Sprache Stimme Gehör 2019; 43: 122-122DOI: 10.1055/a-0895-7582© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: e1-e10DOI: 10.1055/a-0897-6997 Hintergrund Analysen von Sprechstimmprofilen depressiver Kinder weisen spezifische sprechstimmliche Merkmale auf und können einen wichtigen Beitrag zur Diagnostik leisten. Methode Es handelt sich um eine quasiexperimentelle Studie im Querschnittdesign zum Vergleich ausgewählter Faktoren der Sprechstimme depressiver und gesunder Kinder. 2018 wurden zwei Stichproben untersucht und jeweils Sprechstimmprofile erstellt....
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 123-124DOI: 10.1055/a-0881-6698© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 133-138DOI: 10.1055/a-0893-2816© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 124-125DOI: 10.1055/a-0881-6508© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 144-149DOI: 10.1055/a-0893-2964© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 126-127DOI: 10.1055/a-0887-9669© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 154-154DOI: 10.1055/a-0887-9789© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 128-130DOI: 10.1055/a-0887-9776© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Sprache Stimme Gehör 2019; 43: 160-160DOI: 10.1055/a-0887-9682© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
Purpose: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often challenging. We report a noninvasive approach for detection of MSI and TMB-High in the circulation of patients.Patients and Methods: We developed an approach that utilized a hybrid-capture–based 98-kb pan-cancer gene panel, including...
Tue Sep 10, 2019 17:00
Purpose: Cellular immunotherapies are currently being explored to eliminate highly invasive and chemoradioresistant glioblastoma (GBM) cells involved in rapid relapse. We recently showed that concomitant stereotactic injections of non-alloreactive allogeneic V9V2 T lymphocytes eradicate zoledronate-primed human GBM cells. In the present study, we investigated the spontaneous reactivity of allogeneic human V9V2 T lymphocytes toward primary human GBM cells, in vitro and in vivo, in absence of any prior...
Tue Sep 10, 2019 16:19
Purpose: Although extensive-stage small cell lung cancer (SCLC) is highly responsive to first-line therapy, virtually all patients develop resistance with short survival. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate targeting delta-like 3 protein (DLL3). This open-label, single-arm, Phase II study (TRINITY) assessed safety and efficacy of Rova-T in patients with DLL3-expressing SCLC in the third-line and beyond (3L+) setting. Experimental Design: Patients with DLL3-expressing SCLC...
Tue Sep 10, 2019 16:19
Purpose: The 2-part, phase 1/2a, open-label study (NCT01677741) sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced BRAF V600-mutated cancers. Experimental Design: This phase 1 dose-finding part treated patients aged 1 to <18 years with BRAF V600 mutation-positive tumors with oral dabrafenib 3-5.25 mg/kg/day to determine the RP2D based on safety and drug exposure target. Results: Between May 2013 and November...
Tue Sep 10, 2019 16:19
Purpose: Localized radiotherapy (RT) can cause T cell-mediated abscopal effects on non-irradiated metastases, particularly in combination with immune checkpoint blockade (ICB). However, results of prospective clinical trials have not met the expectations. We therefore investigated if additional chemotherapy can enhance RT-induced abscopal effects in conjunction with ICB. Experimental Design: In three different two-tumor mouse models, triple therapy with RT, anti-PD-1, and cisplatin (one of the most...
Tue Sep 10, 2019 16:19
The origin of the genetic code remains enigmatic five decades after it was elucidated, although there is growing evidence that the code co-evolved progressively with the ribosome. A number of primordial codes were proposed as ancestors of the modern genetic code, including comma-free codes such as the RRY, RNY or GNC codes (R = G or A, Y = C or T, N = any nucleotide), and the X circular code, an error-correcting code that also allows identification and maintenance of the reading frame. It was demonstrated...
Tue Sep 10, 2019 20:18
Differential gene isoform expression is a ubiquitous mechanism to enhance proteome diversity and maintain cell homeostasis. Mechanisms such as splicing that drive gene isoform expression changes are highly dynamic and responsive to changes in cell signaling pathways. Wnt/β-catenin signaling has profound effects on cell activity and cell fate and is known to modify several splicing events by altering the expression of individual splicing factors. However, a global assessment of how extensively Wnt...
Tue Sep 10, 2019 19:37
Mon Sep 09, 2019 15:24
Facial plast SurgDOI: 10.1055/s-0039-1695724The objective of the study was to evaluate the clinical safety of endoscopic browlift alone or in combination with blepharoplasty as a treatment for the aging face. This is a retrospective comparative study from 2007 to 2016 at a single tertiary care center. A consecutive sample of patients undergoing surgery for aging of the upper face was included in the study. Surgeries deemed to be inclusive were endoscopic browlift, upper blepharoplasty, and lower...
Tue Sep 10, 2019 02:00
Abstract Objectives To evaluate the expression of brain‐derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and two downstream targets of this pathway, Akt and ribosomal protein S6 (RPS6), in normal oral mucosa (NOM), leukoplakia (OL) and oral squamous cell carcinoma (OSCC), and correlate this expression with OSCC patients' outcomes, cell senescence and “stemness” profile. Materials and methods Ten cases of NOM, 32 OL and 72 primary OSCC were included. Immunohistochemical...
Mon Sep 09, 2019 19:35
Abstract Molecular cross‐talk between the immune system and the nervous system elicit evolutionary responses such as itch (pruritus) to protect the host from potential pathogens 1,2. This neuroimmune, physiological response serves notably to remove pathogens from the skin 1. Pruritus can also be associated with inflammatory disorders such as atopic dermatitis (AD) 3. Indeed, AD is a common skin disease in which IL‐4 and IL‐13 are key players in inflammation and neuroimmune dysfunction.
Tue Sep 10, 2019 21:54
Abstract Systemic sclerosis (SSc) is an autoimmune disease mainly characterized by persistent inflammation and fibrosis. The receptor tyrosine kinase (RTK) signal pathway plays an important role in the process of SSc, and Grb2 associated binding protein (GAB) is crucial in activating RTK signaling. A previous study found elevated levels of GAB1 in bleomycin (BLM)‐induced fibrotic lungs, but the effects of GAB1 in SSc remain unclear. Our aim was to investigate whether GAB1 was dysregulated and its...
Tue Sep 10, 2019 21:48
Abstract Objectives To investigate the in‐vitro diagnostic accuracy of low‐dose cone‐beam computed tomography (LD‐CBCT) for the detection, classification, and measurement of peri‐implant bone lesions. Material and methods Titanium dental implants with all‐ceramic single crowns (n = 24) were inserted into bovine bone. At twelve implants, four types of peri‐implant bone lesions were created. Radiographic imaging was performed using three techniques: LD‐CBCT, high‐definition CBCT (HD‐CBCT),...
Tue Sep 10, 2019 21:54
Transposable Elements (TEs) are mobile elements that contribute the majority of DNA sequences in the maize genome. Due to their repetitive nature, genomic studies of TEs are complicated by the difficulty of properly attributing multi-mapped short reads to specific genomic loci. Here, we utilize a method to attribute RNA-seq reads to TE families rather than particular loci in order to characterize transcript abundance for TE families in the maize genome. We applied this method to assess per-family...
01:17
Platycladus orientalis is an ecologically important native conifer in Northern China and exotic species in many parts of the world; however, knowledge about the species' genetics and genome are very limited. The availability of well-developed battery of genetic markers, with large genome coverage, is a prerequisite for the species genetic dissection of adaptive attributes and efficient selective breeding. Here, we present a genome-wide genotyping method with double-digestion restriction site associated...
01:17
Prostaglandins (PGs) are lipid signaling molecules with numerous physiologic functions, including pain/inflammation, fertility, and cancer. PGs are produced downstream of cyclooxygenase (COX) enzymes, the targets of non-steroidal anti-inflammatory drugs (NSAIDs). In numerous systems, PGs regulate actin cytoskeletal remodeling, however, their mechanisms of action remain largely unknown. To address this deficiency, we undertook a pharmaco-genetic interaction screen during late-stage Drosophila oogenesis....
01:17
Oxytricha trifallax, like other ciliates, has separate germline and somatic nuclei. The diploid germline genome in the micronucleus is composed of long conventional chromosomes, the macronucleus, contains a polyploid somatic genome which is naturally fragmented into thousands of kilobase-sized chromosomes. Here, we develop a method to stably incorporate artificial chromosomes into the macronucleus. We report two cases of successful transformation and demonstrate the use of somatic transformation...
01:17
The ciliate Oxytricha trifallax contains two nuclei: a germline micronucleus and a somatic macronucleus. These two nuclei diverge significantly in genomic structure. The micronucleus contains approximately 100 chromosomes of megabase scale, while the macronucleus contains 16,000 gene-sized, high ploidy "nanochromosomes." During its sexual cycle, a copy of the zygotic germline micronucleus develops into a somatic macronucleus via DNA excision and rearrangement. The rearrangement process is guided...
01:17
Related ArticlesEvaluation of quantitative imaging parameters in head and neck squamous cell carcinoma. Q J Nucl Med Mol Imaging. 2019 Sep 05;: Authors: Gupta T, Chatterjee A, Rangarajan V, Purandare N, Arya S, Murthy V, Budrukkar A, Ghosh-Laskar S, Agarwal JP Abstract BACKGROUND: Functional imaging such as 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT), 18F-fluoro-misonidazole (F-MISO)-PET/CT, and diffusion-weighted...
02:42
Related ArticlesPET imaging of Dopamine Transporter with [18F]LBT-999: initial evaluation in healthy volunteers. Q J Nucl Med Mol Imaging. 2019 Sep 05;: Authors: Arlicot N, Vercouillie J, Malherbe C, Bidault R, Gissot V, Maia S, Barantin L, Cottier JP, Deloye JB, Guilloteau D, Ribeiro MJ Abstract BACKGROUND: To evaluate in healthy human brain the distribution, uptake, and kinetics of [18F]LBT-999, a PET ligand targeting the dopamine transporter, to assess...
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Related ArticlesRole of intravoxel incoherent motion parameters in gastro-esophageal cancer: relationship with 18F-FDG-PET, CT perfusion and MR perfusion imaging parameters. Q J Nucl Med Mol Imaging. 2019 Sep 05;: Authors: Schawkat K, Sah BR, Ter Voert EE, Delso G, Wurnig M, Becker AS, Leibl S, Schneider PM, Reiner CS, Huellner MW, Veithaibach P Abstract BACKGROUND: Identification of pre-therapeutic predictive markers in gastro-esophageal cancer is essential...
02:42
Abstract A week‐long World Vitiligo Day campaign culminates efforts of numerous activists around the world to bring this once forgotten skin disease to the attention of general public, healthcare system and biopharma industry. The campaign international headquarters moves across the globe each year, this year coming to Hanoi, Vietnam. Support for the event is huge and over half a million people from across the world have now signed a petition that asks the UN Secretary General to officially designate...
Tue Sep 10, 2019 19:33
Abstract Cases with multiple molecular diagnoses are challenging to diagnose clinically, yet may be resolved by unbiased exome sequencing analysis. We report an infant with developmental delay, severe growth delay, dysmorphic features, and multiple congenital anomalies including retinal coloboma, congenital pyloric stenosis, and circumferential skin creases. Exome sequencing identified a homozygous missense variant in MAPRE2 and a homozygous stopgain (nonsense) variant in CDON. Variants in MAPRE2,...
Mon Sep 09, 2019 19:52
Horm Metab Res 2019; 51: 586-594DOI: 10.1055/a-0957-3297Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is caused by mutations in the CYP21A2 gene. The study refers to CAH patients of Greek-Cypriot ancestry between years 2007 and 2018. One hundred and twenty patients with various degrees of CAH were categorized and genotyped. The patients were categorized in 4 mutation groups based on their clinical and biochemical findings. The majority of patients (85.0%) belonged...
Tue Sep 10, 2019 02:00
Horm Metab Res 2019; 51: 618-622DOI: 10.1055/a-0975-9268© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Sep 10, 2019 02:00
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