Background: Chimeric antigen receptor T-cell (CART) therapy can significantly improve outcomes for patients with certain hematologic malignancies. The most notable drawbacks of CART are cytokine release syndrome and CART-related encephalopathy syndrome. Gastrointestinal adverse events (GI-AEs) have not yet been reported in association with CART. Herein, we describe the incidence and clinical features of GI-AEs observed after CART. Materials and Methods: We report a case series of patients...
Fri Aug 30, 2019 03:00
Primary percutaneous coronary intervention (PCI) is the preferred method of reperfusion for patients with ST-segment elevation myocardial infarction (STEMI). These patients often have multivessel coronary artery disease, with additional angiographically significant lesions in locations separate…
Sun Sep 01, 2019 03:00
According to the American Heart Association, approximately 720,000 persons in the United States will have a first episode of an acute coronary syndrome and approximately 335,000 will have a recurrent coronary event in 2019. Dual antiplatelet therapy (an adenosine diphosphate receptor antagonist and…
Sun Sep 01, 2019 03:00
Patients with both coronary artery disease and type 2 diabetes mellitus are at high risk for cardiovascular events. Platelet-mediated thrombosis is a major mechanism contributing to ischemic events, and the higher risk among patients with diabetes is due in part to increased platelet activation.…
Sun Sep 01, 2019 03:00
Heart failure with preserved ejection fraction is common and is associated with substantial morbidity and mortality. Several physiological mechanisms have been postulated, including myocardial hypertrophy and fibrosis, impaired diastolic compliance and relaxation, subclinical systolic dysfunction,…
Sun Sep 01, 2019 03:00
Mon Sep 02, 2019 09:47
Related ArticlesThe Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease. Mayo Clin Proc. 2019 Aug 28;: Authors: Goyal G, Young JR, Koster MJ, Tobin WO, Vassallo R, Ryu JH, Davidge-Pitts CJ, Hurtado MD, Ravindran A, Sartori Valinotti JC, Bennani NN, Shah MV, Rech KL, Go RS, Mayo Clinic Histiocytosis Working...
Mon Sep 02, 2019 14:20
Related ArticlesEsophageal carcinoma cuniculatum: systematic review of the literature and report of two cases. Pathol Res Pract. 2019 Aug 17;:152602 Authors: Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F Abstract BACKGROUND AND AIMS: Carcinoma cuniculatum (CC) is a rare variant of an extremely well-differentiated squamous cell carcinoma. The most commonly involved site is the skin,...
Mon Sep 02, 2019 14:20
Related ArticlesSalivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes. Head Neck Pathol. 2019 Aug 31;: Authors: Hsieh MS, Bishop JA, Wang YP, Poh CF, Cheng YL, Lee YH, Jin YT, Chang JYF Abstract Papillary salivary gland neoplasms are rare tumors usually arising in the minor salivary glands of the oral cavity. Their classification has been historically confusing due to overlapping histologic...
Mon Sep 02, 2019 14:20
Abstract Objective The characteristics of children with single-sided deafness (SSD) who become candidates for unilateral cochlear implantation (uCI) were identified. Study design In all, 118 children with SSD presenting from 2013–2019 to a tertiary pediatric children’s hospital were retrospectively assessed regarding candidacy for uCI. ...
Mon Sep 02, 2019 03:00
Abstract Background Patients with single-sided deafness (SSD) lack the ability localize sound sources and have difficulty with speech-in-noise hearing. In addition, there is a high prevalence of tinnitus distress. These problems may result in reduced health-related quality of life (HRQoL) and psychological comorbidities. This study aimed to investigate the influence of treatment with a cochlear implant (CI) on HRQoL, tinnitus distress,...
Mon Sep 02, 2019 03:00
Zusammenfassung Hintergrund Patienten mit einseitiger Taubheit („single-sided deafness“, SSD) sind durch ihr asymmetrisches Hören in verschiedenen Bereichen des alltäglichen Lebens beeinträchtigt. Ziel der Arbeit Ziel der Untersuchungen war es, einen alterskorrelierten Vergleich der Hörschwelle des besseren Ohrs von SSD-Patienten mit einer normalhörenden...
Mon Sep 02, 2019 03:00
Publication date: Available online 2 September 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): De-Run Chen, Yao Xiao, Hao Li, Cong-Cong Wu, Lei-Lei Yang, Qi-Chao Yang, Shao-Chen Yang, Jun-Jie Zhou, Zhi-Jun SunAbstractObjectiveThis study aimed to explore the relationship between the expression of the coxsackie-adenovirus receptor (CAR) in oral squamous cell carcinoma (OSCC) and clinicopathological parameters associated with the disease. The diagnostic and prognostic...
Mon Sep 02, 2019 14:11
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Xiaoqian Xie, He Li, Yale Wang, Zhijie Wan, Shasha Luo, Zeyue Zhao, Jingjing Liu, Xiaohan Wu, Xinxin Li, Xiaotian LiAbstractThe purpose of this research was to evaluate the therapeutic effects of gentiopicroside (GPS) on adjuvant-induced arthritis (AA) rats. Rats were injected with complete Freund's adjuvant (CFA) for 0.1 mL in the right hind paw to induce AA. Thirty rats from three groups were treated with...
Mon Sep 02, 2019 14:44
Related ArticlesThe treatment efficacy of nasal polyposis on olfactory functions, clinical scoring systems and inflammation markers. Eur Arch Otorhinolaryngol. 2019 Aug 31;: Authors: Paksoy ZB, Cayonu M, Yucel C, Turhan T Abstract OBJECTIVE: The aim of this study was to investigate the effect of the medical and the surgical treatment on the olfactory functions, clinical scoring systems and inflammation markers in patients with nasal polyposis. In addition,...
Mon Sep 02, 2019 14:46
Related ArticlesThe association of sulcus vocalis and benign vocal cord lesions: intraoperative findings. Eur Arch Otorhinolaryngol. 2019 Aug 31;: Authors: Sünter AV, Kırgezen T, Yiğit Ö, Çakır M Abstract OBJECTIVE: To investigate the presence of sulcus vocalis in patients who underwent phonomicrosurgery due to benign vocal cord lesions. METHODS: Between January 2013 and June 2018, the records of 133 patients who underwent operations for benign...
Mon Sep 02, 2019 14:46
Publication date: Available online 1 September 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Andreas Max Pabst, Sebastian Blatt, Pia Epperlein, Irene Schmidtmann, Maximilian Krüger, Eik Schiegnitz, Elisabeth Goetze, Thomas Ziebart, Bilal Al-NawasSummaryIntermaxillary fixation (IMF) and osteosynthesis plates (OP) are widely used for the non-surgical and surgical treatment of mandible and condyle fractures. The aim of this retrospective study was to analyze the frequency of tooth root...
Mon Sep 02, 2019 14:48
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Meilan Xue, Ying Liu, Hongwei Xu, Zhitong Zhou, Yan Ma, Ting Sun, Man Liu, Huaqi Zhang, Hui LiangAbstractObjective: Diabetes mellitus is associated with gut microbiota disturbance and intestinal mucosal injuries. This study investigated the influence of propolis on the gut microbiota and intestinal mucosa in rats with diabetes. Methods: Sprague-Dawley (SD) rats were randomly assigned to the control group,...
Mon Sep 02, 2019 14:50
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Bing Yan, Suhuan Liu, Xuejun Li, Yali Zhong, Fei Tong, Shuyu YangAbstractThe purpose of this study was to observe the functions of preconditioning with endoplasmic reticulum stress (ERS) whether alleviated heart ischemia/reperfusion injury (HI/RI) via modulating IRE1/ATF6/RACK1/PERK and PGC-1α expressions in diabetes mellitus (DM) or not. Diabetic rats were pretreated with 0.6 mg/kg tunicamycin (TM, 0.6 mg/kg...
Mon Sep 02, 2019 14:50
Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Nannan Li, Feifei Feng, Ke Wu, Huanan Zhang, Wei Zhang, Wei WangAbstractPurposeTo observe the effect of astragaloside ASV (ASV) on silicosis fibroblasts, and further investigate its regulatory mechanism on TGF-β1/Smad3 signaling pathway.MethodsSilica-induced rats model was established in this study. RT-qPCR was performed to detect α-SMA, Collagen I, Collagen III, Smad2, Smad3 and Smad7 expression. Immunofluorescence...
Mon Sep 02, 2019 14:50
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Shearwood McClelland, Gregory A. Durm, Thomas J. Birdas, Paul M. Musto, Tim LautenschlaegerAbstractIntroductionPulmonary large-cell neuroendocrine carcinoma (LCNEC) is a very rare disease, comprising approximately 3% of lung cancers. Even for Stage I disease, recurrence after resection is common, with a poor five-year overall survival. We present the first report of stereotactic...
Mon Sep 02, 2019 16:00
Mon Sep 02, 2019 03:00
Abstract Purpose Several studies have reported an association between hyponatremia and lethality. However, it remains elusive whether hyponatremia independently contributes to lethality. The aim of the study was to investigate associations between hyponatremia and lethality and differences in lethality between men and women hospitalized due to hyponatremia. Methods ...
Mon Sep 02, 2019 03:00
Abstract Purpose Papillary thyroid cancers (PTCs) are the most common type of thyroid cancers, in which BRAFV600E is the most prevalent driver mutation. It is known that BRAFV600E-positive PTCs are clinically and molecularly heterogenous in terms of aggressiveness and prognosis. The molecular mechanisms of this heterogeneity were evaluated. Methods The publicly...
Mon Sep 02, 2019 03:00
Abstract Purpose Evaluate periodontal status of acromegalics through clinical and biochemical variables. Methods Demographics, hormone and metabolic variables, periodontal variables, gingival crevicular fluid (GCF) volume, and content data were collected from 30 patients with acromegaly, 30 patients with periodontitis, and 20 healthy subjects and comparatively...
Mon Sep 02, 2019 03:00
New Findings What is the central question of this study? Research has reported that some sensory input can affect subliminal visual process, such as auditory and olfactory input. However, it is important to address whether tactile input, another form of elementary sensory input, could influence the interocular rivalry process. What is the main finding and its importance? We present several pieces of evidence regarding the influences of familiar tactile shapes and temperature on...
Mon Sep 02, 2019 12:59
New Findings What is the central question of this study? We investigate whether NADPH oxidase activation mediates cardiac sympathetic nerve denervation and dysfunction in heart failure. What is the main findings and its importance? Cardiac sympathetic nerve terminal density and function were reduced in heart failure after myocardial infarction in rabbits. NADPH oxidase inhibitor apocynin prevents the reduction in cardiac sympathetic nerve terminal density and function in heart failure. These...
Mon Sep 02, 2019 13:37
Leprosy is a disease that was declared eliminated in 2010 from Nepal; however, new cases are diagnosed every year. The difficulty arises when the presentation of the patient is unusual.
Sun Sep 01, 2019 03:00
In this article, we present the protocol that is described as high-resolution melting analysis (HRM)-based Target Induced Local Lesions In Genomes (TILLING). This method utilizes fluorescence changes during the melting of the DNA duplex and is suitable for high-throughput screening of both insertion/deletion (Indel) and single base substition (SBS).
Mon Sep 02, 2019 20:22
Key procedures to optimize the sealing process and achieve real-time monitoring of the metal-to-glass seal (MTGS) structure are described in detail. The embedded fiber Bragg grating (FBG) sensor is designed to achieve online monitoring of temperature and high-level residual stress in the MTGS with simultaneous environmental pressure monitoring.
Mon Sep 02, 2019 21:23
Cognate J-domain proteins cooperate with the Hsp70 chaperone to assist in a myriad of biological processes ranging from protein folding to degradation. Here, we describe an in situ proximity ligation assay, which allows the monitoring of these transiently formed chaperone machineries in bacterial, yeast and human cells.
Mon Sep 02, 2019 22:22
RESUMO Objetivo Analisar os efeitos da eletroestimulação sobre o fluxo salivar de pacientes com hipossalivação induzida por radioterapia em região de cabeça e pescoço. Estratégia de pesquisa Utilizaram-se as bases de dados Medline (via Pubmed), Cochrane Library, Scopus e Lilacs. Critérios de seleção Foram selecionados os ensaios clínicos que avaliaram objetivamente o fluxo salivar, publicados nos últimos 10 anos em português, inglês ou espanhol. Análise dos dados Para avaliação metodológica dos...
Mon Sep 02, 2019 23:02
ABSTRACT Purpose to evaluate the efficacy of orofacial myofunctional therapy in improving orofacial function and nasal breathing in patients with asthma and rhinitis and, consequently, achieve clinical control of these conditions. Research strategies We used the elements of the PICOT method (study population, intervention, comparison, outcomes and type of studies) to define the eligibility criteria: (1) Population: patients with asthma and rhinitis; (2) Intervention: orofacial myofunctional therapy...
Mon Sep 02, 2019 23:02
ABSTRACT Purpose To develop a short educational program about aphasia (SEPA) for family caregivers of people with aphasia and verify its effect in their burden and quality of life. Methods This is a quantitative experimental study. The participants included in the study were family caregivers of people with aphasia. They completed the Zarit interview scale and WHOQOL-Bref instruments pre- and post-intervention. The intervention was a short educational program about aphasia, administered in a group...
Mon Sep 02, 2019 23:02
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