Mon Sep 02, 2019 03:00
Mon Sep 02, 2019 03:00
Mon Sep 02, 2019 03:00
Cancer Informatics, Volume 18, Issue , January-December 2019. Long non-coding RNAs (lncRNAs) are a large and diverse class of transcribed RNAs, which have been shown to play a significant role in developing cancer. In this study, we apply integrative modeling framework to integrate the DNA copy number variation (CNV), lncRNA expression, and downstream target protein expression to predict patient survival in breast cancer. We develop a 3-stage model combining a mechanical model (lncRNA regressed on...
Sat Aug 24, 2019 13:26
Cancer Informatics, Volume 18, Issue , January-December 2019. Metastasis to bone occurs in over 70% of patients with advanced breast cancer resulting in skeletal complications, including pathological fractures, hypercalcaemia, and bone pain. Significant advances have been made in the treatment of bone metastases, including the use of antiresorptive drugs, such as bisphosphonates, as well as antibody-based therapies targeting key signalling intermediates within the process of cancer-mediated bone...
Tue Aug 27, 2019 09:21
Cancer Informatics, Volume 18, Issue , January-December 2019. DNA methylation is an epigenetic event that involves adding a methyl group to the cytosine (C) site, especially the one that pairs with a guanine (G) site (ie, CG or CpG site), in a human genome. This event plays an important role in both cancerous and normal cell development. Previous studies often assume symmetric methylation on both DNA strands. However, asymmetric methylation, or hemimethylation (methylation that occurs only on 1 DNA...
Thu Aug 29, 2019 15:57
Cancer Informatics, Volume 18, Issue , January-December 2019. A cancer of unknown primary (CUP) is a metastatic cancer for which standard diagnostic tests fail to locate the primary cancer. As standard treatments are based on the cancer type, such cases are hard to treat and have very poor prognosis. Using molecular data from the metastatic cancer to predict the primary site can make treatment choice easier and enable targeted therapy. In this article, we first examine the ability to predict cancer...
Sat Aug 31, 2019 08:38
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Local anesthetic injections can be painful and distressing.Objective:The aim of this study was to determine whether nitrous oxide, ice, vibration, or topical anesthetic improves analgesia for local anesthetic injections.Method:A cohort study of 400 patients undergoing Mohs micrographic surgery with local anesthetic was conducted. Patients received no intervention (n = 200), ice (n = 50), topical anesthetic cream (n = 50), vibration...
Mon Aug 12, 2019 12:32
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Rosacea is a chronic, progressive, inflammatory condition phenotypically subtyped into diagnostic features, major features, and minor/secondary features. There is currently no cure for rosacea, and it carries a significant negative psychosocial burden for afflicted patients. While there are a number of treatment modalities at the disposal of the clinician, clinical experience has suggested a need for updated treatments. The pathogenesis of...
Mon Aug 12, 2019 12:33
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Biotin is an essential cofactor for metabolic pathways in humans. It is frequently self-prescribed by consumers and often recommended by dermatologists and primary care physicians, despite limited evidence of its effect on skin, hair, and nail disorders. A recent Food and Drug Administration (FDA) warning stated that biotin can interfere with laboratory tests.Objectives:Our objectives were to determine the perception of biotin...
Wed Aug 14, 2019 08:38
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Treatment of childhood atopic dermatitis (AD) is hindered by nonadherence, but caregiver reassurance may help overcome this hurdle.Objectives:To assess caregivers’ willingness to treat childhood AD with a corticosteroid when presented with clinical trial evidence, anecdote, or both.Methods:A total of 476 caregivers were recruited through a dermatology clinic and online crowdsourcing platform. Subjects were randomized to receive...
Wed Aug 14, 2019 08:39
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Presurgical curettage before nonmelanoma skin cancer surgery may help delineate tumor subclinical extensions.Objective:To determine histologically whether presurgical curettage appropriately or inappropriately changes excision specimen size.Materials and Methods:One hundred fifty consecutive nonmelanoma skin cancers treated with Mohs micrographic surgery. The clinical margin (CM) was marked. Presurgical curettage was then performed...
Sat Aug 17, 2019 12:01
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Melanoma incidence increases with socioeconomic status but the effect of rurality and access to primary care or dermatology on patient outcomes is unclear.Objectives:The objectives of this study were to determine whether access to care, rurality, or socioeconomic status are associated with melanoma stage at presentation and prognosis.Methods:Linked administrative databases from Ontario, Canada, were retrospectively analyzed to...
Thu Aug 29, 2019 08:49
Nature, Published online: 02 September 2019; doi:10.1038/d41586-019-02504-9Alejandra Ortega explains the importance of working efficiently to make time for friends and fun.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11853-yLiquid biopsies are emerging as a useful method for diagnosis and prognosis in cancer. Here, the authors show the prognostic value of monitoring the level of circulating Epstein-barr virus DNA throughout induction chemotherapy and chemo-radiotherapy and its potential utility for risk-adapted individualised therapy in nasopharyngeal carcinomapatients.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11947-7Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of NK development and heterogeneity.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11881-8Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11617-8Reply to ‘Concerns about the feasibility of using “precision guided sterile males” to control insects’
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11914-2Malz et al. show how electromagnetic driving leads to amplification of topological magnon edge states and thus a large steady-state magnon edge current. Their approach should yield experimental signatures of topological magnon edge states and has potential applications in magnon spintronics.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11799-1Drug addiction is a chronic disorder and many sufferers experience relapses even after a period of successful abstinence. Here, the authors reveal a subset of neurons in the rat infralimbic cortex that suppresses relapse into cocaine or alcohol use by responding to drug-omission cues.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11862-xWhether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
Mon Sep 02, 2019 03:00
Nature Communications, Published online: 02 September 2019; doi:10.1038/s41467-019-11825-2Clamping effects in ferroelestastic thin films limits their usefulness for applications such as sensitive mechanical sensors. Here, the authors report on non-local mechanical force induced switching in PbTiO3 thin films by tuning the material to a state of nearly energetically degenerate co-existing domains.
Mon Sep 02, 2019 03:00
Publication date: Available online 2 September 2019Source: Magnetic Resonance ImagingAuthor(s): Yoko Ikoma, Riwa Kishimoto, Yasuhiko Tachibana, Tokuhiko Omatsu, Goro Kasuya, Hirokazu Makishima, Tatsuya Higashi, Takayuki Obata, Hiroshi TsujiAbstractPurposeDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measures changes in the concentration of an administered contrast agent to quantitatively evaluate blood circulation in a tumor or normal tissues. This method uses a pharmacokinetic analysis...
Mon Sep 02, 2019 14:04
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Qiannan Duan, Yuan Hu, Shourong Zheng, Jianchao Lee, Jiayuan Chen, Sifan Bi, Zhaoyi XuAbstractAnalysis on mixture toxicity (Mix-tox) of the multi-chemical space is constantly followed with interest for many researchers. Conventional toxicity tests with time-consuming and costly operations make researchers can only establish some toxicity prediction models aiming to a limited sampling dimension. The rapid development of machine...
Mon Sep 02, 2019 14:15
Related ArticlesConductive hydrogels based on agarose/alginate/chitosan for neural disorder therapy. Carbohydr Polym. 2019 Nov 15;224:115161 Authors: Alizadeh R, Zarrintaj P, Kamrava SK, Bagher Z, Farhadi M, Heidari F, Komeili A, Gutiérrez TJ, Saeb MR Abstract Electroactive scaffolds derived from carbohydrate hydrogels were synthesized, resulting in a large shift in the conductivity of chitosan (CS) from 10-6 S/cm to about 10-3 S/cm, assigned to CS-oligoaniline....
Mon Sep 02, 2019 14:46
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Toxic leukoencephalopathy (TL) is characterized by white matter disease on magnetic resonance imaging (MRI) and evidence of exposure to a neurotoxic agent. We describe a case of cocaine-induced TL in which extensive white matter disease did not preclude full recovery. A 57-year-old man with substance abuse disorder presented with a 5-day history of strange behavior. On admission, he was alert but...
Wed Aug 14, 2019 09:09
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. We report a rare complication of the use of an intrarectal catheter. An 18-year-old female with T-cell acute lymphoblastic leukemia post-matched unrelated donor allogeneic stem cell transplantation (auto-SCT) developed hepatic encephalopathy secondary to hepatic sinusoidal obstructive disease. A fecal management system was used to contain and divert fecal matter in this immobilized patient. Approximately...
Sat Aug 17, 2019 12:06
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Opportunistic infections (OIs) are a significant cause of morbidity and mortality in immunosuppressed patients and may be due to bacteria, virus, protozoa, or fungi. Toxoplasmosis is a common cause of central nervous system infection in human immunodeficiency virus (HIV) patients. Coccidioidomycosis is a relatively common fungal infection that may lead to disseminated disease and fungemia in immune-compromised...
Sat Aug 17, 2019 12:07
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Hypotonic hyponatremia is caused by a serum sodium level of <135 mEq/L in the setting of excess solute loss accompanied by free water retention because of antidiuretic hormone release, subsequent to decreased effective arterial blood volume. Acute hyponatremia can have various neurological manifestations, including drowsiness, lethargy, coma, seizures, respiratory depression, and even death. In...
Sat Aug 17, 2019 12:09
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Leptomeningeal carcinomatosis, leptomeningeal meningitis, or, as referred here, leptomeningeal metastasis (LM), is a rare but frequently fatal complication seen in advanced stage of cancer either locally advanced or after a metastasis of a known primary cancer. We present a rare and uncommon case of leptomeningeal metastases from carcinoma of unknown primary. A 32-year-old female was diagnosed with...
Sat Aug 17, 2019 12:11
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Adrenal myelolipomas (AMLs) are rare benign adrenal tumors, containing adipose and hematopoietic tissue, a result of reticuloendothelial cell metaplasia. Incidence on autopsy has been reported from 0.08% to 0.4%. AMLs are generally considered nonsecretory. The functional aspect of adrenal incidentaloma should be evaluated. In this article, we report a case of a 40-year-old male, who presented with...
Thu Aug 22, 2019 08:21
Journal of International Medical Research, Ahead of Print.
Mon Aug 05, 2019 10:00
Journal of International Medical Research, Ahead of Print.
Mon Aug 05, 2019 10:05
Journal of International Medical Research, Ahead of Print.
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Journal of International Medical Research, Ahead of Print.
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Journal of International Medical Research, Ahead of Print.
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