results There were significant positive correlations between age and VT in the frontal and temporal cortex. BMI showed a significant negative correlation with VT in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher VT. A subgroup analysis revealed a positive correlation between VT and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects. Conclusion These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.