ABSTRACT Purpose To develop a short educational program about aphasia (SEPA) for family caregivers of people with aphasia and verify its effect in their burden and quality of life. Methods This is a quantitative experimental study. The participants included in the study were family caregivers of people with aphasia. They completed the Zarit interview scale and WHOQOL-Bref instruments pre- and post-intervention. The intervention was a short educational program about aphasia, administered in a group...
Mon Sep 02, 2019 23:02
ABSTRACT This study aimed to measure the effects of a Computer-based Auditory Training Program (CBATP) on an adolescent diagnosed with Autism Spectrum Disorder (ASD) and Central Auditory Processing Disorder (CAPD). This is the case report of a male, 14-year-old adolescent diagnosed with ASD. The individual was submitted to basic audiological evaluation, central auditory processing assessment and hearing electrophysiology (EP), pre- and post-therapeutic intervention. Central auditory processing (CAP)...
Mon Sep 02, 2019 23:02
RESUMO Objetivo Mensurar os níveis de pressão sonora em salas de aula de uma Universidade, bem como verificar a autopercepção do ruído e sua influência nas atividades desempenhadas por alunos e professores universitários. Método Trata-se de um estudo realizado em dez salas de aula do Instituto de Ciências Biológicas e da Saúde da Pontifícia Universidade Católica de Minas Gerais. Participaram do estudo 279 alunos e 20 professores. Alunos e professores responderam a um questionário destinado ao levantamento...
Mon Sep 02, 2019 23:02
RESUMO Objetivo Desenvolver um game sobre saúde e higiene vocal (VoxPedia) e aplicá-lo em adultos, para investigar o conhecimento em cuidados vocais e compreender a autoavaliação vocal dos respondentes. Método Participaram 293 adultos, 204 mulheres e 129 profissionais da voz, convidados através de mídias digitais. Os participantes responderam: 1) Termo de Consentimento Livre e Esclarecido (TCLE); 2) Dados de Identificação; 3) Protocolo do Índice de Desvantagem Vocal (IDV-10); 4) Questionário de...
Mon Sep 02, 2019 23:02
ABSTRACT Purpose This study investigated the effects of two levels of noise on the performance of young students of three educational levels and tested their ability to maintain attentional focus in reading and writing tasks. Methods 162 school children in the third, fourth and fifth grades were placed in three groups according to their educational level: Control Group (CG), Experimental Group A (GEA) and Experimental Group B (GEB). All groups were submitted to a Sustained Attention Test, Reading...
Mon Sep 02, 2019 23:02
The purpose of the study was to implement a cross-validation and adaption of the Vocal Fatigue Index (VFI) in German language.
Mon Sep 02, 2019 03:00
British Journal of Cancer, Published online: 03 September 2019; doi:10.1038/s41416-019-0558-7Evaluating radiological response in pancreatic neuroendocrine tumours treated with sunitinib: comparison of Choi versus RECIST criteria (CRIPNET_ GETNE1504 study)
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Deceased after circulatory death (DCD) donors offer a viable solution to the current organ shortage, particularly the Maastricht Class III (arrest subsequent to cessation of life support in the hospital). Although current results from these donors are very satisfactory, the number of included donors is too low and future expansion of inclusion criteria will likely decrease organ quality, with negative consequences on the complication rate. This donor type thus represents a priority in terms of scientific...
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Abstract Purpose To examine the craniofacial and airway morphology as well as the quality of life before and after passive myofunctional therapy (PMFT) for 1 year in children with obstructive sleep apnea (OSA). Methods Forty children with OSA wearing an oral device nightly (treatment group) and seventeen without the device (control group) were followed up...
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This cross sectional study was conducted to investigate cultural adaption and validation of the Persian version of the PASE among the elderly community dwellers in Iran. Out of 278 elderly people, 65% of them ...
Mon Sep 02, 2019 03:00
Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination. Transcription is also coordinated with co-transcriptional processin...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1289: Targeting DNA Replication Stress and DNA Double-Strand Break Repair for Optimizing SCLC Treatment Cancers doi: 10.3390/cancers11091289 Authors: Xing Bian Wenchu Lin Small cell lung cancer (SCLC), accounting for about 15% of all cases of lung cancer worldwide, is the most lethal form of lung cancer. Despite an initially high response rate of SCLC to standard treatment, almost all patients are invariably relapsed within one year. Effective therapeutic strategies...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1290: Radiation-Induced Thyroid Cancers: Overview of Molecular Signatures Cancers doi: 10.3390/cancers11091290 Authors: Keiji Suzuki Vladimir Saenko Shunichi Yamashita Norisato Mitsutake Enormous amounts of childhood thyroid cancers, mostly childhood papillary thyroid carcinomas (PTCs), after the Chernobyl nuclear power plant accident have revealed a mutual relationship between the radiation exposure and thyroid cancer development. While the internal...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1291: Cancers after Chornobyl: From Epidemiology to Molecular Quantification
Cancers, Vol. 11, Pages 1291: Cancers after Chornobyl: From Epidemiology to Molecular Quantification Cancers doi: 10.3390/cancers11091291 Authors: Dimitry Bazyka Natalya Gudzenko Iryna Dyagil Iryna Ilienko David Belyi Vadim Chumak Anatoly Prysyazhnyuk Elena Bakhanova An overview and new data are presented from cancer studies of the most exposed groups of the population after the Chornobyl accident, performed at the National Research Center for Radiation Medicine...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1293: A Radiogenomic Approach for Decoding Molecular Mechanisms Underlying Tumor Progression in Prostate Cancer Cancers doi: 10.3390/cancers11091293 Authors: Fischer Tahoun Klaan Thierfelder Weber Krause Hakenberg Fuellen Hamed Prostate cancer (PCa) is a genetically heterogeneous cancer entity that causes challenges in pre-treatment clinical evaluation, such as the correct identification of the tumor stage. Conventional clinical...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1292: Cutaneous Metastases in Ovarian Cancer Cancers doi: 10.3390/cancers11091292 Authors: Otsuka Skin metastases in ovarian cancer are uncommon, but their incidence may be increasing due to improved survival rates. Skin metastases can be divided into umbilical metastases, which are known as Sister Joseph nodules (SJNs) and are associated with peritoneal metastasis, and non-SJN skin metastases, which usually develop within surgical scars and in the vicinity of...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1294: The Impact of the Epigenetic Cancer Drug Azacitidine on Host Immunity: The Role of Myelosuppression, Iron Overload and tp53 Mutations in a Zebrafish Model Cancers doi: 10.3390/cancers11091294 Authors: Wang Wu Wu Chen Chang Chang The unsatisfactory real-world efficacy of the hypomethylating agent azacitidine in treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) has prompted us to investigate the hematological adverse...
Mon Sep 02, 2019 03:00
Cancers, Vol. 11, Pages 1295: Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study Cancers doi: 10.3390/cancers11091295 Authors: Young Chang Yuri Cho Jeong-Hoon Lee Yun Bin Lee Eun Ju Cho Su Jong Yu Dong Hyun Sinn Bo Hyun Kim Seoung Hoon Kim Nam-Joon Yi Kwang-Woong Lee Jong Man Kim Joong-Won Park Yoon Jun Kim Jung-Hwan Yoon Jae-Won Joh Kyung-Suk...
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Abstract Objectives This network meta-analysis compares different lasers, placebo, and no treatment in terms of their effects on dentine hypersensitivity (DH) immediately after treatment and over the long term (1 month). Methods A systematic electronic literature search of four databases and a manual search were performed to identify randomized controlled...
Mon Sep 02, 2019 03:00
Abstract Objectives To measure the abutment rotation and fracture load of two-piece zirconia implants screwed with three different abutment screw materials. Material and methods Thirty-six zirconia implants with 36 zirconia abutments were distributed into 3 test groups: group G connected with gold screws, group T with titanium screws, and group P with peek...
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Abstract Purpose To search for the risk factors closely related to cerebral cavernous malformation associated with developmental venous anomaly (CCM-DVA) lesions rupture, laying foundations for the development of reasonable individual treatment plans for patients. Methods In this retrospective study, we collected CCM-DVA patients who met the inclusion criteria...
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Abstract Background and purpose Craniopharyngiomas are benign tumors of central nervous system which are known to affect both adults and children. Despite their benign origin, the recurrence is still one of the main postoperative challenges. The aim of this study was to investigate in retrospect factors related to recurrence of craniopharyngioma in a tertiary center in Riyadh, Saudi Arabia. ...
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01328H, PaperMei-Ling Gao, Bin-Cheng Yin, Bang-Ce YeAs exosomes have been playing an increasingly important role in the diagnosis, treatment and prognosis of diseases, the analysis of exosome contents becomes more crucial. Therefore, a cost-effective and simple...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 02, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01259A, PaperWanwan Ma, Yena An, Kyung Ho RowA protein based molecularly imprinted monolithic column was synthesized based on ionic liquids (ILs) and deep eutectic solvents (DESs) within a stainless-steel column (50 mm × 4.6 mm id). An...The content of this RSS Feed (c) The Royal Society of Chemistry
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The Journal of Antibiotics, Published online: 03 September 2019; doi:10.1038/s41429-019-0231-7Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura
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The Journal of Antibiotics, Published online: 03 September 2019; doi:10.1038/s41429-019-0229-1Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007
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New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 05:40
New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 15:30
New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 15:30
New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 15:34
New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 15:35
New England Journal of Medicine, Ahead of Print.
Sun Sep 01, 2019 15:44
New England Journal of Medicine, Ahead of Print.
Mon Sep 02, 2019 12:00
New England Journal of Medicine, Ahead of Print.
Mon Sep 02, 2019 12:00
Cancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant...
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EYA proteins (EYA1-4) are critical developmental transcriptional cofactors that contain an EYA domain (ED) harboring Tyr phosphatase activity. EYA proteins are largely downregulated after embryogenesis but are reexpressed in cancers, and their Tyr phosphatase activity plays an important role in the DNA damage response and tumor progression. We previously identified a class of small-molecule allosteric inhibitors that specifically inhibit the Tyr phosphatase activity of EYA2. Herein, we determined...
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