We report here the catalytic triboration of terminal alkynes with B2pin2 (bis(pinacolato)diboron) using readily available Cu(OAc)2 and P n Bu3. Various 1,1,2‐tris(boryl)alkenes, a class of compounds which have been demonstrated to be potential Matrix Metallo‐Proteinase (MMP‐2) inhibitors, are obtained directly in moderate to good yields. The process features mild reaction conditions, broad substrate scope, and good functional group tolerance were observed. This Cu‐catalyzed reaction can be conducted...
Tue Sep 10, 2019 12:24
Chiral sulfones are of great importance in medicinal chemistry and chemical synthesis. Efficient methods for preparing enantiomerically enriched sulfone‐containing molecules can therefore be of significant value; such methods, however, are uncommon. Herein we report the first general palladium‐catalyzed sulfonylation of vinyl cyclic carbonates with sodium sulfinates. A series of enantiomerically enriched tertiary allylic sulfones were synthesized in good yields with excellent enantiomeric ratios....
Tue Sep 10, 2019 11:32
An S‐shaped gas isotherm pattern displays high working capacity in pressure‐swing adsorption cycle, as established in CO2, CH4, acetylene, and CO, for instance. However, to the best of our knowledge, this type of adsorption behavior has not been revealed for NH3 gas. Herein, we design and characterize a hydrogen‐bonded organic framework (HOF) that can adsorb NH3 uniquely in an S‐shape (type IV) fashion. While conventional porous materials mostly with type I NH3 adsorption behavior require relatively...
Tue Sep 10, 2019 11:30
Rubidium lead halides (RbPbX₃), one important class of all‐inorganic metal halide perovskite next to CsPbX₃, are attracting increasing attention for photovoltaic applications. However, limited by its lower Goldschmidt tolerance factor t ~ 0.78, all‐inorganic perovskite rubidium lead bromide (RbPbBr₃) has never been reported. In this work, we theoretically analyzed the crystal structure, X‐ray diffraction (XRD) pattern, and band structure of perovskite phase RbPbBr₃. The results revealed that perovskite...
Tue Sep 10, 2019 11:30
Development of synthetic helical structures undergoing stimuli responsive chirality transformation is important to understand the role of chirality in natural systems. However, controlling the supramolecular chirality in entropically driven assemblies in aqueous media is challenging. To develop stimuli responsive assemblies, we designed and synthesized pyrazine derivative having L‐alanine groups as chiral building block which undergoes self‐assembly in aqueous media to generate helical fibers and...
Tue Sep 10, 2019 11:29
Metal‐organic framework nanoparticles (MOF NPs) have emerged as an important class of materials that display significantly enhanced performance in many applications compared to bulk MOF materials; their synthesis, however, commonly involves a tedious sequence that controls particle size and surface properties in separate steps. Herein, we report a simple strategy to access functional MOF NPs in one pot, using a polyMOF ligand that possesses a polymer block for surface functionalization and a coordination...
Tue Sep 10, 2019 11:29
Future Oncology, Ahead of Print.
Tue Sep 10, 2019 12:02
Future Oncology, Ahead of Print.
Tue Sep 10, 2019 12:02
Future Oncology, Ahead of Print.
Tue Sep 10, 2019 12:02
Presenting a brief discussion video on bronchogenic cancer presenting with metastases in clavicle diagnosed on Xray and MRI in DAMS Medicine Unplugged series.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Tue Sep 10, 2019 20:11
Stem Cells and Development, Ahead of Print.
Mon Sep 09, 2019 10:00
Stem Cells and Development, Ahead of Print.
Mon Sep 09, 2019 10:00
Those with even a rudimentary knowledge of biomedical progress understand how advances in delineating the components of the immune system have led to new means of manipulating it, including vaccines as well as drugs and biologic agents to ameliorate cancer and autoimmune conditions. The importance…
Tue Sep 10, 2019 03:00
Journal of Neurotrauma, Ahead of Print.
Tue Sep 10, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Sep 06, 2019 10:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11213-wLate Middle Pleistocene (LMP) hominin fossils are scarce, limiting reconstruction of human evolution during this key period. Here, the authors use phylogenetic modelling to predict the modern human last common ancestor’s morphology and inform hypotheses of human origins by comparison to LMP fossils.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11690-zA single species of electric eel, Electrophorus electricus, has been described. Here, de Santana et al. show that there are three major lineages of Electrophorus distributed across Greater Amazonia and describe two new species, one with a much stronger electric discharge than was previously known.
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-12098-5The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11934-yOur experience of pain can be affected by our expectations about how much pain we will feel. Here, the authors show that both social information-driven expectations, and those based on personal experience, are both able to modulate pain, but by different neural pathways.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11900-8Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completion of the process.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11952-wComplex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-12149-xSingle photon devices are needed for many future technologies, but resolving the color of single photons in a compact architecture is still a challenge. The authors present a broadband, chip-scale spectrometer for measuring single photon wavelengths from 600 to 2000 nm with no moving parts.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-11989-xIn flowering plants, the CONSTANS (CO) and Nuclear Factor Y (NF-Y) transcription factors connect light perception to floral induction. Here Tokutsu et al. show that in the green alga Chlamydomonas, CO and NF-Y form an analogous complex that can prevent photodamage in response to excess light.
Tue Sep 10, 2019 03:00
Nature Communications, Published online: 10 September 2019; doi:10.1038/s41467-019-12132-6Thick film is preferred for sufficient light absorption and tolerant processing but it easily spoils the charge transport in the all-polymer solar cells. Here Fan et al. reconcile by tuning the film morphology and deliver high efficiency of 10% in 1 cm2 area devices.
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Tue Sep 10, 2019 03:00
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Zewen Song, Zhaomei Yu, Limin Chen, Zhijiao Zhou, Qiong Zou, Yang LiuAbstractMicro-RNAs regulate multiple biological behaviors of cancers, making them potential targets of new cancer therapies. MiR-1181 has been demonstrated to perform oncogenic or tumor-suppressing function in a tissue-dependent way, but its role in hepatocellular carcinoma (HCC) was unclear. Here, we showed that miR-1181 was significantly...
Tue Sep 10, 2019 19:24
Publication date: Available online 9 September 2019Source: BrachytherapyAuthor(s): Leonel Varela Cagetti, Christophe Zemmour, Naji Salem, Mathieu Minsat, Marjorie Ferrè, Hughes Mailleux, Marc Giovaninni, Bernard Lelong, Cecile De Chaisemartin, Pauline Ries, Flora Poizat, Agnès Tallet, Laurence Moureau-ZabottoAbstractPurposeThe purpose of this study was to analyze and compare clinical outcomes of low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy boost (ISBT) after EBRT or radio...
Tue Sep 10, 2019 19:23
Publication date: Available online 10 September 2019Source: Allergology InternationalAuthor(s): Yukinobu Nakagawa, Kaori Odomari, Yorihisa Kotobuki, Eiji Kiyohara, Ichiro Katayama, Manabu Fujimoto
Tue Sep 10, 2019 19:11
Journal Name: Biological ChemistryIssue: Ahead of print
Tue Sep 10, 2019 19:07
Journal Name: Biological ChemistryIssue: Ahead of print
Tue Sep 10, 2019 19:07
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