We report a case of a patient with progressed retinitis pigmentosa (RP) who underwent bilateral cataract extraction with implantation of a monofocal enlarged optic in the far dominant eye and a high-add AMD intraocular lens (IOL) in the near dominant eye (hybrid monovision XL-MAGS). A 71-year-old woman presented to our clinic complaining of reduced visual acuity additionally to her diagnosis of RP. The high-add IOL LENTIS® MAX LS-313 MF80 (Oculentis, Germany) was implanted in the right eye and the...
Tue Sep 10, 2019 16:47
Upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease is one of the leading causes of death in patients with non-variceal bleeding, resulting in up to 10% mortality rate, and the patient group at ...
Tue Sep 10, 2019 03:00
Thyroid, Ahead of Print.
Fri Sep 06, 2019 10:00
Publication date: Available online 9 September 2019Source: Computer Speech & LanguageAuthor(s): Manuel Vilares Ferro, Víctor M. Darriba Bilbao, Jesús Vilares FerroAbstractWe introduce an adaptive scheduling for adaptive sampling as a novel way of machine learning in the construction of part-of-speech taggers. The goal is to speed up the training on large data sets, without significant loss of performance with regard to an optimal configuration. In contrast to previous methods using a random,...
Tue Sep 10, 2019 18:44
Abstract Individuals with post‐traumatic stress disorder (PTSD) typically experience states of reliving and hypervigilance; however, the dissociative subtype of PTSD (PTSD+DS) presents with additional symptoms of depersonalization and derealization. Although the insula is critical to emotion processing, its association with these contrasting symptom profiles is yet to be fully delineated. Accordingly, we investigated insula subregion resting‐state functional connectivity patterns among individuals...
Tue Sep 10, 2019 18:39
המשמעות: מכיר בנכונותו של דבר־מה (שלא כמו שחשב קודם, שלא כמו שמקובל לחשוב). דוגמה: נודה על האמת, איננו קוראים את האותיות הקטנות של פוליסת הביטוח. מקור הביטוי בספרות חז"ל. במשנה אבות באה רשימה של מידות טובות שחכם ניחן בהן: שבעה דברים בגולם ושבעה בחכם: חכם אינו מדבר בפני מי שהוא גדול ממנו בחכמה, ואינו נכנס לתוך דברי חבירו, ואינו נבהל להשיב, שואל כענין ומשיב כהלכה, ואומר על ראשון ראשון ועל אחרון אחרון, ועל מה שלא שמע אומר לא שמעתי, ומודה על האמת. וחלופיהן בגולם. (ה, ז) במדרש אבות דר' נתן מודגמת...
Tue Sep 10, 2019 17:57
לקריאת המאמר חקר לשונם של ישראלים שמוצאם מארצות האסלאם התפתח מאוד בישראל במחצית השנייה של המאה העשרים. מרבית המחקרים נעשו בידי חוקרים מתחום הסוציולוגיה והחינוך שדגלו בשיטת ה"חסך הלשוני" וסברו כי לשונם של דוברים אלה לקויה בתחומים רבים ומגוונים. אך בחינת התופעות הלשוניות שהעלו חוקרים אלה מגלה כי חלק לא קטן מהן ניתן להסביר על רקע הלשון הערבית־יהודית ששימשה בפיהם של הנחקרים. יתר על כן, מקצת המאפיינים הלשוניים של דוברים אלה ממשיכים. לשמש כיום במאה העשרים ואחת אף בלשונם של ישראלים ילידים, דוברי עברית...
Tue Sep 10, 2019 15:27
לקריאת המאמר יצירתו הפרשנית הענפה של רש"י זכתה למעמד קנוני בעולם הרוח היהודי, וכבר מראשית ימיה של חוכמת ישראל הייתה מושא למחקרים רבים בתחומי דעת מגוונים. בעיון הקצר המחבר מבקש להדגים את תרומת פירושו של רש"י לתורה לחקר לשון חז"ל. The post פירוש רש"י לתורה והמסורת האשכנזית הקדומה של לשון חז"ל appeared first on האקדמיה ללשון העברית.
Tue Sep 10, 2019 15:24
Mon Sep 09, 2019 03:00
Abstract Background Etiological factors, such as a malignant disease, in young stroke patients are often neglected. Therefore, in this study, we aimed to investigate the risk of developing cancer in young stroke survivors. Methods The current case–control study sample included patients who received an initial ischemic stroke diagnosis documented in the Disease...
Tue Sep 10, 2019 03:00
Abstract Purpose Molecular mechanisms of response to hypomethylating agents in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) still remain largely unknown. Therefore, the effects of 5-Azacytidine (Aza) on clonal architecture and DNA methylation were investigated in this study. Methods Using next-generation sequencing...
Tue Sep 10, 2019 03:00
Abstract Purpose We examined whether multi-disciplinary stepped psychosocial care for cancer patients improves quality of care from the patient perspective. Methods In a university hospital, wards were randomly allocated to either stepped or standard care. Stepped care comprised screening for distress, consultation between doctor and patient, and the provision...
Tue Sep 10, 2019 03:00
Publication date: Available online 9 September 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Bettina Pretterklieber, Maria Hader, Niels Hammer, Galyna Pryymachuk, Felicitas Pröls, Franziska Vielmuth, Miriam Barnerßoi, Sebastian Cotofana, Amanda Custozzo, Imke Weyers, Thilo Wedel, Philipp Arnold, Christoph Rahner, Magdalena Müller-Gerbl, Michael L. PretterklieberAbstractBackgroundThe phrenicoabdominal branch of the left phrenic nerve passes between muscle fiber bundles within the...
Tue Sep 10, 2019 18:02
Publication date: Available online 9 September 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Carlo Messina, Valeria Merz, Michela Frisinghelli, Chiara Trentin, Elisabetta Grego, Antonello Veccia, Massimiliano Salati, Marco Messina, Carlo Carnaghi, Orazio CaffoAbstractBackgroundThe role of adjuvant chemotherapy (ACT) is still unclear and there is no specific recommendation by international guidelines.Aimto perform a meta-analysis of randomized clinical trials (RCTs) to better define...
Tue Sep 10, 2019 17:37
Publication date: Available online 9 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Saira Zafar, Alicia Decastro, Suman Pal, Jay Pandav, Naga Kanaparthy
Tue Sep 10, 2019 17:37
Publication date: Available online 9 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Thomas Eiwegger, Katherine Anagnostou, Stefania Arasi, Philippe Bégin, Moshe Ben-Shoshan, Kirsten Beyer, Katharina Blumchen, Helen Brough, Jean-Christoph Caubet, Edmond S. Chan, Sharon Chinthrajah, Carla M. Davis, Anne Des Roches, George Du Toit, Arnon Elizur, Stephen J. Galli, Geir Håland, Karin Hoffmann-Sommergruber, Harold Kim, Donald Y.M. Leung
Tue Sep 10, 2019 17:37
Publication date: Available online 9 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Melody C. Carter, Cem Akin, Mariana C. Castells, Erin P. Scott, Phil LiebermanAbstractAnaphylaxis is considered idiopathic when there is no known trigger. The signs and symptoms of idiopathic anaphylaxis (IA) are identical to those of anaphylaxis due to a known cause and can include cutaneous, circulatory, respiratory, gastrointestinal, and neurologic symptoms. IA can be a frustrating disease...
Tue Sep 10, 2019 17:37
Publication date: Available online 9 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Kavita Pal, Madison Ramsden, Yun M. Shim, Larry Borish, Spencer C. Payne, John W. Steinke19-01-0017R3BackgroundAspirin-exacerbated respiratory disease (AERD) is characterized by severe, sometimes life-threatening reactions to non-steroidal anti-inflammatory drugs(NSAID). Mechanisms driving the disease include overproduction of leukotrienes and loss of anti-inflammatory prostaglandin E2...
Tue Sep 10, 2019 17:37
Key points Some patients with obstructive sleep apnoea (OSA) respond well to oral appliance therapy but others do not for reasons that are unclear. In this study we used gold‐standard measurements to demonstrate that patients with a posteriorly‐located tongue (natural sleep endoscopy) exhibit a preferential improvement in collapsibility (lowered critical closing pressure, Pcrit) with oral appliances. We also show that patients with both posteriorly‐located tongue and less severe collapsibility...
Tue Sep 10, 2019 15:43
Publication date: Available online 9 September 2019Source: Gait & PostureAuthor(s): Azin Zargham, Maarten Afschrift, Joris De Schutter, Ilse Jonkers, Friedl De GrooteAbstractBackgroundAssessment of contact forces is essential for a better understanding of mechanical factors affecting progression of osteoarthritis. Since contact forces cannot be measured non-invasively, computer simulations are often used to assess joint loading. Contact forces are to a large extent determined by muscle forces....
Tue Sep 10, 2019 17:30
Condition: Esophageal Squamous Cell CarcinomaInterventions: Drug: Triprizumab; Drug: Paclitaxel, Albumin-Bound; Radiation: Radiotherapy; Drug: Platinum-Based DrugSponsors: Zhejiang Cancer Hospital; TopAlliance Biosciences, Inc.Recruiting
Tue Sep 10, 2019 17:29
Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors
Condition: Adult Solid TumorInterventions: Biological: SQZ-PBMC-HPV; Drug: AtezolizumabSponsor: SQZ BiotechnologiesNot yet recruiting
Tue Sep 10, 2019 17:29
The computed axial tomography scans of the skull of Aegyptocetus tarfa, a semiaquatic archaeoceti from the middle Eocene of Egypt, show that this whale retained all three sets of turbinates like a land mammal. Ethmoturbinates (olfactory function) in A. tarfa have 26% of the surface area expected for an artiodactyl, indicating that early whales retained a sense of smell in the transition from land to sea. Maxilloturbinates (respiratory function) in A. tarfa have 6% of the surface area expected for...
Mon Sep 09, 2019 19:19
Minuscule auditory and hyoid bones of Arboroharamiya are described and compared with those of other euharamiyidans, an extinct arboreal mammaliaforms lived in Jurassic forests. These small bones are unique in morphology among mammaliaforms and their identification still remains controversial. Interpretations of these elements affect the phylogenetic position of euharamiyidans as well as our understanding on evolution of the mammalian middle ear. Abstract The holotypes of euharamiyidan Arboroharamiya...
Mon Sep 09, 2019 19:06
For patients with acute respiratory insufficiency, mechanical (“invasive”) ventilation is a fundamental therapeutic measure to ensure sufficient gas exchange. Despite decades of strong research efforts, central questions on mechanical ventilation therapy are still answered incompletely. Therefore, many different ventilation modes and settings have been used in daily clinical practice without scientifically sound bases. At the same time, implementation of the few evidence-based therapeutic concepts...
Tue Sep 10, 2019 16:51
Publication date: Available online 9 September 2019Source: Behavioural Brain ResearchAuthor(s): Thiago Wendt Viola, Kerstin Creutzberg, Aline Zaparte, Érika Kestering, Saulo Tractenberg, Anderson Centeno-Silva, Rodrigo Orso, Francisco Sindermann Lumertz, Elisa Brietzke, Luis Eduardo Wearick-Silva, Marco Andrea Riva, Rodrigo Grassi-OliveiraAbstractToll-like Receptors (TLRs) are implicated with the pathogenesis of cognitive impairment induced by inflammation. Early life stress is associated with altered...
Tue Sep 10, 2019 17:16
Publication date: Available online 9 September 2019Source: Behavioural Brain ResearchAuthor(s): Bruk Getachew, Yousef TizabiABSTRACTSubstantial data indicate that an imbalance in gut microbiome (GM), also referred to as dysbiosis, may play an important role in depression. Moreover, drugs that normalize GM can result in an antidepressant-like effect. It was reported recently that moxidectin (MOX), an antiparasitic drug commonly used in veterinary medicine, has a positive influence on microbiota implicated...
Tue Sep 10, 2019 17:16
Abstract Purpose In peripheral artery disease, blockage of the blood supply to the limbs leads to blood flow attenuation and tissue ischemia. We investigated whether growth hormone-releasing hormone (GHRH) could enhance the biological functions and therapeutic effects of endothelial progenitor cells (EPCs) derived from adult human peripheral blood (PB). Methods ...
Tue Sep 10, 2019 03:00
Publication date: Available online 10 September 2019Source: Journal of Communication DisordersAuthor(s): Jeff Searl, Stephanie Knollhoff
Tue Sep 10, 2019 16:42
Publication date: Available online 9 September 2019Source: Journal of Surgical EducationAuthor(s): Ruchi M. Thanawala, Jonathan L. Jesneck, Neal E. SeymourObjectiveThe purpose of this study was to determine whether an automated platform for evaluation selection and delivery would increase participation from surgical teaching faculty in submitting resident operative performance evaluations.DesignWe built a HIPAA-compliant, web-based platform to track resident operative assignments and to link embedded...
Tue Sep 10, 2019 16:37
Publication date: Available online 10 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nuray Bayar Muluk, Sameer Ali Bafaqeeh, Cemal CingiAbstractObjectivesTo review the efficacy of anti-IgE therapy in allergic rhinitis (AR).MethodsLiterature search was performed using the PubMed and Proquest Central databases at Kırıkkale University Library.ResultsAlthough the skin prick testing in patients suffering from AR is positive (indicating that antigen-specific Immunoglobulin...
Tue Sep 10, 2019 16:36
Publication date: Available online 10 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Jozef Babala, Petra Zahradníková, Igor Béder, Lenka Fedorová, Martin Lindák, Ľudmila Košťálová, Zuzana Pribilincová, Juraj Staník, Róbert KrálikAbstractIntroductionThyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. the frequency, 2. etiology, and 3. risk factors of post-surgery complications...
Tue Sep 10, 2019 16:36
Related Articles[Expert Workshop COPD: Lungs and Heart - Quite Often Ill Together]. Pneumologie. 2019 Sep 09;: Authors: Jany B, Bals R, Dreher M, Held M, Jany L, Rembert Koczulla A, Pfeifer M, Randerath W, Watz H, Wilkens H, Steinkamp G Abstract When caring for patients with respiratory diseases, always think of the heart! This is especially important for COPD patients, but also for a variety of other disorders of the respiratory system. At the workshop...
Tue Sep 10, 2019 16:36
Related ArticlesSleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives. Nat Sci Sleep. 2019;11:97-111 Authors: Boentert M Abstract Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading to generalized muscle weakness and premature death. Sleep disturbances are extremely common in patients with ALS and substantially add to the burden of disease for both patients and caregivers. Disruption...
Tue Sep 10, 2019 16:36
Abstract Background This retrospective study aimed to compare the surgical outcomes and morbidity of the vascular control technique in robotic myomectomy with the conventional technique. Methods Thirty‐two consecutive patients who underwent robotic myomectomy using laparoscopic vascular clamps in 2017 and 2019 (the practice change cohort) were retrospectively comparted with 32 case‐matched consecutive patients who underwent the conventional robotic myomectomy (the historical cohort). The...
Tue Sep 10, 2019 15:33
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a relatively newly recognized clinical entity that typically presents with predominant mucositis accompanied by variable cutaneous involvement 7-9 days after the onset of prodromal symptoms. There are no evidence-based guidelines for treatment, and current standards of care may include supportive therapy, antibiotics, corticosteroids, and intravenous immunoglobulin .Objective:This...
Tue Sep 10, 2019 15:49
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Hidradenitis suppurativa (HS) is a common inflammatory disorder characterized by recurrent, painful, and malodorous abscesses and nodules predominantly in skin folds. HS is associated with substantial morbidity and poor quality of life. There are no curative therapies, and the only approved biologic drug has variable efficacy and requires high doses, making adjunct treatments crucial. An important risk factor for disease severity is obesity....
Tue Sep 10, 2019 15:49
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