Sun Sep 01, 2019 20:59
“Sarcomas” in patients with testicular germ cell tumors (GCTs) are a common form of “somatic-type malignancy.” There is support, based on morphology and immunohistochemistry, that many such sarcomatous tumors represent an unusual form of yolk sac tumor (YST). A virtually universal chromosomal anomaly in GCTs is increase in 12p copy number, often in the form of isochromosome 12p [i(12p)], but this aspect of sarcomatoid YSTs has not hitherto been studied. We performed interphase fluorescent in situ...
Fri Aug 30, 2019 03:00
Pericytic tumors comprise a histologic continuum of neoplasms with perivascular myoid differentiation, which includes glomus tumors, myopericytoma, myofibroma, and angioleiomyoma. Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. Moreover, SRF-RELA fusions have been described in a subset of cellular variants of myofibroma and myopericytoma showing...
Fri Aug 30, 2019 03:00
Endometrial carcinosarcoma (ECS) is a rare and aggressive mixed-type epithelial and mesenchymal tumor. This study focused on the histologic appearance, loss of DNA mismatch repair (MMR) protein expression, and aberrant p53 expression in the epithelial component, and overall prognosis of 57 cases with ECS. Histologically, 21 and 36 cases exhibited low-grade (endometrioid grade 1 and 2) and high-grade (others) epithelial components, respectively. In a Kaplan-Meier analysis, patients with a high-grade...
Fri Aug 30, 2019 03:00
Background: Penile inversion vaginoplasty is the most common genital-affirming procedure for transfeminine patients. Patients undergoing this procedure may require revision labiaplasty and clitoroplasty. This study describes complications and outcomes from the largest reported cohort in the United States to undergo penile inversion vaginoplasty with subsequent revision labiaplasty and/or clitoroplasty. Methods: A retrospective chart review was performed of a single surgeon’s experience with...
Fri Aug 30, 2019 03:00
No abstract available
Fri Aug 30, 2019 03:00
Randomized controlled trials (RCTs) are becoming increasingly difficult to organize and conduct efficiently. This, in turn, hinders the ability to derive highest level of evidence. Often investigators forget or remain unaware of essential practices that will help them fulfill their study goals. This manuscript emphasizes the common issues that a study team experiences during the planning and conducting of RCTs. We sought to share remedies to overcome these issues with the experience garnered in conducting...
Fri Aug 30, 2019 03:00
No abstract available
Fri Aug 30, 2019 03:00
Background: Minor cranial sutural synostosis is currently regarded as a rare diagnosis. As clinical awareness grows, a greater number of cases are being documented. This study aims to describe the variants of unicoronal synostosis in regards to major and minor sutural involvement and secondary effects on cranial and orbital morphology. The information is aimed to improve clinical diagnosis and management. Methods: A retrospective study was conducted collecting pre-operative computed tomography...
Fri Aug 30, 2019 03:00
Introduction. Many pathobiological processes that manifest in a patient’s organs could be associated with biomarker levels that are detectable in different human systems. However, biomarkers that promote early disease diagnosis should not be tested only in personalized medicine but also in large-scale diagnostic evaluations of patients, such as for medical management. Objective. We aimed to create an easy algorithmic risk assessment tool that is based on obtainable “everyday” biomarkers, identifying...
Mon Sep 02, 2019 10:05
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